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Author Hirai, Kenta| Ousaka, Daiki| Fukushima, Yosuke| Kondo, Maiko| Eitoku, Takahiro| Shigemitsu, Yusuke| Hara, Mayuko| Baba, Kenji| Iwasaki, Tatsuo| Kasahara, Shingo| Ohtsuki, Shinichi| Oh, Hidemasa|
Note This is the author's version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science Translational Medicine on 573(12), 2020, DOI: 10.1126/scitranslmed.abb3336.|
Published Date 2020-12-09
Publication Title Science Translational Medicine
Volume volume12
Issue issue573
Publisher American Association for the Advancement of Science
Start Page eabb3336
ISSN 1946-6234
NCID AA12519139
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Authors
File Version author
PubMed ID 33298561
DOI 10.1126/scitranslmed.abb3336
Web of Science KeyUT 000597340700004
Related Url isVersionOf https://doi.org/10.1126/scitranslmed.abb3336
JaLCDOI 10.18926/AMO/61217
FullText URL 74_6_557.pdf
Author Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki|
Abstract A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
Keywords 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 557
End Page 562
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361878
Web of Science KeyUT 000601203600014
NAID 120006948944
JaLCDOI 10.18926/AMO/61204
FullText URL 74_6_461.pdf
Author Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Abstract Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted.
Keywords gastric cancer young patients Helicobacter pylori
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 461
End Page 466
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361865
Web of Science KeyUT 000601203600001
NAID 120006948954
FullText URL fulltext.pdf
Author Nishii, Kazuya| Ohashi, Kadoaki| Tamura, Tomoki| Ninomiya, Kiichiro| Matsubara, Takehiro| Senoo, Satoru| Kano, Hirohisa| Watanabe, Hiromi| Oda, Naohiro| Makimoto, Go| Higo, Hisao| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Yamamoto, Hiromasa | Tomida, Shuta| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs
Published Date 2020-12
Publication Title Oncology Letters
Volume volume20
Issue issue6
Publisher Spandidos Publications
Start Page 393
ISSN 1792-1074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 33193853
DOI 10.3892/ol.2020.12256
Web of Science KeyUT 000595649300005
Related Url isVersionOf https://doi.org/10.3892/ol.2020.12256
FullText URL fulltext.pdf
Author Jiao, Yu Yang| Okada, Masahiro| Hara, Emilio Satoshi| Xie, Shi Chao| Nagaoka, Noriyuki| Nakano, Takayoshi| Matsumoto, Takuya|
Keywords bone-like material mechanical property orientation layered structure
Published Date 2020-11-12
Publication Title Materials
Volume volume13
Issue issue22
Publisher MDPI
Start Page 5099
ISSN 1996-1944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33198178
DOI 10.3390/ma13225099
Web of Science KeyUT 000594906000001
Related Url isVersionOf https://doi.org/10.3390/ma13225099
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Author Shimada, Yasushi| Yoshiyama, Masahiro| Tagami, Junji| Sumi, Yasunori|
Keywords Optical coherence tomography Diagnosis Caries Tooth crack NCCL Tooth wear Age-related changes
Published Date 2020-11-30
Publication Title Japanese Dental Science Review
Volume volume56
Issue issue1
Publisher Elsevier
Start Page 109
End Page 118
ISSN 1882-7616
NCID AA12334461
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 33033549
DOI 10.1016/j.jdsr.2020.08.001
Web of Science KeyUT 000598681800015
Related Url isVersionOf https://doi.org/10.1016/j.jdsr.2020.08.001
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Author Tamura, Katsunori| Kunoh, Tatsuki| Nakanishi, Makoto| Kusano, Yoshihiro| Takada, Jun|
Published Date 2020-10-16
Publication Title ACS Omega
Volume volume5
Issue issue42
Publisher American Chemical Society
Start Page 27287
End Page 27294
ISSN 2470-1343
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 American Chemical Society
File Version publisher
PubMed ID 33134691
DOI 10.1021/acsomega.0c03574
Web of Science KeyUT 000586784200036
Related Url isVersionOf https://doi.org/10.1021/acsomega.0c03574
FullText URL fulltext.pdf
Author Kashiwa, Misa| Shimada, Yasushi| Sadr, Alireza| Yoshiyama, Masahiro| Sumi, Yasunori| Tagami, Junji|
Keywords occlusal tooth wear erosive tooth wear SS-OCT 3D imaging enamel thickness dentin exposure demineralization
Published Date 2020-10-23
Publication Title Sensors
Volume volume20
Issue issue21
Publisher MDPI
Start Page 6016
ISSN 1424-8220
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33113981
DOI 10.3390/s20216016
Web of Science KeyUT 000589312100001
Related Url isVersionOf https://doi.org/10.3390/s20216016
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Author Habuta, Munenori| Yasue, Akihiro| Suzuki, Ken-Ichi T.| Fujita, Hirofumi| Sato, Keita| Kono, Hitomi| Takayama, Ayuko| Bando, Tetsuya| Miyaishi, Satoru| Oyadomari, Seiichi| Tanaka, Eiji| Ohuchi, Hideyo|
Published Date 2020-10-15
Publication Title PLoS ONE
Volume volume15
Issue issue10
Publisher Public Library of Science
Start Page e0240333
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Habuta et al.
