result 5995 件
| FullText URL | OncoImmunol_8_12_1671760.pdf |
|---|---|
| Author | Sakamoto, Shuichi| Kagawa, Shunsuke| Kuwada, Kazuya| Ito, Atene| Kajioka, Hiroki| Kakiuchi, Yoshihiko| Watanabe, Megumi| Kagawa, Tetsuya| Yoshida, Ryuichi| Kikuchi, Satoru| Kuroda, Shinji| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination |
| Published Date | 2019-10-22 |
| Publication Title | OncoImmunology |
| Volume | volume8 |
| Issue | issue12 |
| Publisher | TAYLOR & FRANCIS |
| Start Page | e1671760 |
| ISSN | 2162402X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Author(s). |
| File Version | publisher |
| DOI | 10.1080/2162402X.2019.1671760 |
| Web of Science KeyUT | 000494085400001 |
| Related Url | isVersionOf https://doi.org/10.1080/2162402X.2019.1671760 |
| FullText URL | EBioMedicine_2017_154.pdf |
|---|---|
| Author | Kunisada, Yuki| Eikawa, Shingo| Tomonobu, Nahoko| Domae, Shohei| Uehara, Takenori| Hori, Shohei| Furusawa, Yukihiro| Hase, Koji| Sasaki, Akira| Udono, Heiichiro| |
| Keywords | Glycolysis Regulatory T cell (Treg) Tumor immunity Tumor microenvironment mTOR |
| Published Date | 2017-10-16 |
| Publication Title | EBioMedicine |
| Volume | volume25 |
| Publisher | Elsevier Science |
| Start Page | 154 |
| End Page | 164 |
| ISSN | 23523964 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2017 The Authors. |
| File Version | publisher |
| PubMed ID | 29066174 |
| DOI | 10.1016/j.ebiom.2017.10.009 |
| Web of Science KeyUT | 000417440500026 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ebiom.2017.10.009 |
| FullText URL | PlosOne14_1_211505.pdf |
|---|---|
| Author | Miyoshi, Yuichi| Ohtsuki, Takashi| Kashida, Hiromu| Asanuma, Hiroyuki| Watanabe, Kazunori| |
| Published Date | 2019-01-29 |
| Publication Title | PLoS One |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | PUBLIC LIBRARY SCIENCE |
| Start Page | e0211505 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | French |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Miyoshi et al. |
| File Version | publisher |
| PubMed ID | 30695081 |
| DOI | 10.1371/journal.pone.0211505 |
| Web of Science KeyUT | 000457046400041 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0211505 |
| FullText URL | IntJMolSci_20_8_1973.pdf |
|---|---|
| Author | Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Yoshida, Saori| Maeda, Hatsuhiko| Kawakami, Toshiyuki| Nagatsuka, Hitoshi| |
| Keywords | cell differentiation epithelial-mesenchymal interaction immunohistochemistry malignant transformation notch signaling odontogenic tumor pleomorphic adenoma |
| Published Date | 2019-04-23 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1973 |
| ISSN | 14220067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31018488 |
| DOI | 10.3390/ijms20081973 |
| Web of Science KeyUT | 000467648700171 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20081973 |
| FullText URL | Epilepsia_49_3_521.pdf |
|---|---|
| Author | Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Inoue, Takushi| Shimizu, Kenji| Matsui, Hideki| Ohtsuka, Yoko| Maegaki, Yoshihiro| |
| Keywords | Rasmussen encephalitis SCN1A genetic-environmental interaction |
| Published Date | 2007-11-21 |
| Publication Title | Epilepsia |
| Volume | volume49 |
| Issue | issue3 |
| Publisher | Blackwell |
| Start Page | 521 |
| End Page | 526 |
| ISSN | 0013-9580 |
| NCID | AA00180597 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 18031552 |
| DOI | 10.1111/j.1528-1167.2007.01411.x |
| Web of Science KeyUT | 000253477800020 |
| Related Url | isVersionOf https://doi.org/10.1111/j.1528-1167.2007.01411.x |
| FullText URL | AnnGastroenterolSurg_3_4_396.pdf |
|---|---|
| Author | Fujiwara, Toshiyoshi| |
| Keywords | adenovirus clinical trial esophageal cancer radiotherapy telomerase |
| Published Date | 2019-07-05 |
| Publication Title | Annals of gastroenterological surgery |
| Volume | volume3 |
| Issue | issue4 |
| Publisher | John Wiley & Sons |
| Start Page | 396 |
| End Page | 404 |
| ISSN | 24750328 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors |
| File Version | publisher |
| PubMed ID | 31346579 |
| DOI | 10.1002/ags3.12270 |
| Web of Science KeyUT | 000475745100009 |
| Related Url | isVersionOf https://doi.org/10.1002/ags3.12270 |
| FullText URL | CellRep_28_5_1362.pdf |
|---|---|
| Author | Abe, Fumitaka| Haque, Emdadul| Hisano, Hiroshi| Tanaka, Tsuyoshi| Kamiya, Yoko| Mikami, Masafumi| Kawaura, Kanako| Endo, Masaki| Onishi, Kazumitsu| Hayashi, Takeshi| Sato, Kazuhiro| |
| Keywords | CRISPR/Cas9 Qsd1 multiple mutation seed dormancy wheat |
| Published Date | 2019-07-30 |
| Publication Title | Cell Reports |
