result 901 件
FullText URL | fulltext.pdf |
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Author | Hagiya, Hideharu| Koyama, Toshihiro| Otsuka, Fumio| |
Published Date | 2022-09-13 |
Publication Title | Scientific Reports |
Volume | volume12 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 15391 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022 |
File Version | publisher |
PubMed ID | 36100649 |
DOI | 10.1038/s41598-022-19798-x |
Web of Science KeyUT | 000855580800036 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-022-19798-x |
FullText URL | fulltext.pdf |
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Author | Kataoka, Takahiro| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Tanaka, Ayumi| Yamaoka, Kiyonori| |
Keywords | autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation |
Published Date | 2022-08-26 |
Publication Title | International Journal Of Environmental Research And Public Health |
Volume | volume19 |
Issue | issue17 |
Publisher | MDPI |
Start Page | 10632 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 36078348 |
DOI | 10.3390/ijerph191710632 |
Web of Science KeyUT | 000851073300001 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph191710632 |
FullText URL | fulltext.pdf |
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Author | Sumi, Tomonari| Harada, Kouji| |
Published Date | 2022-08-19 |
Publication Title | ISCIENCE |
Volume | volume25 |
Issue | issue8 |
Publisher | CELL PRESS |
Start Page | 104723 |
ISSN | 2589-0042 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Author(s). |
File Version | publisher |
PubMed ID | 35813874 |
DOI | 10.1016/j.isci.2022.104723 |
Web of Science KeyUT | 000843628600010 |
Related Url | isVersionOf https://doi.org/10.1016/j.isci.2022.104723 |
JaLCDOI | 10.18926/AMO/63894 |
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FullText URL | 76_4_399.pdf |
Author | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
Abstract | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
Keywords | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2022-08 |
Volume | volume76 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 399 |
End Page | 408 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 36123154 |
Web of Science KeyUT | 000882167300005 |
JaLCDOI | 10.18926/AMO/63887 |
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FullText URL | 76_4_359.pdf |
Author | Hiramatsu-Asano, Sumie| Wada, Jun| |
Abstract | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
Keywords | systemic lupus erythematosus miRNA miRNA targeting therapy |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2022-08 |
Volume | volume76 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 359 |
End Page | 371 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 36123150 |
Web of Science KeyUT | 000882167300002 |
FullText URL | fulltext.pdf |
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Author | Meguri, Yusuke| Asano, Takeru| Yoshioka, Takanori| Iwamoto, Miki| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Kishi, Yuriko| Nakamura, Makoto| Sando, Yasuhisa| Kondo, Takumi| Sumii, Yuichi| Maeda, Yoshinobu| Matsuoka, Ken-Ichi| |
Keywords | regulatory T cell low-dose interleukin-2 therapy graft-versus-host disease graft-versus-leukemia effect transplantation tolerance |
Published Date | 2022-08-02 |
Publication Title | Frontiers In Immunology |
Volume | volume13 |
Publisher | Frontiers Media |
Start Page | 891925 |
ISSN | 1664-3224 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Meguri, Asano, Yoshioka, Iwamoto, Ikegawa, Sugiura, Kishi, Nakamura, Sando, Kondo, Sumii, Maeda and Matsuoka. |
File Version | publisher |
PubMed ID | 35983059 |
DOI | 10.3389/fimmu.2022.891925 |
Web of Science KeyUT | 000844642000001 |
Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.891925 |
FullText URL | fulltext.pdf |
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Author | Komatsu, Yasuhiro| Shigeyasu, Kunitoshi| Yano, Shuya| Takeda, Sho| Takahashi, Kazutaka| Hata, Nanako| Umeda, Hibiki| Yoshida, Kazuhiro| Mori, Yoshiko| Yasui, Kazuya| Yoshida, Ryuichi| Kondo, Yoshitaka| Kishimoto, Hiroyuki| Teraishi, Fuminori| Umeda, Yuzo| Kagawa, Shunsuke| Michiue, Hiroyuki| Tazawa, Hiroshi| Goel, Ajay| Fujiwara, Toshiyoshi| |
Published Date | 2022-08-08 |
Publication Title | Scientific Reports |
Volume | volume12 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 13540 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © TheAuthor(s)2022 |
File Version | publisher |
PubMed ID | 35941214 |
DOI | 10.1038/s41598-022-17773-0 |
Web of Science KeyUT | 000837764800013 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-022-17773-0 |
FullText URL | fulltext.pdf |
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Author | Nagasaki, Joji| Ishino, Takamasa| Togashi, Yosuke| |
Keywords | cancer immunology exhaustion immune checkpoint inhibitor resistance T cell |
Published Date | 2022-07-18 |
Publication Title | Cancer Science |
Publisher | Wiley |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35848888 |
DOI | 10.1111/cas.15497 |
Web of Science KeyUT | 000832976400001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.15497 |
