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JaLCDOI 10.18926/AMO/65502
FullText URL 77_3_323.pdf
Author Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao|
Abstract In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.
Keywords comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 323
End Page 330
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357634
Web of Science KeyUT 001025850000001
FullText URL fulltext.pdf
Author Okada, Nobuhiro| Ueki, Chihiro| Shimazaki, Masahiro| Tsujimoto, Goki| Kohno, Susumu| Muranaka, Hayato| Yoshikawa, Kiyotsugu| Takahashi, Chiaki|
Note The version of record of this article, first published in Communications Biology, is available online at Publisher’s website: http://dx.doi.org/10.1038/s42003-023-04987-9|
Published Date 2023-06-02
Publication Title Communications Biology
Volume volume6
Issue issue1
Publisher nature portfolio
Start Page 596
ISSN 2399-3642
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 37268670
DOI 10.1038/s42003-023-04987-9
Web of Science KeyUT 000999915600001
Related Url isVersionOf https://doi.org/10.1038/s42003-023-04987-9
JaLCDOI 10.18926/AMO/65495
FullText URL 77_3_301.pdf
Author Kato, Takahide| Miyoshi, Seigo| Hamada, Chizuru| Sano, Yoshifumi| Nogami, Naoyuki| Yamaguchi, Osamu| Hamaguchi, Naohiko|
Abstract Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD.
Keywords lung cancer interstitial lung disease acute exacerbation comorbidity
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 301
End Page 309
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357631
Web of Science KeyUT 001026279600008
JaLCDOI 10.18926/AMO/65490
FullText URL 77_3_255.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Uda, Kazuhiro| Gotoh, Kazuyoshi| Otsuka, Fumio|
Abstract Antimicrobial resistance is an emerging global threat that must be addressed using a multidisciplinary approach. This study aimed to raise awareness of high-level antimicrobial-resistant (AMR) pathogens in Japan by comparing their recent prevalences among prefectures, particularly Okayama. Data for the isolation proportions of meropenem-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae, and levofloxacin-resistant E. coli and K. pneumoniae were collected from the Japan Nosocomial Infections Surveillance, a national database sponsored by the Japanese Ministry of Health, Labour, and Welfare, between 2018 and 2021. The average isolated proportions of the seven AMR pathogens were higher in Okayama compared to other prefectures: the worst (19.9%) was meropenem-resistant P. aeruginosa, the sixth worst (57.2%) was methicillin-resistant S. aureus, the eighth worst (3.3%) was vancomycin-resistant E. faecium, the second (37.8%) and fifth worst (17.6%) were cefotaxime-resistant E. coli and K. pneumoniae, respectively, and the fourth (49.9%) and third worst (8.7%) were levofloxacin-resistant E. coli and K. pneumoniae, respectively. Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama.
Keywords antimicrobial resistance antimicrobial stewardship epidemiology infection prevention and control Japan Nosocomial Infections Surveillance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 255
End Page 262
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357626
Web of Science KeyUT 001026279600003
JaLCDOI 10.18926/65474
Title Alternative How to Support People with APD
FullText URL APD_Support (English).pdf
Author Kataoka, Yuko|
Published Date 2023
language English
Copyright Holders © 2021 by the authors.
File Version publisher
License https://creativecommons.org/licenses/by/4.0/
FullText URL fulltext.pdf
Author Sekito, Takanori| Wada, Koichiro| Ishii, Ayano| Iwata, Takehiro| Matsubara, Takehiro| Tomida, Shuta| Watanabe, Masami| Araki, Motoo| Sadahira, Takuya|
Keywords cystitis vagina microbiota Lactobacillus urinary tract infection
Published Date 2023-05-18
Publication Title Frontiers in Microbiology
Volume volume14
Publisher Frontiers Media
Start Page 1187479
ISSN 1664-302X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Sekito, Wada, Ishii, Iwata, Matsubara, Tomida, Watanabe, Araki and Sadahira.
