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Author Horinouchi, Hidehito| Murakami, Haruyasu| Harada, Hideyuki| Sobue, Tomotaka| Kato, Tomohiro| Atagi, Shinji| Kozuki, Toshiyuki| Tokito, Takaaki| Oizumi, Satoshi| Seike, Masahiro| Ohashi, Kadoaki| Mio, Tadashi| Sone, Takashi| Iwao, Chikako| Iwane, Takeshi| Koto, Ryo| Tsuboi, Masahiro|
Keywords Non-small cell lung cancer Surgery Adjuvant therapy Neoadjuvant therapy Chemoradiotherapy Observational study Retrospective study
Published Date 2025-01
Publication Title Lung Cancer
Volume volume199
Publisher Elsevier BV
Start Page 108027
ISSN 0169-5002
NCID AA10785743
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 39708388
DOI 10.1016/j.lungcan.2024.108027
Web of Science KeyUT 001394244600001
Related Url isVersionOf https://doi.org/10.1016/j.lungcan.2024.108027
FullText URL fulltext.pdf suppl.xlsx
Author Hughes, Holly R.| Ballinger, Matthew J.| Bao, Yiming| Bejerman, Nicolas| Blasdell, Kim R.| Briese, Thomas| Brignone, Julia| Carrera, Jean Paul| De Coninck, Lander| de Souza, William Marciel| Debat, Humberto| Dietzgen, Ralf G.| Dürrwald, Ralf| Erdin, Mert| Fooks, Anthony R.| Forbes, Kristian M.| Freitas-Astúa, Juliana| Garcia, Jorge B.| Geoghegan, Jemma L.| Grimwood, Rebecca M.| Horie, Masayuki| Hyndman, Timothy H.| Johne, Reimar| Klena, John D.| Kondo, Hideki| Koonin, Eugene V.| Kostygov, Alexei Y.| Krupovic, Mart| Kuhn, Jens H.| Letko, Michael| Li, Jun-Min| Liu, Yiyun| Martin, Maria Laura| Mull, Nathaniel| Nazar, Yael| Nowotny, Norbert| Nunes, Márcio Roberto Teixeira| Økland, Arnfinn Lodden| Rubbenstroth, Dennis| Russell, Brandy J.| Schott, Eric| Seifert, Stephanie| Sen, Carina| Shedroff, Elizabeth| Sironen, Tarja| Smura, Teemu| Tavares, Camila Prestes Dos Santos| Tesh, Robert B.| Tilston, Natasha L.| Tordo, Noël| Vasilakis, Nikos| Walker, Peter J.| Wang, Fei| Whitfield, Anna E.| Whitmer, Shannon L.M.| Wolf, Yuri I.| Xia, Han| Ye, Gong-Yin| Ye, Zhuangxin| Yurchenko, Vyacheslav| Zhao, Mingli|
Published Date 2025-07-25
Publication Title Journal of General Virology
Volume volume106
Issue issue7
Publisher Microbiology Society
Start Page 002112
ISSN 0022-1317
NCID AA00698722
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Microbiology Society
File Version publisher
PubMed ID 40711815
DOI 10.1099/jgv.0.002112
Related Url isVersionOf https://doi.org/10.1099/jgv.0.002112
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Author Kawada, Tatsushi| Katayama, Satoshi| Yanagisawa, Takafumi| Mori, Keiichiro| Fukuokaya, Wataru| Komura, Kazumasa| Tsujino, Takuya| Maenosono, Ryoichi| Takahara, Kiyoshi| Nukaya, Takuhisa| Inoki, Lan| Toyoda, Shingo| Hashimoto, Takeshi| Hirasawa, Yosuke| Edamura, Kohei| Kobayashi, Tomoko| Bekku, Kensuke| Nishimura, Shingo| Iwata, Takehiro| Sadahira, Takuya| Tominaga, Yusuke| Yamanoi, Tomoaki| Yoshinaga, Kasumi| Tsuboi, Kazuma| Kobayashi, Yasuyuki| Takamoto, Atsushi| Kurose, Kyohei| Kimura, Takahiro| Azuma, Haruhito| Shiroki, Ryoichi| Fujita, Kazutoshi| Ohno, Yoshio| Araki, Motoo|
Keywords Renal cell carcinoma Immune checkpoint inhibitor ICI Eosinophil Immune-related adverse event Treatment-related adverse event
Published Date 2025-07-25
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 27163
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40715213
DOI 10.1038/s41598-025-08767-9
Related Url isVersionOf https://doi.org/10.1038/s41598-025-08767-9
FullText URL fulltext.pdf suppl1.pdf suppl2.pdf suppl3.xlsx
Author Nicosia, Michael| Fan, Ran| Lee, Juyeun| All, Gabriella| Gorbacheva, Victoria| Valenzuela, José I.| Yamamoto, Yosuke| Beavers, Ashley| Dvorina, Nina| Baldwin, William M.| Chuluyan, Eduardo| Araki, Motoo| Gaudette, Brian T.| Fairchild, Robert L.| Min, Booki| Valujskikh, Anna|
Published Date 2025-05-13
Publication Title Journal of Clinical Investigation
Volume volume135
Issue issue13
Publisher American Society for Clinical Investigation
Start Page e172988
ISSN 1558-8238
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025, Nicosia et al.
