result 984 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakazawa, Atsushi| Iwamoto, Miyuki| Kurazume, Ryo| Nunoi, Masato| Kobayashi, Masaki| Honda, Miwako| |
| Published Date | 2023-07-10 |
| Publication Title | PLoS ONE |
| Volume | volume18 |
| Issue | issue7 |
| Publisher | Public Library of Science |
| Start Page | e0288175 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Nakazawa et al. |
| File Version | publisher |
| PubMed ID | 37428739 |
| DOI | 10.1371/journal.pone.0288175 |
| Web of Science KeyUT | 001027854200002 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0288175 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Cong, Yingnan| Hou, Yufei| Jiang, Jiaming| Chen, Shuangzi| Cai, Xiaojing| |
| Keywords | energy trade complex networks topology evolutionary properties |
| Published Date | 2023-07-28 |
| Publication Title | Energies |
| Volume | volume16 |
| Issue | issue15 |
| Publisher | MDPI |
| Start Page | 5677 |
| ISSN | 1996-1073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| DOI | 10.3390/en16155677 |
| Web of Science KeyUT | 001045434700001 |
| Related Url | isVersionOf https://doi.org/10.3390/en16155677 |
| JaLCDOI | 10.18926/AMO/65751 |
|---|---|
| FullText URL | 77_4_407.pdf |
| Author | Hotta, Kensuke| Kobayashi, Takaomi| |
| Abstract | This study aimed to investigate the usefulness of force-controlled pelvic stress radiographs in the evaluation and treatment of fragility fractures of the pelvis (FFP) using a functional treatment strategy. We conducted a retrospective study of 55 geriatric patients with FFP who underwent pelvic stress radiographs on admission. The differences in the sacral width, pelvic ring width, and medial femoral head width between the radiographs with and without the Sam Sling II M size were defined as Δ sacral width, Δ pelvic ring width, and Δ medial femoral head width, respectively. We used Pearson’s correlation test to assess the relationship between the degree of radiographic instability and the Johns Hopkins highest level of mobility scale (JH-HLM) at 10-days postadmission. Conventional receiver-operating-characteristic curve analysis was used to identify cases requiring surgery using the best cutoff value for radiographic instability. The JH-HLM was significantly correlated with Δ sacral width (r=−0.401, p=0.017), but not with Δ pelvic ring width (r=−0.298, p=0.080) nor with Δ medial femoral head width (r= −0.261, p=0.128). The best cutoff value of Δ sacral width in identifying surgical cases was 10.7 mm (sensitivity 75.0%, specificity 98.0%). Force-controlled pelvic stress radiographs could be helpful in assessing the need for surgery on admission. |
| Keywords | fragility fracture of the pelvis functional treatment strategy Sam Sling stress radiograph Johns Hopkins highest level of mobility scale |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 407 |
| End Page | 414 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635141 |
| Web of Science KeyUT | 001163659800001 |
| JaLCDOI | 10.18926/AMO/65741 |
|---|---|
| FullText URL | 77_4_359.pdf |
| Author | Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao| |
| Abstract | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. |
| Keywords | pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635135 |
| Web of Science KeyUT | 001163659800011 |
| JaLCDOI | 10.18926/AMO/65739 |
|---|---|
| FullText URL | 77_4_341.pdf |
| Author | Otsuka, Motoyuki| |
| Abstract | Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described. |
| Keywords | HBx Smc5/6 DDB1 nitazoxianide DNA repair |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 341 |
| End Page | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635133 |
