result 20704 件
| Author | 岡野 正樹| |
|---|---|
| Published Date | 1993-02 |
| Publication Title | 日本眼科学会雑誌 |
| Volume | volume97 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | 岡野 正樹| |
|---|---|
| Published Date | 1992-03 |
| Publication Title | 日本眼科学会雑誌 |
| Volume | volume96 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | 大枝 忠史| |
|---|---|
| Published Date | 1993-06 |
| Publication Title | 日本泌尿器科學會雜誌 |
| Volume | volume84 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | 永井 敦| |
|---|---|
| Published Date | 1992-08 |
| Publication Title | 日本泌尿器科學會雜誌 |
| Volume | volume83 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | 大橋 洋三| |
|---|---|
| Published Date | 1990-11 |
| Publication Title | 日本泌尿器科學會雜誌 |
| Volume | volume81 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | 徳山 清之| |
|---|---|
| Published Date | 1988-01 |
| Publication Title | 日本腎臓学会誌 |
| Volume | volume30 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Fang, Xing| Nunoshiba, Tatsuo| Yoshida, Midori| Nishikawa, Akiyoshi| Nemoto, Kiyomitsu| Degawa, Masakuni| Arimoto, Sakae| Okamoto, Keinosuke| Takahashi, Eizo| Negishi, Tomoe| |
|---|---|
| Published Date | 2014-02-28 |
| Publication Title | Genes and Environment |
| Volume | volume36 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/bgeou/52429 |
|---|---|
| Title Alternative | Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders |
| FullText URL | 110_0029_0034.pdf |
| Author | Sanada, Satoshi| Asano, Takashi| Oka, Eiji| Kawahara, Michiko| Sakae, Katsumi| Hiraki, Norio| Ohtahara, Shunsuke| |
| Abstract | Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA)，creatine (Cr) and choline (Ch). Hence，clinical applications of this method for neuropediatric diseases can be expected. However，regarding neuronal migration disorders，there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders，ages ranged from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr，Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ～ 3 × 3 × 5cm3 was chosen in the area including lesions，and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41，1.95，2.27 and 1.71 in cases with heterotopic gray matter，0.99 in one case with polymicrogyria，an d 1.30 in one case with hemimegalencephaly，contrasted with a contralataral area without lesions: 1.89， 2.89，2.87，2.55，3.26，2.03，respectively. 2) The ratio of Ch/Cr showed no consistent difference between the area including lesions and contralataral area without lesions. Our findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of neuronal cell population，or reduced metabolism in the lesions. |
| Keywords | MR spectroscopy migration disorder heterotopic gray matter polymicrogyria hemimegalencephaly |
| Publication Title | 岡山大学教育学部研究集録 |
| Published Date | 1999-03-15 |
| Volume | volume110 |
| Start Page | 29 |
| End Page | 34 |
| ISSN | 0471-4008 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005425646 |
| JaLCDOI | 10.18926/bgeou/52426 |
|---|---|
| Title Alternative | Laterality on the Brain Function Measured by Transcranial Doppler Blood Flowmeter |
| FullText URL | bgeou_123_101_105.pdf |
| Author | Sanada, Satoshi| Fujikawa, Yukiko| Tamaki, Ryoko| |
| Abstract | 発達障害の客観的評価法の確立を目指した研究の一環として，健常児・者における課題呈示による脳機能の左右差を経頭蓋的超音波ドプラー血流測定法(TCD) により評価するとともに，同法の有用性を検討することを目的として本研究を行った。対象は10歳から28歳の計9名の健常児・者で，エデインパラ利き手テストによる検討で全例右利きであった。TCDを用いてWISC-IIIの絵画完成カードによる課題呈示前後の血流速度と血管抵抗指数を測定し，比較検討を行った。その結果，中大脳動脈血流速度は9名中6名が右側で， 3名が左側でより大きな変化を認め，血管抵抗指数は， 9名中4名が右側で， 1名が左側でより大きな変化を認めた。エデインパラ利き手指数の結果と左中大脳動脈血流速度や血管抵抗指数の左右差との聞に一定の傾向は認められなかった。本研究で用いた課題では，両側の大脳半球機能が同時に活性化されたため，側性に関しての明瞭な結果が得られなかったものと考えられ，今後，より単純な課題の検討が妥当と思われた。 |
| Keywords | cerebral blood flow transcranial Doppler blood flowmetry Iaterality autism |
| Publication Title | 岡山大学教育学部研究集録 |
| Published Date | 2003-07-10 |
| Volume | volume123 |
