result 167 件
| JaLCDOI | 10.18926/AMO/70073 |
|---|---|
| FullText URL | 80_1_055.pdf |
| Author | Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Yamamoto, Shohei| Nakano, Yasuhiro| Otsuka, Fumio| |
| Abstract | In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations. |
| Keywords | coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 55 |
| End Page | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748150 |
| Web of Science KeyUT | 001712994500007 |
| JaLCDOI | 10.18926/AMO/70072 |
|---|---|
| FullText URL | 80_1_047.pdf |
| Author | Eguchi, Yukiomi| Ushio, Soichiro| Irie, Keiichi| Yamashita, Yuta| Eguchi, Miyu| Nakano, Takafumi| Mishima, Kenichi| |
| Abstract | Deregulation of cannabis use is gradually expanding in Europe and the United States. However, the biological processes driving tolerance to delta-9-tetrahydrocannabinol (Δ9-THC), the main psychoactive component of cannabis, remain unclear. Thus, this study aimed to investigate the mechanisms and time course of tolerance development and loss to Δ9-THC in mice. Male ICR mice (7 weeks old) were administered Δ9-THC once daily for 3 days and then divided into three groups according to the washout period (3-, 10-, and 17-day washout groups). After each washout, changes in body temperature and locomotor activity were measured following re-exposure to Δ9-THC. Furthermore, the mRNA expression levels of CB1 and CB2 receptors in the brain were evaluated using real-time PCR. On day 1, significant hypothermia and reduced spontaneous locomotor activity were observed in the Δ9-THC-treated mice compared with the vehicle-treated mice. Tolerance to the hypothermic and locomotor-suppressing effects of Δ9-THC developed on days 2 and 3, respectively, and dissipated after 3 and 11 days of washout, respectively. These differences in the rates of tolerance development and recovery may reflect distinct underlying mechanisms. No significant changes in receptor mRNA expression were observed. These findings highlight the complexity of Δ9-THC tolerance and its potential implications for long-term cannabis use. |
| Keywords | delta-9-tetrahydrocannabinol cannabis tolerance locomotor hypothermic |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2026-02 |
| Volume | volume80 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 54 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2026 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41748149 |
| Web of Science KeyUT | 001712994500006 |
| JaLCDOI | 10.18926/AMO/69438 |
|---|---|
| FullText URL | 79_5_369.pdf |
| Author | Hisamatsu, Takashi| Kinuta, Minako| Munetomo, Sosuke| Fukuda, Mari| Kojima, Katsuhide| Taniguchi, Kaori| Nakahata, Noriko| Kanda, Hideyuki| |
| Abstract | We applied unsupervised machine learning to analyze blood pressure (BP) and resting heart rate (HR) patterns measured during a 1-year period to assess their cross-sectional relationships with subclinical cerebral and renal target damage. Dimension reduction via uniform manifold approximation and projection, followed by K-means++ clustering, was used to categorize 362 community-dwelling participants (mean age, 56.2 years; 54.9% women) into three groups: Low BP and Low HR (Lo-BP/Lo-HR), High BP and High HR (Hi-BP/Hi-HR), and Low BP and High HR (Lo-BP/Hi-HR). Cerebral vessel lesions were defined as the presence of at least one of the following magnetic resonance imaging findings: lacunar infarcts, white matter hyperintensities, cerebral microbleeds, or intracranial artery stenosis. A high urinary albumin-to-creatinine ratio (UACR) was defined as the top 10% (≥ 12 mg/g) of the mean value from ≥2 measurements. Poisson regression with robust error variance, adjusted for demographics, lifestyle, and medical history, showed that the Hi-BP/Hi-HR group had relative risks of 3.62 (95% confidence interval, 1.75-7.46) for cerebral vessel lesions and 3.58 (1.33-9.67) for high UACR, and the Lo-BP/Hi-HR group had a relative risk of 3.09 (1.12-8.57) for high UACR, compared with the Lo-BP/Lo-HR group. These findings demonstrate the utility of an unsupervised, data-driven approach for identifying physiological patterns associated with subclinical target organ damage. |
