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FullText URL PLoSONE_0050082.PDF
Author Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko|
Published Date 2012-11-26
Publication Title PLoS ONE
Volume volume7
Issue issue11
Publisher Public Library of Science
Start Page e50082
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 23189181
DOI 10.1371/journal.pone.0050082
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0050082
FullText URL NeurobiolDis_50_209.pdf
Author Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Mori, Akiko| Michiue, Hiroyuki| Nishiki, Teiichi| Ohtsuka, Yoko| Matsui, Hideki|
Note CACNA1A variants contribute to severity of seizures in Dravet syndrome|
Published Date 2013-02
Publication Title Neurobiology of disease
Volume volume50
Publisher Academic Press
Start Page 209
End Page 217
ISSN 09699961
NCID AA11645502
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 23103419
DOI 10.1016/j.nbd.2012.10.016
Web of Science KeyUT 000313758100023
Related Url isVersionOf https://doi.org/10.1016/j.nbd.2012.10.016
JaLCDOI 10.18926/AMO/56941
FullText URL 73_4_373.pdf
Author Oda, Yoshiaki| Yamauchi, Tarou| Tanaka, Masato|
Abstract A minimally invasive surgical (MIS) procedure is an ideal surgical procedure. Many MIS techniques have been reported in spinal surgery. In clinical practice, we often encounter two-level canal stenosis cases, in which one level shows instability and the other does not. In such a case, fusion surgery for one level and decompression surgery for the other level is ideal. LLIF/OLIF approached from the lateral side has been reported effective. MIS decompression techniques in the lateral decubitus position have never been reported. We devised a surgical method that can accomplish both fixation and decompression in a consistent lateral decubitus position.
Keywords microendoscopic surgery lateral position navigation minimally invasive surgery image free
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 373
End Page 377
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439962
JaLCDOI 10.18926/AMO/56940
FullText URL 73_4_367.pdf
Author Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Abstract Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
Keywords autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 367
End Page 372
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56937
FullText URL 73_4_349.pdf
Author Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro|
Abstract To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS.
Keywords ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 349
End Page 356
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439958
JaLCDOI 10.18926/AMO/56936
FullText URL 73_4_341.pdf
Author Kitajima, Kazuhiro| Yamamoto, Shingo| Nakanishi, Yukako| Yamada, Yusuke| Hashimoto, Takahiko| Suzuki, Toru| Go, Shuken| Kanematsu, Akihiro| Nojima, Michio| Fujiwara, Masayuki| Kaida, Hayato| Tsurusaki, Masakatsu| Kanda, Tomonori| Tamaki, Yukihisa | Yamakado, Koichiro|
Abstract We investigated the effectiveness of 11C-choline-positron emission tomography/computed tomography (PET/CT) for evaluating treatment response in patients with prostate cancer or renal cell carcinoma. We performed 34 11C-choline PET/CT scans before/after a combined total of 17 courses of treatment in 6 patients with prostate cancer and 2 with renal cell carcinoma. The 17 treatments including hormonal therapy, radiotherapy, chemotherapy, radium-223, molecular target therapy, radiofrequency ablation, transcatheter arterial embolization, and cancer immunotherapy yielded 1 (5.9%) complete metabolic response (CMR), 3 (17.6%) partial metabolic responses (PMRs), 2 (11.8%) stable metabolic diseases (SMDs), and 11 (64.7%) progressive metabolic diseases (PMDs). Target lesions were observed in bone (n=14), lymph nodes (n=5), lung (n=2), prostate (n=2), and pleura (n=1), with CMR in 4, PMR in 10, SMD in 8 and PMD in 2 lesions. SUVmax values of the target lesions before and after treatment were 7.87±2.67 and 5.29±3.98, respectively, for a mean reduction of −35.4±43.6%. The response for the 8 prostate cancer-treatment courses was PMD, which correlated well with changes in serum prostatic specific antigen (PSA) (7 of 8 cases showed increased PSA). 11C-choline-PET/CT may be an effective tool for detecting viable residual tumors and evaluating treatment response in prostate cancer and renal cell carcinoma patients.
