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JaLCDOI 10.18926/AMO/69851
FullText URL 79_6_469.pdf
Author Tsujii, Teruyuki| Matsuda, Tatsuo| Kimura, Yuji| Katsube, Ryoichi| Iwadou, Hironori| Funabiki, Sadami| Kamikawa, Yasuaki| Matsuda, Tadakazu|
Abstract We report a rare case of ileus tube-related intussusception in an adult. A 56-year-old man with adhesive bowel obstruction was treated with a nasointestinal ileus tube. Although his condition initially improved, persistent abdominal pain led to the diagnosis of intussusception via CT imaging. Manual repositioning of the tube resolved the intussusception without the need for bowel resection. A review of 80 previously reported cases of ileus tube-associated intussusception (total 81 cases, 95 lesions) highlighted the timing of onset, treatment strategies, and precautions. Early detection and diagnosis are crucial to prevent severe complications and preserve bowel function.
Keywords nasointestinal ileus tube intussusception small bowel obstruction enterectomy conservative treatment
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 469
End Page 474
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69850
FullText URL 79_6_463.pdf
Author Asano, Yudai| Nishihara, Chika| Kitayama, Takahiro| Okawa, Nanako| Makimoto, Satoko| Higaki, Fumiyo| Kojima, Katsuhide| Sugihara, Hanako| Ida, Naoyuki| Yanai, Hiroyuki| Hiraki, Takao|
Abstract We present a case of a woman in her 70s who was diagnosed with mesonephric adenocarcinoma of the uterine cervix, following biopsy and surgery. Preoperative MRI revealed a 7-cm, well-defined circumferential cervical mass with left lateral wall predominance, bulging into the uterine cavity and vagina. The lesion showed intermediate signal intensity on T2-weighted images, diffusion restriction, and early contrast enhancement weaker than that of the myometrium, followed by washout on contrast-enhanced imaging. The circumferential growth pattern with the lateral wall predominance and its imaging characteristics may suggest this rare entity be routinely included in the differential diagnosis of cervical cancers.
Keywords mesonephric adenocarcinoma cervical cancer MRI imaging characteristics HPV-independent adenocarcinoma
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 463
End Page 468
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69849
FullText URL 79_6_457.pdf
Author Asakawa, Tomohiko| Uchida, Haruhito A.| Katayama, Yu| Sakurabu, Yoshimasa| Katayama, Katsuyoshi| Onishi, Yasuhiro| Matsuoka-Uchiyama, Natsumi| Takeuchi, Hidemi| Tanaka, Keiko| Tsuji, Kenji| Umebayashi, Ryoko| Takemoto, Rika| Wada, Jun|
Abstract This case involves a 23-year-old male who was diagnosed with Behçet’s disease 5 years ago and managed with colchicine. Two months ago, he underwent renal biopsy due to abnormal urinalysis and kidney dysfunction, leading to a diagnosis of IgA nephropathy. He subsequently underwent tonsillectomy followed by glucocorticoid pulse therapy. However, after the tonsillectomy, discontinuing colchicine led to increased proteinuria, despite the glucocorticoid pulse therapy. Upon reintroducing colchicine, urinary protein excretion decreased, achieving incomplete remission. These findings suggest that colchicine may be effective in decreasing proteinuria in patients with Behçet’s disease complicated by IgA nephropathy.
Keywords Behçet’s disease IgA nephropathy colchicine
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 457
End Page 461
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69848
FullText URL 79_6_451.pdf
Author Hagihara, Moe| Seike, Keisuke| Hayashino, Kenta| Yasuhara, Takao| Kin, Kyohei| Hirata, Yuichi| Kobayashi, Hiroki| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Fujii, Nobuharu| Maeda, Yoshinobu|
Abstract Emicizumab, a bispecific monoclonal antibody, benefits patients with severe hemophilia A. It alters laboratory assessments of coagulation activity, requiring anti-idiotype monoclonal antibodies for accurate monitoring. A 64-year-old man, receiving emicizumab regularly, was admitted for laminoplasty. We planned to use FVIII replacement during the perioperative period after confirming the disappearance of inhibitors, monitoring coagulation activity with anti-idiotype monoclonal antibodies. Activated partial thromboplastin time was prolonged on postoperative day 2, prompting an immediate switch to eptacog alfa. The patient recovered without bleeding. This case underscores the necessity of anti-idiotype monoclonal antibodies for accurate monitoring.
