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JaLCDOI 10.18926/AMO/68723
FullText URL 79_3_157.pdf
Author Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori|
Abstract Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.
Keywords advanced glycation end product aging cartilage collagen aggrecan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 157
End Page 166
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/68722
FullText URL 79_3_147.pdf
Author Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun|
Abstract Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 147
End Page 155
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara|
Keywords animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin
Published Date 2025-05-01
Publication Title Infection and Immunity
Publisher American Society for Microbiology
ISSN 0019-9567
NCID AA00673732
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Kuriu et al.
File Version publisher
PubMed ID 40310291
DOI 10.1128/iai.00126-25
Web of Science KeyUT 001479415700001
Related Url isVersionOf https://doi.org/10.1128/iai.00126-25
FullText URL fulltext.pdf
Author Chen, Yuehua| Ohara, Toshiaki| Hamada, Yusuke| Wang, Yuze| Tian, Miao| Noma, Kazuhiro| Tazawa, Hiroshi| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro|
Keywords Colorectal cancer Microsatellite stable Hypoxia-inducible factor Immune checkpoint inhibitors
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04067-3|
Published Date 2025-05-09
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue7
Publisher Springer
Start Page 192
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40343532
DOI 10.1007/s00262-025-04067-3
Web of Science KeyUT 001485530100001
Related Url isVersionOf https://doi.org/10.1007/s00262-025-04067-3
FullText URL fulltext.pdf
Author Zheng, Yilin| Wang, Ziyi| Weng, Yao| Sitosari, Heriati| He, Yuhan| Zhang, Xiu| Shiotsu, Noriko| Fukuhara, Yoko| Ikegame, Mika| Okamura, Hirohiko|
Keywords Porphyromonas gingivalis Gingipain Macrophage Alternative splicing PD-L1 Immune evasion
Published Date 2025-03-26
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 10462
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40140451
DOI 10.1038/s41598-025-94954-7
Web of Science KeyUT 001454462300033
Related Url isVersionOf https://doi.org/10.1038/s41598-025-94954-7
FullText URL fulltext.pdf
Author Matsumoto, Kazuya| Matsumoto, Yoshinori| Wada, Jun|
Keywords PARylation cancer post-transcriptional regulation ubiquitylation immune system
Published Date 2025-03-11
Publication Title Frontiers in Immunology
Volume volume16
Publisher Frontiers Media
Start Page 1537615
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Matsumoto, Matsumoto and Wada.
File Version publisher
PubMed ID 40134437
DOI 10.3389/fimmu.2025.1537615
Web of Science KeyUT 001450818200001
Related Url isVersionOf https://doi.org/10.3389/fimmu.2025.1537615
FullText URL fulltext.pdf
Author Hongo, Takashi| Yumoto, Tetsuya| Naito, Hiromichi| Hiraoka, Tomohiro| Murakami, Yuya| Obara, Takafumi| Nojima, Tsuyoshi| Aokage, Toshiyuki| Nakao, Atsunori|
Keywords brain injury carbon monoxide carboxyhemoglobin cardiac arrest resuscitation
Published Date 2025-03-23
Publication Title Acute Medicine & Surgery
Volume volume12
Issue issue1
Publisher Wiley
Start Page e70053
ISSN 2052-8817
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40130086
DOI 10.1002/ams2.70053
Web of Science KeyUT 001450042700001
Related Url isVersionOf https://doi.org/10.1002/ams2.70053
Author Ninomiya, Toshifumi| Kemmotsu, Naoya| Mukohara, Fumiaki| Magari, Masaki| Miyamoto, Ai| Ueda, Youki| Ishino, Takamasa| Nagasaki, Joji| Fujiwara, Tomohiro| Yamamoto, Hidetaka| Hayashi, Hidetoshi| Tachibana, Kota| Ishida, Joji| Otani, Yoshihiro| Tanaka, Shota| Toyooka, Shinichi| Okamoto, Isamu| Togashi, Yosuke|
Note This is an Accepted Manuscript of an article published by American Association for Cancer Research (AACR).| This fulltext file will be available in Mar. 2026.|
Published Date 2025-03-14
Publication Title Cancer Research
Volume volume85
Issue issue6
Publisher American Association for Cancer Research (AACR)
Start Page 1082
End Page 1096
ISSN 0008-5472
NCID AA00598557
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2025 American Association for Cancer Research
File Version author
PubMed ID 39804971
DOI 10.1158/0008-5472.can-24-2274
Web of Science KeyUT 001444866400013
Related Url isVersionOf https://doi.org/10.1158/0008-5472.can-24-2274
Author Hagiya, Hideharu| Fujita, Yasushi| Kiguchi, Takashi| Manabe, Yohei|
Keywords COVID-19 Immunization Reimbursement Healthcare workers Financial support
Note © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2026.|
Published Date 2025-03
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue3
Publisher Elsevier BV
Start Page 102660
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 39956368
DOI 10.1016/j.jiac.2025.102660
Web of Science KeyUT 001428904200001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2025.102660
JaLCDOI 10.18926/AMO/68362
FullText URL 79_1_051.pdf
Author Miura, Taro| Kawasaki, Yoichi| Hamano, Hirofumi| Zamami, Yoshito| Sendo, Toshiaki|
Abstract Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected in human serum. Here, we investigated the histamine-producing effects in HMC-1 cells and the inflammatory cytokine release effects in RAW264 cells for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; and 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All four promoted histamine production in HMC-1 cells; however, they did not significantly affect the release of inflammatory cytokines in RAW264 cells. These findings suggest that these four photoinitiators induce inflammatory cytokine-independent histamine production, potentially contributing to histamine-mediated chronic inflammation in vitro.
