result 445 件
| FullText URL | fulltext20240801-01.pdf |
|---|---|
| Author | Sekiguchi, Manabu| Reinhard, Nils| Fukuda, Ayumi| Katoh, Shun| Rieger, Dirk| Helfrich-Förster, Charlotte| Yoshii, Taishi| |
| Keywords | period GAL4-UAS clock neuron activity rhythm two-oscillator model |
| Note | This is an Accepted Manuscript published by SAGE Publications.| |
| Published Date | 2024-07-31 |
| Publication Title | Journal of Biological Rhythms |
| Volume | volume39 |
| Issue | issue5 |
| Publisher | SAGE Publications |
| Start Page | 463 |
| End Page | 483 |
| ISSN | 0748-7304 |
| NCID | AA10667882 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | author |
| PubMed ID | 39082442 |
| DOI | 10.1177/07487304241263130 |
| Web of Science KeyUT | 001282701800001 |
| Related Url | isVersionOf https://doi.org/10.1177/07487304241263130 |
| FullText URL | fulltext20240122-02.pdf |
|---|---|
| Author | Mochizuki, Kenji| Adachi, Yuji| Koga, Kenichiro| |
| Keywords | Close-packed ices Ice nanotubes Carbon nanotubes Continuous freezing Ferroelectricices |
| Published Date | 2023-12-18 |
| Publication Title | ACS Nano |
| Volume | volume18 |
| Issue | issue1 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 347 |
| End Page | 354 |
| ISSN | 1936-0851 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| PubMed ID | 38109520 |
| DOI | 10.1021/acsnano.3c07084 |
| Web of Science KeyUT | 001139474500001 |
| Related Url | isVersionOf https://doi.org/10.1021/acsnano.3c07084 |
| Title Alternative | Disaster information and documentation in the Meiji period |
|---|---|
| JaLCDOI | 10.18926/66193 |
| FullText URL | jdc_003_067.pdf |
| Author | AMANO, Masashi| |
| Abstract | This paper focuses on the recording and transmission of disaster information, and examines the accumulation of disaster information, its trends, and the intentions behind its accumulation through a survey of information records accumulated by individuals during the Meiji period. Endō Sanenobu, the subject of this paper, was active mainly in Kyoto during the Meiji period (1868-1912), and in the course of his activities, he accumulated a vast amount of information records called the Seizan Manroku (静山漫録), including records of his investigations of ancient documents handed down in various places and verification records of folk tales and customs passed down in various places. In the course of accumulating such information, he became increasingly interested in disaster information after the Yodogawa river flood in Osaka in 1885, and eventually began to compile a series of Suiin Hikkai（酔蚓筆芥）on disaster information as his main theme. The series of information activities by Sanenobu were also supported by the development and diffusion of information media during that period. At the same time, the fact that Sanenobu paid attention to disaster information among various types of information suggests that he regarded disasters as an important turning point in his understanding of national and social changes. Through this information, the reality of people's social perceptions formed by the media will be revealed. |
| Keywords | the Yodogawa river disaster information information gathering historical awareness |
| Amo Type | 特集：災害と文明・地域社会 (Special Issue: Disasters, civilization, and local society) |
| Publication Title | Dynamics of Civilizations |
| Published Date | 2024-03-25 |
| Volume | volume3 |
| Publisher | 岡山大学文明動態学研究所 |
| Start Page | 67 |
| End Page | 78 |
| ISSN | 2436-8326 |
| Content Type | Journal Article |
| language | Japanese |
| Copyright Holders | © 2024 by RIDC |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/66156 |
|---|---|
| FullText URL | 77_6_635.pdf |
| Author | Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku| |
| Abstract | In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted. |
| Keywords | whey protein electrical stimulation muscle strength healthy volunteers |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-12 |
| Volume | volume77 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 635 |
| End Page | 645 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38145938 |
| Web of Science KeyUT | 001164631200009 |
| Title Alternative | Acute sensorineural hearing loss after using a privately imported PDE-5 inhibitor : A case report |
|---|---|
| FullText URL | fulltext20230731-01.pdf |
| Author | KARIYA, Akifumi| ISHIHARA, Hisashi| AKISADA, Naoki| HAMADA, Koji| FUJI, Sayaka| AKAGI, Seiko| TAKEUCHI, Ayako| |
| Keywords | 急性感音難聴 薬剤性難聴 PDE-5 阻害薬 バルデナフィル 個人輸入薬 |
| Published Date | 2022-07-20 |
| Publication Title | jibi to rinsho |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | 耳鼻と臨床会 |
| Start Page | 273 |
| End Page | 278 |
| ISSN | 0447-7227 |
| NCID | AN00107114 |
| Content Type | Journal Article |
| language | Japanese |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 耳鼻と臨床会 |
| File Version | publisher |
| DOI | 10.11334/jibi.68.4_273 |
| Related Url | isVersionOf https://doi.org/10.11334/jibi.68.4_273 |