| Web of Science KeyUT | 001163659800007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okuda, Kosaku| Nakahara, Kengo| Ito, Akihiro| Iijima, Yuta| Nomura, Ryosuke| Kumar, Ashutosh| Fujikawa, Kana| Adachi, Kazuya| Shimada, Yuki| Fujio, Satoshi| Yamamoto, Reina| Takasugi, Nobumasa| Onuma, Kunishige| Osaki, Mitsuhiko| Okada, Futoshi| Ukegawa, Taichi| Takeuchi, Yasuo| Yasui, Norihisa| Yamashita, Atsuko| Marusawa, Hiroyuki| Matsushita, Yosuke| Katagiri, Toyomasa| Shibata, Takahiro| Uchida, Koji| Niu, Sheng-Yong| Lang, Nhi B.| Nakamura, Tomohiro| Zhang, Kam Y. J.| Lipton, Stuart A.| Uehara, Takashi| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-36232-6| |
| Published Date | 2023-02-04 |
| Publication Title | Nature Communications |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 621 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36739439 |
| DOI | 10.1038/s41467-023-36232-6 |
| Web of Science KeyUT | 001024149400011 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-023-36232-6 |
| FullText URL | fulltext20230725-03.pdf |
|---|---|
| Author | Sugimoto, Seiichiro| Matsubara, Kei| Tanaka, Shin| Miyoshi, Kentaroh| Ishihara, Megumi| Toyooka, Shinichi| |
| Keywords | Lung transplantation chronic lung allograft dysfunction infection malignan cychronic kidney disease |
| Published Date | 2023-06-27 |
| Publication Title | Journal of Thoracic Disease |
| Volume | volume15 |
| Issue | issue9 |
| Publisher | AME Publishing Company |
| Start Page | 5182 |
| End Page | 5194 |
| ISSN | 2072-1439 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Journal of Thoracic Disease. |
| File Version | publisher |
| PubMed ID | 37868843 |
| DOI | 10.21037/jtd-22-1679 |
| Web of Science KeyUT | 001019970500001 |
| Related Url | isVersionOf https://doi.org/10.21037/jtd-22-1679 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Panduman, Yohanes Yohanie Fridelin| Funabiki, Nobuo| Ito, Sho| Husna, Radhiatul| Kuribayashi, Minoru| Okayasu, Mitsuhiro| Shimazu, Junya| Sukaridhoto, Sritrusta| |
| Keywords | Internet of Things edge device framework application server platform SEMAR |
| Published Date | 2023-05-29 |
| Publication Title | Information |
| Volume | volume14 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 312 |
| ISSN | 2078-2489 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| DOI | 10.3390/info14060312 |
| Web of Science KeyUT | 001014882200001 |
| Related Url | isVersionOf https://doi.org/10.3390/info14060312 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Jaunet-Lahary, Titouan| Shimamura, Tatsuro| Hayashi, Masahiro| Nomura, Norimichi| Hirasawa, Kouta| Shimizu, Tetsuya| Yamashita, Masao| Tsutsumi, Naotaka| Suehiro, Yuta| Kojima, Keiichi| Sudo, Yuki| Tamura, Takashi| Iwanari, Hiroko| Hamakubo, Takao| Iwata, So| Okazaki, Kei-Ichi| Hirai, Teruhisa| Yamashita, Atsuko| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-36883-5| |
| Published Date | 2023-04-03 |
| Publication Title | Nature Communications |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 1730 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37012268 |
| DOI | 10.1038/s41467-023-36883-5 |
| Web of Science KeyUT | 001002031500007 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-023-36883-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nagao, Ryo| Kato, Koji| Hamaguchi, Tasuku| Ueno, Yoshifumi| Tsuboshita, Naoki| Shimizu, Shota| Furutani, Miyu| Ehira, Shigeki| Nakajima, Yoshiki| Kawakami, Keisuke| Suzuki, Takehiro| Dohmae, Naoshi| Akimoto, Seiji| Yonekura, Koji| Shen, Jian-Ren| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-36504-1| |
| Published Date | 2023-02-17 |
| Publication Title | Nature Communications |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 920 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36805598 |
| DOI | 10.1038/s41467-023-36504-1 |
