result 281 件
| JaLCDOI | 10.18926/AMO/60376 |
|---|---|
| FullText URL | 74_4_365.pdf |
| Author | Chuma, Masayuki| Kondo, Masateru| Zamami, Yoshito| Takechi, Kenshi| Goda, Mitsuhiro| Okada, Naoto| Shibata, Akitomo| Asada, Mizuho| Oto, Jun| Yanagawa, Hiroaki| Ishizawa, Keisuke| |
| Abstract | Cystatin C-guided vancomycin (VCM) dosing is useful in critically ill patients. Its usefulness in septic patients with bacterial meningitis remains unknown, as there are no published reports. In this study, we sought to clarify its benefit. Cystatin C was used to guide VCM dosing in a septic bacterial meningitis patient with normal kidney function, according to therapeutic drug monitoring (TDM). Using cystatin C, the Bayesian method-based TDM made optimal VCM dosing possible, and decreased the predicted error (4.85 mg/L) compared to serum creatinine (16.83 mg/L). We concluded TDM of VCM using cystatin C can be considered in sepsis patients with bacterial meningitis with normal kidney function. |
| Keywords | vancomycin, therapeutic drug monitoring cystatin C bacterial meningitis sepsis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 365 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843769 |
| Web of Science KeyUT | 000562508700013 |
| NAID | 120006880215 |
| FullText URL | MCP_fulltext.pdf |
|---|---|
| Author | Watanabe, Takaichi| Karita, Kengo| Tawara, Koki| Soga, Takuya| Ono, Tsutomu| |
| Keywords | heterogeneous polymerization internal circulation microreactors microspheres |
| Note | This is the peer reviewed version of the following article: Takaichi Watanabe, et. al. Rapid synthesis of poly(methyl methacrylate) particles with high molecular weight by soap-free emulsion polymerization using water-in-oil slug flow. Macromol. Chem. Phys.,220, 1900021 (2019) , which has been published in final form at https://doi.org/10.1002/macp.201900021. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2019-04-03 |
| Publication Title | Macromolecular Chemistry and Physics |
| Volume | volume220 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | 1900021 |
| ISSN | 1022-1352 |
| NCID | AA10984295 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1002/macp.201900021 |
| Web of Science KeyUT | 000470167700011 |
| Related Url | isVersionOf https://doi.org/10.1002/macp.201900021 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Murai, Masahito| Yamamoto, Masaki| Takai, Kazuhiko| |
| Keywords | alkenylation homogeneous catalysis reaction mechanisms regioselectivity rhenium |
| Note | This is the peer reviewed version of the following article: [Masahito Murai et. al. Mechanistic Insights into Rhenium‐Catalyzed Regioselective C‐Alkenylation of Phenols with Internal Alkynes. Chemistry - A European Journal 25(66) 15189-15197 (2019), which has been published in final form at https://doi.org/10.1002/chem.201903910. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2019-09-18 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume25 |
| Issue | issue66 |
| Publisher | Wiley |
| Start Page | 15189 |
| End Page | 15197 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31532028 |
| DOI | 10.1002/chem.201903910 |
| Web of Science KeyUT | 000493158400001 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201903910 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Araki, Yuya| Miyoshi, Natsumi| Morimoto, Kazuki| Kudoh, Takayuki| Mizoguchi, Haruki| Sakakura, Akira| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form inJournal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.9b02811. | |
| Published Date | 2019-12-18 |
| Publication Title | Journal of Organic Chemistry |
| Volume | volume85 |
| Issue | issue2 |
| Publisher | American Chemical Society |
| Start Page | 798 |
| End Page | 805 |
| ISSN | 0022-3263 |
| NCID | AA00704100 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31850753 |
| DOI | 10.1021/acs.joc.9b02811 |
| Web of Science KeyUT | 000508468900045 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.joc.9b02811 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| FullText URL | JOC84_23_15373.pdf |
|---|---|
| Author | Iwasaki, Masayuki| Nonaka, Kosei| Zou, Song| Sawanaka, Yuta| Shinozaki, Takaaki| Fujii, Tomoya| Nakajima, Kiyohiko| Nishihara, Yasushi| |
| Published Date | 2019-11-04 |
| Publication Title | Journal of Organic Chemistry |
| Volume | volume84 |
| Issue | issue23 |
| Publisher | American Chemical Society |
| Start Page | 15373 |
| End Page | 15379 |
| ISSN | 0022-3263 |
| NCID | AA00704100 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31696696 |
| DOI | 10.1021/acs.joc.9b02392 |
| Web of Science KeyUT | 000502170600035 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.joc.9b02392 |
| FullText URL | J_MedChem_62_19_8809.pdf si_001.pdf si_002.csv |
|---|---|
| Author | Yamada, Shoya| Kawasaki, Mayu| Fujihara, Michiko| Watanabe, Masaki| Takamura, Yuta| Takioku, Maho| Nishioka, Hiromi| Takeuchi, Yasuo| Makishima, Makoto| Motoyama, Tomoharu| Ito, Sohei| Tokiwa, Hiroaki| Nakano, Shogo| Kakuta, Hiroki| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jmedchem.9b00995.| |
