result 273 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sudoh, Taku| Ikeda, Shuhei| Shigenobu, Keisuke| Tsuzuki, Seiji| Dokko, Kaoru| Watanabe, Masayoshi| Shinoda, Wataru| Ueno, Kazuhide| |
| Published Date | 2023-06-20 |
| Publication Title | The Journal of Physical Chemistry C |
| Volume | volume127 |
| Issue | issue25 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 12295 |
| End Page | 12303 |
| ISSN | 1932-7447 |
| NCID | AA1217589X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| DOI | 10.1021/acs.jpcc.3c02112 |
| Web of Science KeyUT | 001016710400001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jpcc.3c02112 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyamoto, Yuki| Hiramoto, Ayami| Iwakuni, Kana| Kuma, Susumu| Enomoto, Katsunari| Nakayama, Naofumi| Baba, Masaaki| |
| Note | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Yuki Miyamoto, Ayami Hiramoto, Kana Iwakuni, Susumu Kuma, Katsunari Enomoto, Naofumi Nakayama, Masaaki Baba; Analysis on high-resolution spectrum of the S1–S0 transition of free-base phthalocyanine. J. Chem. Phys. 14 April 2024; 160 (14): 144304. https://doi.org/10.1063/5.0191810 and may be found at https://doi.org/10.1063/5.0191810.| This fulltext file will be available in Apr. 2025.| |
| Published Date | 2024-04-09 |
| Publication Title | The Journal of Chemical Physics |
| Volume | volume160 |
| Issue | issue14 |
| Publisher | AIP Publishing |
| Start Page | 144304 |
| ISSN | 0021-9606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Author(s). |
| File Version | publisher |
| PubMed ID | 38591681 |
| DOI | 10.1063/5.0191810 |
| Web of Science KeyUT | 001198859200019 |
| Related Url | isVersionOf https://doi.org/10.1063/5.0191810 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naito, Hidefumi| Sumi, Tomonari| Koga, Kenichiro| |
| Published Date | 2024 |
| Publication Title | Faraday Discussions |
| Volume | volume249 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 440 |
| End Page | 452 |
| ISSN | 1359-6640 |
| NCID | AA10836538 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2024 |
| File Version | publisher |
| PubMed ID | 37791511 |
| DOI | 10.1039/d3fd00104k |
| Web of Science KeyUT | 001077081700001 |
| Related Url | isVersionOf https://doi.org/10.1039/d3fd00104k |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Masakazu| Yagasaki, Takuma| Tanaka, Hideki| |
| Note | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Masakazu Matsumoto, Takuma Yagasaki, Hideki Tanaka; GenIce-core: Efficient algorithm for generation of hydrogen-disordered ice structures. J. Chem. Phys. 7 March 2024; 160 (9): 094101. https://doi.org/10.1063/5.0198056 and may be found at https://doi.org/10.1063/5.0198056.| This fulltext file will be available in Mar. 2025.| |
| Published Date | 2024-03-01 |
| Publication Title | The Journal of Chemical Physics |
| Volume | volume160 |
| Issue | issue9 |
| Publisher | AIP Publishing |
| Start Page | 094101 |
| ISSN | 0021-9606 |
| NCID | AA00694991 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Author(s). |
| File Version | publisher |
| PubMed ID | 38426513 |
| DOI | 10.1063/5.0198056 |
| Web of Science KeyUT | 001178860800001 |
| Related Url | isVersionOf https://doi.org/10.1063/5.0198056 |
| JaLCDOI | 10.18926/AMO/66664 |
|---|---|
| FullText URL | 78_1_001.pdf |
| Author | Sun, Cuiming| Matsukawa, Akihiro| |
| Abstract | Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis. |
| Keywords | ERK-MAPK SPRED2 fibrosis macrophages |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419308 |
| Web of Science KeyUT | 001203658200006 |
| FullText URL | fulltext20240205-01.pdf |
|---|---|
| Author | Tokushige, Keisuke| Abe, Takumi| |
| Keywords | C3-N1' bisindoles bromination umpolung rivularin A alkaloid |
| Note | This is the peer reviewed version of the following article: [K. Tokushige, T. Abe, Chem. Eur. J. 2024, 30, e202302963. https://doi.org/10.1002/chem.202302963], which has been published in final form at [https://doi.org/10.1002/chem.202302963]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-01-08 |