| Keywords | blood pressure heart rate subclinical disease uniform manifold approximation and projection unsupervised machine learning |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41126468 |
| Web of Science KeyUT | 001606013200007 |
| JaLCDOI | 10.18926/AMO/69437 |
|---|---|
| FullText URL | 79_5_359.pdf |
| Author | Hirose, Tomohiko| Ikuma, Hisanori| Otsuka, Kazutoshi| Kawasaki, Keisuke| |
| Abstract | Single-position surgery with lateral lumbar interbody fusion (LLIF) and percutaneous pedicle screws (PPSs) is gaining attention for its reduced invasiveness. We developed SPAPS, a technique allowing two surgeons to perform anterior LLIF and posterior PPS insertion simultaneously in a single lateral decubitus position. This retrospective study compared SPAPS (SPAPS-LLIF, Group SL) and minimally invasive posterior/transforaminal lumbar interbody fusion (MIS-PLIF/TLIF, Group PT) in patients treated between 2016 and 2019 with a two-year follow-up. Operative time, estimated blood loss (EBL), length of hospital stay (LOS), JOABPEQ and VAS scores, segmental lordotic angle, lumbar lordotic angle, segmental Cobb’s angle, PPS misplacement, PPS loosening, fusion status, and muscle cross-sectional areas were compared. Fifty-two patients were analyzed (Group SL: 25; Group PT: 27). SPAPS significantly reduced operative time (118.0 vs. 165.3 min, p <0.01) and estimated blood loss (8.6 vs. 164.1 mL, p<0.01). While clinical outcomes and hospital stay were comparable, Group SL had significantly lower PPS loosening (0% vs. 13%, p<0.01) and non-union rates (0% vs. 22.2%, p=0.02). Multifidus muscle atrophy was also less in Group SL (−14.3 vs. −121.5 mm2, p<0.01). SPAPS demonstrated advantages in reducing surgical invasiveness without compromising clinical efficacy, offering a promising alternative to conventional posterior fusion surgery. |
| Keywords | single-position surgery simultaneous lateral decubitus positioning lateral lumbar interbody fusion posterior lumbar interbody fusion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 368 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41126467 |
| Web of Science KeyUT | 001606013200006 |
| JaLCDOI | 10.18926/AMO/69435 |
|---|---|
| FullText URL | 79_5_345.pdf |
| Author | Matsunaga, Nozomu| Egusa, Seira| Aono, Riyo| Tamai, Eiji| Hitusmoto, Yasuo| Katayama, Seiichi| |
| Abstract | Clostridium perfringens is a pathogenic anaerobe that causes gas gangrene and food poisoning. Although autolysin-mediated reorganization of the bacterial cell wall is crucial for cell division, excessive autolysin activity induced by stressors can lead to cell lysis. In C. perfringens, air exposure is a significant stressor that causes cell lysis, and Acp (N-acetylglucosaminidase) is known to be a major autolysin. To further facilitate C. perfringens research, a technology to prevent air-induced cell lysis must be developed. This study investigated the role of Acp in air-induced autolysis and explored potential inhibitors that would prevent cell lysis during experimental procedures. Morphological analyses confirmed that Acp functions as an autolysin in C. perfringens, as acpdeficient strains exhibited filamentous growth. The mutants exhibited negligible autolysis under air-exposure stress, confirming the involvement of Acp in the autolytic process. We also evaluated the effects of various divalent cations on Acp activity in vitro and identified Zn2+ as a potent inhibitor. Brief treatment with a Zn2+- containing buffer induced dose-dependent cell elongation and autolysis inhibition in C. perfringens. These findings demonstrate that simple Zn2+ treatment before experiments stabilizes C. perfringens cells, reducing autolysis under aerobic conditions and facilitating various biological studies, except morphological analyses. |
| Keywords | Clostridium perfringens autolysin zinc air-exposure autolysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-10 |
| Volume | volume79 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 352 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41126465 |
| Web of Science KeyUT | 001606013200004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Liao, Isabel Jiah-Yih| Sakagami, Tosuke| Lewin, Thomas D.| Bailly, Xavier| Hamada, Mayuko| Luo, Yi-Jyun| |
