result 945 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Onishi, Takahisa| Sada, Ken-Ei| Hayashi, Keigo| Miyawaki, Yoshia| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Yajima, Nobuyuki| Kida, Takashi| Matsuo, Yusuke| Nishimura, Keisuke| Yamane, Takashi| |
| Keywords | Systemic lupus erythematosus Pneumocystis jirovecii pneumonia Glucocorticoid Immunosuppressant Practice pattern |
| Note | The version of record of this article, first published in Arthritis Research & Therapy, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13075-024-03434-2| |
| Published Date | 2024-11-12 |
| Publication Title | Arthritis Research & Therapy |
| Volume | volume26 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 198 |
| ISSN | 1478-6354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39533345 |
| DOI | 10.1186/s13075-024-03434-2 |
| Web of Science KeyUT | 001354057800004 |
| Related Url | isVersionOf https://doi.org/10.1186/s13075-024-03434-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Yu| Miyawaki, Yoshia| Shidahara, Kenta| Nawachi, Shoichi| Asano, Yosuke| Katsuyama, Eri| Katsuyama, Takayuki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Oguro, Nao| Yajima, Nobuyuki| Ishikawa, Yuichi| Sakurai, Natsuki| Hidekawa, Chiharu| Yoshimi, Ryusuke| Ohno, Shigeru| Ichikawa, Takanori| Kishida, Dai| Shimojima, Yasuhiro| Sada, Ken-Ei| Wada, Jun| Thom, David H.| Kurita, Noriaki| |
| Keywords | Systemic lupus erythematosus Patient-physician relationship Outpatient visits Patient trust Discontinuity of care |
| Note | The version of record of this article, first published in Arthritis Research & Therapy, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13075-024-03428-0| |
| Published Date | 2024-11-11 |
| Publication Title | Arthritis Research & Therapy |
| Volume | volume26 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 195 |
| ISSN | 1478-6354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39529181 |
| DOI | 10.1186/s13075-024-03428-0 |
| Web of Science KeyUT | 001352382300001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13075-024-03428-0 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtani, Tomoko| Kuroda, Shinji| Kanaya, Nobuhiko| Kakiuchi, Yoshihiko| Kumon, Kento| Hashimoto, Masashi| Yagi, Chiaki| Sugimoto, Ryoma| Kikuchi, Satoru| Kagawa, Shunsuke| Tazawa, Hiroshi| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | Oncolytic adenovirus p53 Dendritic cells Anti-tumor immunity Exosome |
| Note | The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-024-03849-5| |
| Published Date | 2024-11-05 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 12 |
| ISSN | 1432-0851 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39499326 |
| DOI | 10.1007/s00262-024-03849-5 |
| Web of Science KeyUT | 001350703400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00262-024-03849-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuura, Hiroaki| Makimoto, Go| Oda, Naohiro| Ninomiya, Kiichiro| Higo, Hisao| Fujii, Masanori| Rai, Kammei| Ichihara, Eiki| Ohashi, Kadoaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| |
| Keywords | NUT carcinoma BRD4-NUTM1 lung cancer alpha-fetoprotein (AFP) immune checkpoint inhibitor |
| Published Date | 2024-10-01 |
| Publication Title | Internal Medicine |
| Volume | volume63 |
| Issue | issue19 |
| Publisher | Japanese Society of Internal Medicine |
| Start Page | 2655 |
| End Page | 2660 |
| ISSN | 0918-2918 |
| NCID | AA10827774 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 38403772 |
| DOI | 10.2169/internalmedicine.2938-23 |
| Web of Science KeyUT | 001344217900013 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.2938-23 |
| FullText URL | fulltext.pdf correction.pdf |
|---|---|
| Author | Obayashi, Yuka| Hirata, Shoichiro| Kono, Yoshiyasu| Abe, Makoto| Miyahara, Koji| Nakagawa, Masahiro| Ishida, Michihiro| Choda, Yasuhiro| Hamada, Kenta| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Otsuka, Motoyuki| |
| Note | The version of record of this article, first published in Drugs - Real World Outcomes, is available online at Publisher’s website: http://dx.doi.org/10.1007/s40801-024-00460-z| |
| Published Date | 2024-10-19 |
| Publication Title | Drugs - Real World Outcomes |
| Volume | volume11 |
| Issue | issue4 |
| Publisher | Springer Nature |
| Start Page | 557 |
| End Page | 564 |
| ISSN | 2199-1154 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39425893 |
| DOI | 10.1007/s40801-024-00460-z |
| Web of Science KeyUT | 001337505400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s40801-024-00460-z |
| JaLCDOI | 10.18926/AMO/67665 |
|---|---|
| FullText URL | 78_5_407.pdf |
| Author | Shimoyama, Kyoko| Nakajima, Atsushi| Minari, Yoshimitsu| |
