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FullText URL K0006896_abstract_review.pdf K0006896_fulltext.pdf K0006896_summary.pdf
Author MORIMOTO, Yoshimasa|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6896号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023 The Authors.
FullText URL K0006893_abstract_review.pdf K0006893_fulltext.pdf
Author MIYAMOTO, Masakazu|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6893号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023, THE JAPANESE CIRCULATION SOCIETY
JaLCDOI 10.18926/AMO/65978
FullText URL 77_5_545.pdf
Author Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki|
Abstract To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
Keywords esophagogastroduodenoscopy gastric lesion amyloidosis light chain
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 545
End Page 552
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899266
Web of Science KeyUT 001094245100001
JaLCDOI 10.18926/AMO/65970
FullText URL 77_5_479.pdf
Author Murata, Akiko| Matsumoto, Naomi| Miyaji, Chikara| Takao, Soshi| Yorifuji, Takashi|
Abstract For decades, the notion has persisted in developed countries that exclusive care by the mothers is best for the development of children up to 3 years of age. To examine the veracity of this “myth of the first three years” in Japan, we examined the effects of childcare facility use for children younger than 3 years on their development using the cohorts of the Longitudinal Survey of Newborns in the 21st Century conducted in Japan. Of the 47,015 respondents to the survey, we studied the children of 5,508 mothers with university/professional education to evaluate the relationships between primary early (< 2.5 years) childcare providers during weekday daytime hours and specific development indices for the ages of 2.5, 5.5, and 8 years. At the age of 2.5 and 5.5 years, children attending childcare facilities were judged as having more advanced developmental behaviors by their parents, such as being able to compose a two-word sentence (adjusted odds ratio [aOR]: 0.22) or to express emotions (aOR: 0.81), compared with those cared for by mothers. However, at the age of 8 years, children who attended childcare facilities as infants < 2.5 years showed more aggressive behavior in interrupting people (aOR: 1.20) and causing disturbances in public (aOR: 1.26) than those cared for by mothers (after adjustment for numerous child and parental factors). Although these results are generally consistent with previous studies, issues potentially involved with problem behavior such as quality of childcare require further investigation, as does the case of children of mothers with more modest educational attainment.
Keywords “myth of the first three years” childcare child development problem behavior educational attainment
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-10
Volume volume77
Issue issue5
Publisher Okayama University Medical School
Start Page 479
End Page 490
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37899259
Web of Science KeyUT 001108661600005
FullText URL fulltext.pdf
Author Khazan, Negar| Kim, Kyu Kwang| Hansen, Jeanne N.| Singh, Niloy A.| Moore, Taylor| Snyder, Cameron W. A.| Pandita, Ravina| Strawderman, Myla| Fujihara, Michiko| Takamura, Yuta| Jian, Ye| Battaglia, Nicholas| Yano, Naohiro| Teramoto, Yuki| Arnold, Leggy A.| Hopson, Russell| Kishor, Keshav| Nayak, Sneha| Ojha, Debasmita| Sharon, Ashoke| Ashton, John M.| Wang, Jian| Milano, Michael T.| Miyamoto, Hiroshi| Linehan, David C.| Gerber, Scott A.| Kawar, Nada| Singh, Ajay P.| Tabdanov, Erdem D.| Dokholyan, Nikolay V.| Kakuta, Hiroki| Jurutka, Peter W.| Schor, Nina F.| Rowswell-Turner, Rachael B.| Singh, Rakesh K.| Moore, Richard G.|
Published Date 2022-04-11
Publication Title Journal of Medicinal Chemistry
Volume volume65
Issue issue8
Publisher American Chemical Society (ACS)
Start Page 6039
End Page 6055
ISSN 0022-2623
NCID AA00702411
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35404047
DOI 10.1021/acs.jmedchem.1c01878
Web of Science KeyUT 000797573100012
Related Url isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878
FullText URL fulltext.pdf
Author Miyamoto, Kazuya| Matsumoto, Kazuyuki| Obata, Taisuke| Sato, Ryosuke| Matsumi, Akihiro| Morimoto, Kosaku| Ogawa, Taiji| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Kato, Hironari| Otsuka, Motoyuki|
Keywords Balloon-assisted endoscopy Propofol Diazepam Sedation
Note The version of record of this article, first published in BMC Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12876-023-02936-8|
Published Date 2023-09-04
Publication Title BMC Gastroenterology
Volume volume23
Issue issue1
