result 242 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morita, Hiroshi| Asada, Saori T.| Miyamoto, Masakazu| Morimoto, Yoshimasa| Kimura, Tomonari| Mizuno, Tomofumi| Nakagawa, Koji| Watanabe, Atsuyuki| Nishii, Nobuhiro| Ito, Hiroshi| |
| Keywords | Brugada syndrome exercise test premature ventricular contractions sudden death ventricular fibrillation |
| Published Date | 2020-11-23 |
| Publication Title | Journal of the American Heart Association |
| Volume | volume9 |
| Issue | issue23 |
| Publisher | Wiley |
| Start Page | e016907 |
| ISSN | 2047-9980 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 33222599 |
| DOI | 10.1161/JAHA.120.016907 |
| Web of Science KeyUT | 000596225900036 |
| Related Url | isVersionOf https://doi.org/10.1161/JAHA.120.016907 |
| JaLCDOI | 10.18926/AMO/61217 |
|---|---|
| FullText URL | 74_6_557.pdf |
| Author | Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki| |
| Abstract | A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively. |
| Keywords | 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 557 |
| End Page | 562 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361878 |
| Web of Science KeyUT | 000601203600014 |
| NAID | 120006948944 |
| JaLCDOI | 10.18926/AMO/61207 |
|---|---|
| FullText URL | 74_6_483.pdf |
| Author | Miyagi, Yasunari| Miyake, Takahito| |
| Abstract | We developed an artificial intelligence (AI) method for estimating fetal weights of Japanese fetuses based on the gestational weeks and the bi-parietal diameter, abdominal circumference, and femur length. The AI comprised of neural network architecture was trained by deep learning with a dataset that consists of ± 2 standard devia-tion (SD), ± 1.5SD, and ± 0SD categories of the approved standard values of ultrasonic measurements of the fetal weights of Japanese fetuses (Japan Society of Ultrasonics in Medicine [JSUM] data). We investigated the residuals and compared 2 other regression formulae for estimating the fetal weights of Japanese fetuses by t-test and Bland-Altman analyses, respectively. The residuals of the AI for the test dataset that was 12.5% of the JSUM data were 6.4 ± 2.6, −3.8 ± 8.6, and −0.32 ± 6.3 (g) at −2SD, +2SD, and all categories, respectively. The residu-als of another AI method created with all of the JSUM data, of which 20% were randomized validation data, were −1.5 ± 9.4, −2.5 ± 7.3, and −1.1 ± 6.7 (g) for −2SD, +2SD, and all categories, respectively. The residuals of this AI were not different from zero, whereas those of the published formulae differed from zero. Though vali-dation is required, the AI demonstrated potential for generating fetal weights accurately, especially for extreme fetal weights. |
| Keywords | deep learning artificial intelligence fetal weight neural network ultrasound biometry |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 483 |
| End Page | 493 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361868 |
| Web of Science KeyUT | 000601203600004 |
| NAID | 120006948957 |
| JaLCDOI | 10.18926/AMO/61204 |
|---|---|
| FullText URL | 74_6_461.pdf |
| Author | Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Abstract | Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted. |
| Keywords | gastric cancer young patients Helicobacter pylori |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-12 |
| Volume | volume74 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 461 |
| End Page | 466 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33361865 |
| Web of Science KeyUT | 000601203600001 |
| NAID | 120006948954 |
| FullText URL | fulltext.pdf Fig_1-4.pdf |
|---|---|
| Author | Ishihara, Yuki| Matsumoto, Kazuyuki| Kato, Hironari| Tsutsumi, Koichiro| Tomoda, Takeshi| Matsumi, Akihiro| Miyamoto, Kazuya| Yamazaki, Tatsuhiro| Saragai, Yosuke| Fujii, Yuki| Uchida, Daisuke| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Keywords | Peroral direct cholangioscopy Hepatolithiasis Altered gastrointestinal anatomy Double-balloon endoscopy |
| Note | This is an Accepted Manuscript of an article published by Springer.| |
| Published Date | 2020-11-02 |
