result 1238 件
FullText URL | fulltext.pdf |
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Author | Khazan, Negar| Kim, Kyu Kwang| Hansen, Jeanne N.| Singh, Niloy A.| Moore, Taylor| Snyder, Cameron W. A.| Pandita, Ravina| Strawderman, Myla| Fujihara, Michiko| Takamura, Yuta| Jian, Ye| Battaglia, Nicholas| Yano, Naohiro| Teramoto, Yuki| Arnold, Leggy A.| Hopson, Russell| Kishor, Keshav| Nayak, Sneha| Ojha, Debasmita| Sharon, Ashoke| Ashton, John M.| Wang, Jian| Milano, Michael T.| Miyamoto, Hiroshi| Linehan, David C.| Gerber, Scott A.| Kawar, Nada| Singh, Ajay P.| Tabdanov, Erdem D.| Dokholyan, Nikolay V.| Kakuta, Hiroki| Jurutka, Peter W.| Schor, Nina F.| Rowswell-Turner, Rachael B.| Singh, Rakesh K.| Moore, Richard G.| |
Published Date | 2022-04-11 |
Publication Title | Journal of Medicinal Chemistry |
Volume | volume65 |
Issue | issue8 |
Publisher | American Chemical Society (ACS) |
Start Page | 6039 |
End Page | 6055 |
ISSN | 0022-2623 |
NCID | AA00702411 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35404047 |
DOI | 10.1021/acs.jmedchem.1c01878 |
Web of Science KeyUT | 000797573100012 |
Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878 |
FullText URL | fulltext.pdf |
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Author | Ono-Minagi, Hitomi| Nohno, Tsutomu| Serizawa, Takashi| Usami, Yu| Sakai, Takayoshi| Okano, Hideyuki| Ohuchi, Hideyo| |
Keywords | salivary and lacrimal glands development three germ layers neural crest |
Published Date | 2023-09-05 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume24 |
Issue | issue18 |
Publisher | MDPI |
Start Page | 13692 |
ISSN | 1661-6596 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 37761995 |
DOI | 10.3390/ijms241813692 |
Web of Science KeyUT | 001071736900001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms241813692 |
FullText URL | fulltext.pdf |
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Author | Umemori, Koki| Ono, Kisho| Kanemoto, Hideka| Obata, Kyoichi| Kawai, Hotaka| Nakamura, Tomoya| Nakano, Keisuke| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira| |
Keywords | Pleomorphic adenoma (PA) upper lip lower lip minor salivary gland tumor case series |
Published Date | 2022-10-27 |
Publication Title | Gland Surgery |
Volume | volume11 |
Issue | issue10 |
Publisher | AME Publishing Company |
Start Page | 1730 |
End Page | 1740 |
ISSN | 2227-684X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Gland Surgery. |
File Version | publisher |
PubMed ID | 36353586 |
DOI | 10.21037/gs-22-308 |
Web of Science KeyUT | 000860255900001 |
Related Url | isVersionOf https://doi.org/10.21037/gs-22-308 |
FullText URL | fulltext.pdf |
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Author | Ohmori, Iori| Ouchida, Mamoru| Shinohara, Masakazu| Kobayashi, Kiyoka| Ishida, Saeko| Mashimo, Tomoji| |
Keywords | animal model combined generalized and focal epilepsy oxidative stress thioredoxin |
Published Date | 2022-05-28 |
Publication Title | Epilepsia |
Volume | volume63 |
Issue | issue7 |
Publisher | Wiley |
Start Page | e80 |
End Page | e85 |
ISSN | 0013-9580 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35532890 |
DOI | 10.1111/epi.17295 |
Web of Science KeyUT | 000800706600001 |
Related Url | isVersionOf https://doi.org/10.1111/epi.17295 |
FullText URL | fulltext.pdf |
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Author | Nakata, Eiji| Kawai, Hotaka| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Inoue, Hirofumi| Futagawa, Mashu| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
Keywords | giant cell tumor of bone malignant transformation p53 denosumab molecular targeted therapy |
Published Date | 2022-07-19 |
Publication Title | Oncology Letters |
Volume | volume24 |
Issue | issue3 |
Publisher | Spandidos Publications |
Start Page | 319 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Nakata et al. |
File Version | publisher |
PubMed ID | 35949597 |
DOI | 10.3892/ol.2022.13439 |
Web of Science KeyUT | 000840512400001 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13439 |
FullText URL | fulltext20230923-01.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| |
Keywords | myxoma orbital CD34 ethmoid sinus literature review |