| Start Page | 101 |
| End Page | 105 |
| ISSN | 0471-4008 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005425641 |
| Author | Sakata, Kenichiro| Furumatsu, Takayuki| Miyazawa, Shinichi| Okada, Yukimasa| Fujii, Masataka| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | International Orthopaedics |
| Volume | volume37 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho| |
|---|---|
| Published Date | 2013-10 |
| Publication Title | International Journal of Molecular Medicine |
| Volume | volume32 |
| Issue | issue4 |
| Content Type | Journal Article |
| FullText URL | Talanta_122_240–245.pdf |
|---|---|
| Author | Higashidani, Naoki| Kaneta, Takashi| Takeyasu, Nobuyuki| Motomizu, Shoji| Okibe, Naoko| Sasaki, Keiko| |
| Keywords | Thermoacidophilic iron-oxidizing archaeon Acidianus brierleyi Arsenic Speciation Inductively coupled plasma–optical emission spectroscopy Flow injection pretreatment |
| Published Date | 2014-05 |
| Publication Title | Talanta |
| Volume | volume122 |
| Publisher | Elsevier |
| Start Page | 240 |
| End Page | 245 |
| ISSN | 00399140 |
| NCID | AA00856594 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2014 Elsevier B.V. All rights reserved |
| File Version | author |
| PubMed ID | 24720990 |
| DOI | 10.1016/j.talanta.2014.01.057 |
| Web of Science KeyUT | 000335636700037 |
| Related Url | isVersionOf https://doi.org/10.1016/j.talanta.2014.01.057 |
| JaLCDOI | 10.18926/AMO/52407 |
|---|---|
| FullText URL | 68_2_111.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Katsube, Ryoichi| Tanabe, Shunsuke| Ohara, Toshiaki| Sakurama, Kazufumi| Fujiwara, Toshiyoshi| |
| Abstract | Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy. |
| Keywords | thoracoscopic esophagectomy prone position standardization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 111 |
| End Page | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743786 |
| Web of Science KeyUT | 000334652700006 |
| JaLCDOI | 10.18926/AMO/52406 |
|---|---|
| FullText URL | 68_2_101.pdf |
| Author | Izutsu, Masato| Suzuki, Etsuji| Izutsu, Yukako| Doi, Hiroyuki| |
| Abstract | The aim of this study was to examine trends in the geographic distribution of nursing staff in Japan from 2000 to 2010. We examined time trends in the rates of nursing staff per 100,000 population across 349 secondary health service areas. Using the Gini coefficient as a measure of inequality, we separately analyzed the data of 4 nursing staff types:public health nurses (PHN), midwives (MW), nurses (NS), and associate nurses (AN). Then, using multilevel Poisson regression models, we calculated the rate ratios (RRs) and their 95% confidence intervals (CIs) for each type of nursing staff per 1-year change. Overall, the distribution of PHN, MW, and NS improved slightly in terms of the Gini coefficient. After adjusting for prefectural capital and population density, PHN, MW, and NS significantly increased;the RRs per 1-year increment were 1.022 (95% CI:1.020-1.023), 1.021 (95% CI:1.019-1.022), and 1.037 (95% CI:1.037-1.038), respectively. In contrast, AN significantly decreased;the RR per 1-year increment was 0.993 (95% CI:0.993-0.994). Despite the considerable increase in the absolute number of nursing staff in Japan (excluding AN), this increase did not lead to a sufficient improvement in distribution over the last decade. |
| Keywords | health policy inequality Japan multilevel Poisson model nursing staff |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 101 |
| End Page | 110 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743785 |
| Web of Science KeyUT | 000334652700005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52523 |
| JaLCDOI | 10.18926/AMO/52405 |
|---|---|
| FullText URL | 68_2_89.pdf |
