result 5995 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Komoto, Satoshi| Noma, Kazuhiro| Kato, Takuya| Kobayashi, Teruki| Nishiwaki, Noriyuki| Narusaka, Toru| Sato, Hiroaki| Katsura, Yuki| Kashima, Hajime| Kikuchi, Satoru| Ohara, Toshiaki| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment |
| Published Date | 2023-05-30 |
| Publication Title | Cancers |
| Volume | volume15 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 2971 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37296933 |
| DOI | 10.3390/cancers15112971 |
| Web of Science KeyUT | 001006082400001 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers15112971 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Furuta, Kazuyuki| Onishi, Hiroka| Ikada, Yuki| Masaki, Kento| Tanaka, Satoshi| Kaito, Chikara| |
| Published Date | 2023-04 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume299 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 104587 |
| ISSN | 1083-351X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 THE AUTHORS. |
| File Version | publisher |
| PubMed ID | 36889584 |
| DOI | 10.1016/j.jbc.2023.104587 |
| Web of Science KeyUT | 001009229100001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jbc.2023.104587 |
| FullText URL | fulltext20230621-01.pdf |
|---|---|
| Author | Yoshimura, Teizo| Li, Chunning| Wang, Yuze| Matsukawa, Akihiro| |
| Keywords | Breast cancer chemokines chemokine receptors metastasis macrophages |
| Note | The version of record of this article, first published in Cellular & Molecular Immunology, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41423-023-01013-0| |
| Published Date | 2023-05-19 |
| Publication Title | Cellular & Molecular Immunology |
| Volume | volume20 |
| Issue | issue7 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 714 |
| End Page | 738 |
| ISSN | 2042-0226 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37208442 |
| DOI | 10.1038/s41423-023-01013-0 |
| Web of Science KeyUT | 000990897000001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41423-023-01013-0 |
| FullText URL | fulltext20230619-04.pdf |
|---|---|
| Author | Tsuneishi, Taichi| Kojima, Keiichi| Kubota, Fumika| Harashima, Hideyoshi| Yamada, Yuma| Sudo, Yuki| |
| Published Date | 2023 |
| Publication Title | Chemical Communications |
| Volume | volume59 |
| Issue | issue49 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 7591 |
| End Page | 7594 |
| ISSN | 1359-7345 |
| NCID | AA11071130 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2023 |
| File Version | publisher |
| PubMed ID | 37254694 |
| DOI | 10.1039/d3cc02056h |
| Web of Science KeyUT | 000999015900001 |
| Related Url | isVersionOf https://doi.org/10.1039/D3CC02056H |
| FullText URL | fulltext20230619-02.pdf |
|---|---|
| Author | Thu, Myat| Yanai, Kouta| Shigeto, Hajime| Yamamura, Shohei| Watanabe, Kazunori| Ohtsuki, Takashi| |
| Published Date | 2023 |
| Publication Title | Analyst |
| Volume | volume148 |
| Issue | issue11 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 2626 |
| End Page | 2632 |
| ISSN | 0003-2654 |
| NCID | AA00524823 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Royal Society of Chemistry 2023 |
| File Version | publisher |
| PubMed ID | 37191032 |
| DOI | 10.1039/d3an00554b |
| Web of Science KeyUT | 000988019800001 |
| Related Url | isVersionOf https://doi.org/10.1039/D3AN00554B |
| JaLCDOI | 10.18926/AMO/65503 |
|---|---|
| FullText URL | 77_3_331.pdf |
| Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Miyoshi, Kentaroh| Sugimoto, Seiichiro| Toyooka, Shinichi| |
| Abstract | Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well. |
| Keywords | endobronchial metastasis type A thymoma bloody sputum |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 331 |
| End Page | 334 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357635 |
| Web of Science KeyUT | 001026663400001 |
| JaLCDOI | 10.18926/AMO/65502 |
|---|---|
| FullText URL | 77_3_323.pdf |
| Author | Makino, Keigo| Otani, Yoshihiro| Fujii, Kentaro| Ishida, Joji| Hirano, Shuichiro | Suruga, Yasuki| Washio, Kana| Nishida, Kenji| Yanai, Hiroyuki| Tomida, Shuta| Ennishi, Daisuke| Date, Isao| |
| Abstract | In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases. |
| Keywords | comprehensive genomic profiling pediatric brain tumor genome-wide DNA methylation MYCN |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 323 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357634 |
