result 822 件
FullText URL | fulltext.pdf |
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Author | Hirai, Kenta| Ousaka, Daiki| Fukushima, Yosuke| Kondo, Maiko| Eitoku, Takahiro| Shigemitsu, Yusuke| Hara, Mayuko| Baba, Kenji| Iwasaki, Tatsuo| Kasahara, Shingo| Ohtsuki, Shinichi| Oh, Hidemasa| |
Note | This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine on 573(12), 2020, DOI: 10.1126/scitranslmed.abb3336.| |
Published Date | 2020-12-09 |
Publication Title | Science Translational Medicine |
Volume | volume12 |
Issue | issue573 |
Publisher | American Association for the Advancement of Science |
Start Page | eabb3336 |
ISSN | 1946-6234 |
NCID | AA12519139 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Authors |
File Version | author |
PubMed ID | 33298561 |
DOI | 10.1126/scitranslmed.abb3336 |
Web of Science KeyUT | 000597340700004 |
Related Url | isVersionOf https://doi.org/10.1126/scitranslmed.abb3336 |
JaLCDOI | 10.18926/AMO/61217 |
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FullText URL | 74_6_557.pdf |
Author | Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki| |
Abstract | A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively. |
Keywords | 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 557 |
End Page | 562 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361878 |
Web of Science KeyUT | 000601203600014 |
NAID | 120006948944 |
JaLCDOI | 10.18926/AMO/61204 |
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FullText URL | 74_6_461.pdf |
Author | Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki| |
Abstract | Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted. |
Keywords | gastric cancer young patients Helicobacter pylori |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 461 |
End Page | 466 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361865 |
Web of Science KeyUT | 000601203600001 |
NAID | 120006948954 |
FullText URL | fulltext.pdf |
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Author | Nishii, Kazuya| Ohashi, Kadoaki| Tamura, Tomoki| Ninomiya, Kiichiro| Matsubara, Takehiro| Senoo, Satoru| Kano, Hirohisa| Watanabe, Hiromi| Oda, Naohiro| Makimoto, Go| Higo, Hisao| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Yamamoto, Hiromasa | Tomida, Shuta| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs |
Published Date | 2020-12 |
Publication Title | Oncology Letters |
Volume | volume20 |
Issue | issue6 |
Publisher | Spandidos Publications |
Start Page | 393 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33193853 |
DOI | 10.3892/ol.2020.12256 |
Web of Science KeyUT | 000595649300005 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2020.12256 |
FullText URL | fulltext.pdf |
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Author | Jiao, Yu Yang| Okada, Masahiro| Hara, Emilio Satoshi| Xie, Shi Chao| Nagaoka, Noriyuki| Nakano, Takayoshi| Matsumoto, Takuya| |
Keywords | bone-like material mechanical property orientation layered structure |
Published Date | 2020-11-12 |
Publication Title | Materials |
Volume | volume13 |
Issue | issue22 |
Publisher | MDPI |
Start Page | 5099 |
ISSN | 1996-1944 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33198178 |
DOI | 10.3390/ma13225099 |
Web of Science KeyUT | 000594906000001 |
Related Url | isVersionOf https://doi.org/10.3390/ma13225099 |
FullText URL | fulltext.pdf |
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Author | Shimada, Yasushi| Yoshiyama, Masahiro| Tagami, Junji| Sumi, Yasunori| |
Keywords | Optical coherence tomography Diagnosis Caries Tooth crack NCCL Tooth wear Age-related changes |
Published Date | 2020-11-30 |
Publication Title | Japanese Dental Science Review |
Volume | volume56 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 109 |
End Page | 118 |
ISSN | 1882-7616 |
NCID | AA12334461 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33033549 |
DOI | 10.1016/j.jdsr.2020.08.001 |
Web of Science KeyUT | 000598681800015 |
Related Url | isVersionOf https://doi.org/10.1016/j.jdsr.2020.08.001 |
FullText URL | fulltext.pdf |
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Author | Tamura, Katsunori| Kunoh, Tatsuki| Nakanishi, Makoto| Kusano, Yoshihiro| Takada, Jun| |
Published Date | 2020-10-16 |
Publication Title | ACS Omega |
Volume | volume5 |
Issue | issue42 |
Publisher | American Chemical Society |
Start Page | 27287 |
End Page | 27294 |
ISSN | 2470-1343 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 American Chemical Society |
File Version | publisher |
PubMed ID | 33134691 |
DOI | 10.1021/acsomega.0c03574 |
Web of Science KeyUT | 000586784200036 |
