result 5818 件
| JaLCDOI | 10.18926/AMO/54603 |
|---|---|
| FullText URL | 70_5_409.pdf |
| Author | Maeda, Yoshinobu| Nishimori, Hisakazu| Inamoto, Yoshihiro| Nakamae, Hirohisa| Sawa, Masashi| Mori, Yasuo| Ohashi, Kazuteru| Fujiwara, Shin-ichiro| Tanimoto, Mitsune| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD. |
| Keywords | Am80 tamibarotene retinoid chronic GVHD steroid-refractory GVHD |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 409 |
| End Page | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777437 |
| Web of Science KeyUT | 000388098700014 |
| JaLCDOI | 10.18926/AMO/54599 |
|---|---|
| FullText URL | 70_5_393.pdf |
| Author | Kanaya, Nobuhiko| Aoki, Hideki| Yamasaki, Rie| Morihiro, Toshiaki| Takeuchi, Hitoshi| |
| Abstract | We report a case of a granulocyte colony-stimulating factor (G-CSF)-producing gallbladder tumor associated with fever in a middle-aged female. Preoperative blood analysis showed leukocytosis with elevated levels of C-reactive protein and G-CSF. We resected the liver at S4a＋S5, with regional lymph node dissection and partial resection of the duodenum. Histology revealed undifferentiated carcinoma with spindle and giant cells and papillary adenocarcinoma. Immunohistochemistry revealed Stage IIIB G-CSF-producing gallbladder cancer. Postoperatively, leukocyte and serum G-CSF levels decreased to within normal limits. Adjuvant gemcitabine chemotherapy was administered for 16 months, and she has been recurrence-free for 48 months. |
| Keywords | gallbladder cancer G-CSF unidentified fever leukocystosis adenocarcinoma |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 393 |
| End Page | 396 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777433 |
| Web of Science KeyUT | 000388098700010 |
| JaLCDOI | 10.18926/AMO/54596 |
|---|---|
| FullText URL | 70_5_377.pdf |
| Author | Kawakami, Yoshio| Katayama, Takashi| Kishida, Masayuki| Oda, Wakako| Inoue, Yasuro| |
| Abstract | A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results. Blood culture revealed the growth of gram-negative bacilli. Subsequently, 16S rRNA sequencing of DNA confirmed the organism as Streptobacillus moniliformis, which is the causative pathogen of rat-bite fever. He had frequently encountered wild rats in his house although there was no evidence of rat bite on his body. Empiric therapy with intravenous administration of ceftriaxone in combination with azithromycin hydrate led to a prompt resolution of the symptoms. Precise history-taking related to contact with rats and detection of skin eruptions suggestive of leukocytoclastic vasculitis on the extremities, especially on the feet, can be clues to Streptobacillus moniliformis infection. Familiarity with its cutaneous features is important for early diagnosis; the evidence herein may also help in understanding its underlying pathogenesis. |
| Keywords | livedo vasculitis rat bite fever polyarteritis nodosa septic vasculopathy |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 381 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777430 |
| Web of Science KeyUT | 000388098700007 |
| FullText URL | K0005391_abstract_review.pdf K0005391_fulltext.pdf |
|---|---|
| Author | Toma, Kishio| |
| Published Date | 2016-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5391号 |
| Granted Date | 2016-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005390_abstract_review.pdf K0005390_fulltext.pdf |
|---|---|
| Author | Isozaki, Hideko| |
| Published Date | 2016-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5390号 |
| Granted Date | 2016-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Ohtsuki, Takashi| Miki, Shunya| Kobayashi, Shouhei| Haraguchi, Tokuko| Nakata, Eiji| Hirakawa, Kazutaka| Sumita, Kensuke| Watanabe, Kazunori| Okazaki, Shigetoshi| |
|---|---|
| Published Date | 2015-12 |
| Publication Title | Scientific Reports |
| Volume | volume5 |
| Content Type | Journal Article |
| Author | Ohtsuki, Takashi| Kanzaki, Shigeto| Nishimura, Sae| Kunihiro, Yoshio| Sisido, Masahiko| Watanabe, Kazunori| |
|---|---|
| Published Date | 2016-08 |
| Publication Title | Nature Communications |
| Volume | volume7 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54514 |
|---|---|
| FullText URL | 70_4_327.pdf |
| Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