| Web of Science KeyUT | 001025850000001 |
| JaLCDOI | 10.18926/AMO/65495 |
|---|---|
| FullText URL | 77_3_301.pdf |
| Author | Kato, Takahide| Miyoshi, Seigo| Hamada, Chizuru| Sano, Yoshifumi| Nogami, Naoyuki| Yamaguchi, Osamu| Hamaguchi, Naohiko| |
| Abstract | Acute exacerbation (AE) of interstitial lung disease (ILD) is a severe complication of lung resection in lung cancer patients with ILD (LC-ILD). This study aimed to assess the predictive value of comorbidities other than ILD for postoperative AE in patients with LC-ILD. We retrospectively evaluated 68 patients with LC-ILD who had undergone lung resection. We classified them into two groups: those who had developed postoperative AE within 30 days after resection and those who had not. We analyzed patient characteristics, high-resolution computed tomography findings, clinical data, pulmonary function, and intraoperative data. The incidence of postoperative AEs was 11.8%. In univariate analysis, performance status (PS), honeycombing, forced vital capacity (FVC), and high hemoglobin A1c (HbA1c) levels without comorbidities were significantly associated with postoperative AE. Patients were divided into two groups according to cutoff levels of those four variables as determined by receiver operating characteristic curves, revealing that the rates of patients without postoperative AE differed significantly between groups. The present results suggested that preoperative comorbidities other than ILD were not risk factors for postoperative AE in patients with LC-ILD. However, a high preoperative HbA1c level, poor PS, low FVC, and honeycombing may be associated with postoperative AE of LC-ILD. |
| Keywords | lung cancer interstitial lung disease acute exacerbation comorbidity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 309 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357631 |
| Web of Science KeyUT | 001026279600008 |
| JaLCDOI | 10.18926/AMO/65492 |
|---|---|
| FullText URL | 77_3_273.pdf |
| Author | Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi| |
| Abstract | Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue. |
| Keywords | simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 280 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357628 |
| Web of Science KeyUT | 001026279600005 |
| JaLCDOI | 10.18926/AMO/65489 |
|---|---|
| FullText URL | 77_3_243.pdf |
| Author | Shibata, Yusuke| Eguchi, Jun| Wada, Jun| |
| Abstract | Brown adipose tissue (BAT) plays a critical role in metabolic homeostasis. BAT dysfunction is associated with the development of obesity through an imbalance between energy expenditure and energy intake. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis. However, the roles of PPARγ and thiazolidinediones (TZDs) in the regulation of BAT metabolism remain unclear. TZDs, which are selective PPARγ activators, improve systemic insulin resistance in animals and humans. In the present study, we generated brown adipocyte-specific PPARγ-deficient mice (BATγKO) to examine the in vivo roles of PPARγ and TZDs in BAT metabolism. In electron microscopic examinations, brown adipocyte-specific PPARγ deletion promoted severe whitening of brown fat and morphological alteration of mitochondria. Brown adipocyte-specific PPARγ deletion also reduced mRNA expression of BAT-selective genes. Although there was no difference in energy expenditure between control and BATγKO mice in calorimetry, norepinephrine-induced thermogenesis was impaired in BATγKO mice. Moreover, pioglitazone treatment improved diet-induced insulin resistance in the control mice but not in the BATγKO mice. These findings suggest that BAT PPARγ is necessary for the maintenance of brown adipocyte function and for the insulin-sensitizing action of TZDs. |
| Keywords | PPARγ brown adipose tissue thiazolidinediones |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 254 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357625 |
| Web of Science KeyUT | 001026279600002 |
| JaLCDOI | 10.18926/AMO/65488 |
|---|---|
| FullText URL | 77_3_235.pdf |
| Author | Kuraoka, Sakiko| Iwamuro, Masaya| Satomi, Takuya| Yamazaki, Tatsuhiro| Hamada, Kenta| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kato, Hironari| Otsuka, Fumio| Okada, Hiroyuki| |
| Abstract | Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ΔIGF-1 SD score and Δthyroidstimulating hormone (TSH) and between ΔIGF-1 SD score and Δfree testosterone. ΔBody weight and ΔIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (≥ 12 weeks) users. |