Related Url | isVersionOf https://doi.org/10.1021/acsomega.0c03574 |
FullText URL | fulltext.pdf |
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Author | Kashiwa, Misa| Shimada, Yasushi| Sadr, Alireza| Yoshiyama, Masahiro| Sumi, Yasunori| Tagami, Junji| |
Keywords | occlusal tooth wear erosive tooth wear SS-OCT 3D imaging enamel thickness dentin exposure demineralization |
Published Date | 2020-10-23 |
Publication Title | Sensors |
Volume | volume20 |
Issue | issue21 |
Publisher | MDPI |
Start Page | 6016 |
ISSN | 1424-8220 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33113981 |
DOI | 10.3390/s20216016 |
Web of Science KeyUT | 000589312100001 |
Related Url | isVersionOf https://doi.org/10.3390/s20216016 |
FullText URL | fulltext.pdf |
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Author | Habuta, Munenori| Yasue, Akihiro| Suzuki, Ken-Ichi T.| Fujita, Hirofumi| Sato, Keita| Kono, Hitomi| Takayama, Ayuko| Bando, Tetsuya| Miyaishi, Satoru| Oyadomari, Seiichi| Tanaka, Eiji| Ohuchi, Hideyo| |
Published Date | 2020-10-15 |
Publication Title | PLoS ONE |
Volume | volume15 |
Issue | issue10 |
Publisher | Public Library of Science |
Start Page | e0240333 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Habuta et al. |
File Version | publisher |
PubMed ID | 33057360 |
DOI | 10.1371/journal.pone.0240333 |
Web of Science KeyUT | 000581814700082 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0240333 |
FullText URL | fulltext.pdf |
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Author | Naitou, Hiromichi| Nojima, Tsuyoshi| Fujisaki, Noritomo| Tsukahara, Kohei| Yamamoto, Hirotsugu| Yamada, Taihei| Aokage, Toshiyuki| Yumoto, Tetsuya| Osako, Takaaki| Nakao, Atsunori| |
Keywords | Emergency medicine inflammation ischemia reperfusion remote ischemic preconditioning shock therapeutic hypothermia |
Published Date | 2020-04-13 |
Publication Title | Acute Medicine and Surgery |
Volume | volume7 |
Issue | issue1 |
Publisher | Wiley |
Start Page | e501 |
ISSN | 2052-8817 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 32431842 |
DOI | 10.1002/ams2.501 |
Web of Science KeyUT | 000587733600052 |
Related Url | isVersionOf https://doi.org/10.1002/ams2.501 |
FullText URL | fulltext.pdf |
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Author | Yoshikawa, Soichiro| Miyake, Kensuke| Kamiya, Atsunori| Karasuyama, Hajime| |
Keywords | acquired immunity basophil histamine IgE IL‐3 mast cell Tick |
Published Date | 2020-10-30 |
Publication Title | Parasite Immunology |
Volume | volume2021 |
Issue | issue43 |
Publisher | Wiley |
Start Page | e12804 |
ISSN | 0141-9838 |
NCID | AA00361321 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 33124059 |
DOI | 10.1111/pim.12804 |
Web of Science KeyUT | 000588829500001 |
Related Url | isVersionOf https://doi.org/10.1111/pim.12804 |
FullText URL | fulltext.pdf |
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Author | Kuwahara, Miho| Kadoya, Koichi| Kondo, Sei| Fu, Shanqi| Miyake, Yoshiko| Ogo, Ayako| Ono, Mitsuaki| Furumatsu, Takayuki| Nakata, Eiji| Sasaki, Takako| Minagi, Shogo| Takigawa, Masaharu| Kubota, Satoshi| Hattori, Takako| |
Keywords | cellular communication network factor 3 CCN3 NOV primary chondrocytes aging oxidative stress senescence p21 p53 SASP |
Published Date | 2020-10-13 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue20 |
Publisher | MDPI |
Start Page | 7556 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33066270 |
DOI | 10.3390/ijms21207556 |
Web of Science KeyUT | 000585557400001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21207556 |
FullText URL | fulltext.pdf |
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Author | Xu, Caizhe| Pi, Xiong| Huang, Yawen| Han, Guangye| Chen, Xiaobo| Qin, Xiaochun| Huang, Guoqiang| Zhao, Songhao| Yang, Yanyan| Kuang, Tingyun| Wang, Wenda| Sui, Sen-Fang| Shen, Jian-Ren| |
Keywords | Bioenergetics Cryoelectron microscopy Photosystem I |
Published Date | 2020-10-08 |
Publication Title | Nature Communications |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 5081 |
ISSN | 2041-1723 |
NCID | AA12645905 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 33033236 |
DOI | 10.1038/s41467-020-18867-x |
Web of Science KeyUT | 000581918200012 |
Related Url | isVersionOf https://doi.org/10.1038/s41467-020-18867-x |
FullText URL | fulltext.pdf |
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Author | Yoshihama, Tomoko| Hirasawa, Akira| Sugano, Kokichi| Yoshida, Teruhiko| Ushiama, Mineko| Ueki, Arisa| Akahane, Tomoko| Nanki, Yoshiko| Sakai, Kensuke| Makabe, Takeshi| Yamagami, Wataru| Susumu, Nobuyuki| Kameyama, Kaori| Kosaki, Kenjiro| Aoki, Daisuke| |