| Abstract | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines. |
| Keywords | metformin CD8＋ T cells cancer immunology |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 327 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549683 |
| Web of Science KeyUT | 000384748600018 |
| JaLCDOI | 10.18926/AMO/54507 |
|---|---|
| FullText URL | 70_4_295.pdf |
| Author | Araki, Motoo| Wada, Koichiro| Mitsui, Yosuke| Kubota, Risa| Yoshioka, Takashi| Ariyoshi, Yuichi| Kobayashi, Yasuyuki| Kitagawa, Masashi| Tanabe, Katsuyuki| Sugiyama, Hiroshi| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo| |
| Abstract | Although graft survival following renal transplantation (RTx) has improved, outcomes following highrisk RTx are variable. Preexisting antibodies, including donor-specific antibodies (DSA), play an important role in graft dysfunction and survival. We have designed a study to investigate the safety and efficacy of anti-CD20 monoclonal antibodies (rituximab) in high-risk RTx recipients. Major eligibility criteria include: 1) major and minor ABO blood group mismatch, 2) positive DSA. Thirty-five patients will receive 200 mg/body of rituximab. The primary endpoint is the incidence of B cell depletion. This study will clarify whether rituximab is efficacious in improving graft survival in high-risk RTx recipients. |
| Keywords | end-stage renal disease immunosuppression kidney transplantation |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 295 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549676 |
| Web of Science KeyUT | 000384748600011 |
| JaLCDOI | 10.18926/AMO/54504 |
|---|---|
| FullText URL | 70_4_279.pdf |
| Author | Nishimura, Yoshito| Iwamuro, Masaya| Ocho, Kazuki| Hasegawa, Kou| Kimura, Kosuke| Hanayama, Yoshihisa| Kondo, Eisei| Tanaka, Takehiro| Otsuka, Fumio| |
| Abstract | A 61-year-old Japanese man with IgG4-related autoimmune pancreatitis was referred to our hospital because of perspiration during food intake. Abdominal computed tomography (CT) with contrast media revealed multiple mesenteric lymphadenopathies. An open surgical abdominal biopsy and subsequent histopathological analysis revealed abnormally large lymphoid cells that were negative for CD3, CD5, and c-myc and positive for CD20 and bcl-2, leading to a diagnosis of diffuse large B-cell lymphoma. Here, we discuss the risk of malignancies, particularly malignant lymphoma in patients with IgG4-related disease. The importance of pathological analysis to reach the appropriate diagnosis in such cases should be emphasized. |
| Keywords | IgG4-related disease autoimmune pancreatitis immunophenotyping diffuse large B-cell lymphoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549673 |
| Web of Science KeyUT | 000384748600008 |
| JaLCDOI | 10.18926/AMO/54499 |
|---|---|
| FullText URL | 70_4_243.pdf |
| Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
| Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549668 |
| Web of Science KeyUT | 000384748600003 |
| Title Alternative | Drug interaction (36. Combination with oral molecular target drugs in lung cancer) |
|---|---|
| FullText URL | 128_141.pdf |
| Author | Higashionna, Tsukasa| Esumi, Satoru| Kitamura, Yoshihisa| Sendo, Toshiaki| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 141 |
| End Page | 146 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.141 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.141 |
| NAID | 130005262644 |
| Title Alternative | Magnified observation of spontaneous morphological changes of duodenal follicular lymphoma |
|---|---|
| FullText URL | 128_111.pdf |
| Author | Iwamuro, Masaya| Takata, Katsuyoshi| Kawano, Seiji| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki| |
| Abstract | A 63-year-old Japanese woman was diagnosed with duodenal follicular lymphoma. The initial esophagogastroduodenoscopic examination with magnifying observation revealed opaque white spots and enlarged whitish villi. Nine months later, esophagogastroduodenoscopy showed that the size of the lymphoma lesion decreased, and only opaque white spots were visible. The histological analysis of biopsy samples obtained during the initial endoscopy examination showed both neoplastic follicles and an inter-follicular infiltration of lymphoma cells, whereas the biopsy samples obtained at the endoscopy performed 9 months later showed only neoplastic follicle formation. These results suggest that the magnifying endoscopic features may reflect the underlying pathological mechanisms : enlarged whitish villi are probably due to lymphoma cell infiltration in the inter-follicular area, and opaque white spots are probably caused by neoplastic follicle formation. |
