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Isoflurane Induces Transient Impairment of Retention of Spatial Working Memory in Rats
JaLCDOI 10.18926/AMO/54808
FullText URL 70_6_455.pdf
Author Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi|
Abstract Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
Keywords postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 455
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003670
Urinary Cross-linked N-terminal Telopeptide of Type I Collagen Levels of Infants with Osteogenesis Imperfecta and Healthy Infants
JaLCDOI 10.18926/AMO/54805
FullText URL 70_6_435.pdf
Author Yamashita, Miho| Hasegawa, Kosei| Higuchi, Yousuke| Miyai, Takayuki| Okada, Ayumi| Tanaka, Hiroyuki| Tsukahara, Hirokazu|
Abstract The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p＜0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p＜0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
Keywords bone resorption marker bone turnover bone mass
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 435
End Page 439
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003667
スキナー以後の心理学（24）「般化オペラント」概念の意義と課題
JaLCDOI 10.18926/okadai-bun-kiyou/54796
Title Alternative Post-Skinnerian Perspectives in Psychology（24）: The Concept of "Generalized Operant": Its Usefulness and some Problems.
FullText URL jfl_066_001_020.pdf
Author Hasegawa, Yoshinori|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2016-12-26
Volume volume66
Start Page 1
End Page 20
ISSN 0285-4864
language Japanese
File Version publisher
NAID 120005970818
表紙・目次
Author 岡山大学文学部|
Published Date 2016-12-26
Publication Title Journal of the Faculty of Letters Okayama University
Volume volume66
Content Type Others
ジークムント・フロイト／マルタ・ベルナイス『婚約書簡』について（一） ─ 精神分析の胎動 ─
Author Kanaseki, Takeshi|
Published Date 2016-07-25
Publication Title Journal of the Faculty of Letters Okayama University
Volume volume65
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/okadai-bun-kiyou/54792
行動分析学における｢自己」関連概念（1） スキナーの『科学と人間行動』および初期の著作
JaLCDOI 10.18926/okadai-bun-kiyou/54783
Title Alternative “Self” in Behavior Analysis（1）: Skinner’s view in his“ Science and Human Behavior” and related articles.
FullText URL jfl_065_001_028.pdf
Author Hasegawa, Yoshinori|
Publication Title Journal of the Faculty of Letters Okayama University
Published Date 2016-07-25
Volume volume65
Start Page 1
End Page 28
ISSN 0285-4864
language Japanese
File Version publisher
NAID 120005970809
表紙・目次
Author 岡山大学文学部|
Published Date 2016-07-25
Publication Title Journal of the Faculty of Letters Okayama University
Volume volume65
Content Type Others
Variations in capsaicinoid contents in the chili pepper (Capsicum baccatum) and its non-pungent accessions
Author Tanaka, Yoshiyuki| Hara, Motohito| Goto, Tanjuro| Yoshida, Yuichi| Yasuba, Ken-ichiro|
Published Date 2017-02-01
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Volume volume106
Content Type Departmental Bulletin Paper
半強制的な反復学習による基礎科目の徹底教育
Author Izumi, Minoru| Murata, Yoshiyuki|
Published Date 2017-02-01
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Volume volume106
Content Type Departmental Bulletin Paper
表紙
Author Faculty of Agriculture, Okayama University|
Published Date 2017-02-01
Publication Title Scientific Reports of the Faculty of Agriculture, Okayama University
Volume volume106
Content Type Departmental Bulletin Paper
Changing Roles of Traditional Small Urban Green Spaces (Telajakan) in Bali, Indonesia