| JaLCDOI | 10.18926/AMO/65488 |
|---|---|
| FullText URL | 77_3_235.pdf |
| Author | Kuraoka, Sakiko| Iwamuro, Masaya| Satomi, Takuya| Yamazaki, Tatsuhiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kato, Hironari| Otsuka, Fumio| Okada, Hiroyuki| |
| Abstract | Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users. |
| Keywords | anamorelin body weight cancer cachexia endocrine system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357624 |
| Web of Science KeyUT | 001026279600001 |
| Title Alternative | Introduction to Special Feature |
|---|---|
| FullText URL | interdisciplinary_3_11.pdf |
| Author | MOTOMURA, Masafumi| |
| Abstract | This special feature is based on the symposium ,"Feelings of "Meiwaku/Burden" in Modern Japan’s Super-aging Society,” which was held on Monday, September 19, 2022. This symposium was sponsored by JSPS KAKENHI Grant Number JP20A00007. This project focuses on the fact that when people think about aging, end-of-life care, and death in modern Japan, many feel that “they do not want to be a burden to others.” The project is divided into three research groups: historic studies, studies of contemporary Japan, and field research. The symposium reported the results of the contemporary Japan research group, which is halfway through its research. The symposium consisted of two sessions, and this special feature is based on the three participants in the session titled “Feelings of"Meiwaku/Burden" : A Comparison with Other Countries.” Ryozo Suzuki’s study focuses on “the giving of gifts as being mutual actions of giving and receiving” to understand the elderly’s feelings of meiwaku and analyzes the significance and complex structures of the feeling of “being a burden to others” at the end of one’s life. Haruka Hikasa’s study considers the feelings of meiwaku in relation to the subject’s autonomy in the context of medical care provided to people with terminal or chronic illnesses. Natsumi Tanaka’s study examines the feelings of meiwaku among the elderly in France and is based on the work of Simone de Beauvoir. She determines the motivations behind the elderly’s feelings of meiwaku and categorizes them. The abovementioned studies present important research results and facilitate future comparative research on the feelings of meiwaku between Japan and other countries. |
| Publication Title | Interdisciplinary Science |
| Published Date | 2023-03-31 |
| Volume | volume3 |
| Start Page | 11 |
| End Page | 13 |
| ISSN | 2436-3227 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kishida, Kensaku| |
| Keywords | Long-term care Turnover Workforce issues |
| Published Date | 2022-06-06 |
| Publication Title | Innovation In Aging |
| Volume | volume6 |
| Issue | issue4 |
| Publisher | Oxford University Press |
| Start Page | igac035 |
| ISSN | 2399-5300 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35832202 |
| DOI | 10.1093/geroni/igac035 |
| Web of Science KeyUT | 000885693800002 |
| Related Url | isVersionOf https://doi.org/10.1093/geroni/igac035 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro| |
| Keywords | Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment |
| Published Date | 2022-09-12 |
| Publication Title | Breast Cancer Research |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 60 |
| ISSN | 1465-5411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36096830 |
| DOI | 10.1186/s13058-022-01557-5 |
| Web of Science KeyUT | 000853036400001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13058-022-01557-5 |
| JaLCDOI | 10.18926/AMO/63904 |
|---|---|
| FullText URL | 76_4_447.pdf |
| Author | Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro| |
| Abstract | The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner. |
| Keywords | complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 447 |
| End Page | 455 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123160 |
| JaLCDOI | 10.18926/AMO/63887 |
|---|---|
| FullText URL | 76_4_359.pdf |
| Author | Hiramatsu-Asano, Sumie| Wada, Jun| |
| Abstract | Systemic lupus erythematosus (SLE) is a potentially fatal systemic autoimmune disease, and its etiology involves both genetic and environmental factors such as sex hormone imbalance, genetic predisposition, epigenetic regulation, and immunological factors. Dysregulation of microRNA (miRNA) is suggested to be one of the epigenetic factors in SLE. miRNA is a 22-nucleotide single-stranded noncoding RNA that contributes to post-transcriptional modulation of gene expression. miRNA targeting therapy has been suggested to be useful for the treatment of cancers and other diseases. Gene knockout and miRNA targeting therapy have been demonstrated to improve SLE disease activity in mice. However, these approaches have not yet reached the level of clinical application. miRNA targeting therapy is limited by the fact that each miRNA has multiple targets. In addition, the expression of certain miRNAs may differ among cell tissues within a single SLE patient. This limitation can be overcome by targeted delivery and chemical modifications. In the future, further research into miRNA chemical modifications and delivery systems will help us develop novel therapeutic agents for SLE. |