| Keywords | 消化管原発濾胞性リンパ腫（primary gastrointestinal follicular lymphoma） 悪性リンパ腫（malignant lymphoma） 拡大内視鏡検査（magnifying endoscopy） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 111 |
| End Page | 116 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.111 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.111 |
| NAID | 130005262531 |
| Title Alternative | Identification of the adipokine ‘vaspin’ and its significance in metabolic syndrome |
|---|---|
| FullText URL | 128_103.pdf |
| Author | Wada, Jun| |
| Keywords | metabolic syndrome adipokine atherosclerosis endothelial cells apoptosis |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 103 |
| End Page | 109 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.103 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.103 |
| NAID | 130005262534 |
| Title Alternative | The 2015 Incentive Award of the Okayama Medical Association in Neuroscience (2015 Niimi Prize) |
|---|---|
| FullText URL | 128_95.pdf |
| Author | Toyoshima, Atsuhiko| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 95 |
| End Page | 97 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf http://doi.org/10.4044/joma.128.95 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.95 |
| NAID | 130005262637 |
| Title Alternative | The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize) |
|---|---|
| FullText URL | 128_91.pdf |
| Author | Kajita, Ai| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 91 |
| End Page | 94 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.91 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.91 |
| NAID | 130005262638 |
| JaLCDOI | 10.18926/AMO/54416 |
|---|---|
| FullText URL | 70_3_175.pdf |
| Author | Setiawan, Heri| Nagaoka, Kenjiro| Kubo, Masayuki| Fujikura, Yoshihisa| Ogino, Keiki| |
| Abstract | Oxidative stress is widely known to play a role in asthma. However, the contribution of xanthine oxidoreductase (XOR) as a source of the superoxide anion radical (O2－) in oxidative stress associated with asthma has not yet been examined in detail. Here we investigated pathophysiological changes in XOR in an experimental model of asthma induced by the house dust mite Dermatophagoides farinae (Df). In the lungs of Df-treated mice, the production of O2－ from XOR increased and the nitrite concentrations decreased, whereas the protein expression of XOR remained unchanged. Moreover, the protein expression levels of XOR and the hydrogen peroxide (H2O2) concentrations in bronchoalveolar lavage fluid (BALF) were higher in the Df-treated mice than in saline-treated mice. Immunohistochemically, although XOR was highly localized in the bronchial epithelial cells of the saline-treated mice, immunostaining for XOR was absent in the bronchial epithelium of Df-treated mice. These results suggest that oxidative stress is up-regulated by increases in the conversion of the dehydrogenase form (xanthine dehydrogenase; XDH) of XOR to the oxidase form (xanthine oxidase; XOD). |
| Keywords | xanthine oxidase oxidative stress asthma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-06 |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 175 |
| End Page | 182 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27339206 |
| Web of Science KeyUT | 000379406100004 |
| Author | Kudo, Toshiyuki| |
|---|---|
| Published Date | 2016-04 |
| Publication Title | Proceedings of Okayama Association for Laboratory Animal Science |
| Volume | volume32 |
| Content Type | Journal Article |
| FullText URL | K0005374_abstract_review.pdf K0005374_fulltext.pdf K0005374_summary.pdf |
|---|---|
| Author | Abe, Naomi| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5374号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Agriculture |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005335_abstract_review.pdf K0005335_fulltext.pdf |
|---|---|
| Author | Sugii, Yu| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5335号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