| Abstract | Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but they have been known to cause immune-related adverse events (irAEs) by promoting T-cell activation. Neurological irAEs are rare (1%) but have a high fatality rate (11.5%). Here we report the first case of Bickerstaff brainstem encephalitis (BBE) induced by an ICI. A woman in her 60s with metastatic breast cancer was treated with atezolizumab plus nab-paclitaxel once intravenously. Eighteen days later, she lost consciousness with ophthalmoplegia and was diagnosed with a neurological irAE. She recovered consciousness immediately with the administration of intravenous immunoglobulin (IVIG) but suffered severe permanent peripheral neuropathy. Although it is just one case, this experience shows that BBE occurring as a neurological irAE of ICI cancer treatment may be associated with more severe outcomes than conventional BBE in metastatic cancer. Creating a system for multidisciplinary treatment is essential for ICI therapy. |
| Keywords | Bickerstaff brainstem encephalitis immune checkpoint inhibitor atezolizumab neurological immune-related adverse event breast cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-10 |
| Volume | volume78 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39467659 |
| Web of Science KeyUT | 001343346400007 |
| JaLCDOI | 10.18926/AMO/67656 |
|---|---|
| FullText URL | 78_5_363.pdf |
| Author | Takanaga, Satoe| Matsumoto, Naomi| Kadowaki, Tomoka| Takao, Soshi| Yorifuji, Takashi| |
| Abstract | Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD. |
| Keywords | Kawasaki disease (KD) small for gestational age (SGA) cohort epidemiology |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-10 |
| Volume | volume78 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39467654 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Bekku, Kensuke| Kawada, Tatsushi| Yanagisawa, Takafumi| Karakiewicz, Pierre I.| Shariat, Shahrokh F.| |
| Keywords | lymph node dissection lymph node metastasis lymphadenectomy lymphadenopathy Renal cell carcinoma |
| Published Date | 2023-07 |
| Publication Title | Current Opinion in Urology |
| Volume | volume33 |
| Issue | issue4 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Start Page | 294 |
| End Page | 301 |
| ISSN | 0963-0643 |
| NCID | AA10867655 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 37014778 |
| DOI | 10.1097/mou.0000000000001095 |
| Web of Science KeyUT | 001002602200008 |
| Related Url | isVersionOf https://doi.org/10.1097/mou.0000000000001095 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hemelda, Niarsi Merry| Bao, Jiyuan| Watanabe, Megumi| Matsui, Hidenori| Toyoda, Kazuhiro| Ichinose, Yuki| Noutoshi, Yoshiteru| |
| Keywords | Commensal bacteria Nutrient requirements Organic acids Plant-microbe interactions Rhizosphere Sugars |
| Published Date | 2024-08-24 |
| Publication Title | Plant And Cell Physiology |
| Volume | volume65 |
| Issue | issue11 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 1769 |
| End Page | 1786 |
| ISSN | 0032-0781 |
| NCID | AA0077511X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39185583 |
| DOI | 10.1093/pcp/pcae091 |
| Web of Science KeyUT | 001313907100001 |
| Related Url | isVersionOf https://doi.org/10.1093/pcp/pcae091 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ono-Minagi, Hitomi| Nohno, Tsutomu| Takabatake, Kiyofumi| Tanaka, Takehiro| Katsuyama, Takayuki| Miyawaki, Kohta| Wada, Jun| Ibaragi, Soichiro| Iida, Seiji| Yoshino, Tadashi| Nagatsuka, Hitoshi| Sakai, Takayoshi| Ohuchi, Hideyo| |
| Keywords | Autoimmune disease Xerostomia Multiplex immunostaining Spatial analysis Autophagy |
| Note | The version of record of this article, first published in BMC Oral Health, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12903-024-04869-4| |
| Published Date | 2024-09-16 |
| Publication Title | BMC Oral Health |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 1099 |
| ISSN | 1472-6831 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 39285388 |
| DOI | 10.1186/s12903-024-04869-4 |
| Web of Science KeyUT | 001314744100005 |
| Related Url | isVersionOf https://doi.org/10.1186/s12903-024-04869-4 |
| Title Alternative | A case of immune checkpoint inhibitor-associated colitis treated with infliximab |
|---|---|
| Author | Iwamuro, Masaya| Hiraoka, Sakiko| Otsuka, Motoyuki| |