| Publication Title | Surgical Endoscopy |
| Volume | volume35 |
| Publisher | Springer |
| Start Page | 1895 |
| End Page | 1902 |
| ISSN | 0930-2794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33140150 |
| DOI | 10.1007/s00464-020-08139-6 |
| Web of Science KeyUT | 000584333800003 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-08139-6 |
| FullText URL | fulltext.pdf Figure.tif |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | diclofenac low dose post‐ERCP pancreatitis |
| Note | This is the peer reviewed version of the following article: Takeshi Tomoda et. al. Efficacy of low dose rectal diclofenac for preventing post‐endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score‐matched analysis. Digestive Endoscopy, which has been published in final form at https://doi.org/10.1111/den.13828. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-09-02 |
| Publication Title | Digestive Endoscopy |
| Volume | volume33 |
| Publisher | Wiley |
| Start Page | 656 |
| End Page | 662 |
| ISSN | 0915-5635 |
| NCID | AA10907137 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32881078 |
| DOI | 10.1111/den.13828 |
| Web of Science KeyUT | 000577757600001 |
| Related Url | isVersionOf https://doi.org/10.1111/den.13828 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki| |
| Keywords | IPMN PJC LBC BD SurePath |
| Published Date | 2020-09-29 |
| Publication Title | BMC Gastroenterology |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 319 |
| ISSN | 1471-230X |
| NCID | AA12034934 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32993498 |
| DOI | 10.1186/s12876-020-01465-y |
| Web of Science KeyUT | 000576989100004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12876-020-01465-y |
| JaLCDOI | 10.18926/AMO/60796 |
|---|---|
| FullText URL | 74_5_371.pdf |
| Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
| Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-10 |
| Volume | volume74 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 379 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33106692 |
| Web of Science KeyUT | 000581970100001 |
| NAID | 120006892922 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun| |
| Keywords | Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology |
| Published Date | 2020-09-10 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 14928 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32913271 |
| DOI | 10.1038/s41598-020-71946-3 |
| Web of Science KeyUT | 000571915100049 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-71946-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group| |
| Keywords | Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan |
| Published Date | 2020-08-08 |
| Publication Title | Journal of Diabetes Investigation |
| Volume | volume12 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | 207 |
| End Page | 216 |
| ISSN | 2040-1116 |
| NCID | AA12488319 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors |
| File Version | publisher |
| PubMed ID | 32597548 |
| NAID | 120006880216 |
| DOI | 10.1111/jdi.13339 |
| Web of Science KeyUT | 000557091100001 |
| Related Url | isVersionOf https://doi.org/10.1111/jdi.13339 |
| JaLCDOI | 10.18926/AMO/60365 |
|---|---|
| FullText URL | 74_4_285.pdf |
| Author | Tsukahara, Kohei| Naitou, Hiromichi| Yorifuji, Takashi| Nosaka, Nobuyuki| Yamamoto, Hirotsugu| Osako, Takaaki| Nakao, Atsunori| the JaRPAC Study Group| |
| Abstract | The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted. |
| Keywords | kids critical care mortality morbidity centralization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 291 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843759 |
| Web of Science KeyUT | 000562508700003 |
| NAID | 120006880204 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Koshimune, Seijiro| Kosaka, Mitsuko| Mizuno, Nobuhiko| Yamamoto, Hiromasa| Miyamoto, Tomoyuki| Ebisui, Kohta| Toyooka, Shinichi| Ohtsuka, Aiji| |
| Keywords | OCT4 SPP1 lung adenocarcinoma tumour-initiating cell cancer stem cell cell migration |
| Published Date | 2020-06-05 |