File Version publisher
PubMed ID 37275169
DOI 10.3389/fmicb.2023.1187479
Web of Science KeyUT 000998008400001
Related Url isVersionOf https://doi.org/10.3389/fmicb.2023.1187479
FullText URL K0006841_abstract_review.pdf K0006841_fulltext.pdf K0006841_summary.pdf
Author ZHU, JUNJIE|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6841号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL K0006787_abstract_review.pdf K0006787_fulltext.pdf K0006787_summary.pdf
Author ACOSTA GONZALEZ HERIK RODRIGO|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6787号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 The Authors.
FullText URL K0006757_abstract_review.pdf K0006757_fulltext.pdf K0006757_summary.pdf
Author SHIMIZU, Dai|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6757号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 Elsevier Inc.
FullText URL fulltext20230515-03.pdf
Author Hiramoto, Ayami| Baba, Masaaki| Enomoto, Katsunari| Iwakuni, Kana| Kuma, Susumu| Takahashi, Yuiki| Tobaru, Reo| Miyamoto, Yuki|
Published Date 2023-04-13
Publication Title Physical Review A
Volume volume107
Issue issue4
Publisher American Physical Society (APS)
Start Page 043114
ISSN 2469-9926
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2023 American Physical Society
File Version publisher
DOI 10.1103/physreva.107.043114
Web of Science KeyUT 000973450100006
Related Url isVersionOf https://doi.org/10.1103/PhysRevA.107.043114
FullText URL fulltext.pdf
Author Ty, Pham Huu| Laura, Baas| Phuong, Tran Thi| Tan, Nguyen Quang|
Keywords food insecurity hydropower dams impoverishment poverty livelihoods
Published Date 2023-04-06
Publication Title Social Sciences
Volume volume12
Issue issue4
Publisher MDPI
Start Page 222
ISSN 2076-0760
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
DOI 10.3390/socsci12040222
Web of Science KeyUT 000976910000001
Related Url isVersionOf https://doi.org/10.3390/socsci12040222
Title Alternative Experience with a nosocomial cluster of novel coronavirus infection and the cluster response algorithm
Author Fujita, Koji| Ocho, Kazuki| Kadowaki, Tomoka| Yorifuji, Takashi| Otsuka, Fumio|
Abstract  The novel coronavirus disease (COVID-19) pandemic that began in 2019 is yet to end, as of the summer of 2022. During the pandemic, community-acquired infections spread easily to healthcare-associated facilities, resulting in COVID-19 clusters among high-risk individuals that have been difficult to contain. Our regional base hospital also experienced a nosocomial cluster of COVID-19 in October 2020 that took 30 days to contain and affected 9 hospital staff and 14 patients. Six patients died due to COVID-19, and six died due to COVID-19-related complications. Two patients were discharged alive. Patient characteristics included ① advanced age (79.0±8.1 years), ② dementia (64.3%), ③ low Prognostic Nutrition Index (31.1 ±7.9), ④ zinc deficiency (50.2±13.1μg/dL), ⑤ vitamin C deficiency (1.6±1.9μg/mL), ⑥ elevated urea nitrogen-to-creatinine ratio (27.4±23.5), ⑦ anticancer and immunosuppressive drug use (78.6%), and ⑧ malignancy (75.6%). This cluster had a very high mortality rate, but the viral spread was contained in a short period. Algorithmizing the cluster response was crucial to controlling this cluster. We report on our actual cluster response algorithm, as well as our strategy and response procedure during the pandemic.
Keywords 新型コロナウイルス感染症(COVID-19) 院内クラスター(nosocomial cluster) 対応アルゴリズム(response algorithm)
Publication Title Journal of Okayama Medical Association
Published Date 2023-04-01
Volume volume135
Issue issue1
Start Page 22
End Page 33
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.22
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.22
JaLCDOI 10.18926/AMO/65149
FullText URL 77_2_193.pdf
Author Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo|
Abstract This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk.