| Published Date | 2019-09-04 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume62 |
| Issue | issue19 |
| Publisher | American Chemical Society |
| Start Page | 8809 |
| End Page | 8818 |
| ISSN | 00222623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 American Chemical Society |
| File Version | author |
| PubMed ID | 31483660 |
| DOI | 10.1021/acs.jmedchem.9b00995 |
| Web of Science KeyUT | 000490355000010 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.9b00995 |
| FullText URL | J_ChemPhys_144_22_224104.pdf |
|---|---|
| Author | Sumi, Tomonari| Maruyama, Yutaka| Mitsutake, Ayori| Koga, Kenichiro| |
| Published Date | 2016-06-10 |
| Publication Title | Journal of Chemical Physics |
| Volume | volume144 |
| Issue | issue22 |
| Publisher | American Institute of Physics |
| Start Page | 224104 |
| ISSN | 00219606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27305993 |
| DOI | 10.1063/1.4953191 |
| Web of Science KeyUT | 000378926100007 |
| Related Url | isVersionOf https://doi.org/10.1063/1.4953191 |
| FullText URL | PhysChemChemPhys_16_46_25492.pdf |
|---|---|
| Author | Sumi, Tomonari| Imamura, Hiroshi| Morita, Takeshi| Isogai, Yasuhiro| Nishikawa, Keiko| |
| Published Date | 2014-10-17 |
| Publication Title | Physical Chemistry Chemical Physics |
| Volume | volume16 |
| Issue | issue46 |
| Publisher | Royal Society of Chemistry |
| Start Page | 25492 |
| End Page | 25497 |
| ISSN | 14639076 |
| NCID | AA11301773 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 25343423 |
| DOI | 10.1039/c4cp03606a |
| Web of Science KeyUT | 000344989500036 |
| Related Url | isVersionOf https://doi.org/10.1039/c4cp03606a |
| FullText URL | J_ComputChem_36_26_2015.pdf SI_J_Comput_Chem_36_18_135.pdf |
|---|---|
| Author | Sumi, Tomonari| Mitsutake, Ayori| Maruyama, Yutaka| |
| Published Date | 2015-07-31 |
| Publication Title | Journal of computational chemistry |
| Volume | volume36 |
| Issue | issue26 |
| Publisher | Wiley |
| Start Page | 2009 |
| End Page | 2011 |
| ISSN | 01928651 |
| NCID | AA00257341 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 26339760 |
| DOI | 10.1002/jcc.24035 |
| Web of Science KeyUT | 000360807700008 |
| Related Url | isVersionOf https://doi.org/10.1002/jcc.24035 |
| JaLCDOI | 10.18926/AMO/57367 |
|---|---|
| FullText URL | 73_5_383.pdf |
| Author | Fu, Li| Nishibori, Masahiro| |
| Abstract | High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis. |
| Keywords | HMGB1 epileptogenesis inflammation blood-brain barrier |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 383 |
| End Page | 386 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649363 |
| Web of Science KeyUT | 000491886600002 |
| JaLCDOI | 10.18926/AMO/57366 |
|---|---|
| FullText URL | 73_5_379.pdf |
| Author | Wake, Hidenori| |
| Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
| Keywords | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 379 |
| End Page | 382 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649362 |
| Web of Science KeyUT | 000491886600001 |
| JaLCDOI | 10.18926/AMO/56933 |
|---|---|
| FullText URL | 73_4_315.pdf |
| Author | Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya| |
| Abstract | The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains. |
| Keywords | periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439954 |
| JaLCDOI | 10.18926/AMO/56930 |
|---|---|
| FullText URL | 73_4_285.pdf |
| Author | Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion. |
| Keywords | glioma cytoskeletons invasion microtubules |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 297 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439951 |
| JaLCDOI | 10.18926/AMO/56869 |
|---|---|
| FullText URL | 73_3_255.pdf |
| Author | Seki, Daisuke| Takeshita, Nobuo| Seiryu, Masahiro| Deguchi, Toru| Takano-Yamamoto, Teruko| |
| Abstract | Orthodontists need to understand the orthodontic risks associated with systemic disorders. Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant disorder with genetic and morphological variability. The risks of orthodontic treatment in ARS patients have been unclear. Here we describe the correction of an anterior open bite in a 15-year-old Japanese female ARS patient by molar intrusion using sectional archwires with miniscrew implants. An undesirable development of external apical root resorption (EARR) was observed in all intrusive force-applied posterior teeth during the patient’s orthodontic treatment, suggesting that ARS patients have a higher risk of EARR than the general population. |
| Keywords | Axenfeld-Rieger syndrome external apical root resorption miniscrew implant anterior open bite |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 262 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235974 |
| JaLCDOI | 10.18926/AMO/56863 |
|---|---|
| FullText URL | 73_3_213.pdf |
| Author | Nishina, Saori| Matsuura, Koji| Naruse, Keiji| |