| Publication Title | BMC Cancer |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 521 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32503462 |
| DOI | 10.1186/s12885-020-06969-0 |
| Web of Science KeyUT | 000540257600003 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-020-06969-0 |
| JaLCDOI | 10.18926/AMO/59958 |
|---|---|
| FullText URL | 74_3_245.pdf |
| Author | Yamamoto, Shumpei| Takayama, Hiroshi| Shimodate, Yuichi| Takezawa, Rio| Nishimura, Naoyuki| Doi, Akira| Mouri, Hirokazu| Matsueda, Kazuhiro| Mizuno, Motowo| Okada, Hiroyuki| |
| Abstract | Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy. |
| Keywords | vonoprazan endoscopic submucosal dissection antithrombotic drug gastric cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 245 |
| End Page | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577023 |
| Web of Science KeyUT | 000543363400008 |
| NAID | 120006862799 |
| reference | Oda I, Saito D, Tada M, Iishi H, Tanabe S, Oyama T, Doi T, Otani Y, Fujisaki J, Ajioka Y, Hamada T, Inoue H, Gotoda T and Yoshida S: A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer (2006) 9: 262-270.| Lian J, Chen S, Zhang Y and Qiu F: A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer. Gastrointest Endosc (2012) 76: 763-770.| Park YM, Cho E, Kang HY and Kim JM: The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis. Surg Endosc (2011) 25: 2666-2677.| Goto O, Fujishiro M, Oda I, Kakushima N, Yamamoto Y, Tsuji Y, Ohata K, Fujiwara T, Fujiwara J, Ishii N, Yokoi C, Miyamoto S, Itoh T, Morishita S, Gotoda T and Koike K: A multicenter survey of the management after gastric endoscopic submucosal dissection related to postoperative bleeding. Dig Dis Sci (2012) 57: 435-439.| Tsuji Y: Risk factors for bleeding after endoscopic submucosal dissection for gastric lesions. World Journal of Gastroenterology (2010) 16: 2913.| Furuhata T, Kaise M, Hoteya S, Iizuka T, Yamada A, Nomura K, Kuribayashi Y, Kikuchi D, Matsui A, Ogawa O, Yamashta S and Mitani T: Postoperative bleeding after gastric endoscopic submucosal dissection in patients receiving antithrombotic therapy. Gastric Cancer (2017) 20: 207-214.| Okada K, Yamamoto Y, Kasuga A, Omae M, Kubota M, Hirasawa T, Ishiyama A, Chino A, Tsuchida T, Fujisaki J, Nakajima A, Hoshino E and Igarashi M: Risk factors for delayed bleeding after endoscopic submucosal dissection for gastric neoplasm. Surg Endosc (2011) 25: 98-107.| Dong J, Wei K, Deng J, Zhou X, Huang X, Deng M and Lu M: Effects of antithrombotic therapy on bleeding after endoscopic submucosal dissection. Gastrointest Endosc (2017) 86: 807-816.| Kono Y, Obayashi Y, Baba Y, Sakae H, Gotoda T, Miura K, Kanzaki H, Iwamuro M, Kawano S, Kawahara Y, Tanaka T and Okada H: Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy. J Gastroenterol Hepatol (2018) 33: 453-460.| Tounou S, Morita Y and Hosono T: Continuous aspirin use does not increase post-endoscopic dissection bleeding risk for gastric neoplasms in patients on antiplatelet therapy. Endosc Int Open (2015) 3: E31-38.| Gotoda T, Hori K, Iwamuro M, Kono Y, Miura K, Kanzaki H, Kawano S, Kawahara Y and Okada H: Evaluation of the bleeding risk with various antithrombotic therapies after gastric endoscopic submucosal dissection. Endosc Int Open (2017) 5: E653-E662.| Uedo N, Takeuchi Y, Yamada T, Ishihara R, Ogiyama H, Yamamoto S, Kato M, Tatsumi K, Masuda E, Tamai C, Yamamoto S, Higashino K, Iishi H and Tatsuta M: Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. Am J Gastroenterol (2007) 102: 1610-1616.| Hamada K, Uedo N, Tonai Y, Arao M, Suzuki S, Iwatsubo T, Kato M, Shichijo S, Yamasaki Y, Matsuura N, Nakahira H, Kanesaka T, Yamamoto S, Akasaka T, Hanaoka N, Takeuchi Y, Higashino K, Ishihara R, Okada H, Iishi H, Fukui K and Shimokawa T: Efficacy of vonoprazan in prevention of bleeding from endoscopic submucosal dissection-induced gastric ulcers: a prospective randomized phase II study. J Gastroenterol (2018).| Kagawa T, Iwamuro M, Ishikawa S, Ishida M, Kuraoka S, Sasaki K, Sakakihara I, Izumikawa K, Yamamoto K, Takahashi S, Tanaka S, Matsuura M, Hasui T, Wato M and Inaba T: Vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. Aliment Pharmacol Ther (2016) 44: 583-591.