| Keywords | hydra photosymbiosis green algae acoels sponges |
| Published Date | 2025-07 |
| Publication Title | Biology Letters |
| Volume | volume21 |
| Issue | issue7 |
| Publisher | The Royal Society |
| ISSN | 1744-957X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 40734651 |
| DOI | 10.1098/rsbl.2025.0250 |
| Web of Science KeyUT | 001539266500001 |
| Related Url | isVersionOf https://doi.org/10.1098/rsbl.2025.0250 |
| JaLCDOI | 10.18926/AMO/69159 |
|---|---|
| FullText URL | 79_4_311.pdf |
| Author | Matsubara, Kei| Matsubara, Kei| Hirano, Yutaka| Fujiwara, Toshiya| |
| Abstract | A 55-year-old obese Japanese male with left pneumothorax presented to our hospital. Bilateral pulmonary emphysema was confirmed. Persistent air leakage was observed, and a thoracoscopic bullectomy was performed. Although the thoracoscopic bullectomy was completed uneventfully, pre-extubation chest X-ray imaging indicated hyper-lucency occupying the right upper part of the thoracic cavity, suggesting right-sided pneumothorax. CT imaging indicated a right-upper-lobe expanded bulla. Extubation was performed, and the hyperinflated bulla gradually deflated. Careful management of bulla expansion and respiratory status may be necessary for patients with obesity and large bullae, especially in one-lung ventilation cases. |
| Keywords | giant bulla pneumothorax obesity positive pressure ventilation one lung ventilation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 311 |
| End Page | 315 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40859450 |
| Web of Science KeyUT | 001566281000001 |
| JaLCDOI | 10.18926/AMO/69155 |
|---|---|
| FullText URL | 79_4_287.pdf |
| Author | Tanimoto, Shun| Sasaki, Tatsuya| Kawai, Koji| Saijo, Tomoya| Kin, Kyohei| Sasada, Susumu| Tanaka, Shota| |
| Abstract | We report a case of drug-resistant parieto-occipital lobe epilepsy successfully treated with parieto-occipital disconnection (POD). An 18-year-old left-handed female, who had undergone surgery for an acute subdural hematoma at 10 months of age, developed drug-resistant epilepsy at age 15. Despite antiepileptic drug treatment, her seizures remained uncontrolled, and at age 18 she was referred to our hospital for evaluation. Magnetic resonance imaging (MRI) revealed atrophy in the left occipital and parietal lobes. Ictal electroencephalography (EEG) confirmed occipital onset of seizures without temporal lobe involvement. She had pre-existing homonymous hemianopsia. POD surgery was performed, carefully preserving the temporal lobe structures. Postoperatively, she experienced transient right-sided paresis, which fully resolved, and achieved complete seizure control at 3 years without memory loss. This case demonstrates that POD, a rare surgical approach, is a viable option for parieto-occipital lobe epilepsy, effectively controlling seizures while minimizing functional impairment in the absence of temporal lobe involvement. |
| Keywords | parieto-occipital lobe epilepsy parieto-occipital disconnection (POD) |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-08 |
| Volume | volume79 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 287 |
| End Page | 292 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40859446 |
| Web of Science KeyUT | 001566283200001 |
| FullText URL | fulltext.pdf suppl.docx |
|---|---|
| Author | Fortmeier, Vera| Lachmann, Mark| Stolz, Lukas| von Stein, Jennifer| Rommel, Karl-Philipp| Kassar, Mohammad| Gerçek, Muhammed| Schöber, Anne R.| Stocker, Thomas J.| Omran, Hazem| Fett, Michelle| Tervooren, Jule| Körber, Maria I.| Hesse, Amelie| Harmsen, Gerhard| Friedrichs, Kai Peter| Yuasa, Shinsuke| Rudolph, Tanja K.| Joner, Michael| Pfister, Roman| Baldus, Stephan| Laugwitz, Karl-Ludwig| Windecker, Stephan| Praz, Fabien| Lurz, Philipp| Hausleiter, Jörg| Rudolph, Volker| |
| Keywords | machine learning transcatheter tricuspid valve intervention tricuspid regurgitation |
| Published Date | 2025-02 |
| Publication Title | JACC: Advances |
| Volume | volume4 |
| Issue | issue2 |
| Publisher | Elsevier BV |
| Start Page | 101575 |
| ISSN | 2772-963X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Authors. |