| Web of Science KeyUT | 001002516000009 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-023-36504-1 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fujii, Shota| Sato, Takayuki| Aoki, Sho| Tsuda, Yu| Kawaguchi, Nobutaka| Shigemoto, Tomohiro| Terada, Masato| |
| Keywords | Cloaking cyber security geofencing malcious host time-series |
| Published Date | 2023-05-29 |
| Publication Title | IEEE Access |
| Volume | volume11 |
| Publisher | Institute of Electrical and Electronics Engineers |
| Start Page | 52750 |
| End Page | 52762 |
| ISSN | 2169-3536 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1109/ACCESS.2023.3280815 |
| Web of Science KeyUT | 001005635100001 |
| Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2023.3280815 |
| Title Alternative | Awareness about the Establishment of Clinical Evidence among Community Pharmacists: A Large-scale Survey among Members of the Okayama Pharmaceutical Association |
|---|---|
| FullText URL | fulltext20230619-10.pdf |
| Author | Matsumoto, Jun| Itano, Madoka| Iwata, Naohiro| Oro, Masafumi| Kitakaze, Chikako| Hirota, Ayuko| Makino, Katsuhiko| Tateno, Tomoyuki| Terai, Ryohei| Kenmotsu, Hideo| Date, Motohide| |
| Keywords | community pharmacists questionnaire survey research academic conference presentation article publication |
| Published Date | 2023-04-01 |
| Publication Title | YAKUGAKU ZASSHI |
| Volume | volume143 |
| Issue | issue4 |
| Publisher | 日本薬学会 |
| Start Page | 393 |
| End Page | 404 |
| ISSN | 0031-6903 |
| NCID | AN00284903 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 公益社団法人日本薬学会 |
| File Version | publisher |
| PubMed ID | 37005242 |
| DOI | 10.1248/yakushi.22-00151 |
| Web of Science KeyUT | 000999191400012 |
| Related Url | isVersionOf https://doi.org/10.1248/yakushi.22-00151 |
| FullText URL | fulltext20230619-07-2.pdf |
|---|---|
| Author | TSUGITA, Hideaki| DENNO, Satoshi| HOU, Yafei| |
| Keywords | physical layer network coding precoding multihop network singular value decomposition |
| Published Date | 2023-02-01 |
| Publication Title | IEICE Transactions on Communications |
| Volume | volumeE106.B |
| Issue | issue2 |
| Publisher | Institute of Electronics, Information and Communications Engineers (IEICE) |
| Start Page | 193 |
| End Page | 202 |
| ISSN | 0916-8516 |
| NCID | AA10826261 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Institute of Electronics, Information and Communication Engineers |
| File Version | publisher |
| DOI | 10.1587/transcom.2022ebp3062 |
| Web of Science KeyUT | 000989791500002 |
| Related Url | isVersionOf https://doi.org/10.1587/transcom.2022EBP3062 |
| FullText URL | fulltext20230619-07.pdf |
|---|---|
| Author | DENNO, Satoshi| KASHIHARA, Koki| HOU, Yafei| |
| Keywords | soft decision weighted sum lattice reduction linear detectors low computational complexity |
| Published Date | 2023-02-01 |
| Publication Title | IEICE Transactions on Communications |
| Volume | volumeE106.B |
| Issue | issue2 |
| Publisher | Institute of Electronics, Information and Communications Engineers (IEICE) |
| Start Page | 184 |
| End Page | 192 |
| ISSN | 0916-8516 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Institute of Electronics, Information and Communication Engineers |
| File Version | publisher |
| DOI | 10.1587/transcom.2022ebp3051 |
| Web of Science KeyUT | 000989791500001 |
| Related Url | isVersionOf https://doi.org/10.1587/transcom.2022EBP3051 |
| FullText URL | fulltext20230619-04.pdf |
|---|---|
| Author | Tsuneishi, Taichi| Kojima, Keiichi| Kubota, Fumika| Harashima, Hideyoshi| Yamada, Yuma| Sudo, Yuki| |
| Published Date | 2023 |
| Publication Title | Chemical Communications |
| Volume | volume59 |
| Issue | issue49 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 7591 |
| End Page | 7594 |
| ISSN | 1359-7345 |
| NCID | AA11071130 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2023 |