| Abstract | We investigated the relationship between human sperm rheotaxis and motile sperm trajectories by using poly-(dimethylsiloxane) (PDMS)-based cylindrical microfluidic channels with inner diameters of 100 μm, 50 μm, and 70 μm, which corresponded to the inner diameter of the human isthmus, the length of a sperm and a diameter intermediate between the two, respectively. We counted the number of rheotaxic sperm and sperm with spiral motion. We also analyzed motile sperm trajectories. As the cylindrical channel diameter was decreased, the percentage of sperm cells exhibiting rheotaxis, the percentage of sperm cells exhibiting spiral motion, the frequency-to-diameter ratio of the sperm cells’ spiral trajectories, and the surface area of the microfluidic channel increased, while the flagellar motion at the channel wall decreased. The percentage of sperm exhibiting a spiral trajectory and the frequency-to-diameter ratio of the sperm cells’ spiral trajectories were thus affected by the channel diameter. Our findings suggest that the oviduct structure affects the swimming properties of sperm cells, guiding them from the uterus to the ampulla for egg fertilization. These results could contribute to the development of motile sperm-sorting microfluidic devices for assisted reproductive technologies. |
| Keywords | sperm motility trajectory microfluidic channel rheotaxis oviduct structure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-06 |
| Volume | volume73 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 221 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31235968 |
| JaLCDOI | 10.18926/AMO/56649 |
|---|---|
| FullText URL | 73_2_135.pdf |
| Author | Maeba, Takahiro| Yonezawa, Tomoko| Ono, Mitsuaki| Tomono, Yasuko| Heljasvaara, Ritva| Pihlajaniemi, Taina| Inagawa, Kiichi| Oohashi, Toshitaka| |
| Abstract | The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. The ultrastructure of epidermal BM was discontinuous at day 3, whereas on day 6 a continuous BM was observed in the region proximal to the wound edge. Immunohistochemistry demonstrated that collagen XVIII was deposited in the BM zone beneath newly forming epidermis in day 3 and 6 wounds. Laminin-332, known to be the earliest BM component appearing in wounds, was colocalized with collagen XVIII in the epidermal BM zone at days 3 and 6. The deposition of α1(IV) collagen and nidogen-1 in the epidermal BM zone occurred later than that of collagen XVIII. We also observed the short isoform of collagen XVIII in the epidermal BM zone at day 3 post-wounding. Collectively, our results suggested that collagen XVIII plays a role in the formation of the dermal-epidermal junction during re-epithelialization, and that it is the short isoform that is involved in the early phase of re-epithelialization. |
| Keywords | collagen XVIII basement membrane wound healing re-epithelialization skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 146 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015748 |
| JaLCDOI | 10.18926/AMO/56452 |
|---|---|
| FullText URL | 73_1_1.pdf |
| Author | Morizane, Shin| |
| Abstract | Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. |
| Keywords | atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820048 |
| FullText URL | Chemistry_22_6_1984.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Fujiwara, Takayuki| Kawakubo, Yohei| Kadota, Isao| Uemura, Daisuke| |
| Keywords | macrocycles natural products polyols stereodivergent synthesis structure elucidation |
| Note | This is an article published by WILEY‐VCH| We acknowledge JGC-S Scholarship Foundation, The Naito Foundation, The Sumitomo Foundation, and The Uehara Memorial Foundation for their financial supports. This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS).| |
| Published Date | 2016-02 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume22 |
| Issue | issue6 |
| Publisher | WILEY‐VCH |
| Start Page | 1984 |
| End Page | 1996 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26742818 |
| DOI | 10.1002/chem.201503881 |
| Web of Science KeyUT | 000368925200016 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201503881 |
| FullText URL | Chemistry_22_6_1979.pdf |
|---|---|
| Author | Takamura, Hiroyoshi| Fujiwara, Takayuki| Kawakubo, Yohei| Kadota, Isao| Uemura, Daisuke| |
| Keywords | macrocycles natural products polyols stereoselective synthesis structure elucidation |
| Note | This is an article published by Wiley-VCH| We appreciate JGC-S Scholarship Foundation, The Naito Foundation, The Sumitomo Foundation, and The Uehara Memorial Foundation for their financial supports. This research was supported by a Grant-in Aid for Scientific Research (No. 24710250) from the Japan Society for the Promotion of Science (JSPS)| |
| Published Date | 2016-02 |
| Publication Title | Chemistry - A European Journal |
| Volume | volume22 |
| Issue | issue6 |
| Publisher | Wiley-VCH |
| Start Page | 1979 |
| End Page | 1983 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 26661715 |
| DOI | 10.1002/chem.201503880 |
| Web of Science KeyUT | 000368925200015 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.201503880 |
