検索結果 - 岡山大学学術成果リポジトリ

Expression and clinicopathological characteristics of PDX1, PTF1A, and SALL4 in large and small ducts of ectopic pancreas located in gastro-duodenum and jejunum

フルテキストURL	fulltext.pdf
著者	Chen, Mengxi\| Tanaka, Takehiro\| Igawa, Takuro\| Han, Yanyan\| Peng, Fangli\| Jin, Zaishun\| Yoshino, Tadashi\|
キーワード	PDX1 PTF1A SALL4 Ectopic pancreas Gastro-duodenum Jejunum
発行日	2023-07
出版物タイトル	Heliyon
巻	9巻
号	7号
出版者	Cell Press
開始ページ	e18241
ISSN	2405-8440
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37519669
DOI	10.1016/j.heliyon.2023.e18241
Web of Science KeyUT	001043928200001
関連URL	isVersionOf https://doi.org/10.1016/j.heliyon.2023.e18241

Feasibility of Flow Cytometry Analysis of Gastrointestinal Tract-Residing Lymphocytes in Hematopoietic Stem Cell Transplant Recipients

JaLCDOI	10.18926/AMO/65740
フルテキストURL	77_4_347.pdf
著者	Iwamuro, Masaya\| Kondo, Takumi\| Ennishi, Daisuke\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Takahashi, Takahide\| Hirabata, Araki\| Tanaka, Takehiro\| Otsuka, Fumio\| Maeda, Yoshinobu\| Okada, Hiroyuki\|
抄録	The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
キーワード	flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-08
巻	77巻
号	4号
出版者	Okayama University Medical School
開始ページ	347
終了ページ	357
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37635134
Web of Science KeyUT	001163659800002

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

フルテキストURL	fulltext.pdf
著者	Okuda, Kosaku\| Nakahara, Kengo\| Ito, Akihiro\| Iijima, Yuta\| Nomura, Ryosuke\| Kumar, Ashutosh\| Fujikawa, Kana\| Adachi, Kazuya\| Shimada, Yuki\| Fujio, Satoshi\| Yamamoto, Reina\| Takasugi, Nobumasa\| Onuma, Kunishige\| Osaki, Mitsuhiko\| Okada, Futoshi\| Ukegawa, Taichi\| Takeuchi, Yasuo\| Yasui, Norihisa\| Yamashita, Atsuko\| Marusawa, Hiroyuki\| Matsushita, Yosuke\| Katagiri, Toyomasa\| Shibata, Takahiro\| Uchida, Koji\| Niu, Sheng-Yong\| Lang, Nhi B.\| Nakamura, Tomohiro\| Zhang, Kam Y. J.\| Lipton, Stuart A.\| Uehara, Takashi\|
備考	The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-36232-6\|
発行日	2023-02-04
出版物タイトル	Nature Communications
巻	14巻
号	1号
出版者	Nature Portfolio
開始ページ	621
ISSN	2041-1723
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	36739439
DOI	10.1038/s41467-023-36232-6
Web of Science KeyUT	001024149400011
関連URL	isVersionOf https://doi.org/10.1038/s41467-023-36232-6

Preoperative detection of functional somatostatin receptors in a patient with an insulinoma

フルテキストURL	fulltext.pdf
著者	Oguni, Kohei\| Fukushima, Shinnosuke\| Yamamoto, Yukichika\| Hasegawa, Kou\| Hagiya, Hideharu\| Inoshita, Naoko\| Otsuka, Fumio\|
キーワード	Insulinoma octreotide test somatostatin receptor somatostatin scintigraphy
発行日	2023-08-02
出版物タイトル	Clinical Case Reports
巻	11巻
号	8号
出版者	Wiley
開始ページ	e7771
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37546161
DOI	10.1002/ccr3.7771
Web of Science KeyUT	001039569500001
関連URL	isVersionOf https://doi.org/10.1002/ccr3.7771

Update in Molecular Aspects and Diagnosis of Autoimmune Gastritis

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Tanaka, Takehiro\| Otsuka, Motoyuki\|
キーワード	autoimmune gastritis esophagogastroduodenoscopy genetic predisposition lymphocyte oxidative stress
発行日	2023-06-21
出版物タイトル	Current Issues in Molecular Biology
巻	45巻
号	7号
出版者	MDPI
開始ページ	5263
終了ページ	5275
ISSN	1467-3037
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37504250
DOI	10.3390/cimb45070334
Web of Science KeyUT	001035130200001
関連URL	isVersionOf https://doi.org/10.3390/cimb45070334