Published Date | 2023-09-22 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume11 |
Publisher | SAGE Publications |
Start Page | 1 |
End Page | 6 |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 American Federation for Medical Research |
File Version | publisher |
PubMed ID | 37737575 |
DOI | 10.1177/23247096231201013 |
Web of Science KeyUT | 001070220300001 |
Related Url | isVersionOf https://doi.org/10.1177/23247096231201013 |
FullText URL | fulltext.pdf |
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Author | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
Keywords | Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry |
Note | The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6| |
Published Date | 2022-02-08 |
Publication Title | Journal of Gastrointestinal Surgery |
Volume | volume26 |
Issue | issue6 |
Publisher | Springer Science and Business Media LLC |
Start Page | 1213 |
End Page | 1223 |
ISSN | 1091-255X |
NCID | AA11494553 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2022 |
File Version | publisher |
PubMed ID | 35137343 |
DOI | 10.1007/s11605-021-05197-6 |
Web of Science KeyUT | 000752761400001 |
Related Url | isVersionOf https://doi.org/10.1007/s11605-021-05197-6 |
FullText URL | fulltext.pdf |
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Author | Yamamoto, Hiromasa| Soh, Junichi| Okumura, Norihito| Suzuki, Hiroyuki| Nakata, Masao| Fujiwara, Toshiya| Gemba, Kenichi| Sano, Isao| Fujinaga, Takuji| Kataoka, Masafumi| Terazaki, Yasuhiro| Fujimoto, Nobukazu| Kataoka, Kazuhiko| Kosaka, Shinji| Yamashita, Motohiro| Inokawa, Hidetoshi| Inoue, Masaaki| Nakamura, Hiroshige| Yamashita, Yoshinori| Hotta, Katsuyuki| Yoshioka, Hiroshige| Morita, Satoshi| Matsuo, Keitaro| Sakamoto, Junichi| Date, Hiroshi| Toyooka, Shinichi| |
Published Date | 2023-05-19 |
Publication Title | PLoS ONE |
Volume | volume18 |
Issue | issue5 |
Publisher | Public Library of Science |
Start Page | e0285273 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Yamamoto et al. |
File Version | publisher |
PubMed ID | 37205678 |
DOI | 10.1371/journal.pone.0285273 |
Web of Science KeyUT | 001050599900034 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0285273 |
FullText URL | fulltext.pdf |
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Author | Morinaga, Takao| Inozume, Takashi| Kawazu, Masahito| Ueda, Youki| Sax, Nicolas| Yamashita, Kazuo| Kawashima, Shusuke| Nagasaki, Joji| Ueno, Toshihide| Lin, Jason| Ohara, Yuuki| Kuwata, Takeshi| Yukami, Hiroki| Kawazoe, Akihito| Shitara, Kohei| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Kawahara, Yu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Morita, Ayako| Ichihara, Eiki| Kiura, Katsuyuki| Enokida, Tomohiro| Tahara, Makoto| Hasegawa, Yoshinori| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke| |
Published Date | 2022-07-28 |
Publication Title | Cancer Research Communications |
Volume | volume2 |
Issue | issue7 |
Publisher | American Association for Cancer Research |
Start Page | 739 |
End Page | 753 |
ISSN | 2767-9764 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors |
File Version | publisher |
PubMed ID | 36923281 |
DOI | 10.1158/2767-9764.CRC-22-0050 |
Web of Science KeyUT | 001048412300001 |
Related Url | isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050 |
FullText URL | fulltext.pdf |
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Author | Sun, Hongming| Morihara, Ryuta| Feng, Tian| Bian, Zhihong| Yu, Haibo| Hu, Xiao| Hu, Xinran| Bian, Yuting| Sasaki, Ryo| Fukui, Yusuke| Takemoto, Mami| Yunoki, Taijun| Nakano, Yumiko| Abe, Koji| Yamashita, Toru| |
Keywords | ischemic stroke human cord blood-endothelial progenitor cells mechanical thrombectomy intimal hyperplasia |
Published Date | 2023-08-24 |
Publication Title | Cell Transplantation |
Volume | volume32 |
Publisher | SAGE Publications |
ISSN | 0963-6897 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 37615293 |
DOI | 10.1177/09636897231193069 |
Web of Science KeyUT | 001059017900001 |
Related Url | isVersionOf https://doi.org/10.1177/09636897231193069 |
FullText URL | fulltext.pdf |