File Version publisher
PubMed ID 33057360
DOI 10.1371/journal.pone.0240333
Web of Science KeyUT 000581814700082
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0240333
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Author Naitou, Hiromichi| Nojima, Tsuyoshi| Fujisaki, Noritomo| Tsukahara, Kohei| Yamamoto, Hirotsugu| Yamada, Taihei| Aokage, Toshiyuki| Yumoto, Tetsuya| Osako, Takaaki| Nakao, Atsunori|
Keywords Emergency medicine inflammation ischemia reperfusion remote ischemic preconditioning shock therapeutic hypothermia
Published Date 2020-04-13
Publication Title Acute Medicine and Surgery
Volume volume7
Issue issue1
Publisher Wiley
Start Page e501
ISSN 2052-8817
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32431842
DOI 10.1002/ams2.501
Web of Science KeyUT 000587733600052
Related Url isVersionOf https://doi.org/10.1002/ams2.501
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Author Yoshikawa, Soichiro| Miyake, Kensuke| Kamiya, Atsunori| Karasuyama, Hajime|
Keywords acquired immunity basophil histamine IgE IL‐3 mast cell Tick
Published Date 2020-10-30
Publication Title Parasite Immunology
Volume volume2021
Issue issue43
Publisher Wiley
Start Page e12804
ISSN 0141-9838
NCID AA00361321
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 33124059
DOI 10.1111/pim.12804
Web of Science KeyUT 000588829500001
Related Url isVersionOf https://doi.org/10.1111/pim.12804
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Author Kuwahara, Miho| Kadoya, Koichi| Kondo, Sei| Fu, Shanqi| Miyake, Yoshiko| Ogo, Ayako| Ono, Mitsuaki| Furumatsu, Takayuki| Nakata, Eiji| Sasaki, Takako| Minagi, Shogo| Takigawa, Masaharu| Kubota, Satoshi| Hattori, Takako|
Keywords cellular communication network factor 3 CCN3 NOV primary chondrocytes aging oxidative stress senescence p21 p53 SASP
Published Date 2020-10-13
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue20
Publisher MDPI
Start Page 7556
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33066270
DOI 10.3390/ijms21207556
Web of Science KeyUT 000585557400001
Related Url isVersionOf https://doi.org/10.3390/ijms21207556
FullText URL fulltext.pdf
Author Xu, Caizhe| Pi, Xiong| Huang, Yawen| Han, Guangye| Chen, Xiaobo| Qin, Xiaochun| Huang, Guoqiang| Zhao, Songhao| Yang, Yanyan| Kuang, Tingyun| Wang, Wenda| Sui, Sen-Fang| Shen, Jian-Ren|
Keywords Bioenergetics Cryoelectron microscopy Photosystem I
Published Date 2020-10-08
Publication Title Nature Communications
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 5081
ISSN 2041-1723
NCID AA12645905
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33033236
DOI 10.1038/s41467-020-18867-x
Web of Science KeyUT 000581918200012
Related Url isVersionOf https://doi.org/10.1038/s41467-020-18867-x
FullText URL fulltext.pdf
Author Yoshihama, Tomoko| Hirasawa, Akira| Sugano, Kokichi| Yoshida, Teruhiko| Ushiama, Mineko| Ueki, Arisa| Akahane, Tomoko| Nanki, Yoshiko| Sakai, Kensuke| Makabe, Takeshi| Yamagami, Wataru| Susumu, Nobuyuki| Kameyama, Kaori| Kosaki, Kenjiro| Aoki, Daisuke|
Keywords BRCA2 Hereditary breast and ovarian cancer Multigene panel testing Genetic counseling Lynch syndrome
Published Date 2020-10-09
Publication Title International Cancer Conference Journal
Publisher Springer
ISSN 2192-3183
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Author(s)
File Version publisher
DOI 10.1007/s13691-020-00449-9
Web of Science KeyUT 000578322300001
Related Url isVersionOf https://doi.org/10.1007/s13691-020-00449-9
FullText URL fulltext.pdf
Author Shimada, Yasushi| Burrow, Michael F.| Araki, Kazuyuki| Zhou, Yuan| Hosaka, Keiichi| Sadr, Alireza| Yoshiyama, Masahiro| Miyazaki, Takashi| Sumi, Yasunori| Tagami, Junji|
Keywords Dental caries Dental lasers Laboratory techniques and procedures
Published Date 2020-09-25
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 15754
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32978464
DOI 10.1038/s41598-020-72838-2
Web of Science KeyUT 000577248100029
Related Url isVersionOf https://doi.org/10.1038/s41598-020-72838-2
JaLCDOI 10.18926/AMO/60802
FullText URL 74_5_423.pdf
Author Hirabae, Atsuko| Ichihara, Eiki| Sunami, Ryota| Ota, Moeko| Iwamoto, Yoshitaka| Maeda, Yoshinobu| Kiura, Katsuyuki|
Abstract We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks.
