result 18365 件
| JaLCDOI | 10.18926/AMO/43825 |
|---|---|
| FullText URL | 65_1_11.pdf |
| Author | Kuwaki, Kenji| Nouso, Kazuhiro| Kobayashi, Yoshiyuki| Nakamura, Shinichiro| Ito, Yoichi M.| Iwadou, Shouta| Hagihara, Hiroaki| Yasunaka, Tetsuya| Toshimori, Junichi| Miyatake, Hirokazu| Miyoshi, Kenji| Onishi, Hideki| Miyake, Yasuhiro| Shoji, Bon| Takaki, Akinobu| Shiraha, Hidenori| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
| Abstract | The purpose of this study was to build a prognostic model of hepatocellular carcinoma (HCC) using time-dependent covariates to re-evaluate the prognosis at any stage of the disease. The subjects were consecutive HCC patients who were treated at our institute between 1995 and 2007. We constructed time-fixed and time-dependent prognostic models with a training group (n＝336) and compared the prognostic abilities between conventional Cancer of the Liver Italian Program (CLIP) scores, Japan Integrated Staging (JIS) scores, an Okuda classification, and our prognostic models in the testing group (n＝227) with the c-index. The time-dependent prognostic model consisted of main tumor size, tumor number, portal vein invasion, distant metastasis, alpha-fetoprotein, des-gamma-carboxy prothrombin (DCP), bilirubin, and albumin and the weighted scores were set for each factor depending on the hazard ratio for the prognosis. The prognostic index was determined by summing the scores. The c-index values for the CLIP scores, JIS scores, Okuda classification, and our time-dependent model were 0.741, 0.727, 0.609, and 0.870, respectively. These results indicate that our time-dependent model can estimate the prognosis of HCC more precisely than traditional time-fixed models and can be used to re-predict the prognosis of HCC. |
| Keywords | hepatocellular carcinoma humans prognosis proportional hazards models time factors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 11 |
| End Page | 19 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339791 |
| Web of Science KeyUT | 000287620500002 |
| JaLCDOI | 10.18926/AMO/43824 |
|---|---|
| FullText URL | 65_1_1.pdf |
| Author | Han, Xiao-Jian| Tomizawa, Kazuhito| Fujimura, Atsushi| Ohmori, Iori| Nishiki, Tei-ichi| Matsushita, Masayuki| Matsui, Hideki| |
| Abstract | Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent studies, several large GTPases have been identified as key molecular factors in mitochondrial fission and fusion. Moreover, the posttranslational modifications of these large GTPases, including phosphorylation, ubiquitination and SUMOylation, have been shown to be involved in the regulation of mitochondrial dynamics. Neurons are particularly sensitive and vulnerable to any abnormalities in mitochondrial dynamics, due to their large energy demand and long extended processes. Emerging evidences have thus indicated a strong linkage between mitochondria and neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Huntington's disease. In this review, we will describe the regulation of mitochondrial dynamics and its role in neurodegenerative diseases. |
| Keywords | mitochondria phosphorylation ubiquitination SUMOylation neurodegeneration |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-02 |
| Volume | volume65 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 21339790 |
| Web of Science KeyUT | 000287620500001 |
| Author | Gesi, Takamaro| |
|---|---|
| Published Date | 1943-03-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume55 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Gesi, Takamaro| Matumoto, Asao| Kôno, Minuru| Matumura, Yûiti| Nisida, Isamu| |
|---|---|
| Published Date | 1943-03-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume55 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Sekida, Tsutomu| |
|---|---|
| Published Date | 1943-02-28 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume55 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Akaeda, Yutaka| |
|---|---|
| Published Date | 1943-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume55 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | 河野 實| |
|---|---|
| Published Date | 1944-05-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume56 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | Kôno, Minoru| |
|---|---|
| Published Date | 1944-02-29 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume56 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Tsukawaki, Tokutarô| |
|---|---|
| Published Date | 1944-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume56 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Fuzimoto, Motohisa| |
|---|---|
| Published Date | 1944-01-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume56 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Takahashi, Masabumi| |
|---|---|
| Published Date | 1952-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume64 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Iriyama, S.| |
|---|---|
| Published Date | 1953-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume65 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Kawahara, Sadao| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Morishita, Tatsuaki| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Morishita, Tatsuaki| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Hamada, Hisao| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Hamada, Hisao| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Tsuchida, Junichiro| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Utsumi, Takeo| |
|---|---|
| Published Date | 1964-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume76 |
| Issue | issue11-12 |
| Content Type | Journal Article |
| Author | Okamoto, Tadashi| Okano, Takuya| Saito, Tetsuro| Kimura, Ikuro| Tanaka, Motosuke| Yamashita, Miyokichi| Shindo, Tsutomu| Kuninobu, Masuhiro| Tominaga, Hiroshi| Ishida, Toyoshige| Takeda, Toshiteru| Numamoto, Tetsuro| Kotakemori, Yasuo| Nakayama, Akio| Hoen, Sachihiko| |
|---|---|
| Published Date | 1954-12-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume66 |
| Issue | issue12 |
| Content Type | Journal Article |