Keywords emicizumab eptacog alfa hemophilia A inhibitor anti-idiotype monoclonal antibodies to emicizumab
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 451
End Page 455
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69847
FullText URL 79_6_445.pdf
Author Matsumi, Junya|
Abstract Our hospital began a PERIO program (perioperative patient management by a multi-disciplinary team from multiple departments) in 2016 to improve patient outcomes. We retrospectively analyzed the clinical effects of the PERIO program regarding the postoperative hospital stay (PHS) in the patients aged ≥ 18 years who underwent long lower-abdominal surgery at our hospital during the period April 2019 to March 2023. We excluded the cases of patients whose general anesthesia use was < 8 h, those for whom another surgery was performed simultaneously at another site, and emergency surgeries. The outcome was prolonged PHS, defined as exceeding the scheduled number of days specified in the patient’s clinical pathway. Among the 480 patients, prolonged PHS was observed for 270 patients (56.3%). In a multivariate logistic regression using advanced age, sex, high-risk general state, surgery requiring colon resection, serious adverse events (SAEs), and PERIO use, the following were associated with prolonged PHS: advance age (odds ratio [OR] 4.91, 95% confidence interval [CI]: 2.68-8.99, p=0.01), surgery requiring colon resection (OR 4.91, 95%CI: 2.68-8.99, p<0.001), SAE (OR 18.7, 95%CI: 7.22-48.2, p<0.001), and PERIO (OR 0.25, 95%CI: 0.13-0.47, p<0.001). The use of the PERIO program was thus beneficially associated with PHS after long lower-abdominal surgery.
Keywords hospital stay ERAS surgery cancer perioperative management
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 445
End Page 449
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69846
FullText URL 79_6_437.pdf
Author Matsumi, Junya| Sato, Tetsufumi|
Abstract The optimal indications for intensive care unit (ICU) treatment for critically ill cancer survivors whose condition has deteriorated due to medical factors are unclear. To test our hypothesis that frailty before deterioration was associated with hospital mortality in this patient population, we retrospective analyzed the cases of the patients admitted to the ICU at the National Cancer Center Hospital, Japan (April 2014-March 2022). We excluded patients who underwent surgery within 28 days or were denied critical care within 24 h or admitted after cardiopulmonary arrest. Their Clinical Frailty Scale (CFS) scores at 1 month before ICU admission (Pre-ICU) were obtained. Frailty was defined as CFS scores ≥4 points. We analyzed 298 admissions and observed that the mortality rate at hospital discharge was significantly higher in the frailty group (n=119). A multivariate analysis demonstrated that the following factors were significantly associated with hospital mortality: Pre-ICU frailty (OR 2.00, 95%CI: 1.19-3.36, p=0.009), cancer type (hematological: OR 2.93, 95%CI: 1.42-6.05, p=0.004), and Sequential Organ Failure Assessment score at ICU admission (OR 0.88, 95%CI: 0.82-0.95, p=0.0008). Frailty retrospectively assessed using the CFS at 1 month pre-ICU admission is a risk factor for hospital mortality in these cancer survivors.