| Keywords | anamorelin body weight cancer cachexia endocrine system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-06 |
| Volume | volume77 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37357624 |
| Web of Science KeyUT | 001026279600001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Takata, Jun| Kiura, Katsuyuki| Nakasuka, Takamasa| Hirabae, Atsuko| Arimoto-Kobayashi, Sakae| |
| Keywords | Anti-mutagenesis Signal transduction Lung tumorigenesis DNA methylation Tobacco-specific nitrosamine Glycine betaine |
| Note | The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00276-3| |
| Published Date | 2023-06-07 |
| Publication Title | Genes and Environment |
| Volume | volume45 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 19 |
| ISSN | 1880-7046 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37280663 |
| DOI | 10.1186/s41021-023-00276-3 |
| Web of Science KeyUT | 001002195100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s41021-023-00276-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | Diagnosis Diffuse large B-cell lymphoma Duodenal neoplasms Esoph-agogastroduodenoscopy Follicular lymphoma Gastrointestinal lymphoma |
| Published Date | 2023-03-28 |
| Publication Title | World Journal of Gastroenterology |
| Volume | volume29 |
| Issue | issue12 |
| Publisher | Baishideng Publishing Group |
| Start Page | 1852 |
| End Page | 1862 |
| ISSN | 1007-9327 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37032723 |
| DOI | 10.3748/wjg.v29.i12.1852 |
| Web of Science KeyUT | 000982154800007 |
| Related Url | isVersionOf https://doi.org/10.3748/wjg.v29.i12.1852 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Mizukawa, Mami| Nishimura, Noriko| Uddin, Md. Azhar| Kato, Yoshiei| Uchida, Yu-ichi| |
| Keywords | Flotation Multicomponent Waste solar cell Silicon Recovery |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10163-023-01698-5| This fulltext file will be available in May 2024.| |
| Published Date | 2023-05-30 |
| Publication Title | Journal of Material Cycles and Waste Management |
| Volume | volume25 |
| Issue | issue4 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 2407 |
| End Page | 2416 |
| ISSN | 1438-4957 |
| NCID | AA11589627 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer Nature Japan KK, part of Springer Nature 2023 |
| File Version | author |
| DOI | 10.1007/s10163-023-01698-5 |
| Web of Science KeyUT | 000996055700001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10163-023-01698-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sumi, Tomonari| Harada, Kouji| |
| Published Date | 2023-03-17 |
| Publication Title | iScience |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | Cell Press |
| Start Page | 106133 |
| ISSN | 2589-0042 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 36866246 |
| DOI | 10.1016/j.isci.2023.106133 |
| Web of Science KeyUT | 000993415200001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.isci.2023.106133 |
| FullText URL | O0004551‗fulltext.pdf O0004551_abstract_review.pdf O0004551_summary.pdf |
|---|---|
| Author | HIRAMI, Yuki| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4551号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Health Sciences |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 by The Japanese Society for Lymphoreticular Tissue Research |
| FullText URL | O0004550_abstract_review.pdf O0004550_fulltext.pdf |
|---|---|
| Author | Xu, Yanning| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4550号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0006801_abstract_review.pdf K0006801_fulltext.pdf |
|---|---|
| Author | OTA, Tomoyuki| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6801号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022 IOP Publishing Ltd |
| FullText URL | K0006798_abstract_review.pdf K0006798_fulltext.pdf K0006798_summary.pdf |
|---|---|
| Author | TSUDAKA, Shimpei| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6798号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © Society of Surgical Oncology 2021 |
| FullText URL | K0006781_abstract_review.pdf K0006781_fulltext.pdf K0006781_summary.pdf |
|---|---|
| Author | ITANO, Junko| |
| Published Date | 2023-03-24 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6781号 |
| Granted Date | 2023-03-24 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | Copyright © 2022 by the American Thoracic Society |