Keywords esophageal cancer exercise tolerance rehabilitation
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 193
End Page 197
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094957
Web of Science KeyUT 000982503800009
JaLCDOI 10.18926/AMO/65143
FullText URL 77_2_139.pdf
Author Namio, Keiichi| Kondo, Takashi| Miyatake, Nobuyuki| Hishii, Shuhei| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Suzuki, Hiromi| Koumoto, Kiichi|
Abstract We investigated the link between prolonged sedentary bouts and all-cause mortality in patients on chronic hemodialysis, using a prospective cohort. A total of 104 outpatients on chronic hemodialysis from 2013 to 2019, aged 71.4±11.4 years, were enrolled. Prolonged sedentary bouts (≥ 30 min and ≥60 min) (min and bouts) and relative prolonged sedentary bouts (≥ 30 min and ≥ 60 min) (%) on the patients’ non-hemodialysis days were measured by a tri-accelerometer, and we also analyzed the patients’ clinical parameters. The relationship between prolonged sedentary bouts and all-cause mortality was evaluated by a survival analysis and the Cox proportional hazard model. Thirty-five patients died during the follow-up period. A Kaplan-Meier analysis detected significant differences in the survival rate between two groups stratified by the median for all prolonged sedentary-bout parameters. After the adjustment for confounding factors, all of the prolonged sedentary-bout parameters were determinant factors for all-cause mortality. These results indicate that prolonged sedentary bouts on non-hemodialysis days were closely related to all-cause mortality in the patients on hemodialysis.
Keywords sedentary bout mortality hemodialysis survival analysis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 139
End Page 145
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094951
Web of Science KeyUT 000982503800003
JaLCDOI 10.18926/CTED/65078
Title Alternative A trial support for children with foreign roots from a perspective of multicultural coexistence: A case study of language education and culture learning as core of the curriculum
FullText URL cted_013_275.pdf
Author Xie, Xinyi| Kuwabara, Toshinori|
Abstract  本稿では,多文化共生社会の構築を目指して,筆者(謝)が取り組んでいる外国にルーツを持つ子どもに対する多文化交流活動の実践を検討し,その意義を解明しようとするものである。具体的には,筆者(謝)が岡山県内で主催している地域教育支援活動団体「週末エウレカ」の実践の取り組みを取り上げ検討する。本実践は,日本語の学習だけではなく,様々な国の文化を学ぶことによって,多文化共生社会の一員としての資質を育成しようとする点に特質がある。活動の中では,日本で学ぶ外国人留学生によって,外国にルーツを持つ子どもに対する教育活動が行われた。本研究では,そのような支援の特徴と課題を明らかにしたい。そして,今後,このような外国人留学生による活動支援団体を,地域においてコミュニティの協力のもとで運営するための示唆を得たい。
Keywords 多文化共生 (multicultural conviviality) 外国にルーツをもつ子ども (children with foreign roots) 地域教育 (local education) コミュニティ (community) 外国人散在地域 (foreigner dispersed area)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2023-03-30
Volume volume13
Start Page 275
End Page 284
ISSN 2186-1323
language Japanese
Copyright Holders Copyright © 2023 岡山大学教師教育開発センター
File Version publisher
JaLCDOI 10.18926/CTED/65070
FullText URL cted_013_145.pdf
Author Yamada, Nagisa| Kuwabara, Toshinori|
Abstract 本研究は,高等学校の総合的な探究の時間などで取り組まれている地域課題探究学習について,そのねらいを生徒のファシリテーション能力の育成として捉え直そうとするものである。そのために,地域課題探究学習をワークショップの形式で実施している高等学校の実践を調査した。実際には,プログラムの企画・準備段階から実践までのプロセスに支援者として参画するとともに,全体司会やグループ活動のリーダーを務めた生徒に対してアンケートや聞き取り調査を行った。調査の結果,ファシリテーション能力の育成を行うことで,個人の成長や将来を見通した指導の実現に繋がることが明らかになった。また,地域住民や中学生,大学生といった普段の学校生活で関わらない人々とともにワークショップをおこなうことで,大学生から刺激を受けたり,中学生をリードしたりしなければいけないという環境の変化が,ファシリテーション能力の育成をさらに促進させると考える。
Keywords ファシリテーション (facilitation) 地域課題 (community issues) ワークショップ (workshop) 高等学校 地域連携 (community collaboration)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2023-03-30
Volume volume13
