result 5724 件
| Author | Yoshimoto, Kaori| Takamura, Hiroyoshi| Kadota, Isao| Motose, Hiroyasu| Takahashi, Taku| |
|---|---|
| Published Date | 2016-02-16 |
| Publication Title | Scientific Reports |
| Volume | volume6 |
| Content Type | Journal Article |
| Author | Taniguchi, Masanari| Fukunaka, Ayako| Hagihara, Mitsue| Watanabe, Keiko| Kamino, Shinichiro| Kambe, Taiho| Enomoto, Shuichi| Hiromura, Makoto| |
|---|---|
| Published Date | 2013-03-07 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-05-25 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54007 |
|---|---|
| FullText URL | 70_1_63.pdf |
| Author | Torigoe, Hidejiro| Toyooka, Shinichi| Katsui, Kuniaki| Soh, Junichi| Maki, Yuho| Kiura, Katsuyuki| Miyoshi, Shinichiro| |
| Abstract | We present the case of a 77-year-old Japanese man diagnosed with lung squamous cell carcinoma with mediastinal lymph node metastasis. He was treated with induction chemoradiotherapy for T1bN2M0 stage IIIA disease. Considering his age, we selected S-1 as the chemotherapeutic drug. Observing an objective response with no severe adverse events, we performed a left upper lobectomy with sleeve resection of the pulmonary artery. No residual tumor cells were found in the resected specimens, and no critical complication was observed in the clinical course. This case suggests that induction chemoradiotherapy using S-1 combined with concurrent radiation followed by surgery can be a therapeutic option for elderly patients with locally advanced non-small-cell lung cancer. |
| Keywords | lung cancer S-1 elderly induction chemoradiotherapy |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 65 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899612 |
| Web of Science KeyUT | 000371288700009 |
| JaLCDOI | 10.18926/AMO/53999 |
|---|---|
| FullText URL | 70_1_13.pdf |
| Author | Arum Tri Wahyuningsih| Shen, Lianhua| Kobayashi, Kazuko| Sasaki, Takanori| Takenaka, Fumiaki| Hanada, Takahisa| Akehi, Masaru| Akahoshi, Akiya| Ozeki, Eiichi| Ando, Eiji| Matsuura, Eiji| |
| Abstract | Intact β2-glycoprotein I (iβ2GPI) is a glycoprotein that regulates coagulation and fibrinolysis. Nicked β2GPI (nβ2GPI) possesses an angiogenic property at a relatively low concentration, and an antiangiogenic property at a high concentration. Here we investigated the functions of βi 2GPI and nβ2GPI in vascular endothelial growth factor (VEGF)-A-induced endothelial cell proliferation and tube formation. We used noninvasive PET imaging to analyze the in vivo distribution of intravenously injected β2GPI variants in tumor lesions in mice. iβ2GPI was incubated with plasmin to obtain nβ2GPI, and its N-terminal sequence was analyzed. nβ2GPI had at least one other cleavage site upstream of the β2GPIʼs domain V, whereas the former plasmin-cleavage site locates between K317 and T318. Both of intact and nicked β2GPI significantly inhibited the VEGF-A-induced cell proliferation and the tube formation of human umbilical vein endothelial cells (HUVECs). PET imaging visualized considerably distributed intensities of all tested β2GPI variants in tumor lesions of pancreatic tumor cell-xenografts. These results indicate that β2GPI may be physiologically and pathophysiologically important in the regulation of not only coagulation and fibrinolysis, but also angiogenesis. |
| Keywords | β2-glycoprotein I (β2GPI) angiogenesis vascular endothelial growth factor-A (VEGF-A) positron emission tomography (PET) imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-02 |