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Author | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
Keywords | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
Published Date | 2021-12-09 |
Publication Title | DEN Open |
Volume | volume2 |
Issue | issue1 |
Publisher | Wiley |
Start Page | e83 |
ISSN | 2692-4609 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Authors. |
File Version | publisher |
PubMed ID | 35310725 |
DOI | 10.1002/deo2.83 |
Web of Science KeyUT | 001047024900091 |
Related Url | isVersionOf https://doi.org/10.1002/deo2.83 |
FullText URL | fulltext.pdf |
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Author | Hiraoka, Tomohiro| Kawamura, Mai| Takada, Keisuke| Moriwake, Tadashi| |
Keywords | Cystinuria Ureterolithiasis Cystine Acute appendicitis Case report |
Published Date | 2022-10 |
Publication Title | International Journal of Surgery Case Reports |
Volume | volume99 |
Publisher | Elsevier |
Start Page | 107596 |
ISSN | 2210-2612 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 36115118 |
DOI | 10.1016/j.ijscr.2022.107596 |
Web of Science KeyUT | 001043865800003 |
Related Url | isVersionOf https://doi.org/10.1016/j.ijscr.2022.107596 |
FullText URL | fulltext.pdf |
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Author | Kanzaki, Hiromitsu| Horii, Joichiro| Takenaka, Ryuta| Nakagawa, Hiroyuki| Matsueda, Kazuhiro| Tsuzuki, Takao| Kita, Masahide| Yamasaki, Yasushi| Tanaka, Takehiro| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Tomoda, Jun| Okada, Hiroyuki| |
Published Date | 2022-06-10 |
Publication Title | Endoscopy International Open |
Volume | volume10 |
Issue | issue06 |
Publisher | Georg Thieme Verlag KG |
Start Page | E712 |
End Page | E718 |
ISSN | 2364-3722 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022. The Author(s). |
File Version | publisher |
PubMed ID | 35859656 |
DOI | 10.1055/a-1793-9439 |
Web of Science KeyUT | 000826506700001 |
Related Url | isVersionOf https://doi.org/10.1055/a-1793-9439 |
JaLCDOI | 10.18926/AMO/65752 |
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FullText URL | 77_4_415.pdf |
Author | Jelcic, Dzenis| Puzovic, Velibor| Benzon, Benjamin| Palada, Ivan| Jerković, Jelena| Vulic, Marko| |
Abstract | The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset. |
Keywords | vitamin D receptor immunohistochemistry early and late-onset preeclampsia |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 415 |
End Page | 422 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635142 |
Web of Science KeyUT | 001163659800006 |
JaLCDOI | 10.18926/AMO/65748 |
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FullText URL | 77_4_377.pdf |
Author | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
Abstract | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
Keywords | NAFLD NASH liver fibrosis chemokine FIB-4 |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 377 |
End Page | 385 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635138 |
Web of Science KeyUT | 001163659800009 |
JaLCDOI | 10.18926/AMO/65746 |
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FullText URL | 77_4_371.pdf |
Author | Iwamoto, Yosuke| Kaya, Mitsunori| Kijima, Hiroaki| Fujii, Masashi| Nagahata, Itsuki| Miyakoshi, Naohisa| |
Abstract | In recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 years). Arthroscopic findings confirmed bursitis in all 24 joints. In all cases, debridement of the greater trochanter bursa provided rapid relief of greater trochanter pain. The Numerical Rating Scale showed significant improvement, from the preoperative mean of 7.8 (range, 6-10) to the postoperative day 7 mean of 1.6 (range, 0-3). The modified Harris Hip Score was significantly improved from the preoperative mean of 65.5 (range, 52.5-78.3) to the final follow-up (average 2.9 months) mean of 96.0 (range, 85.2-100). Fascial damage of the gluteus medius muscle was observed in 21 joints while only 2 patients had a gluteus medius tendinous injury. Greater trochanteric bursitis and fascia or muscle-fiber injury of the gluteus medius muscle are the most common pathologies in patients with lateral hip pain. |
Keywords | greater trochanteric pain syndrome endoscopic findings bursitis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 371 |