| File Version | publisher |
| PubMed ID | 39848099 |
| DOI | 10.1016/j.jacadv.2024.101575 |
| Web of Science KeyUT | 001493699800001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jacadv.2024.101575 |
| FullText URL | fulltext.pdf suppl.xlsx |
|---|---|
| Author | Hughes, Holly R.| Ballinger, Matthew J.| Bao, Yiming| Bejerman, Nicolas| Blasdell, Kim R.| Briese, Thomas| Brignone, Julia| Carrera, Jean Paul| De Coninck, Lander| de Souza, William Marciel| Debat, Humberto| Dietzgen, Ralf G.| Dürrwald, Ralf| Erdin, Mert| Fooks, Anthony R.| Forbes, Kristian M.| Freitas-Astúa, Juliana| Garcia, Jorge B.| Geoghegan, Jemma L.| Grimwood, Rebecca M.| Horie, Masayuki| Hyndman, Timothy H.| Johne, Reimar| Klena, John D.| Kondo, Hideki| Koonin, Eugene V.| Kostygov, Alexei Y.| Krupovic, Mart| Kuhn, Jens H.| Letko, Michael| Li, Jun-Min| Liu, Yiyun| Martin, Maria Laura| Mull, Nathaniel| Nazar, Yael| Nowotny, Norbert| Nunes, Márcio Roberto Teixeira| Økland, Arnfinn Lodden| Rubbenstroth, Dennis| Russell, Brandy J.| Schott, Eric| Seifert, Stephanie| Sen, Carina| Shedroff, Elizabeth| Sironen, Tarja| Smura, Teemu| Tavares, Camila Prestes Dos Santos| Tesh, Robert B.| Tilston, Natasha L.| Tordo, Noël| Vasilakis, Nikos| Walker, Peter J.| Wang, Fei| Whitfield, Anna E.| Whitmer, Shannon L.M.| Wolf, Yuri I.| Xia, Han| Ye, Gong-Yin| Ye, Zhuangxin| Yurchenko, Vyacheslav| Zhao, Mingli| |
| Published Date | 2025-07-25 |
| Publication Title | Journal of General Virology |
| Volume | volume106 |
| Issue | issue7 |
| Publisher | Microbiology Society |
| Start Page | 002112 |
| ISSN | 0022-1317 |
| NCID | AA00698722 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Microbiology Society |
| File Version | publisher |
| PubMed ID | 40711815 |
| DOI | 10.1099/jgv.0.002112 |
| Related Url | isVersionOf https://doi.org/10.1099/jgv.0.002112 |
| FullText URL | fulltext.pdf suppl.xlsx |
|---|---|
| Author | Rubino, Luisa| Abrahamian, Peter| An, Wenxia| Aranda, Miguel A.| Ascencio-Ibañez, José T.| Bejerman, Nicolas| Blouin, Arnaud G.| Candresse, Thierry| Canto, Tomas| Cao, Mengji| Carr, John P.| Cho, Won Kyong| Constable, Fiona| Dasgupta, Indranil| Debat, Humberto| Dietzgen, Ralf G.| Digiaro, Michele| Donaire, Livia| Elbeaino, Toufic| Fargette, Denis| Filardo, Fiona| Fischer, Matthias G.| Fontdevila, Nuria| Fox, Adrian| Freitas-Astua, Juliana| Fuchs, Marc| Geering, Andrew D.W.| Ghafari, Mahan| Hafrén, Anders| Hammond, John| Hammond, Rosemarie| Hasiów-Jaroszewska, Beata| Hebrard, Eugenie| Hernández, Carmen| Hily, Jean-Michel| Hosseini, Ahmed| Hull, Roger| Inoue-Nagata, Alice K.| Jordan, Ramon| Kondo, Hideki| Kreuze, Jan F.| Krupovic, Mart| Kubota, Kenji| Kuhn, Jens H.| Leisner, Scott| Lett, Jean-Michel| Li, Chengyu| Li, Fan| Li, Jun Min| López-Lambertini, Paola M.| Lopez-Moya, Juan J.| Maclot, Francois| Mäkinen, Kristiina| Martin, Darren| Massart, Sebastien| Miller, W. Allen| Mohammadi, Musa| Mollov, Dimitre| Muller, Emmanuelle| Nagata, Tatsuya| Navas-Castillo, Jesús| Neriya, Yutaro| Ochoa-Corona, Francisco M.| Ohshima, Kazusato| Pallás, Vicente| Pappu, Hanu| Petrzik, Karel| Pooggin, Mikhail| Prigigallo, Maria Isabella| Ramos-González, Pedro L.| Ribeiro, Simone| Richert-Pöggeler, Katja R.| Roumagnac, Philippe| Roy, Avijit| Sabanadzovic, Sead| Šafářová, Dana| Saldarelli, Pasquale| Sanfaçon, Hélène| Sarmiento, Cecilia| Sasaya, Takahide| Scheets, Kay| Schravesande, Willem E.W.| Seal, Susan| Shimomoto, Yoshifumi| Sõmera, Merike| Stavolone, Livia| Stewart, Lucy R.| Teycheney, Pierre-Yves| Thomas, John E.| Thompson, Jeremy R.| Tiberini, Antonio| Tomitaka, Yasuhiro| Tzanetakis, Ioannis| Umber, Marie| Urbino, Cica| van den Burg, Harrold A.| Van der Vlugt, René A.A.| Varsani, Arvind| Verhage, Adriaan| Villamor, Dan| von Bargen, Susanne| Walker, Peter J.| Wetzel, Thierry| Whitfield, Anna E.| Wylie, Stephen J.| Yang, Caixia| Zerbini, F. Murilo| Zhang, Song| |
| Published Date | 2025-07-25 |
| Publication Title | Journal of General Virology |
| Volume | volume106 |
| Issue | issue7 |
| Publisher | Microbiology Society |
| Start Page | 002114 |
| ISSN | 0022-1317 |
| NCID | AA00698722 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Microbiology Society |
| File Version | publisher |
| PubMed ID | 40711908 |