Keywords lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 423
End Page 425
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106698
Web of Science KeyUT 000581970100007
NAID 120006892928
JaLCDOI 10.18926/AMO/60796
FullText URL 74_5_371.pdf
Author Makimoto, Go| Ohashi, Kadoaki| Maeda, Yoshinobu| Kiura, Katsuyuki|
Abstract The prognosis of advanced non-small cell lung cancer (NSCLC) patients has improved in recent decades, especially for patients with an oncogenic driver mutation. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are effective for patients with the echinoderm microtubule-associated protein-like 4-ALK fusion gene. Several ALK-TKIs have been established: the first-generation ALK-TKI, crizotinib; second-generation ALK-TKIs, alectinib and ceritinib; and third-generation ALK-TKI, lorlatinib. Some ALK-TKIs are effective for tumors that are resistant to other ALK-TKIs; however, as is known in epidermal growth factor receptormutant lung cancer, tumor resistance is inevitable. ALK-positive NSCLCs acquire resistance via various mechanisms, making it a heterogeneous disease. Therefore, it is necessary to develop next-generation treatment strategies, such as the use of next-generation ALK-TKIs for secondary mutations, or combination therapies with ALK-TKIs and other TKIs. In this review, we summarize the development and use of ALK-TKIs, prior pivotal clinical trials, and resistance mechanisms.
Keywords lung cancer anaplastic lymphoma kinase tyrosine kinase inhibitors resistance mechanism
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 371
End Page 379
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106692
Web of Science KeyUT 000581970100001
NAID 120006892922
FullText URL APL_117_101103.pdf
Author Iida, Takumi | Ishikawa, Atsushi| Tanaka, Takuo| Muranaka, Atsuya| Uchiyama, Masanobu| Hayashi, Yasuhiko| Tsuruta, Kenji|
Note This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Takumi Iida et. al. Super-chiral vibrational spectroscopy with metasurfaces for high-sensitive identification of alanine enantiomers. Appl. Phys. Lett. 117, 101103 (2020) and may be found at https://doi.org/10.1063/5.0012331.|
Published Date 2020-09-09
Publication Title Applied Physics Letters
Volume volume117
Issue issue10
Publisher American Institute of Physics
Start Page 101103
ISSN 0003-6951
NCID AA00543431
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.1063/5.0012331
Web of Science KeyUT 000571581400002
Related Url isVersionOf https://doi.org/10.1063/5.0012331
FullText URL RSC_Adv_10.pdf
Author Guo, Yuxin| Yoshioka, Kaito| Hamao, Shino| Kubozono, Yoshihiro| Tani, Fumito| Goto, Kenta| Okamoto, Hideki|
Published Date 2020-08-26
Publication Title RSC Advances
Volume volume10
Issue issue52
Publisher Royal Society of Chemistry
Start Page 31547
End Page 31552
ISSN 2046-2069
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Royal Society of Chemistry
File Version publisher
DOI 10.1039/D0RA06629J
Web of Science KeyUT 000566579400055
Related Url isVersionOf https://doi.org/10.1039/D0RA06629J
FullText URL fulltext.pdf
Author Mitalo, Oscar W.| Otsuki, Takumi| Okada, Rui| Obitsu, Saeka| Masuda, Kanae| Hojo, Yuko| Matsuura, Takakazu| Mori, Izumi C.| Abe, Daigo| Asiche, William O.| Akagi, Takashi| Kubo, Yasutaka| Ushijima, Koichiro|
Keywords 1-methylcyclopropene carotenoids chlorophyll Citrus limon ethylene low temperature peel degreening phytohormones transcriptome
Published Date 2020-05-06
Publication Title Journal of Experimental Botany
Volume volume71
Issue issue16
Publisher Oxford University Press
Start Page 4778
End Page 4796
ISSN 0022-0957
NCID AA00697526
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 32374848
DOI 10.1093/jxb/eraa206
Web of Science KeyUT 000573250000015
Related Url isVersionOf https://doi.org/10.1093/jxb/eraa206