Keywords | BRCA2 Hereditary breast and ovarian cancer Multigene panel testing Genetic counseling Lynch syndrome |
Published Date | 2020-10-09 |
Publication Title | International Cancer Conference Journal |
Publisher | Springer |
ISSN | 2192-3183 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Author(s) |
File Version | publisher |
DOI | 10.1007/s13691-020-00449-9 |
Web of Science KeyUT | 000578322300001 |
Related Url | isVersionOf https://doi.org/10.1007/s13691-020-00449-9 |
FullText URL | fulltext.pdf |
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Author | Shimada, Yasushi| Burrow, Michael F.| Araki, Kazuyuki| Zhou, Yuan| Hosaka, Keiichi| Sadr, Alireza| Yoshiyama, Masahiro| Miyazaki, Takashi| Sumi, Yasunori| Tagami, Junji| |
Keywords | Dental caries Dental lasers Laboratory techniques and procedures |
Published Date | 2020-09-25 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 15754 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 32978464 |
DOI | 10.1038/s41598-020-72838-2 |
Web of Science KeyUT | 000577248100029 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-72838-2 |
JaLCDOI | 10.18926/AMO/60802 |
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FullText URL | 74_5_423.pdf |
Author | Hirabae, Atsuko| Ichihara, Eiki| Sunami, Ryota| Ota, Moeko| Iwamoto, Yoshitaka| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Abstract | We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks. |
Keywords | lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 423 |
End Page | 425 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106698 |
Web of Science KeyUT | 000581970100007 |
NAID | 120006892928 |
JaLCDOI | 10.18926/AMO/60796 |
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FullText URL | 74_5_371.pdf |
Author | Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Abstract | The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms. |
Keywords | lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 371 |
End Page | 379 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106692 |
Web of Science KeyUT | 000581970100001 |
NAID | 120006892922 |
FullText URL | APL_117_101103.pdf |
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Author | Iida, Takumi | Ishikawa, Atsushi| Tanaka, Takuo| Muranaka, Atsuya| Uchiyama, Masanobu| Hayashi, Yasuhiko| Tsuruta, Kenji| |
Note | This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takumi Iida et. al. Super-chiral vibrational spectroscopy with metasurfaces for high-sensitive identification of alanine enantiomers. Appl. Phys. Lett. 117, 101103 (2020) and may be found at https://doi.org/10.1063/5.0012331.| |
Published Date | 2020-09-09 |
Publication Title | Applied Physics Letters |
Volume | volume117 |
Issue | issue10 |
Publisher | American Institute of Physics |
Start Page | 101103 |
ISSN | 0003-6951 |
NCID | AA00543431 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
DOI | 10.1063/5.0012331 |
Web of Science KeyUT | 000571581400002 |
Related Url | isVersionOf https://doi.org/10.1063/5.0012331 |
FullText URL | RSC_Adv_10.pdf |
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Author | Guo, Yuxin| Yoshioka, Kaito| Hamao, Shino| Kubozono, Yoshihiro| Tani, Fumito| Goto, Kenta| Okamoto, Hideki| |
Published Date | 2020-08-26 |
Publication Title | RSC Advances |
Volume | volume10 |
Issue | issue52 |
Publisher | Royal Society of Chemistry |
Start Page | 31547 |
End Page | 31552 |
ISSN | 2046-2069 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Royal Society of Chemistry |
File Version | publisher |
DOI | 10.1039/D0RA06629J |
Web of Science KeyUT | 000566579400055 |
Related Url | isVersionOf https://doi.org/10.1039/D0RA06629J |
FullText URL | fulltext.pdf |
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Author | Mitalo, Oscar W.| Otsuki, Takumi| Okada, Rui| Obitsu, Saeka| Masuda, Kanae| Hojo, Yuko| Matsuura, Takakazu| Mori, Izumi C.| Abe, Daigo| Asiche, William O.| Akagi, Takashi| Kubo, Yasutaka| Ushijima, Koichiro| |
Keywords | 1-methylcyclopropene carotenoids chlorophyll Citrus limon ethylene low temperature peel degreening phytohormones transcriptome |
Published Date | 2020-05-06 |
Publication Title | Journal of Experimental Botany |
Volume | volume71 |
Issue | issue16 |
Publisher | Oxford University Press |
Start Page | 4778 |
End Page | 4796 |
ISSN | 0022-0957 |
NCID | AA00697526 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020. |
File Version | publisher |
PubMed ID | 32374848 |
DOI | 10.1093/jxb/eraa206 |
Web of Science KeyUT | 000573250000015 |
Related Url | isVersionOf https://doi.org/10.1093/jxb/eraa206 |