| Volume | volume28 |
| Issue | issue5 |
| Publisher | Cell Press |
| Start Page | 1362 |
| End Page | 1369 |
| ISSN | 22111247 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31365876 |
| DOI | 10.1016/j.celrep.2019.06.090 |
| Related Url | isVersionOf https://doi.org/10.1016/j.celrep.2019.06.090 |
| FullText URL | K0006059_abstract_review.pdf K0006059_fulltext.pdf |
|---|---|
| Author | SAID MOHAMED ABDELSABOUR AFIFY| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6059号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006044_abstract_review.pdf.pdf summary.pdf.pdf fulltext.pdf.pdf |
|---|---|
| Author | Kunitomo, Yuri| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6044号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006040_abstract_review.pdf K0006040_fulltext.pdf K0006040_Other2(Suppl Figure).pdf |
|---|---|
| Author | Mitsui, Yosuke| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6040号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006037_abstract_review.pdf K0006037_fulltext.pdf K0006037_other_1 supplementary figure.pdf K0006037_other_2 supplementary material.pdf |
|---|---|
| Author | Katsura, Yuki| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6037号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006034_abstract_review.pdf K0006034_fulltext.pdf |
|---|---|
| Author | Nishimura, Yoshito| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6034号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006031_abstract_review.pdf K0006031_fulltext.pdf |
|---|---|
| Author | Iwata, Nahoko| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6031号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006024_abstract_review.pdf K0006024_fulltext.pdf K0006024_other_1 figure.pdf K0006024_other_2 Supplementary figures and legends.pdf |
|---|---|
| Author | Watanabe, Shin-ichiro| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6024号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | fcell_2019_00160_p.pdf fcell_2019_00160_a.pdf |
|---|---|
| Author | Satoh, Ayano| Hayashi-Nishino, Mitsuko| Shakuno, Takuto| Masuda, Junko| Koreishi, Mayuko| Murakami, Runa| Nakamura, Yoshimasa| Nakamura, Toshiyuki| Abe-Kanoh, Naomi| Honjo, Yasuko| Malsam, Joerg| Yu, Sidney| ishino, Kunihiko | |
| Keywords | Golgi golgins glycosylation endoplasmic reticulum electron tomography |
| Published Date | 2019-08-27 |
| Publication Title | Frontiers in Cell and Developmental Biology |
| Volume | volume7 |
| Start Page | 160 |
| ISSN | 2296634X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31544102 |
| DOI | 10.3389/fcell.2019.00160 |
| Related Url | isVersionOf https://doi.org/10.3389/fcell.2019.00160 |
| JaLCDOI | 10.18926/AMO/57379 |
|---|---|
| FullText URL | 73_5_469.pdf |
| Author | Yamasaki, Satoshi| Kada, Akiko| Nagai, Hirokazu| Yoshida, Isao| Choi, Ilseung| Saito, Akiko M.| Iwasakia, Hiromi| |
| Abstract | Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies. |
| Keywords | peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649375 |
| Web of Science KeyUT | 000491886600014 |
| JaLCDOI | 10.18926/AMO/57377 |
|---|---|
| FullText URL | 73_5_457.pdf |
| Author | Iwamuro, Masaya| Takahara, Masahiro| Yamazaki, Tatsuhiro| Tanaka, Takehiro| Kondo, Yoshitaka| Hiraoka, Sakiko| Okada, Hiroyuki| |
| Abstract | A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis. |
| Keywords | colonoscopy colonic neoplasms granulation polyp |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 457 |
| End Page | 461 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649373 |
| Web of Science KeyUT | 000491886600012 |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| FullText URL | 73_5_433.pdf |
| Author | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| Keywords | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 433 |
| End Page | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57367 |
|---|---|
| FullText URL | 73_5_383.pdf |
| Author | Fu, Li| Nishibori, Masahiro| |
| Abstract | High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis. |
| Keywords | HMGB1 epileptogenesis inflammation blood-brain barrier |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 383 |
| End Page | 386 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649363 |
| Web of Science KeyUT | 000491886600002 |
| JaLCDOI | 10.18926/AMO/57366 |
|---|---|
| FullText URL | 73_5_379.pdf |
| Author | Wake, Hidenori| |
| Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
| Keywords | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 379 |
| End Page | 382 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649362 |
| Web of Science KeyUT | 000491886600001 |