Publisher BMC
Start Page 296
ISSN 1471-230X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37667224
DOI 10.1186/s12876-023-02936-8
Web of Science KeyUT 001063014700002
Related Url isVersionOf https://doi.org/10.1186/s12876-023-02936-8
FullText URL fulltext.pdf
Author Miyamoto, Satoshi| Heerspink, Hiddo J. L.| de Zeeuw, Dick| Toyoda, Masao| Suzuki, Daisuke| Hatanaka, Takashi| Nakamura, Tohru| Kamei, Shinji| Murao, Satoshi| Hida, Kazuyuki| Ando, Shinichiro| Akai, Hiroaki| Takahashi, Yasushi| Koya, Daisuke| Kitada, Munehiro| Sugano, Hisashi| Nunoue, Tomokazu| Nakamura, Akihiko| Sasaki, Motofumi| Nakatou, Tatsuaki| Fujimoto, Kei| Kawanami, Daiji| Wada, Takashi| Miyatake, Nobuyuki| Yoshida, Michihiro| Shikata, Kenichi| the CANPIONE study Investigators|
Keywords canagliflozin CANPIONE study diabetic kidney disease eGFR slope SGLT2 inhibitor urinary albumin-to-creatinine ratio
Published Date 2022-05-18
Publication Title Diabetes, Obesity and Metabolism
Volume volume24
Issue issue8
Publisher Wiley
Start Page 1429
End Page 1438
ISSN 1462-8902
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Authors.
File Version publisher
PubMed ID 35491532
DOI 10.1111/dom.14731
Web of Science KeyUT 000822653700001
Related Url isVersionOf https://doi.org/10.1111/dom.14731
FullText URL fulltext.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Morimoto, Kosaku| Miyamoto, Kazuya| Saragai, Yosuke| Kawamoto, Hirofumi| Okada, Hiroyuki|
Keywords Bile duct obstruction Neoplasms Endoscopic biliary drainage Bilateral drainage Self-expandable metallic stents
Published Date 2022-07-19
Publication Title Gut and Liver
Volume volume17
Issue issue1
Publisher The Editorial Office of Gut and Liver
Start Page 170
End Page 178
ISSN 1976-2283
NCID AA12329814
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Gut and Liver.
File Version publisher
PubMed ID 35851039
DOI 10.5009/gnl220012
Web of Science KeyUT 000830704600001
Related Url isVersionOf https://doi.org/10.5009/gnl220012
JaLCDOI 10.18926/AMO/65749
FullText URL 77_4_387.pdf
Author Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori|
Abstract No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis.
Keywords radon hot spring bathing habit self-rated health cross-section study
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 387
End Page 394
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635139
Web of Science KeyUT 001163659800003
JaLCDOI 10.18926/AMO/65748
FullText URL 77_4_377.pdf
Author Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki|
Abstract Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker.
Keywords NAFLD NASH liver fibrosis chemokine FIB-4
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 377
End Page 385
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635138
Web of Science KeyUT 001163659800009
JaLCDOI 10.18926/AMO/65740
FullText URL 77_4_347.pdf
Author Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki|
Abstract The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
Keywords flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 347
End Page 357
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635134
Web of Science KeyUT 001163659800002
FullText URL fulltext.pdf
Author Tsuchiya, Keisuke| Horikoshi, Kanako| Fujita, Minami| Hirano, Motoharu| Miyamoto, Maho| Yokoo, Hidetomo| Demizu, Yosuke|
Keywords cell-penetrating peptide stapled peptide hydrophobic peptide helical structure plasmid DNA delivery
Published Date 2023-07-21
Publication Title International Journal of Molecular Sciences
Volume volume24
Issue issue14
Publisher MDPI
Start Page 11768
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37511527
DOI 10.3390/ijms241411768
Web of Science KeyUT 001038508200001
Related Url isVersionOf https://doi.org/10.3390/ijms241411768
FullText URL fulltext.pdf
Author Morimoto, Yoshimasa| Morita, Hiroshi| Ejiri, Kentaro| Mizuno, Tomofumi| Masuda, Takuro| Ueoka, Akira| Asada, Saori| Miyamoto, Masakazu| Kawada, Satoshi| Nakagawa, Koji| Nishii, Nobuhiro| Nakamura, Kazufumi| Ito, Hiroshi|
Keywords activation pattern body surface map Brugada syndrome complete right bundle-branch block
Published Date 2023-05-16
Publication Title Journal of the American Heart Association
Volume volume12
Issue issue10
Publisher Wiley
Start Page e028706
ISSN 2047-9980
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 37158059
DOI 10.1161/JAHA.122.028706
Web of Science KeyUT 001003633600014
Related Url isVersionOf https://doi.org/10.1161/JAHA.122.028706
JaLCDOI 10.18926/AMO/65503
FullText URL 77_3_331.pdf
Author Watanabe, Mototsugu| Yamamoto, Hiromasa| Miyoshi, Kentaroh| Sugimoto, Seiichiro| Toyooka, Shinichi|
Abstract Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well.