| Publication Title | Chemistry – A European Journal |
| Volume | volume30 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | e202302963 |
| ISSN | 0947-6539 |
| NCID | AA11076269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Wiley-VCH GmbH |
| File Version | author |
| PubMed ID | 37988219 |
| DOI | 10.1002/chem.202302963 |
| Web of Science KeyUT | 001142083100001 |
| Related Url | isVersionOf https://doi.org/10.1002/chem.202302963 |
| FullText URL | fulltext20240130-01.pdf |
|---|---|
| Author | Miyazaki, Yusuke| Shinoda, Wataru| |
| Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical Information and Modeling, copyright © 2023 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jcim.3c01611.| This fulltext file will be available in Dec. 2024.| |
| Published Date | 2023-12-29 |
| Publication Title | Journal of Chemical Information and Modeling |
| Volume | volume64 |
| Issue | issue2 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 532 |
| End Page | 542 |
| ISSN | 1549-9596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 American Chemical Society |
| File Version | author |
| PubMed ID | 38156656 |
| DOI | 10.1021/acs.jcim.3c01611 |
| Web of Science KeyUT | 001146739900001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jcim.3c01611 |
| FullText URL | fulltext20240109-03.pdf |
|---|---|
| Author | Yamada, Koji| Tsubogo, Tetsu| Kanazawa, Hikaru| Ishizuka, Sayaka| Ohyama, Koutaro| Kaida, Masaki| Abe, Takumi| |
| Keywords | hemiaminals indoles ring-switch thiazolo[4.5-b]indoles thioamides |
| Note | This is the peer reviewed version of the following article: [K. Yamada, T. Tsubogo, H. Kanazawa, S. Ishizuka, K. Ohyama, M. Kaida, T. Abe, Eur. J. Org. Chem. 2024, 27, e202301130. https://doi.org/10.1002/ejoc.202301130], which has been published in final form at [https://doi.org/10.1002/ejoc.202301130]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Dec. 2024.| |
| Published Date | 2023-12-19 |
| Publication Title | European Journal of Organic Chemistry |
| Volume | volume27 |
| Issue | issue4 |
| Publisher | Wiley |
| Start Page | e202301130 |
| ISSN | 1434-193X |
| NCID | AA1118165X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Wiley-VCH GmbH |
| File Version | author |
| DOI | 10.1002/ejoc.202301130 |
| Web of Science KeyUT | 001127624500001 |
| Related Url | isVersionOf https://doi.org/10.1002/ejoc.202301130 |
| FullText URL | fulltext20231128-01.pdf |
|---|---|
| Author | Mitsudo, Koichi| Okumura, Yasuyuki| Sato, Eisuke| Suga, Seiji| |
| Keywords | electrocatalysis electrochemistry electrosynthesis indirect electrolysis mediator |
| Note | This is the peer reviewed version of the following article: [K. Mitsudo, Y. Okumura, E. Sato, S. Suga, Eur. J. Org. Chem. 2023, 26, e202300835. https://doi.org/10.1002/ejoc.202300835], which has been published in final form at [https://doi.org/10.1002/ejoc.202300835]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Nov. 2024.| |
| Published Date | 2023-11-13 |
| Publication Title | European Journal of Organic Chemistry |
| Volume | volume26 |
| Issue | issue47 |
| Publisher | Wiley |
| Start Page | e202300835 |
| ISSN | 1434-193X |
| NCID | AA1118165X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Wiley-VCH GmbH |
| File Version | author |
| DOI | 10.1002/ejoc.202300835 |
| Web of Science KeyUT | 001100702300001 |
| Related Url | isVersionOf https://doi.org/10.1002/ejoc.202300835 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Khazan, Negar| Kim, Kyu Kwang| Hansen, Jeanne N.| Singh, Niloy A.| Moore, Taylor| Snyder, Cameron W. A.| Pandita, Ravina| Strawderman, Myla| Fujihara, Michiko| Takamura, Yuta| Jian, Ye| Battaglia, Nicholas| Yano, Naohiro| Teramoto, Yuki| Arnold, Leggy A.| Hopson, Russell| Kishor, Keshav| Nayak, Sneha| Ojha, Debasmita| Sharon, Ashoke| Ashton, John M.| Wang, Jian| Milano, Michael T.| Miyamoto, Hiroshi| Linehan, David C.| Gerber, Scott A.| Kawar, Nada| Singh, Ajay P.| Tabdanov, Erdem D.| Dokholyan, Nikolay V.| Kakuta, Hiroki| Jurutka, Peter W.| Schor, Nina F.| Rowswell-Turner, Rachael B.| Singh, Rakesh K.| Moore, Richard G.| |