| Kato M, Uedo N, Hokimoto S, Ieko M, Higuchi K, Murakami K and Fujimoto K: Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants. Dig Endosc (2018) 30: 433-440.| Fujimoto K, Fujishiro M, Kato M, Higuchi K, Iwakiri R, Sakamoto C, Uchiyama S, Kashiwagi A, Ogawa H, Murakami K, Mine T, Yoshino J, Kinoshita Y, Ichinose M, Matsui T and Japan Gastroenterological Endoscopy S: Guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment. Dig Endosc (2014) 26: 1-14.| Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y, Ashida K and Sugano K: Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut (2018) 67: 1033-1041.| |
| JaLCDOI | 10.18926/AMO/59950 |
|---|---|
| FullText URL | 74_3_199.pdf |
| Author | Fujita, Hirofumi| Bando, Tetsuya| Oyadomari, Seiichi| Ochiai, Kazuhiko| Watanabe, Masami| Kumon, Hiromi| Ohuchi, Hideyo| |
| Abstract | Dickkopf 3 (Dkk3) is a secreted protein belonging to the Dkk family and encoded by the orthologous gene of REIC. Dkk3/REIC is expressed by mouse and human adrenal glands, but the understanding of its roles in this organ is still limited. To determine the functions of Dkk3 in the mouse adrenal gland, we first identified that the mouse Dkk3 protein is N-glycosylated in the adrenal gland as well as in the brain. We performed proteome analysis on adrenal glands from Dkk3-null mice, in which exons 5 and 6 of the Dkk3 gene are deleted. Twodimensional polyacrylamide gel electrophoresis of adrenal proteins from wild-type and Dkk3-null mice revealed 5 protein spots whose intensities were altered between the 2 genotypes. Mass spectrometry analysis of these spots identified binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) chaperone. To determine whether mouse Dkk3 is involved in the unfolded protein response (UPR), we carried out a reporter assay using ER-stress responsive elements. Forced expression of Dkk3 resulted in the induction of distinct levels of reporter expression, showing the UPR initiated by the ER membrane proteins of activating transcription factor 6 (ATF6) and inositol-requring enzyme 1 (IRE1). Thus, it is possible that Dkk3 is a physiological ER stressor in the mouse adrenal gland. |
| Keywords | Dkk3 knockout mouse adrenal gland glucose-regulated protein 78 proteome endoplasmic reticulum stress |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-06 |
| Volume | volume74 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 199 |
| End Page | 208 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32577017 |
| Web of Science KeyUT | 000543363400003 |
| NAID | 120006862792 |
| FullText URL | text_correction.pdf table3_correction.pdf |
|---|---|
| Author | Tomoda, Takeshi | Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Note | Correction to: Surgical Endoscopy https://doi.org/10.1007/s00464-020-07385-y| |
| Published Date | 2020-02-06 |
| Publication Title | Surgical Endoscopy |
| Volume | volume35 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 239 |
| End Page | 240 |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32030547 |
| DOI | 10.1007/s00464-020-07399-6 |
| Web of Science KeyUT | 000515963500002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07399-6 |
| FullText URL | fulltext.pdf table.pdf |
|---|---|
| Author | Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| chida, Daisuke| atsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki| |
| Keywords | Malignant biliary obstruction Double-balloon enteroscope Endoscopic retrograde cholangiopancreatography Surgically altered anatomy |
| Note | This fulltext is aailable in Jan. 2021.| |
| Published Date | 2020-01-16 |
| Publication Title | Surgical Endoscopy |
| ISSN | 09302794 |
| NCID | AA10750363 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31950273 |
| DOI | 10.1007/s00464-020-07385-y |
| Web of Science KeyUT | 000507705600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07385-y |
| JaLCDOI | 10.18926/AMO/58266 |
|---|---|
| FullText URL | 74_2_95.pdf |