Keywords treatment response 11C-choline PET/CT prostate cancer renal cell carcinoma
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 341
End Page 347
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439957
JaLCDOI 10.18926/AMO/56935
FullText URL 73_4_333.pdf
Author Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
Abstract Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
Keywords antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 333
End Page 339
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439956
JaLCDOI 10.18926/AMO/56934
FullText URL 73_4_325.pdf
Author Ueno, Tsuyoshi| Maki, Yuho| Sugimoto, Ryujiro| Suehisa, Hiroshi| Yamashita, Motohiro| Harada, Daijiro| Kozuki, Toshiyuki| Nogami, Naoyuki|
Abstract Therapeutic approaches to bronchopleural fistula (BPF) closure after lung resection are surgical or endoscopic interventions. We evaluated therapeutic outcomes to determine the optimal approach. We reviewed 15 patients who had developed BPF after lung resection for thoracic malignant diseases at our institution in the 10 years since 2008. The patients were 11 men and 4 women (mean age 68 years). We performed one pneumonectomy, 6 lobectomies, 7 segmentectomies, and one partial resection for malignant diseases. The median interval from lung resection to the BPF diagnosis was 46 days. The BPF-associated mortality rate was 26.7% (4/15). The rate of successful BPF closure was 66.6% (10/15). The endoscopic and surgical intervention success rates were 14.2% (1/7) and 69.2% (9/13), respectively (p<0.01). Of 5 patients who had failed BPF treatments, 4 died, and one transferred out without BPF closure. The therapeutic outcomes were related to preoperative comorbidities, performance status at the BPF diagnosis, time intervals from lung resection to BPF diagnosis, and presence of active pneumonia. The difference between endoscopic and surgical outcomes was nonsignificant, although the surgical intervention success rate was somewhat higher. The selection of endoscopic or surgical intervention for BPF does not significantly affect therapeutic outcomes.
Keywords bronchopleural fistula endoscopic intervention surgical intervention
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 325
End Page 331
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439955
JaLCDOI 10.18926/AMO/56933
FullText URL 73_4_315.pdf
Author Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya|
Abstract The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
Keywords periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 315
End Page 323
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439954
JaLCDOI 10.18926/AMO/56931
FullText URL 73_4_299.pdf
Author Hiranaka, Takaaki| Nishida, Keiichiro| Konishiike, Taizo| Ozaki, Toshifumi| Mikasa, Motohiko|
Abstract The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable
Keywords humeral head replacement tuberosity-overlapping technique bone union of tuberosities cable wire cementless stem
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 299
End Page 305
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439952
JaLCDOI 10.18926/AMO/56930
FullText URL 73_4_285.pdf
Author Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
Abstract Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
Keywords glioma cytoskeletons invasion microtubules
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2019-08
Volume volume73
Issue issue4
Publisher Okayama University Medical School
Start Page 285
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31439951
JaLCDOI 10.18926/bgeou/56927
Title Alternative A Study of Dazai Osamu’s Hashire Merosu : Focusing on “Being Trusted”