FullText URL | fulltext.pdf |
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Author | Oiwa, Masahiko| Kuroda, Kosuke| Kawanoue, Naoya| Morimatsu, Hiroshi| |
Keywords | Biomarker Clavien-Dindo classification Histidine-rich glycoprotein Intensive care unit Perioperative management Postoperative complication Predictor |
Published Date | 2022-07-20 |
Publication Title | BMC Anesthesiology |
Volume | volume22 |
Issue | issue1 |
Publisher | BMC |
Start Page | 232 |
ISSN | 1471-2253 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022. |
File Version | publisher |
PubMed ID | 35858852 |
DOI | 10.1186/s12871-022-01774-7 |
Web of Science KeyUT | 000828247900001 |
Related Url | isVersionOf https://doi.org/10.1186/s12871-022-01774-7 |
FullText URL | fulltext.pdf |
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Author | Chao, Ruoyu| Nishida, Mikako| Yamashita, Nahoko| Tokumasu, Miho| Zhao, Weiyang| Kudo, Ikuru| Udono, Heiichiro| |
Keywords | CD8+T lymphocytes glycolysis FAO glutaminolysis IFNg autophagy plus T metformin |
Published Date | 2022-06-29 |
Publication Title | Frontiers In Immunology |
Volume | volume13 |
Publisher | Frontiers Media SA |
Start Page | 864225 |
ISSN | 1664-3224 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Chao, Nishida, Yamashita, Tokumasu, Zhao, Kudo and Udono. |
File Version | publisher |
PubMed ID | 35844589 |
DOI | 10.3389/fimmu.2022.864225 |
Web of Science KeyUT | 000826727800001 |
Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.864225 |
FullText URL | fulltext.pdf |
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Author | Mitoma, Tomohiro| Hayata, Kei| Yokohata, Satomi| Ohira, Akiko| Kashino, Chiaki| Kirino, Satoe| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Masuyama, Hisashi| |
Keywords | Lupus Myometrium Placenta accreta spectrum Estrogen Uterine atony |
Published Date | 2022-07-02 |
Publication Title | BMC Pregnancy And Childbirth |
Volume | volume22 |
Issue | issue1 |
Publisher | BMC |
Start Page | 535 |
ISSN | 1471-2393 |
NCID | AA12035416 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022. |
File Version | publisher |
PubMed ID | 35780086 |
DOI | 10.1186/s12884-022-04864-z |
Web of Science KeyUT | 000820223600001 |
Related Url | isVersionOf https://doi.org/10.1186/s12884-022-04864-z |
FullText URL | fulltext.pdf |
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Author | Yanase, Yuta| Tsuji, Genichiro| Nakamura, Miki| Shibata, Norihito| Demizu, Yosuke| |
Keywords | STING cyclic dinucleotide amines drug design agonist antagonist |
Published Date | 2022-06-20 |
Publication Title | International Journal Of Molecular Sciences |
Volume | volume23 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 6847 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 35743289 |
DOI | 10.3390/ijms23126847 |
Web of Science KeyUT | 000815885700001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms23126847 |
FullText URL | fulltext.pdf |
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Author | Muzembo, Basilua Andre| Kitahara, Kei| Mitra, Debmalya| Ohno, Ayumu| Miyoshi, Shin-Ichi| |
Keywords | cholera antibodies vibriocidal cholera toxin B lipopolysaccharide immunoglobulin immunity waning |
Published Date | 2022-06-10 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume19 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 7141 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 35742404 |
DOI | 10.3390/ijerph19127141 |
Web of Science KeyUT | 000817347300001 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph19127141 |
FullText URL | fulltext20220630-1.pdf |
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Author | Udono, Heiichiro| Nishida, Mikako| |
Keywords | Mitochondrial ROS Oxidative stress Apoptosis Ageing Nrf2 |
Note | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbagen.2022.130171] . This fulltext is available in Aug. 2023.| |
Published Date | 2022-08 |
Publication Title | Biochimica et Biophysica Acta (BBA) - General Subjects |
Volume | volume1866 |
Issue | issue8 |
Publisher | Elsevier BV |
Start Page | 130171 |
ISSN | 0304-4165 |
NCID | AA00564679 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Elsevier B.V. |
File Version | author |
PubMed ID | 35588955 |
DOI | 10.1016/j.bbagen.2022.130171 |
Web of Science KeyUT | 000806942900004 |
Related Url | isVersionOf https://doi.org/10.1016/j.bbagen.2022.130171 |
FullText URL | fulltext20220630-7.pdf figure20220630-7.pdf |
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Author | Nagasaki, Joji| Togashi, Yosuke| |
Keywords | CD4(+) T cell cytotoxic CD4(+ )T cell regulatory T cell T-cell exhaustion |
Note | This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Joji Nagasaki, Yosuke Togashi, A variety of ‘exhausted’ T cells in the tumor microenvironment, International Immunology, Volume 34, Issue 11, November 2022, Pages 563–570, https://doi.org/10.1093/intimm/dxac013] is available online at: [https://doi.org/10.1093/intimm/dxac013] This fulltext is available in April 2023.| |
Published Date | 2022-4-23 |
Publication Title | International Immunology |
Volume | volume34 |
Issue | issue11 |
Publisher | Oxford University Press |
