result 1433 件
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| FullText URL | 76_4_399.pdf |
| Author | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Abstract | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| Keywords | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 399 |
| End Page | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ahmed, Feroz| Shimizu, Masashi| Wang, Jin| Sakai, Kenji| Kiwa, Toshihiko| |
| Keywords | microfluidics fluid dynamics 3D simulation ReLU dense layers Leaky ReLU swish activation functions deep learning model |
| Published Date | 2022-08-20 |
| Publication Title | Micromachines |
| Volume | volume13 |
| Issue | issue8 |
| Publisher | MDPI |
| Start Page | 1352 |
| ISSN | 2072-666X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36014274 |
| DOI | 10.3390/mi13081352 |
| Web of Science KeyUT | 000845405500001 |
| Related Url | isVersionOf https://doi.org/10.3390/mi13081352 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanimoto, Terutaka| Noda, Takuo| Imaji, Reisuke| Nouso, Hiroshi| |
| Keywords | Esophageal atresia Communicating bronchopulmonary foregut malformation Broncho-esophageal fistula |
| Published Date | 2022-08-15 |
| Publication Title | Surgical Case Reports |
| Volume | volume8 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 156 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35969287 |
| DOI | 10.1186/s40792-022-01513-7 |
| Web of Science KeyUT | 000840835900001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-022-01513-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Nakamura, Tomoya| Fujimura, Ai| Fujisawa, Ayaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Mukainaka, Yumika| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Keywords | hepatitis B hepatitis C human immunodeficiency virus pre-operative examination |
| Published Date | 2022-07-20 |
| Publication Title | Healthcare |
| Volume | volume10 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 1348 |
| ISSN | 2227-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35885875 |
| DOI | 10.3390/healthcare10071348 |
| Web of Science KeyUT | 000832459200001 |
| Related Url | isVersionOf https://doi.org/10.3390/healthcare10071348 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Oiwa, Masahiko| Kuroda, Kosuke| Kawanoue, Naoya| Morimatsu, Hiroshi| |
| Keywords | Biomarker Clavien-Dindo classification Histidine-rich glycoprotein Intensive care unit Perioperative management Postoperative complication Predictor |
| Published Date | 2022-07-20 |
| Publication Title | BMC Anesthesiology |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 232 |
| ISSN | 1471-2253 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35858852 |
| DOI | 10.1186/s12871-022-01774-7 |
| Web of Science KeyUT | 000828247900001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12871-022-01774-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kametaka, Daisuke| Iwamuro, Masaya| Takahashi, Takahide| Hirabata, Araki| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Otsuka, Fumio| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Keywords | flow cytometry autoimmune gastritis atrophic gastritis Helicobacter pylori |
| Published Date | 2022-05-25 |
| Publication Title | Current Issues In Molecular Biology |
| Volume | volume44 |
| Issue | issue6 |
| Publisher | MDPI |
| Start Page | 2443 |
| End Page | 2452 |
| ISSN | 1467-3037 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35735608 |
| DOI | 10.3390/cimb44060167 |
| Web of Science KeyUT | 000816477400001 |
| Related Url | isVersionOf https://doi.org/10.3390/cimb44060167 |
| JaLCDOI | 10.18926/AMO/63747 |
|---|---|
| FullText URL | 76_3_349.pdf |
| Author | Ariyasu, Kanazu| Kimura, Shuhei| Matoba, Ryo| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Kanzaki, Yuki| Morizane, Yuki| |
| Abstract | An 18-year-old male high school student presented to our clinic with bilateral blunt ocular trauma caused by an exercise resistance band (ERB) during a muscle-building exercise. Best-corrected decimal visual acuities (BCVAs) for right and left eyes were light perception and 0.15, respectively. The right eye was operated 10 days after injury for persistent vitreous hemorrhage, and the left eye 5 months later because of macular hole onset. After 36 months, the right eye showed extensive retinal degeneration (BCVA 0.04), and the left eye macular hole closure (BCVA 1.2). ERBs should be used cautiously as they can cause serious ocular trauma. |
| Keywords | exercise resistance band traumatic macular hole traumatic retinal degeneration bilateral blunt ocular trauma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 354 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790368 |
| Web of Science KeyUT | 000823568300016 |
| JaLCDOI | 10.18926/AMO/63744 |
|---|---|
| FullText URL | 76_3_333.pdf |