FullText URL fulltext.pdf
Author Kato, Sadahisa| Hishiyama, Kosuke| Anak Agung Ketut Darmadi| Dewa Ngurah Suprapta|
Keywords Telajakan Bali Urban Green Spaces
Published Date 2017-01-16
Publication Title Open Journal of Ecology
Volume volume7
Issue issue1
Publisher Scientific Research Publishing
Start Page 1
End Page 11
ISSN 2162-1993
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2017 by authors
File Version publisher
DOI 10.4236/oje.2017.71001
Related Url isVersionOf https://doi.org/10.4236/oje.2017.71001
レトリックと共和政(1)
Title Alternative Rhetoric and Republic （1）
FullText URL olj_66_2_425_464.pdf
Author Omori, H.|
Publication Title Okayama Law Journal
Published Date 2016-12-28
Volume volume66
Issue issue2
Start Page 425
End Page 464
ISSN 0386-3050
language Japanese
File Version publisher
NAID 120005951485
表紙・目次
FullText URL olj_66_2_contents.pdf
Author 岡山大学法学会|
Publication Title Okayama Law Journal
Published Date 2016-12-28
Volume volume66
Issue issue2
ISSN 0386-3050
language Japanese
File Version publisher
Evaluation of Rapid Immunochromatographic Tests for Norovirus in Neonatal and Infant Faecal Specimens
FullText URL fulltext.pdf
Author Takahashi Nobumasa| Nojima, Ikuko| Araki, Tooru| Takasugi, Mizue| Sakane, Tomoko| Kodera, Aya| Ikeda, Masanori| Tsukahara, Hirokazu|
Keywords Norovirus false positive immunochromatography neonate rapid detection test specificity
Published Date 2015-09-03
Publication Title Journal of International Medical Research
Volume volume43
Issue issue5
Publisher Sage
Start Page 648
End Page 652
ISSN 0300-0605
NCID AA00700686
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 26338763
DOI 10.1177/0300060515592902
Web of Science KeyUT 000361592500006
Related Url isVersionOf https://doi.org/10.1177/0300060515592902
Predictive Values of Egg-Specific IgE by Two Commonly Used Assay Systems for the Diagnosis of Egg Allergy in Young Children: A Prospective Multicenter Study
FullText URL fulltext.pdf
Author Furuya, K.| Nagao, M.| Sato, Y.| Ito, S.| Fujisawa, T.| IPAD3g investigators|
Keywords egg allergy oral food challenge predictive value probability curve specific IgE
Note Masanori Ikeda as IPAD3g investigators|
Published Date 2016-04
Publication Title Allergy
Volume volume71
Issue issue10
Publisher Wiley
Start Page 1435
End Page 1443
ISSN 0105-4538
NCID AA00518456
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 27061295
DOI 10.1111/all.12912
Web of Science KeyUT 000386085800007
Related Url isVersionOf https://doi.org/10.1111/all.12912
数学的理解の水準を高める指導計画の再校正と授業実践　―算数科「図形の面積」（5年）の場合―
Author 山野 定寿|
Published Date 2016-10-22
Publication Title 岡山大学算数・数学教育学会誌 : パピルス
Volume volume23
Content Type Departmental Bulletin Paper
図形への多様な見方を育成するための素地指導の在り方　～1年「かたちづくり」の実践を通して～
Author 小林 秀訓|
Published Date 2016-10-22
Publication Title 岡山大学算数・数学教育学会誌 : パピルス
Volume volume23
Content Type Departmental Bulletin Paper
構成活動による図形の初期指導の在り方に関する研究　―第1学年「色板ならべ」の授業を通して―
Author 圓井 大介|
Published Date 2016-10-22
Publication Title 岡山大学算数・数学教育学会誌 : パピルス
Volume volume23
Content Type Departmental Bulletin Paper
図形の動的な見方の深まりに関する研究 ～第6学年　ジオボードの操作活動と協働的な対話を通して～
Author 磯野 嵩|
Published Date 2016-10-22
Publication Title 岡山大学算数・数学教育学会誌 : パピルス
Volume volume23
Content Type Departmental Bulletin Paper
表紙
Author 岡山大学算数・数学教育学会 |
Published Date 2016-10-22
Publication Title 岡山大学算数・数学教育学会誌 : パピルス
Volume volume23
Content Type Others
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