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Author Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio|
Published Date 2022-09-13
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 15391
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 36100649
DOI 10.1038/s41598-022-19798-x
Web of Science KeyUT 000855580800036
Related Url isVersionOf https://doi.org/10.1038/s41598-022-19798-x
FullText URL fulltext.pdf
Author Kataoka, Takahiro| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Tanaka, Ayumi| Yamaoka, Kiyonori|
Keywords autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation
Published Date 2022-08-26
Publication Title International Journal Of Environmental Research And Public Health
Volume volume19
Issue issue17
Publisher MDPI
Start Page 10632
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36078348
DOI 10.3390/ijerph191710632
Web of Science KeyUT 000851073300001
Related Url isVersionOf https://doi.org/10.3390/ijerph191710632
FullText URL fulltext.pdf
Author Sumi, Tomonari| Harada, Kouji|
Published Date 2022-08-19
Publication Title ISCIENCE
Volume volume25
Issue issue8
Publisher CELL PRESS
Start Page 104723
ISSN 2589-0042
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 35813874
DOI 10.1016/j.isci.2022.104723
Web of Science KeyUT 000843628600010
Related Url isVersionOf https://doi.org/10.1016/j.isci.2022.104723
JaLCDOI 10.18926/AMO/63894
FullText URL 76_4_399.pdf
Author Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Abstract According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67.
Keywords breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 399
End Page 408
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123154
Web of Science KeyUT 000882167300005
JaLCDOI 10.18926/AMO/63887
FullText URL 76_4_359.pdf
Author Hiramatsu-Asano, Sumie| Wada, Jun|
Abstract Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE.
Keywords systemic lupus erythematosus miRNA miRNA targeting therapy
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 359
End Page 371
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123150
Web of Science KeyUT 000882167300002
FullText URL fulltext.pdf
Author Meguri, Yusuke| Asano, Takeru| Yoshioka, Takanori| Iwamoto, Miki| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Kishi, Yuriko| Nakamura, Makoto| Sando, Yasuhisa| Kondo, Takumi| Sumii, Yuichi| Maeda, Yoshinobu| Matsuoka, Ken-Ichi|
Keywords regulatory T cell low-dose interleukin-2 therapy graft-versus-host disease graft-versus-leukemia effect transplantation tolerance
Published Date 2022-08-02
Publication Title Frontiers In Immunology
Volume volume13
Publisher Frontiers Media
Start Page 891925
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka.
File Version publisher
PubMed ID 35983059
DOI 10.3389/fimmu.2022.891925
Web of Science KeyUT 000844642000001
Related Url isVersionOf https://doi.org/10.3389/fimmu.2022.891925
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Author Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi|
Published Date 2022-08-08
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 13540
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © TheAuthor(s)2022
File Version publisher
PubMed ID 35941214
DOI 10.1038/s41598-022-17773-0
Web of Science KeyUT 000837764800013
Related Url isVersionOf https://doi.org/10.1038/s41598-022-17773-0
FullText URL fulltext.pdf
Author Nagasaki, Joji| Ishino, Takamasa| Togashi, Yosuke|
Keywords cancer immunology exhaustion immune checkpoint inhibitor resistance T cell
Published Date 2022-07-18
Publication Title Cancer Science
Publisher Wiley
ISSN 1347-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35848888
DOI 10.1111/cas.15497
Web of Science KeyUT 000832976400001
Related Url isVersionOf https://doi.org/10.1111/cas.15497
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Author Oiwa, Masahiko| Kuroda, Kosuke| Kawanoue, Naoya| Morimatsu, Hiroshi|
Keywords Biomarker Clavien-Dindo classification Histidine-rich glycoprotein Intensive care unit Perioperative management Postoperative complication Predictor
Published Date 2022-07-20
Publication Title BMC Anesthesiology
Volume volume22
Issue issue1
Publisher BMC
Start Page 232
ISSN 1471-2253
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35858852
DOI 10.1186/s12871-022-01774-7
Web of Science KeyUT 000828247900001
Related Url isVersionOf https://doi.org/10.1186/s12871-022-01774-7
FullText URL fulltext.pdf
Author Chao, Ruoyu| Nishida, Mikako| Yamashita, Nahoko| Tokumasu, Miho| Zhao, Weiyang| Kudo, Ikuru| Udono, Heiichiro|
Keywords CD8+T lymphocytes glycolysis FAO glutaminolysis IFNg autophagy plus T metformin
Published Date 2022-06-29
Publication Title Frontiers In Immunology
Volume volume13
Publisher Frontiers Media SA
Start Page 864225
ISSN 1664-3224
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Chao, Nishida, Yamashita, Tokumasu, Zhao, Kudo and Udono.