Keywords frailty cancer survivor clinical frailty scale cancer critically ill
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 437
End Page 444
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69845
FullText URL 79_6_431.pdf
Author Inoue, Takahiro| Kuwabara, Hiroyo| Yamamoto, Koh|
Abstract The effect of weekend admission on patient mortality has been investigated in several therapeutic areas, including acute myeloid leukemia (AML), but the investigations’ results are controversial. We evaluated the relationship between in-hospital mortality and weekend admission in adult patients with AML in Japan by conducting a retrospective observational study using administrative data from 144 acute care hospitals from which patients were discharged between April 2014 and March 2019. The primary endpoint was in-hospital mortality, compared between weekend and weekday admissions. Among the 1,340 eligible patients, 11% (150) were admitted during a weekend. The in-hospital mortality rates of the patients admitted during weekends and those admitted on a weekday were 28% (42/150) and 17% (204/1190), respectively. After an adjustment for covariates, weekend admission was associated with a significantly higher risk of in-hospital mortality than weekday admission (HR 1.70, 95%CI: 1.20-2.40; p=0.003). However, such an association was not observed in patients treated in a bio-clean room (HR 1.26, 95%CI: 0.65-2.42). Our results demonstrate that for patients with AML, weekend admission was independently associated with a higher risk of death during hospitalization. An appropriate system is necessary for these patients.
Keywords acute leukemia weekend admission in-hospital mortality bio-clean room
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 431
End Page 436
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69844
FullText URL 79_6_421.pdf
Author Tanaka, Ayumi| Naoe, Shota| Takenaka, Reiju| Kanzaki, Norie| Sakoda, Akihiro| Yamaoka, Kiyonori| Kataoka, Takahiro|
Abstract Radon (222Rn; Rn) and thoron (220Rn; Tn) inhalation have been reported to enhance antioxidant activity in various organs. However, the effects of Tn on the colon have not been investigated. This study aimed to clarify the effects of Tn inhalation, alone and in combination with cyclosporin A (CsA), on dextran sulfate sodium (DSS)-induced colitis, and the accompanying oxidative stress, in mice. Male BALB/c mice were subjected to continuous 8-day Tn inhalation (c-Tn, 533±128 Bq/m3) or alternate-day Tn inhalation over the same period (f-Tn, 577±63Bq/m3), followed by treatment with 3% DSS and either CsA or vehicle for 7 days. Although the disease activity index (DAI) decreased significantly by day 2 in the c-Tn group, scores remained significantly higher than those in the f-Tn group. In the c-Tn group, superoxide dismutase and catalase activity in the colon were significantly elevated compared with those in sham controls. Thus, DSS-induced damage was effectively inhibited in the earlier stages by the c-Tn mode of inhalation than by the f-Tn mode. These findings suggest that continuous Tn inhalation more effectively attenuated early colitis symptoms than alternate-day inhalation, potentially through upregulation of antioxidant defenses. Tn and CsA showed no combined effects.
Keywords thoron DSS antioxidant activity CsA colon
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 421
End Page 429
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69843
FullText URL 79_6_413.pdf
Author Jiang, Zhiyun| Xi, Ying|
Abstract Several observational studies suggested that migraine headache attacks were associated with coronavirus disease 2019 (COVID-19). We investigated genetic causal links between COVID-19 phenotypes and the development of headache and migraine, including migraine with aura (MA) and migraine without aura (MO). We conducted a two-sample Mendelian randomization (MR) analysis to estimate the genetic association in European populations. The inverse-variance weighted (IVW) method was used as the main approach in the MR analyses, together with weighted median and MR-Egger methods. We also performed a series of sensitivity tests to assess the robustness of the MR results. The MR results demonstrated that COVID-19 severity, hospitalization, and susceptibility had no causal effect on the risks of headache, migraine, MA, or MO. No horizontal pleiotropy was detected, and the results were robust as supported by the sensitivity analysis findings. Our analyses identified no casual effect of COVID-19 severity, hospitalization, or susceptibility on the risks of headache or migraine in European populations.