Collagenous Colitis in a Patient With Gastric Cancer Who Underwent Chemotherapy

フルテキストURL	fulltext.pdf
著者	Iwamuro, Masaya\| Tanaka, Takehiro\| Kagawa, Shunsuke\| Inoo, Shoko\| Otsuka, Motoyuki\|
キーワード	immune checkpoint inhibitor chemotherapy-induced diarrhea immune-related adverse event colitis colonoscopy collagenous colitis
発行日	2023-05-25
出版物タイトル	Cureus
巻	15巻
号	5号
出版者	Springer
開始ページ	e39466
ISSN	2168-8184
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Iwamuro et al.
論文のバージョン	publisher
PubMed ID	37378156
DOI	10.7759/cureus.39466
Web of Science KeyUT	001023091300016
関連URL	isVersionOf https://doi.org/10.7759/cureus.39466

Positive chemotaxis to plant apoplastic fluids of Pseudomonas syringae pv. tabaci 6605 and metabolome analysis

フルテキストURL	fulltext20230728-01.pdf
著者	Watanabe, Yuta\| Tumewu, Stephany Angelia\| Yamada, Hajime\| Matsui, Hidenori\| Yamamoto, Mikihiro\| Noutoshi, Yoshiteru\| Toyoda, Kazuhiro\| Ichinose, Yuki\|
キーワード	Apoplastic fluid Chemotaxis Chemoattractants Metabolome Pseudomonas syringae
備考	The version of record of this article, first published in Journal of General Plant Pathology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10327-023-01126-4\|
発行日	2023-06-12
出版物タイトル	Journal of General Plant Pathology
巻	89巻
号	4号
出版者	Springer Science and Business Media LLC
開始ページ	219
終了ページ	223
ISSN	1345-2630
NCID	AA11449093
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
DOI	10.1007/s10327-023-01126-4
Web of Science KeyUT	001003602200001
関連URL	isVersionOf https://doi.org/10.1007/s10327-023-01126-4

Bilateral Lacrimal Gland Mantle Cell Lymphoma in 11-Year Follow-Up: Case Report and Review of 48 Cases With Ocular Adnexal Presentation in the Literature

フルテキストURL	fulltext20230708-01.pdf
著者	Matsuo, Toshihiko\| Tanaka, Takehiro\| Okada, Kazuya\| Notohara, Kenji\| Fujii, Keiko\| Fujii, Nobuharu\|
キーワード	mantle cell lymphoma lacrimal gland autologous peripheral blood stem cell transplantation breast cancer tracheal and bronchial infiltration
発行日	2023-07-05
出版物タイトル	Journal of Investigative Medicine High Impact Case Reports
巻	11巻
出版者	SAGE Publications
ISSN	2324-7096
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 American Federation for Medical Research
論文のバージョン	publisher
PubMed ID	37403948
DOI	10.1177/23247096231185483
関連URL	isVersionOf https://doi.org/10.1177/23247096231185483

Super acute-onset disseminated BCG infection: A case report

フルテキストURL	fulltext20230711-01.pdf fig20230711-01.pdf
著者	Takase, Ryosuke\| Hagiya, Hideharu\| Fujimori, Takumi\| Yokoyama, Yukika\| Iio, Koji\| Honda, Hiroyuki\| Hasegawa, Kou\| Otsuka, Fumio\|
備考	© 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jul. 2024.\|
発行日	2023-09
出版物タイトル	Journal of Infection and Chemotherapy
巻	29巻
号	9号
出版者	Elsevier Ltd.
開始ページ	919
終了ページ	921
ISSN	1341-321X
NCID	AA11057978
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
論文のバージョン	author
PubMed ID	37230385
DOI	10.1016/j.jiac.2023.05.017
Web of Science KeyUT	001050515100001
関連URL	isVersionOf https://doi.org/10.1016/j.jiac.2023.05.017