| Published Date | 2022-04-11 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume65 |
| Issue | issue8 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 6039 |
| End Page | 6055 |
| ISSN | 0022-2623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35404047 |
| DOI | 10.1021/acs.jmedchem.1c01878 |
| Web of Science KeyUT | 000797573100012 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878 |
| JaLCDOI | 10.18926/AMO/65750 |
|---|---|
| FullText URL | 77_4_395.pdf |
| Author | Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana| |
| Abstract | We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia. |
| Keywords | tumor necrosis factor-alpha schizophrenia psychopathology immune system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 395 |
| End Page | 405 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635140 |
| Web of Science KeyUT | 001163659800010 |
| JaLCDOI | 10.18926/AMO/65749 |
|---|---|
| FullText URL | 77_4_387.pdf |
| Author | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
| Abstract | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
| Keywords | radon hot spring bathing habit self-rated health cross-section study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 387 |
| End Page | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635139 |
| Web of Science KeyUT | 001163659800003 |
| JaLCDOI | 10.18926/AMO/65741 |
|---|---|
| FullText URL | 77_4_359.pdf |
| Author | Koshida, Tomohiro| Maruta, Toyoaki| Tanaka, Nobuhiko| Hidaka, Kotaro| Kurogi, Mio| Nemoto, Takayuki| Yanagita, Toshihiko| Takeya, Ryu| Tsuneyoshi, Isao| |
| Abstract | Pulsed radiofrequency (PRF) is a safe method of treating neuropathic pain by generating intermittent electric fields at the needle tip. Resiniferatoxin (RTX) is an ultrapotent agonist of transient receptor potential vanilloid subtype-1 (TRPV1) receptors. We investigated the mechanism of PRF using a rat model of RTX-induced neuropathic pain. After administering RTX intraperitoneally, PRF was applied to the right sciatic nerve. We observed the changes in TRPV1, calcitonin gene-related peptide (CGRP), and brain-derived neurotrophic factor (BDNF) in the dorsal root ganglia by western blotting. Expressions of TRPV1 and CGRP were significantly lower in the contralateral (RTX-treated, PRF-untreated) tissue than in control rats (p<0.0001 and p<0.0001, respectively) and the ipsilateral tissues (p<0.0001 and p<0.0001, respectively). BDNF levels were significantly higher in the contralateral tissues than in the control rats (p<0.0001) and the ipsilateral tissues (p<0.0001). These results suggest that, while TRPV1 and CGRP are decreased by RTX-induced neuronal damage, increased BDNF levels result in pain development. PRF may promote recovery from neuronal damage with concomitant restoration of TRPV1 and CGRP, and exert its analgesic effect by reversing BDNF increase. Further research is required to understand the role of TRPV1 and CGRP restoration in improving mechanical allodynia. |
| Keywords | pulsed radiofrequency resiniferatoxin transient receptor potential vanilloid subtype-1 (TRPV1) calcitonin gene-related peptide (CGRP) brain-derived neurotrophic factor (BDNF) |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 359 |
| End Page | 364 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635135 |
| Web of Science KeyUT | 001163659800011 |
| FullText URL | fulltext20230721-01.pdf |
|---|---|
| Author | Yamada, Iori| Terasaki, Hidenori| Urakawa, Satoru| Kondo, Tadashi| Machida, Akihiko| Tange, Yoshinori| Higo, Yuji| |
| Keywords | Fe alloy Sound velocity Liquid Core Mercury Light element |
| Note | The version of record of this article, first published in Physics and Chemistry of Minerals, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00269-023-01243-8| |
| Published Date | 2023-07-01 |
| Publication Title | Physics and Chemistry of Minerals |
| Volume | volume50 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 19 |
| ISSN | 0342-1791 |