| Author | Kuba, Sayaka| Yamanouchi, Kosho| Morita, Michi| Sakimura, Chika| Inamasu, Eiko| Hatachi, Toshiko| Otsubo, Ryota| Matsumoto, Megumi| Yano, Hiroshi| Miyamoto, Junya| Sato, Shuntaro| Nakagawa, Hiroo| Kanetaka, Kengo| Takatsuki, Mitsuhisa| Nagayasu, Takeshi| Eguchi, Susumu| |
| Abstract | We assessed the usefulness of ChemoCalc, a software package for calculating drug costs, in helping patients understand these costs. We randomly assigned, in a 1 : 1 ratio, 20 women who had undergone surgery for early breast cancer to a group that discussed adjuvant treatment with their physicians using the ChemoCalc software (ChemoCalc group) or a group that discussed adjuvant treatment without ChemoCalc (Usual Explanation group). The participants completed a five-grade evaluation questionnaire after these discussions. The primary endpoint was the intergroup comparison of the questionnaire scores regarding participants’ understanding of their treatment-associated drug costs. Median age was not significantly different between the ChemoCalc group and Usual Explanation group (57 vs. 50, respectively; p=0.27). Patients in the ChemoCalc group had a significantly higher perceived level of understanding of the drug cost than those in the Usual Explanation group (5 [4-5] vs. 2.5 [1-5], respectively; p=0.002). Scores related to the patients’ perception that understanding drug costs is an important part of breast cancer treatment were also higher in the ChemoCalc group than the Usual Explanation group (5 [2-5] vs. 3 [1-5], respectively; p=0.049). ChemoCalc was found to be useful for understanding drug costs. |
| Keywords | breast cancer drug costs ChemoCalc |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-04 |
| Volume | volume74 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 101 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32341582 |
| Web of Science KeyUT | 000528278500001 |
| NAID | 120006839445 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsuge, Mitsuru| Miyamoto, Machiko| Miyawaki, Reiji| Kondo, Yoichi| Tsukahara, Hirokazu| |
| Keywords | Child Hemophagocytic lymphohistiocytosis Invasive pneumococcal disease Pneumococcal conjugate vaccine Serotype replacement |
| Published Date | 2020-01-13 |
| Publication Title | BMC Pediatrics |
| Volume | volume20 |
| Issue | issue1 |
| Publisher | BMC |
| ISSN | 1471-2431 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 31931763 |
| DOI | 10.1186/s12887-020-1915-7 |
| Web of Science KeyUT | 000514577300003 |
| Related Url | isVersionOf https://doi.org/10.1186/s12887-020-1915-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Akihiro| Tone, Atsuhito| Watanabe, Mayu| Teshigawara, Sanae| Miyamoto, Satoshi| Eguchi, Jun| Nakatsuka, Atsuko| Shikata, Kenichi| Wada, Jun| |
| Keywords | Hypoglycemia Predictive low glucose management (PLGM) Type 1 diabetes mellitus (T1DM) Sensor-augmented pump therapy (SAP) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Diabetology International. The final authenticated version is available online at: http://dx.doi.org/10.1007/s13340-019-00408-7.| |
| Published Date | 2019-09-16 |
| Publication Title | Diabetology International |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | Springer |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 2190-1678 |
| NCID | AA12503387 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32206479 |
| NAID | 40022198977 |
| DOI | 10.1007/s13340-019-00408-7 |
| Web of Science KeyUT | 000520711100004 |
| Related Url | isVersionOf https://doi.org/10.1007/s13340-019-00408-7 |
| FullText URL | jnima201810029.pdf |
|---|---|
| Author | Masuda, T.| Hiraki, T.| Kaino, H.| Kishimoto, S.| Miyamoto, Y.| Okai, K.| Okubo, S.| Ozaki, R.| Sasao, N.| Suzuki, K.| Uetake, S.| Yoshimi, A.| Yoshimura, K.| |
| Keywords | Avalanche photodiode X-ray |
| Published Date | 2019-01-01 |
| Publication Title | Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment |
| Volume | volume913 |
| Publisher | Elsevier Science |
| Start Page | 72 |
| End Page | 77 |
| ISSN | 01689002 |
| NCID | AA10529991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1016/j.nima.2018.10.029 |
| Web of Science KeyUT | 000450880700010 |
| Related Url | isVersionOf https://doi.org/10.1016/j.nima.2018.10.029 |