| DOI | 10.1099/jgv.0.002114 |
| Related Url | isVersionOf https://doi.org/10.1099/jgv.0.002114 |
| FullText URL | fulltext.pdf suppl.docx |
|---|---|
| Author | Wang, Weiwei| Liu, Yanting| Gu, Jiayi| An, Shaoya| Ma, Cheng| Gao, Haichun| Jiao, Nianzhi| Shen, Jian‐Ren| Beatty, John Thomas| Koblížek, Michal| Zhang, Xing| Zheng, Qiang| Chen, Jing‐Hua| |
| Keywords | energy transfer photoheterotrophic bacteria photosynthesis reaction center structure |
| Published Date | 2025-03-20 |
| Publication Title | Advanced Science |
| Volume | volume12 |
| Issue | issue18 |
| Publisher | Wiley |
| Start Page | 2413456 |
| ISSN | 2198-3844 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | ©2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 40112203 |
| DOI | 10.1002/advs.202413456 |
| Web of Science KeyUT | 001448217300001 |
| Related Url | isVersionOf https://doi.org/10.1002/advs.202413456 |
| JaLCDOI | 10.18926/AMO/68724 |
|---|---|
| FullText URL | 79_3_167.pdf |
| Author | Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator| |
| Abstract | This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy. |
| Keywords | non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 167 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574255 |
| Web of Science KeyUT | 001524768800003 |
| JaLCDOI | 10.18926/AMO/68722 |
|---|---|
| FullText URL | 79_3_147.pdf |
| Author | Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun| |
| Abstract | Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes. |
| Keywords | systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-06 |
| Volume | volume79 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 147 |
| End Page | 155 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40574253 |
| Web of Science KeyUT | 001524768800001 |
| JaLCDOI | 10.18926/AMO/68644 |
|---|---|
| FullText URL | 79_2_065.pdf |
| Author | Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka| |
| Abstract | Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy. |
| Keywords | anamorelin cancer-associated cachexia body mass index albumin efficacy rate |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-04 |
| Volume | volume79 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 73 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 40302277 |
| Web of Science KeyUT | 001485544200001 |
| JaLCDOI | 10.18926/AMO/67877 |
|---|---|
| FullText URL | 78_6_469.pdf |
| Author | Hirata, Yuichi| Nagase, Takayuki| Sasada, Susumu| Ayada, Yoshiyuki| Miyake, Hayato| Sugahara, Chiaki| Yamamoto, Hidetaka| Oda, Yoshinao| Yasuhara, Takao| Tanaka, Shota| |
| Abstract | Tenosynovial giant cell tumor (TGCT) is a fibrous histiocytic tumor originating in the synovial membrane. While cervical TGCT may not be considered a common diagnosis preoperatively because it is relatively rare, it has a high recurrence rate and should be considered. Total resection is preferable, but it can be challenging due to the risk of damaging the vertebral artery. Denosumab has shown effectiveness as a postoperative treatment for osteolytic bone lesion. Denosumab administration coupled with close follow-up might offer an effective postoperative treatment option for unresectable TGCT with bone invasion. |
| Keywords | tenosynovial giant cell tumor bone tumor spine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719321 |
| Web of Science KeyUT | 001397269500003 |
| JaLCDOI | 10.18926/AMO/67871 |
|---|---|
| FullText URL | 78_6_453.pdf |
| Author | Kawata, Yujiro| Watanabe, Kenta| Tokiya, Ryoji| Matsuno, Takeshi| Tanaka, Ryo| Taira, Naruto| Katsui, Kuniaki| |
| Abstract | Radiation-induced angiosarcoma (RIAS) is a rare, late adverse event of radiotherapy comprising approximately half of all radiation-induced sarcomas. It has a relatively short latency period and generally unfavorable prognosis. This study presents a case of RIAS that developed 5 years and 11 months after the completion of hypofractionated radiotherapy (42.56 Gy/16 fractions) following partial mastectomy. The patient was diagnosed with RIAS 10 months after the onset of skin redness. She underwent skin tumor resection, followed by paclitaxel, then pazopanib administration, but no radiotherapy. At 6 years and 2 months after surgery, no RIAS recurrence has been detected. |