| NCID | AA00773930 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| DOI | 10.1007/s00269-023-01243-8 |
| Web of Science KeyUT | 001020912400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00269-023-01243-8 |
| JaLCDOI | 10.18926/AMO/65489 |
|---|---|
| FullText URL | 77_3_243.pdf |
| Author | Shibata, Yusuke| Eguchi, Jun| Wada, Jun| |
| Abstract | Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. |
| Keywords | PPARγ brown adipose tissue thiazolidinediones |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357625 |
| Web of Science KeyUT | 001026279600002 |
| FullText URL | K0006824_abstract_review.pdf K0006824_summary.pdf |
|---|---|
| Author | Wang, Yaming| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6824号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Royal Society of Chemistry 2021 |
| FullText URL | K0006817_abstract_review .pdf K0006817_fulltext.pdf K0006817_summary.pdf |
|---|---|
| Author | ANADA, Risa| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6817号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Royal Society of Chemistry 2023 |
| FullText URL | fulltext20230508-02.pdf |
|---|---|
| Author | Formica, Michele| Rogova, Tatiana| Shi, Heyao| Sahara, Naoto| Ferko, Branislav| Farley, Alistair J. M.| Christensen, Kirsten E.| Duarte, Fernanda| Yamazaki, Ken| Dixon, Darren J.| |
| Note | The version of record of this article, first published in Nature Chemistry, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41557-023-01165-6| |
| Published Date | 2023-05-01 |
| Publication Title | Nature Chemistry |
| Volume | volume15 |
| Issue | issue5 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 714 |
| End Page | 721 |
| ISSN | 1755-4330 |
| NCID | AA12391432 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37127757 |
| DOI | 10.1038/s41557-023-01165-6 |
| Related Url | isVersionOf https://doi.org/10.1038/s41557-023-01165-6 |
| JaLCDOI | 10.18926/AMO/64122 |
|---|---|
| FullText URL | 76_6_715.pdf |
| Author | Mohammed Zahedul Islam Nizami| Gorduysus, Melahat| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Nishina, Yuta| Takashiba, Shogo| Arias, Zulema| |
| Abstract | The failure of endodontic treatment is directly associated with microbial infection in the root canal or periapical areas. An endodontic sealer that is both bactericidal and biocompatible is essential for the success of root canal treatments. This is one of the vital issues yet to be solved in clinical dental practice. This in vitro study assessed the effectiveness of graphene oxide (GO) composites GO-CaF2 and GO-Ag-CaF2 as endodontic sealer materials. Dentin slices were coated with either the GO-based composites or commonly used root canal sealers (non-eugenol zinc oxide sealer). The coated slices were treated in 0.9% NaCl, phosphate-buffered saline (PBS), and simulated body fluid (SBF) at 37˚C for 24 hours to compare their sealing effect on the dentin surface. In addition, the radiopacity of these composites was examined to assess whether they complied with the requirements of a sealer for good radiographic visualization. Scanning electron microscopy showed the significant sealing capability of the composites as coating materials. Radiographic images confirmed their radiopacity. Mineral deposition indicated their bioactivity, especially of GO-Ag-CaF2, and thus it is potential for regenerative application. They were both previously shown to be bactericidal to oral microbes and cytocompatible with host cells. With such a unique assemblage of critical properties, these GO-based composites show promise as endodontic sealers for protection against reinfection in root canal treatment and enhanced success in endodontic treatment overall. |
| Keywords | bioactive sealer graphene oxide mineral deposition antimicrobial activity radiopacity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-12 |
| Volume | volume76 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 715 |
| End Page | 721 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36549774 |
| Web of Science KeyUT | 000905195100012 |
