検索結果 - 岡山大学学術成果リポジトリ

Gene Expression Profiling between Patient Groups with High and Low Ki67 Levels after Short-term Preoperative Aromatase Inhibitor Treatment for Breast Cancer

JaLCDOI	10.18926/AMO/63894
フルテキストURL	76_4_399.pdf
著者	Kajiwara, Yukiko\| Iwamoto, Takayuki\| Zhu, Yidan\| Kochi, Mariko\| Shien, Tadahiko\| Taira, Naruto\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
抄録	According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67.
キーワード	breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	399
終了ページ	408
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123154
Web of Science KeyUT	000882167300005

Optimization of Microchannels and Application of Basic Activation Functions of Deep Neural Network for Accuracy Analysis of Microfluidic Parameter Data

フルテキストURL	fulltext.pdf
著者	Ahmed, Feroz\| Shimizu, Masashi\| Wang, Jin\| Sakai, Kenji\| Kiwa, Toshihiko\|
キーワード	microfluidics fluid dynamics 3D simulation ReLU dense layers Leaky ReLU swish activation functions deep learning model
発行日	2022-08-20
出版物タイトル	Micromachines
巻	13巻
号	8号
出版者	MDPI
開始ページ	1352
ISSN	2072-666X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36014274
DOI	10.3390/mi13081352
Web of Science KeyUT	000845405500001
関連URL	isVersionOf https://doi.org/10.3390/mi13081352

A case of esophageal atresia with the bronchial-like lower esophagus which originates from the left lower lobe bronchus

フルテキストURL	fulltext.pdf
著者	Tanimoto, Terutaka\| Noda, Takuo\| Imaji, Reisuke\| Nouso, Hiroshi\|
キーワード	Esophageal atresia Communicating bronchopulmonary foregut malformation Broncho-esophageal fistula
発行日	2022-08-15
出版物タイトル	Surgical Case Reports
巻	8巻
号	1号
出版者	Springer
開始ページ	156
ISSN	2198-7793
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35969287
DOI	10.1186/s40792-022-01513-7
Web of Science KeyUT	000840835900001
関連URL	isVersionOf https://doi.org/10.1186/s40792-022-01513-7

The Effectiveness of Pre-Operative Screening Tests in Determining Viral Infections in Patients Undergoing Oral and Maxillofacial Surgery

フルテキストURL	fulltext.pdf
著者	Sukegawa, Shintaro\| Sukegawa, Yuka\| Hasegawa, Kazuaki\| Ono, Sawako\| Nakamura, Tomoya\| Fujimura, Ai\| Fujisawa, Ayaka\| Nakano, Keisuke\| Takabatake, Kiyofumi\| Kawai, Hotaka\| Mukainaka, Yumika\| Nagatsuka, Hitoshi\| Furuki, Yoshihiko\|
キーワード	hepatitis B hepatitis C human immunodeficiency virus pre-operative examination
発行日	2022-07-20
出版物タイトル	Healthcare
巻	10巻
号	7号
出版者	MDPI
開始ページ	1348
ISSN	2227-9032
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35885875
DOI	10.3390/healthcare10071348
Web of Science KeyUT	000832459200001
関連URL	isVersionOf https://doi.org/10.3390/healthcare10071348

Histidine-rich glycoprotein as a novel predictive biomarker of postoperative complications in intensive care unit patients: a prospective observational study

フルテキストURL	fulltext.pdf
著者	Oiwa, Masahiko\| Kuroda, Kosuke\| Kawanoue, Naoya\| Morimatsu, Hiroshi\|
キーワード	Biomarker Clavien-Dindo classification Histidine-rich glycoprotein Intensive care unit Perioperative management Postoperative complication Predictor
発行日	2022-07-20
出版物タイトル	BMC Anesthesiology
巻	22巻
号	1号
出版者	BMC
開始ページ	232
ISSN	1471-2253
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35858852
DOI	10.1186/s12871-022-01774-7
Web of Science KeyUT	000828247900001
関連URL	isVersionOf https://doi.org/10.1186/s12871-022-01774-7