| Keywords | breast cancer hypofractionated radiotherapy radiation-induced angiosarcoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 453 |
| End Page | 458 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719318 |
| Web of Science KeyUT | 001397808000001 |
| JaLCDOI | 10.18926/AMO/67868 |
|---|---|
| FullText URL | 78_6_429.pdf |
| Author | Kubota, Risa| Bekku, Kensuke| Katayama, Satoshi| Iwata, Takehiro| Nishimura, Shingo| Edamura, Kohei| Kobayashi, Tomoko| Kobayashi, Yasuyuki| Araki, Motoo| |
| Abstract | Although partial nephrectomy (PN) is preferred over radical nephrectomy (RN) for preserving renal function in patients with cT1 renal cancer, its impact on cardiovascular events (CVe) remains controversial. This study aimed to compare PN and RN in regard to the occurrence of CVe, including cerebrovascular events and exacerbation of hypertension (HT). We retrospectively analyzed 418 consecutive patients who underwent PN or RN for cT1 renal cancer. Propensity score-matching analysis was used to adjust for imbalances between patients who underwent PN and RN, leaving 102 patients in each group. The 5-year probability of cumulative CVe incidence was 6% in the PN group and 12% in the RN group (p=0.03), with a median follow-up of 73.5 months. The statistical significance was retained after propensity score matching for patients without preoperative proteinuria (p=0.03). For all CVe including cerebrovascular events and exacerbation of HT analyzed, PN provided a lower probability of occurrence than RN in patients with small renal cancers. |
| Keywords | chronic kidney disease hypertension nephrectomy proteinuria |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-12 |
| Volume | volume78 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 429 |
| End Page | 437 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39719315 |
| Web of Science KeyUT | 001397799300001 |
| JaLCDOI | 10.18926/AMO/67665 |
|---|---|
| FullText URL | 78_5_407.pdf |
| Author | Shimoyama, Kyoko| Nakajima, Atsushi| Minari, Yoshimitsu| |
| Abstract | Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but they have been known to cause immune-related adverse events (irAEs) by promoting T-cell activation. Neurological irAEs are rare (1%) but have a high fatality rate (11.5%). Here we report the first case of Bickerstaff brainstem encephalitis (BBE) induced by an ICI. A woman in her 60s with metastatic breast cancer was treated with atezolizumab plus nab-paclitaxel once intravenously. Eighteen days later, she lost consciousness with ophthalmoplegia and was diagnosed with a neurological irAE. She recovered consciousness immediately with the administration of intravenous immunoglobulin (IVIG) but suffered severe permanent peripheral neuropathy. Although it is just one case, this experience shows that BBE occurring as a neurological irAE of ICI cancer treatment may be associated with more severe outcomes than conventional BBE in metastatic cancer. Creating a system for multidisciplinary treatment is essential for ICI therapy. |
| Keywords | Bickerstaff brainstem encephalitis immune checkpoint inhibitor atezolizumab neurological immune-related adverse event breast cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-10 |
| Volume | volume78 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 39467659 |
| Web of Science KeyUT | 001343346400007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Saida, Yuri| Gauthier, Thomas| Suzuki, Hiroo| Ohmura, Satoshi| Shikata, Ryo| Iwasaki, Yui| Noyama, Godai| Kishibuchi, Misaki| Tanaka, Yuichiro| Yajima, Wataru| Godin, Nicolas| Privault, Gael| Tokunaga, Tomoharu| Ono, Shota| Koshihara, Shin-Ya| Tsuruta, Kenji| Hayashi, Yasuhiko| Bertoni, Roman| Hada, Masaki| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48880-3| |
| Published Date | 2024-05-30 |
| Publication Title | Nature Communications |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4600 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38816382 |
| DOI | 10.1038/s41467-024-48880-3 |
| Web of Science KeyUT | 001236316700036 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-024-48880-3 |