End Page | 375 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635137 |
Web of Science KeyUT | 001163659800005 |
JaLCDOI | 10.18926/AMO/65745 |
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FullText URL | 77_4_365.pdf |
Author | Moldovan, Elena| Bănescu, Claudia| Cucerea, Manuela| Moldovan, Valeriu| Gozar, Liliana| Pușcașiu, Lucian| |
Abstract | Congenital heart disease is the most common malformative pathology in newborns, with a worldwide incidence at 0.4-5%. We investigated the possible relationship between variations in nucleotide sequences and specific cardiac malformations in the GATA-binding factor 4 (GATA4) exon 1 region by using Sanger sequencing. Forty-four newborns from a third-level neonatal intensive care unit who were diagnosed with nonsyndromic, ductal-dependent congenital heart disease (i.e., transposition of the great arteries or ductal-dependent coarctation of the aorta) were enrolled. Their DNA was extracted using commercial methods and tested using the multiplex ligation-dependent probe amplification (MLPA) technique. The Sanger sequencing for GATA4 exon 1 in the newborns’ DNA identified rs61277615, rs73203482, and rs35813172 variants not reported in the ClinVar archive of human variations in newborns previously diagnosed with transposition of the great arteries (n=5) and coarctation of the aorta (n=1). The identification of these novel variants in newborns with transposition of the great arteries or ductal-dependent coarctation of the aorta may be the first step in determining the variants’ contribution to the occurrence of congenital heart disease. However, these results may be inconclusive, since the observed variants within GATA4 gene were not previously reported. |
Keywords | transposition of the great arteries ductal-dependent coarctation of the aorta GATA4 MLPA Sanger sequencing |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 365 |
End Page | 370 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635136 |
Web of Science KeyUT | 001163659800008 |
FullText URL | fulltext.pdf |
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Author | Sukegawa, Shintaro| Ono, Sawako| Tanaka, Futa| Inoue, Yuta| Hara, Takeshi| Yoshii, Kazumasa| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Katsumitsu, Shimada| Nakai, Fumi| Nakai, Yasuhiro| Miyazaki, Ryo| Murakami, Satoshi| Nagatsuka, Hitoshi| Miyake, Minoru| |
Note | The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-38343-y| |
Published Date | 2023-07-19 |
Publication Title | Scientific Reports |
Volume | volume13 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 11676 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023 |
File Version | publisher |
PubMed ID | 37468501 |
DOI | 10.1038/s41598-023-38343-y |
Web of Science KeyUT | 001033545700013 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-023-38343-y |
FullText URL | fulltext.pdf |
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Author | Chen, Mengxi| Tanaka, Takehiro| Igawa, Takuro| Han, Yanyan| Peng, Fangli| Jin, Zaishun| Yoshino, Tadashi| |
Keywords | PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum |
Published Date | 2023-07 |
Publication Title | Heliyon |
Volume | volume9 |
Issue | issue7 |
Publisher | Cell Press |
Start Page | e18241 |
ISSN | 2405-8440 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 The Authors. |
File Version | publisher |
PubMed ID | 37519669 |
DOI | 10.1016/j.heliyon.2023.e18241 |
Web of Science KeyUT | 001043928200001 |
Related Url | isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241 |
JaLCDOI | 10.18926/AMO/65740 |
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FullText URL | 77_4_347.pdf |
Author | Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki| |
Abstract | The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry. |
Keywords | flow cytometry stem cell transplantation transplantation-associated microangiopathy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-08 |
Volume | volume77 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 347 |
End Page | 357 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37635134 |
Web of Science KeyUT | 001163659800002 |