result 892 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sada, Ken-ei| Katayama, Yu| Asano, Yosuke| Hayashi, Keigo| Miyawaki, Yoshia| Ohashi, Keiji| Katsuyama, Eri| Katsuyama, Takayuki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Yajima, Nobuyuki| |
| Keywords | systemic lupus erythematosus glucocorticoids outcome assessment health care epidemiology |
| Published Date | 2022-09-27 |
| Publication Title | Lupus Science & Medicine |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | BMJ |
| Start Page | e000772 |
| ISSN | 2053-8790 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Author(s) (or their employer(s)) 2022. |
| File Version | publisher |
| PubMed ID | 36167483 |
| DOI | 10.1136/lupus-2022-000772 |
| Web of Science KeyUT | 000861425300002 |
| Related Url | isVersionOf https://doi.org/10.1136/lupus-2022-000772 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ishida, Konan| Noutoshi, Yoshiteru| |
| Keywords | Plant cell wall Plant–microbe interaction Cell wall integrity Receptor-like kinase Plant immunity |
| Published Date | 2022-12-01 |
| Publication Title | Plant Physiology and Biochemistry |
| Volume | volume192 |
| Publisher | Elsevier BV |
| Start Page | 273 |
| End Page | 284 |
| ISSN | 0981-9428 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 36279746 |
| DOI | 10.1016/j.plaphy.2022.10.015 |
| Web of Science KeyUT | 000877515100003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.plaphy.2022.10.015 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morinaga, Takao| Inozume, Takashi| Kawazu, Masahito| Ueda, Youki| Sax, Nicolas| Yamashita, Kazuo| Kawashima, Shusuke| Nagasaki, Joji| Ueno, Toshihide| Lin, Jason| Ohara, Yuuki| Kuwata, Takeshi| Yukami, Hiroki| Kawazoe, Akihito| Shitara, Kohei| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Kawahara, Yu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Morita, Ayako| Ichihara, Eiki| Kiura, Katsuyuki| Enokida, Tomohiro| Tahara, Makoto| Hasegawa, Yoshinori| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke| |
| Published Date | 2022-07-28 |
| Publication Title | Cancer Research Communications |
| Volume | volume2 |
| Issue | issue7 |
| Publisher | American Association for Cancer Research |
| Start Page | 739 |
| End Page | 753 |
| ISSN | 2767-9764 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors |
| File Version | publisher |
| PubMed ID | 36923281 |
| DOI | 10.1158/2767-9764.CRC-22-0050 |
| Web of Science KeyUT | 001048412300001 |
| Related Url | isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050 |
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| FullText URL | 77_4_395.pdf |
| Author | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| Keywords | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 395 |
| End Page | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| JaLCDOI | 10.18926/AMO/65740 |
|---|---|
| FullText URL | 77_4_347.pdf |
| Author | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
| Abstract | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
| Keywords | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 347 |
| End Page | 357 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635134 |
| Web of Science KeyUT | 001163659800002 |
| JaLCDOI | 10.18926/AMO/65739 |
|---|---|
| FullText URL | 77_4_341.pdf |
| Author | Otsuka, Motoyuki| |
| Abstract | Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described. |
| Keywords | HBx Smc5/6 DDB1 nitazoxianide DNA repair |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 341 |
| End Page | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635133 |
| Web of Science KeyUT | 001163659800007 |
| FullText URL | fulltext20230817-01.pdf fig20230817-01.pdf suppl_fig20230817-01.pdf suppl_table20230817-01.pdf |
|---|---|
| Author | Kawase, Katsushige| Kawashima, Shusuke| Nagasaki, Joji| Inozume, Takashi| Tanji, Etsuko| Kawazu, Masahito| Hanazawa, Toyoyuki| Togashi, Yosuke| |
| Note | This is an Accepted Manuscript of an article published by American Association for Cancer Research.| This fulltext file will be available in Jul. 2024.| |
| Published Date | 2023-07-05 |
| Publication Title | Cancer Immunology Research |
| Volume | volume11 |
| Issue | issue7 |
| Publisher | American Association for Cancer Research (AACR) |
| Start Page | 895 |
| End Page | 908 |
| ISSN | 2326-6066 |
| NCID | AA12626809 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 American Association for Cancer Research |
| File Version | author |
| PubMed ID | 37062030 |
| DOI | 10.1158/2326-6066.cir-22-0815 |