| Keywords | systemic lupus erythematosus miRNA miRNA targeting therapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 371 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123150 |
| Web of Science KeyUT | 000882167300002 |
| FullText URL | fulltext20220810-1.pdf |
|---|---|
| Author | Nanba, Tokuro| Benino, Yasuhiko| Akai, Tomoko| |
| Published Date | 2022-8-1 |
| Publication Title | Journal of the Ceramic Society of Japan |
| Volume | volume130 |
| Issue | issue8 |
| Publisher | Ceramic Society of Japan |
| Start Page | 605 |
| End Page | 610 |
| ISSN | 1348-6535 |
| NCID | AA11556832 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2022 The Ceramic Society of Japan. |
| File Version | publisher |
| DOI | 10.2109/jcersj2.22052 |
| Web of Science KeyUT | 000830869600001 |
| JaLCDOI | 10.18926/OER/63485 |
|---|---|
| Title Alternative | Political, Economic, and Social Changes since the System Transformation Period in Poland: Doctrinal Trends of the Catholic Church and the Rise of Populism |
| FullText URL | oer_053_3_021_044.pdf |
| Author | Iemoto, Hiroichi| Taguchi, Masahiro| |
| Abstract | This paper describes the doctrinal trends of the Catholic Church and the rise of populist politics by analyzing the political, economic, and social changes that have occurred since the system transformation period. In 1989, Poland became the first socialist country to establish a non-communist government and led the system transformations in Eastern European countries. Politically, Poland has broken the communist dictatorship and introduced political pluralism, economically she has promoted market liberalization, and socially she has achieved democratization and cultural pluralism. However, politicians, while superficially advocating political pluralism, often engaged in a battle of mutual accusations through “lustration,” which refers to policies that limit the participation of former communists, especially informants of the communist secret police, resulting in political chaos. In recent years, under the “Law and Justice” regime, Catholic traditions and conservative national and family values have been honored as values that must be upheld by Poles, while EU skepticism has been propagated, anti-immigrant sentiments have been fanned, and the clampdown on LGBT people has been tightened. Conflicts with the EU have also intensified, including political intervention in the judiciary and the supremacy of domestic law over EU law. Put simply, Law and Justice, while claiming to reintroduce pluralism into a Polish polity dominated by the monolithic technocratic liberalism that was dominant in the early years of the transition, has in fact empowered social groups that felt excluded from the post-1989 reforms to create a more exclusive monism. Thus, while Poland received international attention as a country that led the way in democratization among the former Eastern European countries, even today pluralism has not taken stable root. In Chapter 1, the political and economic situation and changes of doctrine of the Church during the transition period will be analyzed. In Chapter 2, the political changes during the EU accession period and the church’s search for its position will mentioned. The chapter ３ will analyze the rise of populism after 2015 and its relationship to the Catholic Church. |
| Publication Title | Okayama Economic Review |
| Published Date | 2022-05-20 |
| Volume | volume53 |
| Issue | issue3 |
| Start Page | 21 |
| End Page | 44 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2022 岡山大学経済学会 |
| File Version | publisher |
| JaLCDOI | 10.18926/AMO/63209 |
|---|---|
| FullText URL | 76_1_51.pdf |
| Author | Eto, Eriko| Tani, Kazumasa| Maki, Jota| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that is associated with high insulin resistance and obesity. However, ~70% of women with PCOS in Japan are non-obese. We retrospectively analyzed the cases of 163 Japanese women with PCOS who visited our Ob/Gyn department in 2006-2018 to determine which has a greater effect on insulin resistance: PCOS or obesity. We reviewed the women’s medical records and calculated their insulin resistance and insulin secretion. The women’s mean age and pre-pregnancy body mass index (BMI) were 30±5.8 years and 24.8±5.6 kg/m2, respectively; their mean ± SD fasting plasma glucose, 94.1±13.7 mg/dL; HOMA-IR, 2.1±2.0; QUICKI, 0.4±0.0; and HOMA-β, 108.9±88.0%. Sixtyeight women were pregnant, and 37% (n=25) were obese (BMI ≥ 25 kg/m2). Obesity had a greater effect on insulin resistance: fasting plasma glucose F(1, 53)=6.134, p<0.05; fasting insulin F(1, 53)=31.606, p<0.01; HOMA-IR F(1, 53)=31.670, p<0.01; QUICKI F(1, 53)=16.156, p<0.01. There was no significant difference in values other than QUICKI and testosterone between the women with and without PCOS. Obesity thus had a greater effect on increased insulin resistance in pregnant women with PCOS. Further studies of the insulin resistance of non-obese women with PCOS is needed, as non-obese women with PCOS are common in Asia. |