Keywords headache migraine Mendelian randomization COVID-19
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 413
End Page 419
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/69842
FullText URL 79_6_405.pdf
Author Ouchi, Chihiro| Morizane Hosokawa, Mio| Kimura, Shuhei| Shiode, Yusuke| Matoba, Ryo| Morita, Tetsuro| Morizane, Yuki|
Abstract We investigated the treatment outcomes of patients aged ≥85 years with neovascular age-related macular degeneration (nAMD) who received anti-vascular endothelial growth factor (anti-VEGF) therapy using either treat-and-extend (TAE) or pro re nata (PRN) regimens for 1 year in real-world clinical practice. Eighty-five eyes from 85 patients were included. Among them, types 1, 2, and 3 macular neovascularization and polypoidal choroidal vasculopathy were present in 27.1%, 17.6%, 18.8%, and 36.5%, respectively. TAE and PRN regimens were used in 43.5% and 56.5% of patients, respectively. At baseline, the PRN group was older and had worse best-corrected visual acuity (BCVA), greater central retinal thickness, and more intraretinal fluid than the TAE group. In the TAE group, the mean number of injections was 7.6, BCVA improved significantly, and all retinal fluid rates decreased. In the PRN group, the mean number of injections was 3.9, BCVA remained unchanged, and the rates of macular fibrosis and atrophy increased. No serious adverse events were observed in either group. Anti-VEGF therapy was safe for patients aged ≥ 85 years with nAMD, and the TAE regimen effectively improved BCVA in this population. BCVA remained unchanged in the PRN-treated patients, with baseline disease severity and/or undertreatment potentially influencing the outcomes.
Keywords anti-vascular endothelial growth factor therapy neovascular age-related macular degeneration age treat-and-extend pro re nata
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-12
Volume volume79
Issue issue6
Publisher Okayama University Medical School
Start Page 405
End Page 412
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Luo, Yuxi| Guo, Ao| Wu, Jinglong| Yang, Jiajia|
Keywords workingmemory load attentional resource allocation modality-specific interference inhibitory control executive function sensory modality
Published Date 2025-10-30
Publication Title Brain Sciences
Volume volume15
Issue issue11
Publisher MDPI AG
Start Page 1178
ISSN 2076-3425
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 41300185
DOI 10.3390/brainsci15111178
Web of Science KeyUT 001624051800001
Related Url isVersionOf https://doi.org/10.3390/brainsci15111178
FullText URL fulltext.pdf
Author Wu, Fengxia| Ren, Yanna| Hao, Tengfei| Yang, Jingjing| Wu, Qiong| Yang, Jiajia| Wang, Meng|
Keywords spatial frequency visual orientation discrimination audiovisual integration early sensory stage late cognitive stage event-related potentials
Published Date 2025-05-19
Publication Title Frontiers in Neuroscience
Volume volume19
Publisher Frontiers Media SA
Start Page 1599114
ISSN 1662-453X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Wu, Ren, Hao, Yang, Wu, Yang and Wang.
File Version publisher
PubMed ID 40470293
DOI 10.3389/fnins.2025.1599114
Web of Science KeyUT 001503785600001
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FullText URL fulltext.pdf
Author Taya, Satoshi| Yoshida, Masatoki| Ejiri, Kentaro| Toda, Hironobu| Nakamura, Kazufumi| Morita, Hiroshi| Yuasa, Shinsuke|
Keywords complication coronary angiography imaging
Published Date 2025-10
Publication Title JACC: Case Reports
Volume volume30
Issue issue32
Publisher Elsevier BV
Start Page 105347
ISSN 2666-0849
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
PubMed ID 40928440
DOI 10.1016/j.jaccas.2025.105347
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Author Sung, Ping-chin| Bikharudin, Ahmad| Okada, Masahiro| Musa, Randa| Uchida, Kenta| Otaka, Akihisa| Matsusaka, Tadaaki| Matsugaki, Aira| Nakano, Takayoshi| Matsumoto, Takuya|
Keywords Cadmium Bone deterioration Calcium phosphate Bone quality
Published Date 2025-12
Publication Title Applied Food Research
Volume volume5
Issue issue2
Publisher Elsevier BV
Start Page 101482
ISSN 2772-5022
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
DOI 10.1016/j.afres.2025.101482
Web of Science KeyUT 001619467000005
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FullText URL fulltext.pdf
Author Yu, Hongwu| Ikeda, Naoshi| Mori, Masakazu| Kano, Jun| Park, Jae-Hyuk| Akedo, Jun|
Keywords Aerosol deposition Thick film Room temperature Ceramic coating RTIC Carbon fiber
Published Date 2025-12
Publication Title Materials &amp; Design
Volume volume260
Publisher Elsevier BV
Start Page 115195
ISSN 0264-1275
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
DOI 10.1016/j.matdes.2025.115195
Web of Science KeyUT 001631505000001
Related Url isVersionOf https://doi.org/10.1016/j.matdes.2025.115195
Author Miyamoto, Yuki| Ooe, Hiroki| Kuma, Susumu|
Note This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Yuki Miyamoto, Hiroki Ooe, Susumu Kuma; Fourier-transform infrared spectroscopy of hydrogen fluoride dimers in solid parahydrogen. J. Chem. Phys. 14 December 2025; 163 (22): 224312. https://doi.org/10.1063/5.0304689 and may be found at https://doi.org/10.1063/5.0304689.| This fulltext file will be available in Dec. 2026.|
Published Date 2025-12-10
Publication Title The Journal of Chemical Physics
Volume volume163
Issue issue22
Publisher AIP Publishing
Start Page 224312
ISSN 0021-9606
NCID AA00694991
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Author(s).