| Author | Sako, Shinichi| Kariyama, Reiko| Mitsuhata, Ritsuko| Yamamoto, Masumi| Wada, Koichiro| Ishii, Ayano| Uehara, Shinya| Kokeguchi, Susumu| Kusano, Nobuchika| Kumon, Hiromi| |
| Abstract | We conducted a study on molecular epidemiology and clinical implications of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolated from urine. Over a 10-year period from 2001 through 2010, a total of 92 MBL-producing P. aeruginosa urine isolates were collected from patients (one isolate per patient) who were admitted to 5 hospitals in Okayama Prefecture, Japan. When cross-infection was suspected in the hospital, pulsed-field gel electrophoresis was performed. In the resulting dendrogram of 79 MBL-producing P. aeruginosa urine isolates, no identical isolates and 7 pairs of isolates with ≥80% similarity were found. The biofilm-forming capabilities of 92 MBL-producing P. aeruginosa urine isolates were significantly greater than those of 92 non-MBL-producing urine isolates in a medium of modified artificial urine. The imipenem resistance transferred in 16 of 18 isolates tested, and these frequencies were in the range of 10－3 to 10－9. All of 18 isolates tested belonged to internationally spread sequence type 235 and had 3 gene cassettes of antimicrobial resistance genes in the class 1 integron. The strong biofilm-forming capabilities of MBL-producing P. aeruginosa urine isolates could be seriously implicated in nosocomial infections. To prevent spread of the organism and transferable genes, effective strategies to inhibit biofilm formation in medical settings are needed. |
| Keywords | Pseudomonas aeruginosa metallo-β-lactamase molecular epidemiology biofilm urinary tract infection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 89 |
| End Page | 99 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743784 |
| Web of Science KeyUT | 000334652700004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52504 |
| JaLCDOI | 10.18926/AMO/52404 |
|---|---|
| FullText URL | 68_2_79.pdf |
| Author | Mu-Mu-Shwe| Harano, Teruo| Okada, Shigeru| Aye-Aye-Win| Khin-Saw-Aye| Hlaing-Myat-Thu| Mo-Mo-Win| Khin-Khin-Oo| Myo-Khin| |
| Abstract | This study aimed to determine the prevalence of normal and abnormal cervical cytology in women who attended the cervical cancer screening clinic of the Department of Medical Research in Lower Myanmar, and to determine the proportion of high-risk (HR) human papillomavirus (HPV) infection and HPV genotypes in women with normal and abnormal cervical cytology. A total of 1,771 women were screened from 2010 to 2011. Among them, 762 women (43.0%) had a normal smear, and 866 (48.9%) and 87 (4.9%) were diagnosed with inflammatory smears and atypical squamous cells of undetermined significance (ASCUS), respectively. Diagnoses of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) numbered 42 (2.3%) and 11 (0.6%) respectively. Three cases of squamous cell carcinoma (SCC) (0.2%) were detected. Cervical swabs were collected from 96 women with abnormal cervical cytology and 20 with normal cytology. HR-HPV DNA testing was performed by polymerase chain reaction (PCR) with pU1M/pU2R primers. HR-HPV were identified in 35.5% (22/62) of inflammatory smears, 60% (6/10) of ASCUS, 86.7% (13/15) of LSIL, 50% (3/6) of HSIL, 100% (3/3) of SCC and 5% (1/20) of normal cytology. In PCR-positive cases, HPV genotyping was analyzed by the cleaved amplification polymorphism method. The most prevalent HPV genotypes were HPV-16 (60.4%) followed by HPV-31 (14.6%), HPV-18 (12.5%) and HPV-58 (12.5%). Women with abnormal cervical cytology were 10 times more likely to be HR-HPV positive than those with normal cytology (p＝0.0001). This study suggests that the implementation of a cervical cytology screening program and routine vaccination against HPV in preadolescent and adolescent groups are needed to reduce the burden of HPV-associated cervical cancer. |