Start Page 145
End Page 159
ISSN 2186-1323
language Japanese
Copyright Holders Copyright © 2023 岡山大学教師教育開発センター
File Version publisher
JaLCDOI 10.18926/CTED/65065
Title Alternative Implementing a Professional Learning Community (PLC) at Early Childhood Education Institutions Focus on the Process of Curriculum Management
FullText URL cted_013_069.pdf
Author Fujii, Yushi| Kumagai, Shinnosuke|
Abstract  本研究では,幼稚園・保育所・幼保連携型認定こども園においてP L C 醸成をめざした際の,教育・保育課程等編成のプロセスを明らかにすることを目的とした。カリキュラム・マネジメントによる学校文化変革のプロセスとP T L C の関係性を整理した上で,PLC 醸成をめざしたカリキュラム編成のプロセスを示し,それをもとに, P L C 醸成にむけた教育・保育課程等編成のプロセスを示した。そして,『幼稚園教育要領解説』,『保育所保育指針解説』,『幼保連携型認定こども園教育・保育要領解説』で示された教育・保育課程等編成の手順と比較し,プロセスやリーダーシップのあり方に関する違いが確認できた。
Keywords 専門職の学習共同体(Professional Learning Community) 専門性(Expertise) 教育・保育課程の編成 (Curriculum Management)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2023-03-30
Volume volume13
Start Page 69
End Page 82
ISSN 2186-1323
language Japanese
Copyright Holders Copyright © 2023 岡山大学教師教育開発センター
File Version publisher
FullText URL fulltext.pdf
Author Jiang, Jiaming| Zhao, Yu|
Keywords patents green innovation social network analysis carbon reduction transportation management
Published Date 2023-02-24
Publication Title Energies
Volume volume16
Issue issue5
Publisher MDPI
Start Page 2221
ISSN 1996-1073
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
DOI 10.3390/en16052221
Web of Science KeyUT 000947913300001
Related Url isVersionOf https://doi.org/10.3390/en16052221
FullText URL 11_setouchi_project_en.pdf
Author Nishita, Yosuke|
Published Date 2023-03
Publication Title Setouchi Sustainability and Well-being Research Project Final Report
Content Type Research Paper
language English
OAI-PMH Set 岡山大学
File Version publisher
Title Alternative Developing a scale to measure nurses' difficulty related to the treatment of gender dysphoric patients
FullText URL 134_22.pdf
Author Miyake, Maki| Oshima, Yoshitaka| Namba, Shihoko| Matsumoto, Yosuke| Horiuchi, Makiko| Yamada, Norihito|
Abstract  This study aimed to develop a scale to measure the perceived difficulty experienced by nurses in treating and caring for patients diagnosed with gender dysphoria and examine its reliability and validity. We developed a 26-item preliminary scale through discussions with experts in gender dysphoria treatment. We administered a questionnaire including this scale to 1,010 nurses working at Okayama University Hospital and analyzed the data of 346 nurses who had been involved in the treatment of gender dysphoria and had no missing responses.
 A total of 20 items consisting of two factors, “relationship building” and “negative emotion for gender dysphoria,” were extracted by exploratory factor analysis, and we used them in the final version of the scale. Cronbach's alpha coefficient for the entire scale was 0.879, indicating a high degree of internal consistency.
 However, the correlations with a communication skills scale (ENDCOREs) and the Scale of Gender Conception were limited, and the external validity could not be proven. This scale may be useful for evaluating nursing practice and educational support for nurses; however, there is room for further study on the scale validation.
Keywords 性別違和 (gender dysphoria) 関わりにくさ (difficulty in relating) コミュニケーション (communication) 性差観 (gender conception)
Publication Title Journal of Okayama Medical Association
Published Date 2022-04-01
Volume volume134
Issue issue1
Start Page 22
End Page 27
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.134.22
language Japanese
Copyright Holders Copyright (c) 2022 岡山医学会
File Version publisher
DOI 10.4044/joma.134.22