| Web of Science KeyUT | 001038030200001 |
| Related Url | isVersionOf https://doi.org/10.1158/2326-6066.CIR-22-0815 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kemmotsu, Naoya| Zhu, Li| Nagasaki, Joji| Otani, Yoshihiro| Ueda, Youki| Dansako, Hiromichi| Fang, Yue| Date, Isao| Togashi, Yosuke| |
| Keywords | abscopal effect dendritic cell hydrogen peroxide radiosensitizer radiotherapy tumor-draining lymph node |
| Published Date | 2023-07-23 |
| Publication Title | Cancer Science |
| Volume | volume114 |
| Issue | issue10 |
| Publisher | Wiley |
| Start Page | 3848 |
| End Page | 3856 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 37485636 |
| DOI | 10.1111/cas.15911 |
| Web of Science KeyUT | 001034657700001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15911 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Tanaka, Takehiro| Kagawa, Shunsuke| Inoo, Shoko| Otsuka, Motoyuki| |
| Keywords | immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis |
| Published Date | 2023-05-25 |
| Publication Title | Cureus |
| Volume | volume15 |
| Issue | issue5 |
| Publisher | Springer |
| Start Page | e39466 |
| ISSN | 2168-8184 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 37378156 |
| DOI | 10.7759/cureus.39466 |
| Web of Science KeyUT | 001023091300016 |
| Related Url | isVersionOf https://doi.org/10.7759/cureus.39466 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gohda, Eiichi| |
| Keywords | COVID-19 SARS-CoV-2 mRNA vaccine immune response |
| Published Date | 2022-01-30 |
| Publication Title | Journal of Disaster Research |
| Volume | volume17 |
| Issue | issue1 |
| Publisher | Fuji Technology Press Ltd. |
| Start Page | 7 |
| End Page | 20 |
| ISSN | 1883-8030 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Fuji Technology Press Ltd. |
| File Version | publisher |
| DOI | 10.20965/jdr.2022.p0007 |
| Web of Science KeyUT | 000748695600002 |
| Related Url | isVersionOf https://doi.org/10.20965/jdr.2022.p0007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furuta, Kazuyuki| Onishi, Hiroka| Ikada, Yuki| Masaki, Kento| Tanaka, Satoshi| Kaito, Chikara| |
| Published Date | 2023-04 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume299 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 104587 |
| ISSN | 1083-351X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 THE AUTHORS. |
| File Version | publisher |
| PubMed ID | 36889584 |
| DOI | 10.1016/j.jbc.2023.104587 |
| Web of Science KeyUT | 001009229100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jbc.2023.104587 |
| FullText URL | K0006805_abstract_review.pdf K0006805_fulltext.pdf K0006805_summary.pdf |
|---|---|
| Author | ZHU, YIDAN| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6805号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s), under exclusive licence to The Japanese Breast Cancer Society 2022 |
| FullText URL | K0006767_abstract_review.pdf K0006767_fulltext.pdf K0006767_summary.pdf |
|---|---|
| Author | URAGUCHI, Kensuke| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6767号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2021 Uraguchi et al. |
| FullText URL | K0006743_abstract_review.pdf K0006743_fulltext.pdf K0006743_other1.pdf K0006743_other2.PDF K0006743_summary.pdf |
|---|---|
| Author | MEGURI, Yusuke| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6743号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishimura, Tomoka| Ninomiya, Kiichiro| Nakashima, Mitsutaka| Akagi, Satoshi| Kuribayashi, Tadahiro| Higo, Hisao| Hotta, Katsuyuki| Maeda, Yoshinobu| Ito, Hiroshi| Kiura, Katsuyuki| |
| Keywords | myocarditis nivolumab plus ipilimumab irAE case report |
| Published Date | 2023-05-01 |
| Publication Title | Internal Medicine |
| Volume | volume62 |
| Issue | issue9 |
| Publisher | The Japanese Society of Internal Medicine |
| Start Page | 1319 |
| End Page | 1322 |
| ISSN | 0918-2918 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Japanese Society of Internal Medicine |
| File Version | publisher |
| PubMed ID | 36130891 |
| DOI | 10.2169/internalmedicine.0505-22 |
| Web of Science KeyUT | 000988462100001 |
| Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.0505-22 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sumii, Yuichi| Kondo, Takumi| Ikegawa, Shuntaro| Fukumi, Takuya| Iwamoto, Miki| Nishimura, Midori Filiz| Sugiura, Hiroyuki| Sando, Yasuhisa| Nakamura, Makoto| Meguri, Yusuke| Matsushita, Takashi| Tanimine, Naoki| Kimura, Maiko| Asada, Noboru| Ennishi, Daisuke| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