Keywords photoinitiator ink injection histamine inflammation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 51
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012160
Web of Science KeyUT 001440463800007
JaLCDOI 10.18926/AMO/68353
FullText URL 79_1_001.pdf
Author Thiha, Moe| Hikita, Takao| Nakayama, Masanori|
Abstract Endothelial cell polarity is fundamental to the organization and function of blood vessels, influencing processes such as angiogenesis, vascular stability, and response to shear stress. This review elaborates on the molecular mechanisms that regulate endothelial cell polarity, focusing on key players like the PAR polarity complex and Rho family GTPases. These pathways coordinate the front–rear, apical–basal and planar polarity of endothelial cells, which are essential for the proper formation and maintenance of vascular structures. In health, endothelial polarity ensures not only the orderly development of blood vessels, with tip cells adopting distinct polarities during angiogenesis, but also ensures proper vascular integrity and function. In disease states, however, disruptions in polarity contribute to pathologies such as coronary artery disease, where altered planar polarity exacerbates atherosclerosis, and cancer, where disrupted polarity in tumor vasculature leads to abnormal vessel growth and function. Understanding cell polarity and its disruption is fundamental not only to comprehending how cells interact with their microenvironment and organize themselves into complex, organ-specific tissues but also to developing novel, targeted, and therapeutic strategies for a range of diseases, from cardiovascular disorders to malignancies, ultimately improving patient outcomes.
Keywords blood vessel endothelial cell cell polarity atherosclerosis cancer
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-02
Volume volume79
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 7
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40012154
Web of Science KeyUT 001440463800001
FullText URL fulltext20250213-02.pdf suppl20250213-02.pdf
Author Mukohara, Fumiaki| Iwata, Kazuma| Ishino, Takamasa| Inozume, Takashi| Nagasaki, Joji| Ueda, Youki| Suzawa, Ken| Ueno, Toshihide| Ikeda, Hideki| Kawase, Katsushige| Saeki, Yuka| Kawashima, Shusuke| Yamashita, Kazuo| Kawahara, Yu| Nakamura, Yasuhiro| Honobe-Tabuchi, Akiko| Watanabe, Hiroko| Dansako, Hiromichi| Kawamura, Tatsuyoshi| Suzuki, Yutaka| Honda, Hiroaki| Mano, Hiroyuki| Toyooka, Shinichi| Kawazu, Masahito| Togashi, Yosuke|
Keywords cancer immunology somatic mutation T cell tumor-infiltrating lymphocytes
Note This is an Accepted Manuscript of an article published by Proceedings of the National Academy of Sciences.| This fulltext file will be available in Feb. 2025.|
Published Date 2024-08-21
Publication Title Proceedings of the National Academy of Sciences
Volume volume121
Issue issue35
Publisher Proceedings of the National Academy of Sciences
Start Page e2320189121
ISSN 0027-8424
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 the Author(s).