| File Version | publisher |
| PubMed ID | 37254694 |
| DOI | 10.1039/d3cc02056h |
| Web of Science KeyUT | 000999015900001 |
| Related Url | isVersionOf https://doi.org/10.1039/D3CC02056H |
| JaLCDOI | 10.18926/AMO/65502 |
|---|---|
| FullText URL | 77_3_323.pdf |
| Author | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
| Abstract | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
| Keywords | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357634 |
| Web of Science KeyUT | 001025850000001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okada, Nobuhiro| Ueki, Chihiro| Shimazaki, Masahiro| Tsujimoto, Goki| Kohno, Susumu| Muranaka, Hayato| Yoshikawa, Kiyotsugu| Takahashi, Chiaki| |
| Note | The version of record of this article, first published in Communications Biology, is available online at Publisher’s website: http://dx.doi.org/10.1038/s42003-023-04987-9| |
| Published Date | 2023-06-02 |
| Publication Title | Communications Biology |
| Volume | volume6 |
| Issue | issue1 |
| Publisher | nature portfolio |
| Start Page | 596 |
| ISSN | 2399-3642 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37268670 |
| DOI | 10.1038/s42003-023-04987-9 |
| Web of Science KeyUT | 000999915600001 |
| Related Url | isVersionOf https://doi.org/10.1038/s42003-023-04987-9 |
| JaLCDOI | 10.18926/AMO/65495 |
|---|---|
| FullText URL | 77_3_301.pdf |
| Author | Kato, Takahide| Miyoshi, Seigo| Hamada, Chizuru| Sano, Yoshifumi| Nogami, Naoyuki| Yamaguchi, Osamu| Hamaguchi, Naohiko| |
| Abstract | Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD. |
| Keywords | lung cancer interstitial lung disease acute exacerbation comorbidity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 309 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357631 |
| Web of Science KeyUT | 001026279600008 |
| JaLCDOI | 10.18926/AMO/65490 |
|---|---|
| FullText URL | 77_3_255.pdf |
| Author | Fukushima, Shinnosuke| Hagiya, Hideharu| Uda, Kazuhiro| Gotoh, Kazuyoshi| Otsuka, Fumio| |
| Abstract | Antimicrobial resistance is an emerging global threat that must be addressed using a multidisciplinary approach. This study aimed to raise awareness of high-level antimicrobial-resistant (AMR) pathogens in Japan by comparing their recent prevalences among prefectures, particularly Okayama. Data for the isolation proportions of meropenem-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae, and levofloxacin-resistant E. coli and K. pneumoniae were collected from the Japan Nosocomial Infections Surveillance, a national database sponsored by the Japanese Ministry of Health, Labour, and Welfare, between 2018 and 2021. The average isolated proportions of the seven AMR pathogens were higher in Okayama compared to other prefectures: the worst (19.9%) was meropenem-resistant P. aeruginosa, the sixth worst (57.2%) was methicillin-resistant S. aureus, the eighth worst (3.3%) was vancomycin-resistant E. faecium, the second (37.8%) and fifth worst (17.6%) were cefotaxime-resistant E. coli and K. pneumoniae, respectively, and the fourth (49.9%) and third worst (8.7%) were levofloxacin-resistant E. coli and K. pneumoniae, respectively. Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama. |
| Keywords | antimicrobial resistance antimicrobial stewardship epidemiology infection prevention and control Japan Nosocomial Infections Surveillance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357626 |
| Web of Science KeyUT | 001026279600003 |
| JaLCDOI | 10.18926/65474 |
|---|---|
| Title Alternative | How to Support People with APD |
| FullText URL | APD_Support (English).pdf |
| Author | Kataoka, Yuko| |
| Published Date | 2023 |
| language | English |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| License | https://creativecommons.org/licenses/by/4.0/ |