| Keywords | human papillomavirus cervical neoplasia genotyping Myanmar |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 87 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743783 |
| Web of Science KeyUT | 000334652700003 |
| JaLCDOI | 10.18926/AMO/52403 |
|---|---|
| FullText URL | 68_2_63.pdf |
| Author | Fujii, Yasuyuki| Hoshino, Tyuji| Kumon, Hiromi| |
| Abstract | Dickkopf (DKK) proteins interact with low-density lipoprotein receptor-related protein 5/6 (LRP5/6) to modulate WNT signaling. The interaction is mediated by a cysteine-rich domain (C2) in the DKK protein and β-propeller domains (PD) of LRP5/6. However, the third member of the DKK family (DKK3) does not bind to LRP5/6. To determine why DKK3 does not bind to the receptor domains, we performed a molecular modeling simulation study including homology modeling, protein-protein docking and molecular dynamics (MD). The computed affinities (ΔGbinding) between the C2 and PD models were consistent with the previously reported experimental results. The C2 model of DKK3 showed the lowest affinity for PD models. Multiple sequence alignment of C2 domains revealed that the DKK3 genes have a unique 7-amino-acid insertion (L249-E255 in human DKK3) and P258 in a finger loop 1 (FL1). Interestingly, the insertion sequence is evolutionally conserved. MD simulations of high-affinity complex models of C2 and PD showed that FL1 directly interacts with the PD models and stabilizes the complex models. We also built a 7-amino-acid-deletion/P258G mutant model of DKK3C2 and estimated its affinities for the PD models. The affinity for human LRP5PD2 was increased by the substitution (ΔGbinding＝－48.9kcal/mol) and the affinity was compatible with that of high-affinity ligands. The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. The sequence differences thus suggest an explanation for this unique property of DKK3. |
| Keywords | DKK3 molecular modeling protein-protein docking LRP5/6 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 63 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743782 |
| Web of Science KeyUT | 000334652700002 |
| JaLCDOI | 10.18926/AMO/52402 |
|---|---|
| FullText URL | 68_2_57.pdf |
| Author | Hagiya, Hideharu| Naito, Hiromichi| Hagioka, Shingo| Okahara, Shuji| Morimoto, Naoki| Kusano, Nobuchika| Otsuka, Fumio| |
| Abstract | The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups:those administered antibiotics perioperatively and those not administered antibiotics. Wound infections were noted in 7 cases (incidence rate, 2.36%) and no death was recorded. Of the 69 patients without antibiotics, 5 developed wound infections (incidence rate, 7.25%), while only 2 of the 228 patients with antibiotics developed wound infections (incidence rate, 0.88%) (p＝0.002;risk ratio, 8.82;95% confidence interval, 1.67-46.6). Of the 7 cases of wound infection, 5 cases occurred during the early period after PDT (within 7 days). Collectively, the present results suggest that prophylactic administration of antibiotics may prevent the incidence of PDT-induced wound infection, especially in the early phase after the PDT procedures. The need for antibiotics in PDT should be reconsidered. |
| Keywords | airway management critically ill patient percutaneous dilatational tracheostomy surgical site infection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 57 |
| End Page | 62 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743781 |
| Web of Science KeyUT | 000334652700001 |
| Author | 三宅 通博| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | 環境制御 |
| Volume | volume35 |
| Content Type | Others |
| Author | 岡山大学環境管理センター| |
|---|---|
| Published Date | 2015-02 |
| Publication Title | 環境制御 |
| Volume | volume36 |
| Content Type | Others |