| Published Date | 2023-04-24 |
| Publication Title | JCI Insight |
| Volume | volume8 |
| Issue | issue8 |
| Publisher | American Society for Clinical Investigation |
| Start Page | e162180 |
| ISSN | 2379-3708 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023, Sumii et al. |
| File Version | publisher |
| PubMed ID | 37092551 |
| DOI | 10.1172/jci.insight.162180 |
| Web of Science KeyUT | 000978256300001 |
| Related Url | isVersionOf https://doi.org/10.1172/jci.insight.162180 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Arias, Zulema| Nizami, Mohammed Zahedul Islam| Chen, Xiaoting| Chai, Xinyi| Xu, Bin| Kuang, Canyan| Omori, Kazuhiro| Takashiba, Shogo| |
| Keywords | apical periodontitis contemporary approaches nonsurgical endodontic treatment immune inflammatory disease alternative treatments |
| Published Date | 2023-04-19 |
| Publication Title | Bioengineering |
| Volume | volume10 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 488 |
| ISSN | 2306-5354 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37106675 |
| DOI | 10.3390/bioengineering10040488 |
| Web of Science KeyUT | 000977447300001 |
| Related Url | isVersionOf https://doi.org/10.3390/bioengineering10040488 |
| Title Alternative | Clusters of coronavirus disease 2019 in medical institutions and elderly care facilities in Okayama Prefecture |
|---|---|
| FullText URL | 134_86.pdf |
| Author | Kadowaki, Tomoka| Irie, Saori| Takahashi, Yukari| Yakushiji, Hiromasa| Takao, Soshi| Yorifuji, Takashi| |
| Abstract | Coronavirus disease 2019 has spread worldwide and has yet to be contained. The Japanese government has taken measures against the occurrence of clusters. However, there has little evaluation of the occurrence of the clusters and their changes. Therefore, we investigated the occurrence of the clusters in medical institutions and elderly care facilities in Okayama Prefecture. We compared the characteristics of the clusters that occurred in each of the wave between October 21, 2020, and September 30, 2021, by using the data published that interval. As a case study, we also evaluated the characteristics of positive patients at a medical institution over where a cluster occurred in case the fourth wave. The overall number of cluster outbreaks decreased with the spread of vaccination. In the fourth wave, there was a period in which the vaccination of staff members at medical institutions became widespread, while patients or facility users were unvaccinated, resulting in a longer convergence period and an increase in the number of positive cases among patients relative to the number of staff members. The impact of the spread of vaccination and the duration of immunity acquired after vaccination on the occurrence of clusters should be closely monitored in the future. |
| Keywords | 新型コロナウイルス感染症 (coronavirus disease 2019) 岡山県 (Okayama Prefecture) クラスター (cluster) ワクチン接種 (vaccination) 疫学 (epidemiology) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2022-08-01 |
| Volume | volume134 |
| Issue | issue2 |
| Start Page | 86 |
| End Page | 91 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.134.86 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2022 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.134.86 |
| Title Alternative | The 2021 Incentive Award of the Okayama Medical Association in Cancer Research (2021 Hayashibara Prize and Yamada Prize) |
|---|---|
| FullText URL | 134_73.pdf |
| Author | Nishida, Mikako| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2022-08-01 |
| Volume | volume134 |
| Issue | issue2 |
| Start Page | 73 |
| End Page | 75 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.134.73 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2022 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.134.73 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Wataru| Kobayashi, Hiroki| Urata, Tomohiro| Sato, Yumiko| Naoi, Yusuke| Yoshino, Tadashi| Maeda, Yoshinobu| Kuyama, Shoichi| |
| Keywords | nodal peripheral T-cell lymphoma with T follicular helper phenotype immune thrombocytopenia prednisolone |
| Published Date | 2023 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume63 |
| Issue | issue1 |
| Publisher | The Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 37 |
| End Page | 42 |
| ISSN | 1346-4280 |
| NCID | AA11556796 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 36990775 |
| DOI | 10.3960/jslrt.22038 |
| Web of Science KeyUT | 000960504100006 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.22038 |