File Version author
PubMed ID 39167601
DOI 10.1073/pnas.2320189121
Web of Science KeyUT 001408603100001
Related Url isVersionOf https://doi.org/10.1073/pnas.2320189121
Title Alternative Precision Medicine for Patients with Renal Cell Carcinoma Based on Drug-metabolizing Enzyme Expression Levels
FullText URL fulltext.pdf
Author Matsumoto, Jun|
Keywords renal cell carcinoma (RCC) kidney CYP uridine diphosphate glucose (UDP)-glucuronosyltransferase metabolism
Published Date 2025-01-01
Publication Title YAKUGAKU ZASSHI
Volume volume145
Issue issue1
Publisher Pharmaceutical Society of Japan
Start Page 7
End Page 14
ISSN 0031-6903
NCID AN00284903
Content Type Journal Article
language Japanese
OAI-PMH Set 岡山大学
Copyright Holders © 2025 公益社団法人日本薬学会
File Version publisher
PubMed ID 39756928
DOI 10.1248/yakushi.24-00166
Web of Science KeyUT 001392549800002
Related Url isVersionOf https://doi.org/10.1248/yakushi.24-00166
FullText URL fulltext.pdf
Author Kuribayashi, Tadahiro| Kinoshita, Rie| Ninomiya, Kiichiro| Makimoto, Go| Kubo, Toshio| Rai, Kammei| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| Toyooka, Shinichi| Sakaguchi, Masakiyo| Ohashi, Kadoaki|
Keywords S100A8/A9 Lung cancer Immune checkpoint inhibitors
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-025-87232-z|
Published Date 2025-01-20
Publication Title Scientific Reports
Volume volume15
Issue issue1
Publisher Nature Portfolio
Start Page 2577
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 39833332
DOI 10.1038/s41598-025-87232-z
Web of Science KeyUT 001400880600002
Related Url isVersionOf https://doi.org/10.1038/s41598-025-87232-z
FullText URL fulltext.pdf
Author Tsuji, Kenji| Uchida, Naruhiko| Nakanoh, Hiroyuki| Fukushima, Kazuhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun|
Keywords gut-kidney axis chronic kidney disease uremic toxin dysbiosis gut microbiota
Published Date 2024-12-25
Publication Title Diagnostics
Volume volume15
Issue issue1
Publisher MDPI
Start Page 21
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 39795549
DOI 10.3390/diagnostics15010021
Web of Science KeyUT 001393962400001
Related Url isVersionOf https://doi.org/10.3390/diagnostics15010021
FullText URL fulltext.pdf
Author Watanabe, Mayu| Eguchi, Jun| Takamoto, Atsushi| Kanzaki, Hiromitsu| Noda, Yohei| Kagawa, Syunsuke| Wada, Jun|
Keywords anti-PD1 immune checkpoint inhibitors insulin secretory capacity cancer prognosis insulin secretion glucose metabolism markers
Published Date 2024-12-11
Publication Title Frontiers in Endocrinology
Volume volume15
Publisher Frontiers Media
Start Page 1439705
ISSN 1664-2392
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Watanabe, Eguchi, Takamoto, Kanzaki, Noda, Kagawa and Wada.
File Version publisher
PubMed ID 39722806
DOI 10.3389/fendo.2024.1439705
Web of Science KeyUT 001382975000001
Related Url isVersionOf https://doi.org/10.3389/fendo.2024.1439705
FullText URL fulltext.pdf
Author Vo, Quan Duy| Nakamura, Kazufumi| Saito, Yukihiro| Iida, Toshihiro| Yoshida, Masashi| Amioka, Naofumi| Akagi, Satoshi| Miyoshi, Toru| Yuasa, Shinsuke|
Keywords sinoatrial node HCN channels induced pluripotent stem cell
Published Date 2024-12-11
Publication Title Cells
Volume volume13
Issue issue24
Publisher MDPI
Start Page 2045
ISSN 2073-4409
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 39768137
DOI 10.3390/cells13242045
Web of Science KeyUT 001383802800001
Related Url isVersionOf https://doi.org/10.3390/cells13242045
FullText URL fulltext.pdf
Author Wang, Kuanyu| Mitoh, Yoshihiro| Horie, Kengo| Yoshida, Ryusuke|
Keywords bioinformatics Ccn3 Type III taste cell
Published Date 2024-12-22
Publication Title Journal of Neurochemistry
Volume volume169
Issue issue1
Publisher Wiley
Start Page e16291
ISSN 0022-3042
NCID AA00703243
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39709613
DOI 10.1111/jnc.16291
Web of Science KeyUT 001381431100001
Related Url isVersionOf https://doi.org/10.1111/jnc.16291
Author Shimbe, Madoka| Otsuka, Yuki| Hagiya, Hideharu| Yamada, Yoichi| Otsuka, Fumio|
Keywords Cervical cancer Human Papillomavirus Immunization Vaccine literacy
Note © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2026.|
Published Date 2024-11-05
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue2
Publisher Elsevier
Start Page 102554
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 39510445
DOI 10.1016/j.jiac.2024.11.004
Web of Science KeyUT 001416618400001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2024.11.004
FullText URL fulltext.pdf
Author Matsuo, Toshihiko| Ogata, Takeshi| Waki, Takahiro| Tanaka, Takehiro| Tachibana, Kota| Fuji, Tomokazu| Adachi, Takuya| Yamasaki, Osamu|
Keywords Ocular surface Conjunctiva Malignant melanoma Proton beam therapy Nivolumab PD-1 inhibitor Immune checkpoint inhibitor
Published Date 2025-01
Publication Title Journal of Medical Cases
Volume volume16
Issue issue1
Publisher Elmer Press, Inc.
Start Page 28
End Page 36
ISSN 1923-4155
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders (c) 2024 Journal of Medical Cases
File Version publisher
PubMed ID 39759165
DOI 10.14740/jmc4351
Web of Science KeyUT 001406943500006
Related Url isVersionOf https://doi.org/10.14740/jmc4351