File Version publisher
PubMed ID 40359031
DOI 10.1172/jci172988
Web of Science KeyUT 001530480600007
Related Url isVersionOf https://doi.org/10.1172/jci172988
FullText URL fulltext.pdf suppl.docx
Author Tsuboi, Ichiro| Matsukawa, Akihiro| Parizi, Mehdi Kardoust| Miszczyk, Marcin| Fazekas, Tamás| Schulz, Robert J| Laukhtina, Ekaterina| Kawada, Tatsushi| Katayama, Satoshi| Iwata, Takehiro| Bekku, Kensuke| Rajwa, Pawel| Wada, Koichiro| Oberneder, Katharina| Chlosta, Piotr| Karakiewicz, Pierre I.| Araki, Motoo| Shariat, Shahrokh F.|
Keywords Concomitant medications Proton pump inhibitors Antibiotics steroids Opioids Histamine type-2 receptor antagonists Immune checkpoint inhibitors Urothelial carcinoma
Published Date 2025-04-28
Publication Title BMC Urology
Volume volume25
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 107
ISSN 1471-2490
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40296069
DOI 10.1186/s12894-025-01754-2
Web of Science KeyUT 001478272600002
Related Url isVersionOf https://doi.org/10.1186/s12894-025-01754-2
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Author Nicolussi, Paola| Pilo, Giovannantonio| Cancedda, Maria Giovanna| Peng, Guotao| Chau, Ngoc Do Quyen| De la Cadena, Alejandro| Vanna, Renzo| Samad, Yarjan Abdul| Ahmed, Tanweer| Marcellino, Jeremia| Tedde, Giuseppe| Giro, Linda| Ylmazer, Acelya| Loi, Federica| Carta, Gavina| Secchi, Loredana| Dei Giudici, Silvia| Macciocu, Simona| Polli, Dario| Nishina, Yuta| Ligios, Ciriaco| Cerullo, Giulio| Ferrari, Andrea| Bianco, Alberto| Fadeel, Bengt| Franzoni, Giulia| Delogu, Lucia Gemma|
Keywords 2D materials biocompatibility immune system porcine model toxicity
Published Date 2024-10-10
Publication Title Advanced Healthcare Materials
Volume volume14
Issue issue10
Publisher Wiley
Start Page 2401783
ISSN 2192-2640
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39385652
DOI 10.1002/adhm.202401783
Web of Science KeyUT 001329514700001
Related Url isVersionOf https://doi.org/10.1002/adhm.202401783
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Author Goto, Yukihisa| Kadota, Yasuhiro| Mbengue, Malick| Lewis, Jennifer D| Matsui, Hidenori| Maki, Noriko| Ngou, Bruno Pok Man| Sklenar, Jan| Derbyshire, Paul| Shibata, Arisa| Ichihashi, Yasunori| Guttman, David S| Nakagami, Hirofumi| Suzuki, Takamasa| Menke, Frank L H| Robatzek, Silke| Desveaux, Darrell| Zipfel, Cyril| Shirasu, Ken|
Published Date 2024-10-21
Publication Title The Plant Cell
Volume volume36
Issue issue12
Publisher Oxford University Press (OUP)
Start Page 4932
End Page 4951
ISSN 1040-4651
NCID AA10682070
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 39431742
DOI 10.1093/plcell/koae267
Web of Science KeyUT 001339531100001
Related Url isVersionOf https://doi.org/10.1093/plcell/koae267
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Author Akter, Rojina| Inoue, Yasuhiro| Masumoto, Saori| Mimata, Yoshiharu| Matsuura, Takakazu| Mori, Izumi C.| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Murata, Yoshiyuki| Munemasa, Shintaro|
Keywords calcium signaling CNGC stomata
Published Date 2025-07
Publication Title Physiologia Plantarum
Volume volume177
Issue issue4
Publisher Wiley
Start Page e70396
ISSN 0031-9317
NCID AA00774354
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40635129
DOI 10.1111/ppl.70396
Web of Science KeyUT 001524789000001
Related Url isVersionOf https://doi.org/10.1111/ppl.70396
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Author Liang, Di| Yang, Dongyong| Li, Tai| Zhu, Zhe| Yan, Bingxiao| He, Yang| Li, Xiaoyuan| Zhai, Keran| Liu, Jiyun| Kawano, Yoji| Deng, Yiwen| Wu, Xu Na| Liu, Junzhong| He, Zuhua|
Keywords Prenylated Rab acceptor PigmR Trafficking vesicles OsRab5a Blast resistance
Published Date 2025-03
Publication Title Science Bulletin
Volume volume70
Issue issue5
Publisher Elsevier BV
Start Page 733
End Page 747
ISSN 2095-9273
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 39736493
DOI 10.1016/j.scib.2024.12.007
Related Url isVersionOf https://doi.org/10.1016/j.scib.2024.12.007
FullText URL K0007229_abstract_review.pdf K0007229_fulltext.pdf K0007229_summary.pdf
Author WATANABE, Tomofumi|
Published Date 2025-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7229号
Granted Date 2025-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023 The Authors.