Start Page | 563 |
End Page | 570 |
ISSN | 1460-2377 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022. |
File Version | author |
PubMed ID | 35460561 |
DOI | 10.1093/intimm/dxac013 |
Web of Science KeyUT | 000805278200001 |
Related Url | isVersionOf https://doi.org/10.1093/intimm/dxac013 |
JaLCDOI | 10.18926/AMO/63722 |
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FullText URL | 76_3_281.pdf |
Author | Yu, Bo| Wang, Rui| Luo, Huikun| Yang, Di| Wang, Simo| Yu, Yaqiong| Okamura, Hirohiko| Qiu, Lihong| |
Abstract | Periodontal ligament (PDL) cells are critical for the bone remodeling process in periapical lesions since they can differentiate into osteoblasts and secrete osteoclastogenesis-promoting cytokines. Post-translational histone modifications including alterations of the methylation status of H3K27 are involved in cell differentiation and inflammatory reaction. The histone demethylase Jumonji domain-containing 3 (Jmjd3) specifically removes methylation of H3K27. We investigated whether Jmjd3 is involved in the osteogenic differentiation and secretion of PDL cells’ inflammatory factors. Jmjd3 expression in periapical lesions was examined by immunostaining. Using siRNA specific for Jmjd3 or the specific Jmjd3 inhibitor GSK-J4, we determined Jmjd3’s roles in osteogenic differentiation and cytokine production by real-time RT-PCR. The locations of Jmjd3 and NF-κB were analyzed by immunocytochemistry. Compared to healthy PDLs, the periapical lesion samples showed higher Jmjd3 expression. Treatment with GSK-J4 or Jmjd3 siRNA suppressed PDL cells’ osteogenic differentiation by suppressing the expressions of bone-related genes (Runx2, Osterix, and osteocalcin) and mineralization. Jmjd3 knockdown decreased the expressions of cytokines (TNF-α, IL-1β, and IL-6) induced by lipopolysaccharide extracted from Porphyromonas endodontalis (Pe-LPS). Pe-LPS induced the nuclear translocations of Jmjd3 and NF-κB; the latter was inhibited by GSK-J4 treatment. Jmjd3 appears to regulate PDL cells’ osteogenic differentiation and proinflammatory cytokine expressions. |
Keywords | periapical lesions histone demethylase Jmjd3 periodontal ligament cell osteogenic differentiation proinflammatory cytokines |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2022-06 |
Volume | volume76 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 281 |
End Page | 290 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 35790358 |
Web of Science KeyUT | 000823568300007 |
JaLCDOI | 10.18926/AMO/63718 |
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FullText URL | 76_3_247.pdf |
Author | Yoshida, Shohei| Fujii, Nobuharu| Kamoi, Chihiro| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Matsuoka, Ken-ichi| Maeda, Yoshinobu| |
Abstract | Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients. |
Keywords | vaccine-preventable disease vaccination allogeneic hematopoietic stem cell transplantation adult |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2022-06 |
Volume | volume76 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 247 |
End Page | 253 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 35790354 |
Web of Science KeyUT | 000823568300003 |
FullText URL | K0006679_abstract_review.pdf K0006679_fulltext.pdf K0006679_summary.pdf |
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Author | Yoshida, Shohei| |
Published Date | 2022-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第6679号 |
Granted Date | 2022-03-25 |
Thesis Type | Doctor of Philosophy in Medical Science |
Grantor | 岡山大学 |
language | English |
Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
FullText URL | fulltext.pdf |
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Author | Uchida-Fukuhara, Yoko| Hattori, Takako| Fu, Shanqi| Kondo, Sei| Kuwahara, Miho| Fukuhara, Daiki| Islam, Md Monirul| Kataoka, Kota| Ekuni, Daisuke| Kubota, Satoshi| Morita, Manabu| Iikegame, Mika| Okamura, Hirohiko| |
Keywords | maternal microbiome endochondral ossification fetal chondrocytes |
Published Date | 2022-05-10 |
Publication Title | Microorganisms |
Volume | volume10 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 1000 |
ISSN | 2076-2607 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 35630443 |
DOI | 10.3390/microorganisms10051000 |
Web of Science KeyUT | 000801692300001 |
Related Url | isVersionOf https://doi.org/10.3390/microorganisms10051000 |
FullText URL | fulltext.pdf |
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Author | Miyamoto, Ai| Honjo, Tomoko| Masui, Mirei| Kinoshita, Rie| Kumon, Hiromi| Kakimi, Kazuhiro| Futami, Junichiro| |
Keywords | autoantibody biomarker protein engineering cancer-immunity cycle immune monitoring cancer testis antigens |
Published Date | 2022-05-04 |
Publication Title | Frontiers In Oncology |
Volume | volume12 |
Publisher | FRONTIERS MEDIA SA |
Start Page | 869393 |
ISSN | 2234-943X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Miyamoto, Honjo, Masui, Kinoshita, Kumon, Kakimi and Futami. |
File Version | publisher |
PubMed ID | 35600379 |
DOI | 10.3389/fonc.2022.869393 |
Web of Science KeyUT | 000797484100001 |
Related Url | isVersionOf https://doi.org/10.3389/fonc.2022.869393 |