Refining the evolutionary tree of the horse Y chromosome

フルテキストURL	fulltext.pdf
著者	Bozlak, Elif\| Radovic, Lara\| Remer, Viktoria\| Rigler, Doris\| Allen, Lucy\| Brem, Gottfried\| Stalder, Gabrielle\| Castaneda, Caitlin\| Cothran, Gus\| Raudsepp, Terje\| Okuda, Yu\| Moe, Kyaw Kyaw\| Moe, Hla Hla\| Kounnavongsa, Bounthavone\| Keonouchanh, Soukanh\| Van, Nguyen Huu\| Vu, Van Hai\| Shah, Manoj Kumar\| Nishibori, Masahide\| Kazymbet, Polat\| Bakhtin, Meirat\| Zhunushov, Asankadyr\| Paul, Ripon Chandra\| Dashnyam, Bumbein\| Nozawa, Ken\| Almarzook, Saria\| Brockmann, Gudrun A.\| Reissmann, Monika\| Antczak, Douglas F.\| Miller, Donald C.\| Sadeghi, Raheleh\| Butler-Wemken, Ines von\| Kostaras, Nikos\| Han, Haige\| Manglai, Dugarjaviin\| Abdurasulov, Abdugani\| Sukhbaatar, Boldbaatar\| Ropka-Molik, Katarzyna\| Stefaniuk-Szmukier, Monika\| Lopes, Maria Susana\| Machado, Artur da Câmara\| Kalashnikov, Valery V.\| Kalinkova, Liliya\| Zaitev, Alexander M.\| Novoa-Bravo, Miguel\| Lindgren, Gabriella\| Brooks, Samantha\| Rosa, Laura Patterson\| Orlando, Ludovic\| Juras, Rytis\| Kunieda, Tetsuo\| Wallner, Barbara\|
備考	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-35539-0\|
発行日	2023-06-02
出版物タイトル	Scientific Reports
巻	13巻
号	1号
出版者	Nature Portfolio
開始ページ	8954
ISSN	2045-2322
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37268661
DOI	10.1038/s41598-023-35539-0
Web of Science KeyUT	001000613900036
関連URL	isVersionOf https://doi.org/10.1038/s41598-023-35539-0

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

フルテキストURL	fulltext.pdf
著者	Komoto, Satoshi\| Noma, Kazuhiro\| Kato, Takuya\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Sato, Hiroaki\| Katsura, Yuki\| Kashima, Hajime\| Kikuchi, Satoru\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
キーワード	cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
発行日	2023-05-30
出版物タイトル	Cancers
巻	15巻
号	11号
出版者	MDPI
開始ページ	2971
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 by the authors.
論文のバージョン	publisher
PubMed ID	37296933
DOI	10.3390/cancers15112971
Web of Science KeyUT	001006082400001
関連URL	isVersionOf https://doi.org/10.3390/cancers15112971

ATP and its metabolite adenosine cooperatively upregulate the antigen-presenting molecules on dendritic cells leading to IFN-gamma production by T cells

フルテキストURL	fulltext.pdf
著者	Furuta, Kazuyuki\| Onishi, Hiroka\| Ikada, Yuki\| Masaki, Kento\| Tanaka, Satoshi\| Kaito, Chikara\|
発行日	2023-04
出版物タイトル	Journal of Biological Chemistry
巻	299巻
号	4号
出版者	Elsevier
開始ページ	104587
ISSN	1083-351X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 THE AUTHORS.
論文のバージョン	publisher
PubMed ID	36889584
DOI	10.1016/j.jbc.2023.104587
Web of Science KeyUT	001009229100001
関連URL	isVersionOf https://doi.org/10.1016/j.jbc.2023.104587

ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review

フルテキストURL	fulltext20230625-01.pdf
著者	Matsuo, Toshihiko\| Hiramatsu‐Asano, Sumie\| Sawachika, Hiroshi\| Nishimura, Hirotake\|
キーワード	ANCA-associated vasculitis corneal melt and perforation rituximab scleritis temporal artery biopsy
発行日	2023-06-20
出版物タイトル	Clinical Case Reports
巻	11巻
号	6号
出版者	Wiley
開始ページ	e7595
ISSN	2050-0904
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2023 The Authors.
論文のバージョン	publisher
PubMed ID	37351359
DOI	10.1002/ccr3.7595
関連URL	isVersionOf https://doi.org/10.1002/ccr3.7595

The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis

フルテキストURL	fulltext20230621-01.pdf
著者	Yoshimura, Teizo\| Li, Chunning\| Wang, Yuze\| Matsukawa, Akihiro\|
キーワード	Breast cancer chemokines chemokine receptors metastasis macrophages
備考	The version of record of this article, first published in Cellular & Molecular Immunology, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41423-023-01013-0\|
発行日	2023-05-19
出版物タイトル	Cellular & Molecular Immunology
巻	20巻
号	7号
出版者	Springer Science and Business Media LLC
開始ページ	714
終了ページ	738
ISSN	2042-0226
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2023
論文のバージョン	publisher
PubMed ID	37208442
DOI	10.1038/s41423-023-01013-0
Web of Science KeyUT	000990897000001
関連URL	isVersionOf https://doi.org/10.1038/s41423-023-01013-0