| Author | Akagawa, Manabu| Miyakoshi, Naohisa| Tsuchie, Hiroyuki| Kasukawa, Yuji| Kawaragi, Takashi| Nagahata, Itsuki| Suzuki, Masazumi| Yoshikawa, Takayuki| Abe, Toshiki| Shimada, Yoichi| |
| Abstract | We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture. |
| Keywords | atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 338 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790365 |
| Web of Science KeyUT | 000823568300013 |
| JaLCDOI | 10.18926/AMO/63741 |
|---|---|
| FullText URL | 76_3_317.pdf |
| Author | Yamamoto, Norio| Inoue, Tomoo| Yusuke, Mochizuki| Tomoyuki, Noda| Keisuke, Kawasaki| Toshifumi, Ozaki| |
| Abstract | Secondary hip fractures (SHFs) rarely occur after intramedullary nailing (IMN) fixation without femoral neck fixation for atypical femoral fractures (AFFs). We report three cases of older Japanese women who sustained SHFs presumably caused by osteoporosis and peri-implant stress concentration around the femoral neck after undergoing IMN without femoral neck fixation for AFF. All cases were fixed with malalignment. In AFF patients, postoperative changes due to postoperative femoral bone malalignment may affect the peri-implant mechanical environment around the femoral neck, which can result in insufficiency fractures. At the first AFF surgery, we recommend femoral neck fixation after adequate reduction is achieved. |
| Keywords | atypical femoral fracture bone malalignment intramedullary nail femoral neck fracture hip fracture |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 317 |
| End Page | 321 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790362 |
| Web of Science KeyUT | 000823568300010 |
| JaLCDOI | 10.18926/AMO/63738 |
|---|---|
| FullText URL | 76_3_291.pdf |
| Author | Miyake, Yoshiaki| Mitani, Shigeru| Namba, Yoshifumi| Umehara, Norifumi| Kawamoto, Toyohiro| Furuichi, Shuro| |
| Abstract | Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure. |
| Keywords | total hip arthroplasty bacterial contamination periprosthetic joint infection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-06 |
| Volume | volume76 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 291 |
| End Page | 295 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35790359 |
| Web of Science KeyUT | 000823568300008 |
| FullText URL | fulltext20220630-6.pdf |
|---|---|
| Author | Tsunata, Ren| Takemoto, Masatsugu| Ogasawara, Satoshi| Saito, Tatsuya| Ueno, Tomoyuki| |
| Note | © 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | |
| Published Date | 2022-5 |
| Publication Title | IEEE Transactions on Industry Applications |
| Volume | volume58 |
| Issue | issue3 |
| Publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| Start Page | 3470 |
| End Page | 3485 |
| ISSN | 0093-9994 |
| NCID | AA00667900 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | Copyright © 2022, IEEE |
| File Version | author |
| DOI | 10.1109/tia.2022.3154336 |
| Web of Science KeyUT | 000799279300052 |
| Related Url | isVersionOf https://doi.org/10.1109/tia.2022.3154336 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishimura, Yoshito| Acoba, Jared D.| |
| Keywords | Breast Cancer Awareness Month breast cancer Google Trends trend analysis |
| Published Date | 2022-05-21 |
| Publication Title | Cancers |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 2534 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35626141 |
| DOI | 10.3390/cancers14102534 |
| Web of Science KeyUT | 000803386600001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers14102534 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tanaka, Masato| Chan, Tsang-Tung| Misawa, Haruo| Uotani, Koji| Arataki, Shinaya| Takigawa, Tomoyuki| Mazaki, Tetsuro| Sugimoto, Yoshihisa| |
| Keywords | achondroplasia vertebral column osteotomy long-term follow-up navigation |
| Published Date | 2022-04-27 |
| Publication Title | Medicina |
| Volume | volume58 |
| Issue | issue5 |
| Publisher | MDPI |
| Start Page | 605 |
| ISSN | 1010-660X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35630021 |
| DOI | 10.3390/medicina58050605 |
| Web of Science KeyUT | 000802445600001 |
| Related Url | isVersionOf https://doi.org/10.3390/medicina58050605 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Tsuyoshi| Naito, Hiromichi| Obara, Takafumi| Ageta, Kohei| Yakushiji, Hiromasa| Yumoto, Tetsuya| Fujisaki, Noritomo| Nakao, Atsunori| |
| Keywords | ammonia cardiopulmonary resuscitation neurological outcome biomarkers |
| Published Date | 2022-05-04 |
| Publication Title | Journal Of Clinical Medicine |
| Volume | volume11 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 2566 |
| ISSN | 2077-0383 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 35566692 |
| DOI | 10.3390/jcm11092566 |
| Web of Science KeyUT | 000794498600001 |
| Related Url | isVersionOf https://doi.org/10.3390/jcm11092566 |
| FullText URL | fulltext20220428-3.pdf |