Characterization of Gastric Tissue-Resident T Cells in Autoimmune and Helicobacter pylori-Associated Gastritis

フルテキストURL	fulltext.pdf
著者	Kametaka, Daisuke\| Iwamuro, Masaya\| Takahashi, Takahide\| Hirabata, Araki\| Hamada, Kenta\| Kono, Yoshiyasu\| Kanzaki, Hiromitsu\| Kawano, Seiji\| Tanaka, Takehiro\| Otsuka, Fumio\| Kawahara, Yoshiro\| Okada, Hiroyuki\|
キーワード	flow cytometry autoimmune gastritis atrophic gastritis Helicobacter pylori
発行日	2022-05-25
出版物タイトル	Current Issues In Molecular Biology
巻	44巻
号	6号
出版者	MDPI
開始ページ	2443
終了ページ	2452
ISSN	1467-3037
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35735608
DOI	10.3390/cimb44060167
Web of Science KeyUT	000816477400001
関連URL	isVersionOf https://doi.org/10.3390/cimb44060167

Bilateral Blunt Ocular Trauma Caused by an Exercise Resistance Band during Muscle Building Exercise for Swimming

JaLCDOI	10.18926/AMO/63747
フルテキストURL	76_3_349.pdf
著者	Ariyasu, Kanazu\| Kimura, Shuhei\| Matoba, Ryo\| Morizane Hosokawa, Mio\| Shiode, Yusuke\| Doi, Shinichiro\| Kanzaki, Yuki\| Morizane, Yuki\|
抄録	An 18-year-old male high school student presented to our clinic with bilateral blunt ocular trauma caused by an exercise resistance band (ERB) during a muscle-building exercise. Best-corrected decimal visual acuities (BCVAs) for right and left eyes were light perception and 0.15, respectively. The right eye was operated 10 days after injury for persistent vitreous hemorrhage, and the left eye 5 months later because of macular hole onset. After 36 months, the right eye showed extensive retinal degeneration (BCVA 0.04), and the left eye macular hole closure (BCVA 1.2). ERBs should be used cautiously as they can cause serious ocular trauma.
キーワード	exercise resistance band traumatic macular hole traumatic retinal degeneration bilateral blunt ocular trauma
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	349
終了ページ	354
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790368
Web of Science KeyUT	000823568300016

Successful Treatment of Atypical Femoral Fracture with Bowed Femur Using Contralateral Intramedullary Nail Combined with Early Daily Teriparatide

JaLCDOI	10.18926/AMO/63744
フルテキストURL	76_3_333.pdf
著者	Akagawa, Manabu\| Miyakoshi, Naohisa\| Tsuchie, Hiroyuki\| Kasukawa, Yuji\| Kawaragi, Takashi\| Nagahata, Itsuki\| Suzuki, Masazumi\| Yoshikawa, Takayuki\| Abe, Toshiki\| Shimada, Yoichi\|
抄録	We report a case of atypical femoral fracture achieving early fracture union with combination therapy comprising contralateral nail and immediate teriparatide injection. Fracture union of atypical fractures is often delayed due to bowing deformity and bone metabolic disorders. Combination treatment that takes both problems into consideration represents a useful treatment option for atypical femoral fracture.
キーワード	atypical femoral fracture bowing deformity intramedullary nail teriparatide cephalomedullary screw
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	333
終了ページ	338
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790365
Web of Science KeyUT	000823568300013

Hip Fractures after Intramedullary Nailing Fixation for Atypical Femoral Fractures: Three Cases