A Case of High-Grade Glioma in an Eloquent Area Treated with Awake Craniotomy in an 85-year-old Patient

JaLCDOI	10.18926/AMO/65504
フルテキストURL	77_3_335.pdf
著者	Fujii, Kentaro\| Hirano, Shuichiro\| Kurozumi, Kazuhiko\| Date, Isao\|
抄録	An 85-year-old woman presented with aphasia due to an occupying lesion in the left frontal lobe near the language area. Complete resection of the contrast-enhancing lesion was performed under awake conditions. The pathological diagnosis was anaplastic astrocytoma, and postoperative radiochemotherapy was administered. Awake surgery is a useful technique to reduce postoperative neurological sequelae and to maximize surgical resection. Although the patient was elderly, which is generally considered high risk, she did not have any severe neurological deficits and had a good outcome. Even in the extreme elderly, awake surgery can be useful for gliomas in language cortices.
キーワード	awake surgery high-grade glioma eloquent area elderly patient
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	335
終了ページ	340
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357636
Web of Science KeyUT	001026663400002

Endobronchial Metastasis with Bloody Sputum 20 Years after Complete Resection of type A Non-Invasive Thymoma

JaLCDOI	10.18926/AMO/65503
フルテキストURL	77_3_331.pdf
著者	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Miyoshi, Kentaroh\| Sugimoto, Seiichiro\| Toyooka, Shinichi\|
抄録	Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well.
キーワード	endobronchial metastasis type A thymoma bloody sputum
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	331
終了ページ	334
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357635
Web of Science KeyUT	001026663400001

Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma

JaLCDOI	10.18926/AMO/65502
フルテキストURL	77_3_323.pdf
著者	Makino, Keigo\| Otani, Yoshihiro\| Fujii, Kentaro\| Ishida, Joji\| Hirano, Shuichiro \| Suruga, Yasuki\| Washio, Kana\| Nishida, Kenji\| Yanai, Hiroyuki\| Tomida, Shuta\| Ennishi, Daisuke\| Date, Isao\|
抄録	In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.
キーワード	comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	323
終了ページ	330
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357634
Web of Science KeyUT	001025850000001

A Comparison of the Efficacy of Plastic Stent Placement Above and Across the Sphincter of Oddi for Benign Biliary Hilar Stricture

JaLCDOI	10.18926/AMO/65494
フルテキストURL	77_3_291.pdf
著者	Himei, Hitomi\| Kato, Hironari\| Saragai, Yosuke\| Fujii, Yuki\| Yamazaki, Tatsuhiro\| Uchida, Daisuke\| Matsumoto, Kazuyuki\| Horiguchi, Shigeru\| Tsutsumi, Koichiro\| Okada, Hiroyuki\|
抄録	We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal.
キーワード	benign biliary stricture inside stent plastic stent
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	299
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357630
Web of Science KeyUT	001026279600007

Usefulness of Simple Diffusion Kurtosis Imaging for Head and Neck Tumors: An Early Clinical Study

JaLCDOI	10.18926/AMO/65492
フルテキストURL	77_3_273.pdf
著者	Shimizu, Yudai\| Kuroda, Masahiro\| Nakamitsu, Yuki\| Al-Hammad, Wlla E.\| Yoshida, Suzuka\| Fukumura, Yuka\| Nakamura, Yoshihide\| Kuroda, Kazuhiro\| Kamizaki, Ryo\| Imajoh, Satoshi\| Tanabe, Yoshinori\| Sugimoto, Kohei\| Oita, Masataka\| Sugianto, Irfan\| Bamgbose, Babatunde O.\| Yanagi, Yoshinobu\| Asaumi, Junichi\|
抄録	Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
キーワード	simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	273
終了ページ	280
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357628
Web of Science KeyUT	001026279600005

Brown Adipose Tissue PPARγ Is Required for the Insulin-Sensitizing Action of Thiazolidinediones

JaLCDOI	10.18926/AMO/65489
フルテキストURL	77_3_243.pdf
著者	Shibata, Yusuke\| Eguchi, Jun\| Wada, Jun\|
抄録	Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs.
キーワード	PPARγ brown adipose tissue thiazolidinediones
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2023-06
巻	77巻
号	3号
出版者	Okayama University Medical School
開始ページ	243
終了ページ	254
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2023 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	37357625
Web of Science KeyUT	001026279600002