| Abstract | A 52-year-old Japanese man diagnosed with non-small cell lung cancer initiated chemotherapy with tremelimumab, durvalumab, nanoparticle albumin-bound paclitaxel, and carboplatin. On the fourth day of the first treatment course, he developed a fever, followed by watery diarrhea exceeding 10 episodes per day and bloody stools the next day. Immunotherapy-related adverse event colitis was diagnosed through CT scans and colonoscopy examinations. Despite the ineffectiveness of systemic steroid administration, prompt alleviation of symptoms was achieved through the administration of infliximab. In our case, the patient developed Grade 3 diarrhea, prompting the initiation of intravenous prednisolone at 80mg/day in accordance with guidelines. However, symptom improvement was not attained. In situations where symptoms persist beyond three days despite systemic steroid administration, the consideration of adjunctive infliximab use at a dosage of 5mg/kg becomes necessary. |
| Keywords | インフリキシマブ（infliximab） 免疫関連有害事象（immune-related adverse events） 大腸炎（colitis） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-08-01 |
| Volume | volume136 |
| Issue | issue2 |
| Start Page | 69 |
| End Page | 73 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.69 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.69 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sumi, Tomonari| Harada, Kouji| |
| Keywords | post-acute sequelae of SARS-CoV-2 infection PASC long Covid persistent viruses vaccine antiviral drug mathematical model immune response |
| Published Date | 2024-08-09 |
| Publication Title | Frontiers in Immunology |
| Volume | volume15 |
| Publisher | Frontiers Media |
| Start Page | 1329162 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Sumi and Harada. |
| File Version | publisher |
| PubMed ID | 39185419 |
| DOI | 10.3389/fimmu.2024.1329162 |
| Web of Science KeyUT | 001295899400001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2024.1329162 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujimoto, Takuya| Yamasaki, Osamu| Kanehira, Noriyuki| Matsushita, Hirokazu| Sakurai, Yoshinori| Kenmotsu, Naoya| Mizuta, Ryo| Kondo, Natsuko| Takata, Takushi| Kitamatsu, Mizuki| Igawa, Kazuyo| Fujimura, Atsushi| Otani, Yoshihiro| Shirakawa, Makoto| Shigeyasu, Kunitoshi| Teraishi, Fuminori| Togashi, Yosuke| Suzuki, Minoru| Fujiwara, Toshiyoshi| Michiue, Hiroyuki| |
| Keywords | abscopal effect advanced melanoma boron neutron capture therapy boron-neutron immunotherapy immune combination therapy |
| Published Date | 2024-08-09 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 3231 |
| End Page | 3247 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39119813 |
| DOI | 10.1111/cas.16298 |
| Web of Science KeyUT | 001287521700001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16298 |
| FullText URL | fulltext20240820-02.pdf fig20240820-02.pdf table20240820-02.pdf suppl_fig20240820-02.pdf suppl_table20240820-02.pdf |
|---|---|
| Author | Matsumoto, Naomi| Sasaki, Ayako| Kadowaki, Tomoka| Mitsuhashi, Toshiharu| Takao, Soshi| Yorifuji, Takashi| |
| Keywords | SARS-CoV-2 Vaccine Antibody Mixed-effects model Omicron |
| Note | © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2025.| |
| Published Date | 2024-08 |
| Publication Title | Vaccine |
| Volume | volume42 |
| Issue | issue21 |
| Publisher | Elsevier BV |
| Start Page | 126156 |
| ISSN | 0264-410X |
| NCID | AA10491877 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 39088986 |
| DOI | 10.1016/j.vaccine.2024.126156 |
| Web of Science KeyUT | 001285745600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.vaccine.2024.126156 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nagao, Shoji| Nishio, Shin| Takehara, Kazuhiro| Sato, Shinya| Satoh, Toyomi| Shimada, Muneaki| Yamaguchi, Satoshi| Tanabe, Hiroshi| Takano, Masashi| Horie, Kouji| Takei, Yuji| Imai, Yuichi| Hibino, Yumi| Hasegawa, Kosei| Takekuma, Munetaka| Nakamura, Kazuto| Takano, Hirokuni| Fujiwara, Keiichi| Masuyama, Hisashi| |
| Keywords | Recurrent endometrial cancer Re-administration of platinum-based chemotherapy Platinum-free interval Secondary platinum response |
| Note | The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02585-1| |
| Published Date | 2024-07-13 |
| Publication Title | International Journal of Clinical Oncology |
| Volume | volume29 |
| Issue | issue10 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1594 |
| End Page | 1601 |
| ISSN | 1341-9625 |
| NCID | AA11086579 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39001945 |
| DOI | 10.1007/s10147-024-02585-1 |
| Web of Science KeyUT | 001272243200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10147-024-02585-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuda, Yoshihiro| Miyake, Tomoko| Toda, Hironobu| Tachibana, Kota| Nomura, Hayato| Hirai, Yoji| Kawakami, Yoshio| Sakoda, Naoya| Morizane, Shin| |
| Keywords | chronic limb-threatening ischemia (CLTI) endovascular therapy (EVT) revascularization systemic sclerosis (SSc) |