JaLCDOI	10.18926/AMO/63741
フルテキストURL	76_3_317.pdf
著者	Yamamoto, Norio\| Inoue, Tomoo\| Yusuke, Mochizuki\| Tomoyuki, Noda\| Keisuke, Kawasaki\| Toshifumi, Ozaki\|
抄録	Secondary hip fractures (SHFs) rarely occur after intramedullary nailing (IMN) fixation without femoral neck fixation for atypical femoral fractures (AFFs). We report three cases of older Japanese women who sustained SHFs presumably caused by osteoporosis and peri-implant stress concentration around the femoral neck after undergoing IMN without femoral neck fixation for AFF. All cases were fixed with malalignment. In AFF patients, postoperative changes due to postoperative femoral bone malalignment may affect the peri-implant mechanical environment around the femoral neck, which can result in insufficiency fractures. At the first AFF surgery, we recommend femoral neck fixation after adequate reduction is achieved.
キーワード	atypical femoral fracture bone malalignment intramedullary nail femoral neck fracture hip fracture
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	317
終了ページ	321
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790362
Web of Science KeyUT	000823568300010

Factors Associated with Surgical Field Bacterial Detection during Total Hip Arthroplasty

JaLCDOI	10.18926/AMO/63738
フルテキストURL	76_3_291.pdf
著者	Miyake, Yoshiaki\| Mitani, Shigeru\| Namba, Yoshifumi\| Umehara, Norifumi\| Kawamoto, Toyohiro\| Furuichi, Shuro\|
抄録	Total hip arthroplasty (THA) provides relief from hip pain and improves hip function. However, periprosthetic joint infection (PJI) remains an area of concern. We examined the detection rate of bacteria from surgical fields in wound closure, along with the relationship between bacterial detection rate and type of antiseptic, surgery time, and surgeon experience for 500 patients who underwent THA at our department. The mean age at surgery was 64.3 (± 27.3) years. The bacterial detection rate was 4.6%. None of the cases revealed PJI. No significant association between the detection rate and type of antiseptic used or surgery time was observed. However, for patients treated by surgeons with < 10 years of orthopedic experience, a detection rate of 7.3% was found, while a rate of 1.3% was observed for those treated by surgeons with ≥ 10 years of orthopedic experience. This finding indicated that orthopedic experience of less than 10 years was significantly associated with an increased bacterial detection rate (chi-square test, p=0.002). The detection rate was associated with surgeon experience but not with antiseptic type or surgery time. It is possible that intraoperative handling may increase the number of bacteria in surgical fields in wound closure.
キーワード	total hip arthroplasty bacterial contamination periprosthetic joint infection
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	291
終了ページ	295
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790359
Web of Science KeyUT	000823568300008

SMC Development Guidelines for Axial Flux PM Machines Employing Coreless Rotor Structure for Enhancing Efficiency Based on Experimental Results

フルテキストURL	fulltext20220630-6.pdf
著者	Tsunata, Ren\| Takemoto, Masatsugu\| Ogasawara, Satoshi\| Saito, Tatsuya\| Ueno, Tomoyuki\|
備考	© 2022 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. \|
発行日	2022-5
出版物タイトル	IEEE Transactions on Industry Applications
巻	58巻
号	3号
出版者	Institute of Electrical and Electronics Engineers (IEEE)
開始ページ	3470
終了ページ	3485
ISSN	0093-9994
NCID	AA00667900
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	Copyright © 2022, IEEE
論文のバージョン	author
DOI	10.1109/tia.2022.3154336
Web of Science KeyUT	000799279300052
関連URL	isVersionOf https://doi.org/10.1109/tia.2022.3154336

Impact of Breast Cancer Awareness Month on Public Interest in the United States between 2012 and 2021: A Google Trends Analysis

フルテキストURL	fulltext.pdf
著者	Nishimura, Yoshito\| Acoba, Jared D.\|
キーワード	Breast Cancer Awareness Month breast cancer Google Trends trend analysis
発行日	2022-05-21
出版物タイトル	Cancers
巻	14巻
号	10号
出版者	MDPI
開始ページ	2534
ISSN	2072-6694
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35626141
DOI	10.3390/cancers14102534
Web of Science KeyUT	000803386600001
関連URL	isVersionOf https://doi.org/10.3390/cancers14102534

Long-Term Results of Posterior Vertebral Column Resection for Severe Thoracolumbar Kyphosis with Achondroplastic Patients: A Case Series