| Volume | volume70 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26899605 |
| Web of Science KeyUT | 000371288700002 |
| Author | Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi| |
|---|---|
| Published Date | 2014-01-22 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yoshimura, Teizo| Howard, O. M. Zack| Ito, Toshihiro| Kuwabara, Masaki| Matsukawa, Akihiro| Chen, Keqiang| Liu, Ying| Liu, Mingyong| Oppenheim, Joost J.| Wang, Ji Ming| |
|---|---|
| Published Date | 2013-03-18 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Tani, Akio| Takai, Yuichiro| Suzukawa, Ikko| Akita, Motomu| Murase, Haruhiko| Kimbara, Kazuhide| |
|---|---|
| Published Date | 2012-03-29 |
| Publication Title | PLOS ONE |
| Volume | volume7 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Tani, Akio| Nurettin, Sahin| Matsuyama, Yumiko| Enomoto, Takashi| Nishimura, Naoki| Yokota, Akira| Kimbara, Kazuhide| |
|---|---|
| Published Date | 2012-07-12 |
| Publication Title | PLOS ONE |
| Volume | volume7 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Yoshii, Taishi| Hermann-Luibl, Christiane| Kistenpfennig, Christa| Schmid, Benjamin| Tomioka, Kenji| Helfrich-Förster, Charlotte| |
|---|---|
| Published Date | 2015-04-15 |
| Publication Title | The Journal of neuroscience |
| Volume | volume35 |
| Issue | issue15 |
| Content Type | Journal Article |
| Author | Yamamoto, Yuki| |
|---|---|
| Published Date | 2016-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume105 |
| Content Type | Departmental Bulletin Paper |
| Author | Nakamura, Toshiyuki| |
|---|---|
| Published Date | 2016-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume105 |
| Content Type | Departmental Bulletin Paper |
| Author | Hamada, Yoshimasa| Bando, Tetsuya| Nakamura, Taro| Ishimaru, Yoshiyasu| Mito, Taro| Noji, Sumihare| Tomioka, Kenji| Ohuchi, Hideyo| |
|---|---|
| Published Date | 2015-09 |
| Publication Title | Development |
| Volume | volume142 |
| Issue | issue17 |
| Content Type | Journal Article |
| Author | Asanuma, Masato| Miyazaki, Ikuko| Francisco J., Diaz-Corrales| Higashi, Youichirou| Namba, Masayoshi| Ogawa, Norio| |
|---|---|
| Published Date | 2013-06-12 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Eguchi, Takanori| Watanabe, Ken| Hara, Emilio Satoshi| Ono, Mitsuaki| Kuboki, Takuo| Stuart K., Calderwood| |
|---|---|
| Published Date | 2013-03-22 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Hara, Emilio Satoshi| Ono, Mitsuaki| Eguchi, Takanori| Kubota, Satoshi| Hai, Thanh Pham| Sonoyama, Wataru| Tajima, Shoji| Takigawa, Masaharu| Stuart K., Calderwood| Kuboki, Takuo| |
|---|---|
| Published Date | 2013-12-27 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Yoshioka, Shin| Abe, Hironori| Sakumoto, Ryosuke| Okuda, Kiyoshi| |
|---|---|
| Published Date | 2013-12-27 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Kato, Nobuyuki| Sejima, Hiroe| Ueda, Youki| Mori, Kyoko| Satoh, Shinya| Dansako, Hiromichi| Ikeda, Masanori| |
|---|---|
| Published Date | 2014-03-13 |
| Publication Title | PLOS ONE |
| Volume | volume9 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Ueda, Youki| Takeda, Midori| Mori, Kyoko| Dansako, Hiromichi| Wakita, Takaji| Kim, Hye-Sook| Sato, Akira| Wataya, Yusuke| Ikeda, Masanori| Kato, Nobuyuki| |
|---|---|
| Published Date | 2013-08-30 |
| Publication Title | PLOS ONE |
| Volume | volume8 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun| |
|---|---|
| Published Date | 2015 |
| Publication Title | Scientific reports |
| Volume | volume5 |
| Content Type | Journal Article |