|---|---|
| Author | Fukushima, Yukinobu| Suda, Tatsuya| Murase, Tutomu| Tarutani, Yuya| Yokohira, Tokumi| |
| Keywords | IaaS SMS (server migration service) server locations energy cost monetary penaltymixed-integer programming |
| Note | This is the peer reviewed version of the following article: [Fukushima, Y, Suda, T, Murase, T, Tarutani, Y, Yokohira, T. Minimizing the monetary penalty and energy cost of server migration service. Trans Emerging Tel Tech. 2022;e4511. doi:10.1002/ett.4511], which has been published in final form at [https://doi.org/10.1002/ett.4511]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2022-04-10 |
| Publication Title | Transactions on Emerging Telecommunications Technologies |
| Volume | volume33 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | e4511 |
| ISSN | 2161-3915 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 John Wiley & Sons, Ltd. |
| File Version | author |
| DOI | 10.1002/ett.4511 |
| Web of Science KeyUT | 000779978300001 |
| Related Url | isVersionOf https://doi.org/10.1002/ett.4511 |
| JaLCDOI | 10.18926/AMO/63426 |
|---|---|
| FullText URL | 76_2_217.pdf |
| Author | Yabuno, Satoru| Sasada, Susumu| Umakoshi, Michiari| Nagase, Takayuki| Sugahara, Chiaki| Kawauchi, Satoshi| Yasuhara, Takao| Date, Isao| |
| Abstract | A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery. |
| Keywords | cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 217 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503450 |
| Web of Science KeyUT | 000792291900004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takatsu, Fumiaki| Yamamoto, Hiromasa| Tomioka, Yasuaki| Tanaka, Shin| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Toyooka, Shinichi| |
| Keywords | Retroperitoneal sarcoma Lung metastasis Metastasectomy |
| Published Date | 2022-04-08 |
| Publication Title | World Journal Of Surgical Oncology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 114 |
| ISSN | 1477-7819 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35395855 |
| DOI | 10.1186/s12957-022-02552-y |
| Web of Science KeyUT | 000780301100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12957-022-02552-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Higaki, Fumiyo| Inoue, Satoshi| Oda, Wakako| Matsusue, Eiji| Hiraki, Takao| |
| Keywords | pial blood supply peritumoral brain edema arachnoid plane peritumoral flow void magnetic resonance imaging |
| Published Date | 2022-04-08 |
| Publication Title | Acta Radiologica Open |
| Volume | volume11 |
| Issue | issue4 |
| Publisher | Sage Publications Ltd. |
| ISSN | 2058-4601 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35425642 |
| DOI | 10.1177/20584601221091208 |
| Web of Science KeyUT | 000780184200001 |
| Related Url | isVersionOf https://doi.org/10.1177/20584601221091208 |
| JaLCDOI | 10.18926/AMO/63406 |
|---|---|
| FullText URL | 76_2_129.pdf |
| Author | Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi| |
| Abstract | Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC. |
| Keywords | D-dimer gynecologic cancer venous thromboembolism |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 135 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503440 |
| Web of Science KeyUT | 000792374900004 |
| JaLCDOI | 10.18926/AMO/63403 |
|---|---|
| FullText URL | 76_2_105.pdf |
| Author | Takaoka, Megumi| Ohsumi, Shozo| Ikejiri, Haruka| Shidahara, Tomohiro| Miyoshi, Yuichiro| Takahashi, Mina| Takashima, Seiki| Aogi, Kenjiro| |
| Abstract | Cases of breast cancer metastasis after achieving a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) are sometimes encountered in clinical practice. We investigated the prognostic factors for pCR in patients with breast cancer after NAC. This retrospective cohort study included patients with localized breast cancer who underwent NAC followed by surgery between 2004 and 2020 and achieved a pCR. The associations between clinical factors and distant metastasis-free survival rate were statistically analyzed. We analyzed data for 127 patients. Twelve patients (9.4%) had distant metastases, and seven (5.5%) died. For estrogen receptor (ER)-positive patients, the distant metastasis-free survival rate was 94.6% for both 5 and 8 years. In contrast, ER-negative patients had a distant metastasis-free survival rate of 87.6% and 85.4% for 5 and 8 years (p=0.094), respectively. In cT0-2 patients, the distant metastasis-free survival rate was 92.4% for 5 years and 90.5% for 8 years, whereas in cT3-4 patients, the distant metastasis-free survival rate was 83.5% for 5 years and 83.5% for 8 years (p=0.301). This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis. |
| Keywords | breast carcinoma neoadjuvant therapy prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 111 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503437 |
| Web of Science KeyUT | 000792374900001 |