FullText URL K0007207_abstract_review.pdf K0007207_fulltext.pdf K0007207_summary.pdf
Author OTANI, Tomoko|
Published Date 2025-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7207号
Granted Date 2025-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © The Author(s) 2024
FullText URL K0007181_abstract_review.pdf K0007181_fulltext.pdf K0007181_summary.pdf
Author TABUCHI, Motoyasu|
Published Date 2025-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7181号
Granted Date 2025-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2024 The Author(s).
JaLCDOI 10.18926/AMO/68724
FullText URL 79_3_167.pdf
Author Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator|
Abstract This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy.
Keywords non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 167
End Page 176
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574255
Web of Science KeyUT 001524768800003
JaLCDOI 10.18926/AMO/68723
FullText URL 79_3_157.pdf
Author Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori|
Abstract Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.
Keywords advanced glycation end product aging cartilage collagen aggrecan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 157
End Page 166
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574254
Web of Science KeyUT 001524768800002
JaLCDOI 10.18926/AMO/68722
FullText URL 79_3_147.pdf
Author Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun|
Abstract Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 147
End Page 155
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574253
Web of Science KeyUT 001524768800001
FullText URL fulltext.pdf
Author Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara|
Keywords animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin
Published Date 2025-05-01
Publication Title Infection and Immunity
Publisher American Society for Microbiology
ISSN 0019-9567
NCID AA00673732
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Kuriu et al.
File Version publisher
PubMed ID 40310291
DOI 10.1128/iai.00126-25
Web of Science KeyUT 001479415700001
Related Url isVersionOf https://doi.org/10.1128/iai.00126-25
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Author Chen, Yuehua| Ohara, Toshiaki| Hamada, Yusuke| Wang, Yuze| Tian, Miao| Noma, Kazuhiro| Tazawa, Hiroshi| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro|
Keywords Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3|
Published Date 2025-05-09
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue7
Publisher Springer
Start Page 192
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40343532
DOI 10.1007/s00262-025-04067-3
Web of Science KeyUT 001485530100001
Related Url isVersionOf https://doi.org/10.1007/s00262-025-04067-3
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Author Zheng, Yilin| Wang, Ziyi| Weng, Yao| Sitosari, Heriati| He, Yuhan| Zhang, Xiu| Shiotsu, Noriko| Fukuhara, Yoko| Ikegame, Mika| Okamura, Hirohiko|
Keywords Porphyromonas gingivalis Gingipain Macrophage Alternative splicing PD-L1 Immune evasion
Published Date 2025-03-26
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 10462
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40140451
DOI 10.1038/s41598-025-94954-7
Web of Science KeyUT 001454462300033
Related Url isVersionOf https://doi.org/10.1038/s41598-025-94954-7
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Author Matsumoto, Kazuya| Matsumoto, Yoshinori| Wada, Jun|
Keywords PARylation cancer post-transcriptional regulation ubiquitylation immune system
Published Date 2025-03-11
Publication Title Frontiers in Immunology
Volume volume16
Publisher Frontiers Media
Start Page 1537615
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Matsumoto, Matsumoto and Wada.
File Version publisher
PubMed ID 40134437
DOI 10.3389/fimmu.2025.1537615
Web of Science KeyUT 001450818200001
Related Url isVersionOf https://doi.org/10.3389/fimmu.2025.1537615
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Author Hongo, Takashi| Yumoto, Tetsuya| Naito, Hiromichi| Hiraoka, Tomohiro| Murakami, Yuya| Obara, Takafumi| Nojima, Tsuyoshi| Aokage, Toshiyuki| Nakao, Atsunori|
Keywords brain injury carbon monoxide carboxyhemoglobin cardiac arrest resuscitation
Published Date 2025-03-23
Publication Title Acute Medicine & Surgery
Volume volume12
Issue issue1
Publisher Wiley
Start Page e70053
ISSN 2052-8817
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40130086
DOI 10.1002/ams2.70053
Web of Science KeyUT 001450042700001
Related Url isVersionOf https://doi.org/10.1002/ams2.70053