File Version publisher
PubMed ID 41369060
DOI 10.1063/5.0304689
Web of Science KeyUT 001636121300010
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FullText URL fulltext.pdf
Author Masuda, Yohei| Otsuka, Yuki| Soejima, Yoshiaki| Otsuka, Fumio|
Keywords extragastric compression focal liver lesions focal nodular hyperplasia gastric submucosal tumor spoke-wheel pattern
Published Date 2025-12
Publication Title Clinical Case Reports
Volume volume13
Issue issue12
Publisher Wiley
Start Page e71666
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 41368062
DOI 10.1002/ccr3.71666
Web of Science KeyUT 001633808000001
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Author Motohashi, Kanon| Soejima, Yoshiaki| Yamamoto, Koichiro| Iwata, Nahoko| Suyama, Atsuhito| Nakano, Yasuhiro| Otsuka, Fumio|
Keywords bone morphogenetic protein (BMP) thyroid hormone steroidogenesis ovary
Published Date 2025-09-18
Publication Title International Journal of Molecular Sciences
Volume volume26
Issue issue18
Publisher MDPI AG
Start Page 9127
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 41009688
DOI 10.3390/ijms26189127
Web of Science KeyUT 001580156800001
Related Url isVersionOf https://doi.org/10.3390/ijms26189127
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Author Mese, Osamu| Otsuka, Yuki| Sakurada, Yasue| Tokumasu, Kazuki| Soejima, Yoshiaki| Morita, Satoru| Nakano, Yasuhiro| Honda, Hiroyuki| Eguchi, Akiko| Fukuda, Sanae| Nojima, Junzo| Otsuka, Fumio|
Keywords biological antioxidant potential (BAP) Coronavirus disease 2019 (COVID-19) diacron-reactive oxygen metabolites (d-ROM) Long COVID oxidative stress index (OSI)
Published Date 2025-08-30
Publication Title Antioxidants
Volume volume14
Issue issue9
Publisher MDPI AG
Start Page 1068
ISSN 2076-3921
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 41008975
DOI 10.3390/antiox14091068
Web of Science KeyUT 001579416500001
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Author Kitamura, Wataru| Fujii, Keiko| Kobayashi, Hiroki| Abe, Masaya| Fukumi, Takuya| Ikeuchi, Kazuhiro| Otsuka, Fumio| Maeda, Yoshinobu| Fujii, Nobuharu|
Keywords Allogeneic Peripheral blood stem cells Hypokalemia Acid citrate dextrose solution A Healthy donors
Published Date 2025-08
Publication Title Transfusion and Apheresis Science
Volume volume64
Issue issue4
Publisher Elsevier BV
Start Page 104195
ISSN 1473-0502
NCID AA11555942
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors.
File Version publisher
PubMed ID 40561934
DOI 10.1016/j.transci.2025.104195
Web of Science KeyUT 10.1016/j.transci.2025.104195
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