| Keywords | polycystic ovary syndrome insulin resistance obesity pregnancy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-02 |
| Volume | volume76 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 56 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35236998 |
| Web of Science KeyUT | 000762812700007 |
| FullText URL | fulltext20220106-5.pdf |
|---|---|
| Author | Fukumoto, Yusei| Harada, Yuhei| Ohtsuka, Satomi| Kanayama, Naoki| Magari, Masaki| Hatano, Naoya| Sakagami, Hiroyuki| Tokumitsu, Hiroshi| |
| Keywords | CaMKK oligomerization Ca2+-signaling phosphorylation CaM kinase cascade |
| Note | © 2021 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.bbrc.2021.11.105] .| |
| Published Date | 2022-1 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume587 |
| Publisher | Elsevier BV |
| Start Page | 160 |
| End Page | 165 |
| ISSN | 0006-291X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Elsevier Inc. |
| File Version | author |
| PubMed ID | 34875535 |
| DOI | 10.1016/j.bbrc.2021.11.105 |
| Web of Science KeyUT | 000729413200005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2021.11.105 |
| FullText URL | fulltext20220104-3.pdf |
|---|---|
| Author | Suzuki, Etsuji| Tsuda, Toshihide| Yamamoto, Eiji| |
| Keywords | bias causality confounding factors epidemiologic methods |
| Note | © 2017 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.annepidem.2017.11.005] .| |
| Published Date | 2018-1 |
| Publication Title | Annals of Epidemiology |
| Volume | volume28 |
| Issue | issue1 |
| Publisher | Elsevier BV |
| Start Page | 48 |
| End Page | 53 |
| ISSN | 1047-2797 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2017 Elsevier Inc. |
| File Version | author |
| PubMed ID | 29241736 |
| DOI | 10.1016/j.annepidem.2017.11.005 |
| Web of Science KeyUT | 000425081000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.annepidem.2017.11.005 |
| JaLCDOI | 10.18926/AMO/62806 |
|---|---|
| FullText URL | 75_6_677.pdf |
| Author | Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy. |
| Keywords | endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 677 |
| End Page | 684 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955534 |
| Web of Science KeyUT | 000735297900002 |
| NAID | 120007180286 |
| FullText URL | fulltext20211015-5.pdf |
|---|---|
| Author | Potiszil, Christian| Montgomery, Wren| Sephton, Mark A.| |
| Keywords | carbonaceous chondrite Raman spectroscopy refractory organic matter heterogeneity alteration |
| Note | © 2021 Published by Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.epsl.2021.117149] .| |
| Published Date | 2021-11 |
| Publication Title | Earth and Planetary Science Letters |
| Volume | volume574 |
| Issue | issue15 |
| Publisher | Elsevier B.V. |
| Start Page | 117149 |
| ISSN | 0012-821X |
| NCID | AA00631029 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Published by Elsevier B.V. |
| File Version | author |
| DOI | 10.1016/j.epsl.2021.117149 |
| Web of Science KeyUT | 000701635400003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.epsl.2021.117149 |
| FullText URL | fulltext20210706-1.pdf |
|---|---|
| Author | Doi, Seita| Fujioka, Naoki| Ohtsuka, Satomi| Kondo, Rina| Yamamoto, Maho| Denda, Miwako| Magari, Masaki| Kanayama, Naoki| Hatano, Naoya| Morishita, Ryo| Hasegawa, Takafumi| Tokumitsu, Hiroshi| |
| Note | ©2021 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ceca.2021.102404] .| |
| Published Date | 2021-6 |
| Publication Title | Cell Calcium |
| Volume | volume96 |
| Publisher | Elsevier BV |
| Start Page | 102404 |
| ISSN | 0143-4160 |
| NCID | AA00142099 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2021 Elsevier Ltd. All rights reserved |
| File Version | author |
| PubMed ID | 33831707 |
| DOI | 10.1016/j.ceca.2021.102404 |
| Web of Science KeyUT | 000663580100007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ceca.2021.102404 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Maho| Kondo, Rina| Hozumi, Haruka| Doi, Seita| Denda, Miwako| Magari, Masaki| Kanayama, Naoki| Hatano, Naoya| Morishita, Ryo| Tokumitsu, Hiroshi| |
| Keywords | S100 protein HMG20A protein-protein interaction Ca2+-signal transduction genome-wide screening |
| Published Date | 2021-03-30 |
| Publication Title | Biomolecules |
| Volume | volume11 |
| Issue | issue4 |
| Publisher | MDPI |
| Start Page | 510 |
| ISSN | 2218-273X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 33808200 |
| NAID | 120007037385 |
| DOI | 10.3390/biom11040510 |
| Web of Science KeyUT | 000642769800001 |
| Related Url | isVersionOf https://doi.org/10.3390/biom11040510 |