フルテキストURL	fulltext.pdf
著者	Tanaka, Masato\| Chan, Tsang-Tung\| Misawa, Haruo\| Uotani, Koji\| Arataki, Shinaya\| Takigawa, Tomoyuki\| Mazaki, Tetsuro\| Sugimoto, Yoshihisa\|
キーワード	achondroplasia vertebral column osteotomy long-term follow-up navigation
発行日	2022-04-27
出版物タイトル	Medicina
巻	58巻
号	5号
出版者	MDPI
開始ページ	605
ISSN	1010-660X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35630021
DOI	10.3390/medicina58050605
Web of Science KeyUT	000802445600001
関連URL	isVersionOf https://doi.org/10.3390/medicina58050605

Can Blood Ammonia Level, Prehospital Time, and Return of Spontaneous Circulation Predict Neurological Outcomes of Out-of-Hospital Cardiac Arrest Patients? A Nationwide, Retrospective Cohort Study

フルテキストURL	fulltext.pdf
著者	Nojima, Tsuyoshi\| Naito, Hiromichi\| Obara, Takafumi\| Ageta, Kohei\| Yakushiji, Hiromasa\| Yumoto, Tetsuya\| Fujisaki, Noritomo\| Nakao, Atsunori\|
キーワード	ammonia cardiopulmonary resuscitation neurological outcome biomarkers
発行日	2022-05-04
出版物タイトル	Journal Of Clinical Medicine
巻	11巻
号	9号
出版者	MDPI
開始ページ	2566
ISSN	2077-0383
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	35566692
DOI	10.3390/jcm11092566
Web of Science KeyUT	000794498600001
関連URL	isVersionOf https://doi.org/10.3390/jcm11092566

Minimizing the monetary penalty and energy cost of server migration service

フルテキストURL	fulltext20220428-3.pdf
著者	Fukushima, Yukinobu\| Suda, Tatsuya\| Murase, Tutomu\| Tarutani, Yuya\| Yokohira, Tokumi\|
キーワード	IaaS SMS (server migration service) server locations energy cost monetary penaltymixed-integer programming
備考	This is the peer reviewed version of the following article: [Fukushima, Y, Suda, T, Murase, T, Tarutani, Y, Yokohira, T. Minimizing the monetary penalty and energy cost of server migration service. Trans Emerging Tel Tech. 2022;e4511. doi:10.1002/ett.4511], which has been published in final form at [https://doi.org/10.1002/ett.4511]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\|
発行日	2022-04-10
出版物タイトル	Transactions on Emerging Telecommunications Technologies
巻	33巻
号	9号
出版者	Wiley
開始ページ	e4511
ISSN	2161-3915
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 John Wiley & Sons, Ltd.
論文のバージョン	author
DOI	10.1002/ett.4511
Web of Science KeyUT	000779978300001
関連URL	isVersionOf https://doi.org/10.1002/ett.4511

A Pediatric Case of Cauda Equina Dermoid Cyst Resected by Minimally Invasive Unilateral Hemilaminectomy

JaLCDOI	10.18926/AMO/63426
フルテキストURL	76_2_217.pdf
著者	Yabuno, Satoru\| Sasada, Susumu\| Umakoshi, Michiari\| Nagase, Takayuki\| Sugahara, Chiaki\| Kawauchi, Satoshi\| Yasuhara, Takao\| Date, Isao\|
抄録	A 3-year-old boy had difficulty sitting up and walking for several months. Magnetic resonance imaging (MRI) revealed an intradural tumor at the L3-4 level. The tumor was successfully resected by unilateral hemilaminectomy and diagnosed as dermoid cyst. The patient had an uneventful postoperative course without pain, and MRI found no recurrence after surgery. A small bone defect remained that might be favorably reconstructed with autologous and artificial bone. Hemilaminectomy allowed us to resect the cauda equina dermoid cyst with minimal invasiveness. Pediatric patients require follow-up as they are more likely to experience spinal deformity or instability after surgery.
キーワード	cauda equina tumor child dermoid cyst hemilaminectomy spinal tumor
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	217
終了ページ	223
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503450
Web of Science KeyUT	000792291900004

Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

フルテキストURL	fulltext.pdf
著者	Takatsu, Fumiaki\| Yamamoto, Hiromasa\| Tomioka, Yasuaki\| Tanaka, Shin\| Shien, Kazuhiko\| Suzawa, Ken\| Miyoshi, Kentaroh\| Otani, Shinji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Takahashi, Katsuhito\| Toyooka, Shinichi\|
キーワード	Retroperitoneal sarcoma Lung metastasis Metastasectomy
発行日	2022-04-08
出版物タイトル	World Journal Of Surgical Oncology
巻	20巻
号	1号
出版者	BMC
開始ページ	114
ISSN	1477-7819
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022.
論文のバージョン	publisher
PubMed ID	35395855
DOI	10.1186/s12957-022-02552-y
Web of Science KeyUT	000780301100001
関連URL	isVersionOf https://doi.org/10.1186/s12957-022-02552-y

MRI multiparametric scoring system for pial blood supply of intracranial meningiomas

フルテキストURL	fulltext.pdf
著者	Higaki, Fumiyo\| Inoue, Satoshi\| Oda, Wakako\| Matsusue, Eiji\| Hiraki, Takao\|
キーワード	pial blood supply peritumoral brain edema arachnoid plane peritumoral flow void magnetic resonance imaging
発行日	2022-04-08
出版物タイトル	Acta Radiologica Open
巻	11巻
号	4号
出版者	Sage Publications Ltd.
ISSN	2058-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	35425642
DOI	10.1177/20584601221091208
Web of Science KeyUT	000780184200001
関連URL	isVersionOf https://doi.org/10.1177/20584601221091208

The Combination of D-dimer and Glasgow Prognostic Score Can Be Useful in Predicting VTE in Patients with Stage IIIC and IVA Ovarian Cancer

JaLCDOI	10.18926/AMO/63406
フルテキストURL	76_2_129.pdf
著者	Kubo, Kotaro\| Nakamura, Keiichiro\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Ida, Naoyuki\| Haruma, Tomoko\| Ogawa, Chikako\| Masuyama, Hisashi\|
抄録	Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
キーワード	D-dimer gynecologic cancer venous thromboembolism
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	129
終了ページ	135
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503440
Web of Science KeyUT	000792374900004

Pathological Complete Response Patients after Neoadjuvant Chemotherapy in Breast Cancer

JaLCDOI	10.18926/AMO/63403
フルテキストURL	76_2_105.pdf
著者	Takaoka, Megumi\| Ohsumi, Shozo\| Ikejiri, Haruka\| Shidahara, Tomohiro\| Miyoshi, Yuichiro\| Takahashi, Mina\| Takashima, Seiki\| Aogi, Kenjiro\|
抄録	Cases of breast cancer metastasis after achieving a pathological complete response (pCR) with neoadjuvant chemotherapy (NAC) are sometimes encountered in clinical practice. We investigated the prognostic factors for pCR in patients with breast cancer after NAC. This retrospective cohort study included patients with localized breast cancer who underwent NAC followed by surgery between 2004 and 2020 and achieved a pCR. The associations between clinical factors and distant metastasis-free survival rate were statistically analyzed. We analyzed data for 127 patients. Twelve patients (9.4%) had distant metastases, and seven (5.5%) died. For estrogen receptor (ER)-positive patients, the distant metastasis-free survival rate was 94.6% for both 5 and 8 years. In contrast, ER-negative patients had a distant metastasis-free survival rate of 87.6% and 85.4% for 5 and 8 years (p=0.094), respectively. In cT0-2 patients, the distant metastasis-free survival rate was 92.4% for 5 years and 90.5% for 8 years, whereas in cT3-4 patients, the distant metastasis-free survival rate was 83.5% for 5 years and 83.5% for 8 years (p=0.301). This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis.
キーワード	breast carcinoma neoadjuvant therapy prognosis
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	105
終了ページ	111
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503437
Web of Science KeyUT	000792374900001