| Published Date | 2024-06-19 |
| Publication Title | The Journal of Dermatology |
| Volume | volume51 |
| Issue | issue8 |
| Publisher | Wiley |
| Start Page | 1108 |
| End Page | 1112 |
| ISSN | 0385-2407 |
| NCID | AA00696658 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 38895834 |
| DOI | 10.1111/1346-8138.17334 |
| Web of Science KeyUT | 001249540400001 |
| Related Url | isVersionOf https://doi.org/10.1111/1346-8138.17334 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Yuying| Wang, Qiong| Jia, Huimin| Ishikawa, Kazuya| Kosami, Ken-Ichi| Ueba, Takahiro| Tsujimoto, Atsumi| Yamanaka, Miki| Yabumoto, Yasuyuki| Miki, Daisuke| Sasaki, Eriko| Fukao, Yoichiro| Fujiwara, Masayuki| Kaneko-Kawano, Takako| Tan, Li| Kojima, Chojiro| Wing, Rod A.| Sebastian, Alfino| Nishimura, Hideki| Fukada, Fumi| Niu, Qingfeng| Shimizu, Motoki| Yoshida, Kentaro| Terauchi, Ryohei| Shimamoto, Ko| Kawano, Yoji| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5| |
| Published Date | 2024-05-30 |
| Publication Title | Nature Communications |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4610 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38816417 |
| DOI | 10.1038/s41467-024-48943-5 |
| Web of Science KeyUT | 001236316700012 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-024-48943-5 |
| JaLCDOI | 10.18926/AMO/67201 |
|---|---|
| FullText URL | 78_3_259.pdf |
| Author | Vural, Gonul| Demir, Esra| Gumusyayla, Sadiye| Eren, Funda| Barakli, Serdar| Neselioglu, Salim| Erel, Ozcan| |
| Abstract | The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol–disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol–disulfide homeostasis and ischaemia-modified albumin were measured. We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol–disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol–disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol–disulfide homeostasis in multiple sclerosis patients. |
| Keywords | multiple sclerosis dysfunctional HDL thiol–disulfide homeostasis cognitive decline |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 259 |
| End Page | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902214 |
| Web of Science KeyUT | 001267351000007 |
| JaLCDOI | 10.18926/AMO/67197 |
|---|---|
| FullText URL | 78_3_227.pdf |
| Author | Wada, Yudai| Ushio, Soichiro| Kitamura, Yoshihisa| Zamami, Yoshito| Sendo, Toshiaki| |
| Abstract | Zolpidem, a non-benzodiazepine hypnotic, is primarily used to treat insomnia. In a previous study, pior treatment with non-benzodiazepine receptor agonists was associated with inflammation. The present study aimed to clarify the association between the effects of zolpidem and inflammation in mice treated with lipopolysaccharide (LPS), a known model of inflammation. We assessed the zolpidem-induced loss of righting reflex (LORR) duration 24 h after LPS treatment in mice. Additionally, the expressions of γ-aminobutyric acid (GABA)A receptor subunit and K+-Cl− cotransporter isoform 2 (KCC2) mRNA in the hippocampus and frontal cortex were examined in LPS-treated mice. Pretreatment with LPS was associated with significantly prolonged duration of zolpidem-induced LORR compared to control mice. This effect was significantly attenuated by administering bicuculline, a GABAA receptor antagonist, or flumazenil, a benzodiazepine receptor antagonist, in LPS-treated mice. Compared to controls, LPS-treated mice showed no significant change in the expression of GABAA receptor subunits in the hippocampus or frontal cortex. Bumetanide, an Na+-K+-2Cl− cotransporter isoform 1 blocker, attenuated the extended duration of zolpidem-induced LORR observed in LPS-treated mice. LPS significantly decreased Kcc2 mRNA expression in the hippocampus and the frontal cortex. These findings suggest that inflammation increases zolpidem-induced LORR, possibly through a reduction in KCC2 expression. |
| Keywords | lipopolysaccharide zolpidem GABAA receptor K+-Cl− cotransporters |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 227 |
| End Page | 235 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902210 |
| Web of Science KeyUT | 001267351000003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sue, Masahiko| Takeuchi, Yasuto| Hirata, Shoichiro| Takaki, Akinobu| Otsuka, Motoyuki| |
| Keywords | immune-related adverse events serum albumin real-world practice |
| Published Date | 2024-05-09 |
| Publication Title | Cancers |
| Volume | volume16 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 1811 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38791890 |
| DOI | 10.3390/cancers16101811 |
| Web of Science KeyUT | 001233134000001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers16101811 |