Keywords endobronchial metastasis type A thymoma bloody sputum
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 331
End Page 334
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357635
Web of Science KeyUT 001026663400001
FullText URL fulltext.pdf
Author Miki, Takashi| Nakagawa, Koji| Ichikawa, Keishi| Mizuno, Tomofumi| Nakayama, Rie| Ejiri, Kentaro| Kawada, Satoshi| Takaya, Yoichi| Miyamoto, Masakazu| Miyoshi, Toru| Akagi, Teiji| Ito, Hiroshi|
Keywords patent foramen ovale cardiac computed tomography transesophageal echocardiography catheterization channel-like appearance channel-like appearance with contrast jet flow
Published Date 2023-04-26
Publication Title Journal of Cardiovascular Development and Disease
Volume volume10
Issue issue5
Publisher MDPI
Start Page 193
ISSN 2308-3425
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37233160
DOI 10.3390/jcdd10050193
Web of Science KeyUT 000997040200001
Related Url isVersionOf https://doi.org/10.3390/jcdd10050193
FullText URL K0006862_abstract_review.pdf K0006862_fulltext.pdf
Author MIYAMOTO, Ai|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6862号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy
Grantor 岡山大学
language English
FullText URL K0006783_abstract_review.pdf K0006783_fulltext.pdf K0006783_summary.pdf
Author TSUMURA, Munechika|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6783号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 by the authors.
FullText URL K0006760_abstract_review.pdf K0006760_fulltext.pdf K0006760_other1.pdf K0006760_other2.pdf K0006760_other3.pdf K0006760_summary.pdf
Author ODA, Kaori|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6760号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 The Authors.
FullText URL fulltext20230515-03.pdf
Author Hiramoto, Ayami| Baba, Masaaki| Enomoto, Katsunari| Iwakuni, Kana| Kuma, Susumu| Takahashi, Yuiki| Tobaru, Reo| Miyamoto, Yuki|
Published Date 2023-04-13
Publication Title Physical Review A
Volume volume107
Issue issue4
Publisher American Physical Society (APS)
Start Page 043114
ISSN 2469-9926
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©2023 American Physical Society
File Version publisher
DOI 10.1103/physreva.107.043114
Web of Science KeyUT 000973450100006
Related Url isVersionOf https://doi.org/10.1103/PhysRevA.107.043114
FullText URL fulltext20230508-05.pdf table20230508-05.pdf fig20230508-05.pdf
Author Fujimori, Takumi| Hagiya, Hideharu| Iio, Koji| Yamasaki, Osamu| Miyamoto, Yuji| Hoshino, Yoshihiko| Kakehi, Ayaka| Okura, Mami| Minabe, Hiroshi| Yokoyama, Yukika| Otsuka, Fumio| Higashikage, Akihito|
Keywords Buruli ulcer Mycobacterium ulcerans Mycobacterium ulcerans subsp shinshuense 16S rRNA sequencing analysis
Note © 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2023.02.009. | This fulltext file will be available in May 2024.|
Published Date 2023-05
Publication Title Journal of Infection and Chemotherapy
Volume volume29
Issue issue5
Publisher Elsevier BV
Start Page 523
End Page 526
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 36813163
DOI 10.1016/j.jiac.2023.02.009
Web of Science KeyUT 000972082300001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2023.02.009