FullText URL bgeou_171_(001)_(008).pdf
Author KIMURA, Takumi|
Abstract  本論では、「走れメロス」の主人公メロスの人物像を、「葡萄の季節」、「二つの約束」、「信頼されてゐる」ことの、三つの観点から読みなおした。「葡萄の季節」では、メロスと妹婿になる牧人の、結婚式の時期の齟齬から見えてくる問題を指摘した。「二つの約束」では、王とセリヌンティウスの二人にとっての約束の意味の相違に注目し、メロスがセリヌンティウスへの意識が低いことを指摘した上で、メロスが「信頼されてゐる」ことの意味を理解したことが、「恐ろしく大きいもの」という発言に繋がると考えた。以上の考察から、「走れメロス」は友情をテーマとする作品というだけでなく、他者から信頼される意味を理解することに注目した作品であることを明らかにした。
Publication Title Bulletin of Graduate School of Education, Okayama University
Published Date 2019-07-26
Volume volume171
Start Page (1)
End Page (8)
ISSN 1883-2423
language Japanese
File Version publisher
NAID 120006711420
JaLCDOI 10.18926/bgeou/56919
Title Alternative A Comparative Study on Teacher Training Systems
FullText URL bgeou_171_001_012.pdf
Author ONOUE, Masanobu| KAJII, Kazuaki| KAWANO, Masayuki| AKINAGA, Saho| SERA, Miria| WANG, Yunjia|
Abstract  本研究では現在の日本において喫緊の課題である教員の働き方改革について,現行の教員養成制度と諸外国の教員養成制度について取り上げ,研究対象とした諸外国の教員養成の歴史を踏まえて比較・考察を行った。その結果,日本では教員養成の高度化が進んでいないことなどが明らかになっただけでなく,教員養成制度を改革することで新任教員だけでなく現職の教員にとっても良い影響を及ぼす可能性があることがわかった。長時間労働,新任教員の依願退職者数の増加など多くの課題を抱えている日本において諸外国の教員養成制度は,これからの教員養成について示唆を与えている。
Keywords 教員養成制度 国際比較 日本 アメリカ フランス 中国
Publication Title Bulletin of Graduate School of Education, Okayama University
Published Date 2019-07-26
Volume volume171
Start Page 1
End Page 12
ISSN 1883-2423
language Japanese
File Version publisher
NAID 120006711412
FullText URL bgeou_171_contents.pdf
Publication Title Bulletin of Graduate School of Education, Okayama University
Published Date 2019-07-26
Volume volume171
ISSN 1883-2423
language Japanese
File Version publisher
Title Alternative Annual report / Institute of Plant Science and Resources, Okayama University
FullText URL IPSR_26.pdf
Author Institute of Plant Science and Resources, Okayama University|
Publication Title Annual Report, Institute of Plant Science and Resources Okayama University
Published Date 2019-03-31
Volume volume26
Start Page 1
End Page 71
ISSN 2186-4918
language Japanese
File Version publisher
File URL 04631kogomemizu.jpg k-kogomemizu.jpg
APG3family イラクサ科 (Urticaceae)
YList ylist.info/ylist_detail_display.php?pass=2561
Database Naturalized plants in Japan : Seed-Image database
Database(alternative) Naturalized plants in Japan : Seed-Image database
Publisher 岡山大学 資源植物科学研究所 野生植物グループ
Resource Type Data or Dataset
Official URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
FullText URL NatCom_10_1_3022.pdf
Author Belay, Iyasu Getachew| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Nakamura, Eizo|
Published Date 2019-07
Publication Title Nature Communications
Volume volume10
Issue issue1
Publisher Springer Nature Publishing AG
Start Page 3022
ISSN 20411723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31289264
DOI 10.1038/s41467-019-10832-7
Web of Science KeyUT 000474506700008
Related Url isVersionOf https://doi.org/10.1038/s41467-019-10832-7
FullText URL oer_051_1_contents_eng.pdf
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
JaLCDOI 10.18926/OER/56912
Title Alternative J. H. Clapham, An Economic History of Modern Britain, vol. 3, Machines and National Rivalries (1887-1914), with an Epilogue (1914-1929), Outline, Chap.8
FullText URL oer_051_1_059_083.pdf
Author Ichinose, Atsushi|
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 59
End Page 83
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
NAID 120006652411
JaLCDOI 10.18926/OER/56911
FullText URL oer_051_1_035_058.pdf
Author Matsuo, Nobushige|
Publication Title Okayama Economic Review
Published Date 2019-07-16
Volume volume51
Issue issue1
Start Page 35
End Page 58
ISSN 2433-4146
language Japanese
Copyright Holders Copyright © 2019 岡山大学経済学会
File Version publisher
NAID 120006652410