File Version publisher
PubMed ID 35844589
DOI 10.3389/fimmu.2022.864225
Web of Science KeyUT 000826727800001
Related Url isVersionOf https://doi.org/10.3389/fimmu.2022.864225
FullText URL fulltext.pdf
Author Mitoma, Tomohiro| Hayata, Kei| Yokohata, Satomi| Ohira, Akiko| Kashino, Chiaki| Kirino, Satoe| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Masuyama, Hisashi|
Keywords Lupus Myometrium Placenta accreta spectrum Estrogen Uterine atony
Published Date 2022-07-02
Publication Title BMC Pregnancy And Childbirth
Volume volume22
Issue issue1
Publisher BMC
Start Page 535
ISSN 1471-2393
NCID AA12035416
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 35780086
DOI 10.1186/s12884-022-04864-z
Web of Science KeyUT 000820223600001
Related Url isVersionOf https://doi.org/10.1186/s12884-022-04864-z
FullText URL fulltext.pdf
Author Yanase, Yuta| Tsuji, Genichiro| Nakamura, Miki| Shibata, Norihito| Demizu, Yosuke|
Keywords STING cyclic dinucleotide amines drug design agonist antagonist
Published Date 2022-06-20
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue12
Publisher MDPI
Start Page 6847
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35743289
DOI 10.3390/ijms23126847
Web of Science KeyUT 000815885700001
Related Url isVersionOf https://doi.org/10.3390/ijms23126847
FullText URL fulltext.pdf
Author Muzembo, Basilua Andre| Kitahara, Kei| Mitra, Debmalya| Ohno, Ayumu| Miyoshi, Shin-Ichi|
Keywords cholera antibodies vibriocidal cholera toxin B lipopolysaccharide immunoglobulin immunity waning
Published Date 2022-06-10
Publication Title International Journal of Environmental Research and Public Health
Volume volume19
Issue issue12
Publisher MDPI
Start Page 7141
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35742404
DOI 10.3390/ijerph19127141
Web of Science KeyUT 000817347300001
Related Url isVersionOf https://doi.org/10.3390/ijerph19127141
FullText URL fulltext20220630-1.pdf
Author Udono, Heiichiro| Nishida, Mikako|
Keywords Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2
Note © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] .
This fulltext is available in Aug. 2023.|
Published Date 2022-08
Publication Title Biochimica et Biophysica Acta (BBA) - General Subjects
Volume volume1866
Issue issue8
Publisher Elsevier BV
Start Page 130171
ISSN 0304-4165
NCID AA00564679
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Elsevier B.V.
File Version author
PubMed ID 35588955
DOI 10.1016/j.bbagen.2022.130171
Web of Science KeyUT 000806942900004
Related Url isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171
FullText URL fulltext20220630-7.pdf figure20220630-7.pdf
Author Nagasaki, Joji| Togashi, Yosuke|
Keywords CD4(+) T cell cytotoxic CD4(+ )T cell regulatory T cell T-cell exhaustion
Note This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Joji Nagasaki, Yosuke Togashi, A variety of ‘exhausted’ T cells in the tumor microenvironment, International Immunology, Volume 34, Issue 11, November 2022, Pages 563–570, https://doi.org/10.1093/intimm/dxac013] is available online at: [https://doi.org/10.1093/intimm/dxac013]
This fulltext is available in April 2023.|
Published Date 2022-4-23
Publication Title International Immunology
Volume volume34
Issue issue11
Publisher Oxford University Press
Start Page 563
End Page 570
ISSN 1460-2377
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version author
PubMed ID 35460561
DOI 10.1093/intimm/dxac013
Web of Science KeyUT 000805278200001
Related Url isVersionOf https://doi.org/10.1093/intimm/dxac013
JaLCDOI 10.18926/AMO/63722
FullText URL 76_3_281.pdf
Author Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong|
Abstract Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions.
Keywords periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 281
End Page 290
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790358
Web of Science KeyUT 000823568300007
JaLCDOI 10.18926/AMO/63718
FullText URL 76_3_247.pdf
Author Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu|
Abstract Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
Keywords vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-06
Volume volume76
Issue issue3
Publisher Okayama University Medical School
Start Page 247
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35790354
Web of Science KeyUT 000823568300003
FullText URL K0006679_abstract_review.pdf K0006679_fulltext.pdf K0006679_summary.pdf
Author Yoshida, Shohei|
Published Date 2022-03-25
Content Type Thesis or Dissertation
Grant Number 甲第6679号
Granted Date 2022-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
FullText URL fulltext.pdf
Author Uchida-Fukuhara, Yoko| Hattori, Takako| Fu, Shanqi| Kondo, Sei| Kuwahara, Miho| Fukuhara, Daiki| Islam, Md Monirul| Kataoka, Kota| Ekuni, Daisuke| Kubota, Satoshi| Morita, Manabu| Iikegame, Mika| Okamura, Hirohiko|
Keywords maternal microbiome endochondral ossification fetal chondrocytes
Published Date 2022-05-10
Publication Title Microorganisms
Volume volume10
Issue issue5
Publisher MDPI
Start Page 1000
ISSN 2076-2607
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35630443
DOI 10.3390/microorganisms10051000
Web of Science KeyUT 000801692300001
Related Url isVersionOf https://doi.org/10.3390/microorganisms10051000
FullText URL fulltext.pdf
Author Miyamoto, Ai| Honjo, Tomoko| Masui, Mirei| Kinoshita, Rie| Kumon, Hiromi| Kakimi, Kazuhiro| Futami, Junichiro|
Keywords autoantibody biomarker protein engineering cancer-immunity cycle immune monitoring cancer testis antigens
Published Date 2022-05-04
Publication Title Frontiers In Oncology
Volume volume12
Publisher FRONTIERS MEDIA SA
Start Page 869393
ISSN 2234-943X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Miyamoto, Honjo, Masui, Kinoshita, Kumon, Kakimi and Futami.
File Version publisher
PubMed ID 35600379
DOI 10.3389/fonc.2022.869393
Web of Science KeyUT 000797484100001
Related Url isVersionOf https://doi.org/10.3389/fonc.2022.869393