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フルテキストURL olj_69_1_contents.pdf
出版物タイトル 岡山大學法學會雜誌
発行日 2019-08-30
69巻
1号
ISSN 0386-3050
言語 日本語
論文のバージョン publisher
フルテキストURL PLoSONE_0050082.PDF
著者 Kobuchi, Hirotsugu| Moriya, Koko| Ogino, Tetsuya| Fujita, Hirofumi| Inoue, Keiji| Shuin, Taro| Yasuda, Tatsuji| Utsumi, Kozo| Utsumi, Toshihiko|
発行日 2012-11-26
出版物タイトル PLoS ONE
7巻
11号
出版者 Public Library of Science
開始ページ e50082
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン publisher
PubMed ID 23189181
DOI 10.1371/journal.pone.0050082
関連URL isVersionOf https://doi.org/10.1371/journal.pone.0050082
フルテキストURL NeurobiolDis_50_209.pdf
著者 Ohmori, Iori| Ouchida, Mamoru| Kobayashi, Katsuhiro| Jitsumori, Yoshimi| Mori, Akiko| Michiue, Hiroyuki| Nishiki, Teiichi| Ohtsuka, Yoko| Matsui, Hideki|
備考 CACNA1A variants contribute to severity of seizures in Dravet syndrome|
発行日 2013-02
出版物タイトル Neurobiology of disease
50巻
出版者 Academic Press
開始ページ 209
終了ページ 217
ISSN 09699961
NCID AA11645502
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 23103419
DOI 10.1016/j.nbd.2012.10.016
Web of Science KeyUT 000313758100023
関連URL isVersionOf https://doi.org/10.1016/j.nbd.2012.10.016
JaLCDOI 10.18926/AMO/56941
フルテキストURL 73_4_373.pdf
著者 Oda, Yoshiaki| Yamauchi, Tarou| Tanaka, Masato|
抄録 A minimally invasive surgical (MIS) procedure is an ideal surgical procedure. Many MIS techniques have been reported in spinal surgery. In clinical practice, we often encounter two-level canal stenosis cases, in which one level shows instability and the other does not. In such a case, fusion surgery for one level and decompression surgery for the other level is ideal. LLIF/OLIF approached from the lateral side has been reported effective. MIS decompression techniques in the lateral decubitus position have never been reported. We devised a surgical method that can accomplish both fixation and decompression in a consistent lateral decubitus position.
キーワード microendoscopic surgery lateral position navigation minimally invasive surgery image free
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 373
終了ページ 377
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439962
JaLCDOI 10.18926/AMO/56940
フルテキストURL 73_4_367.pdf
著者 Mifune-Morioka, Tomoyo| A. Uchida, Haruhito| Fukushima, Kazuhiko| Watanabe, Mayu| Ouchi, Chihiro| Mise, Koki| Kawakita, Chieko| Kano, Yuzuki| Onishi, Akifumi| Toma, Kishio| Eguchi, Jun| Wada, Nozomu| Ikeda, Fusao| Sasaki, Erika| Suganami, Yu| Kishida, Masayuki| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
抄録 Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
キーワード autoimmune polyglandular syndrome type 3 systemic lupus erythematosus autoimmune hepatitis slowly progressive insulin-dependent diabetes mellitus chronic thyroiditis
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 367
終了ページ 372
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439961
JaLCDOI 10.18926/AMO/56937
フルテキストURL 73_4_349.pdf
著者 Isozaki, Hiroshi| Yamamoto, Yasuhisa| Murakami, Shigeki| Matsumoto, Sasau| Takama, Takehiro|
抄録 To clarify the surgical outcomes of breast cancer patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) by core needle biopsy (CNB) (abbreviated as CNBDCIS), we retrospectively analyzed the cases of 131 patients with CNBDCIS who underwent surgery at Oomoto Hospital (32 total mastectomies, 99 conservative mastectomies). Our analysis of underestimation and predictors of invasive breast cancer of CNBDCIS revealed that the underestimation rate of CNBDCIS was 40.5% (53/131). A logistic regression analysis revealed that palpable tumors (yes to no, odds ratio [OR] 3.25), mammography (MMG) category group (category 4 or 5 to categories 1 , 2, or 3, OR 4.69) and MMG microcalcifications (no to yes, OR 0.24) were significant predictive factors for CNBDCIS invasion. In our analysis of the predictors of positive margins during CNBDCIS surgery, 36 (27.5%) of the 131 patients had positive margins after postoperative pathological examination. A logistic regression analysis revealed that the operative procedure (conservative surgery to total mastectomy, OR 21.4) and MMG microcalcifications (yes to no, OR 3.35) were significant factors related to positive margins during CNBDCIS surgery. Thus, MMG microcalcifications are a negative predictor of upgrading of CNBDCIS and a positive predictor of positive surgical margins for CNBDCIS.
キーワード ductal carcinoma in situ core needle biopsy underestimation positive margins microcalcifications on mammography
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 349
終了ページ 356
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439958
JaLCDOI 10.18926/AMO/56936
フルテキストURL 73_4_341.pdf
著者 Kitajima, Kazuhiro| Yamamoto, Shingo| Nakanishi, Yukako| Yamada, Yusuke| Hashimoto, Takahiko| Suzuki, Toru| Go, Shuken| Kanematsu, Akihiro| Nojima, Michio| Fujiwara, Masayuki| Kaida, Hayato| Tsurusaki, Masakatsu| Kanda, Tomonori| Tamaki, Yukihisa | Yamakado, Koichiro|
抄録 We investigated the effectiveness of 11C-choline-positron emission tomography/computed tomography (PET/CT) for evaluating treatment response in patients with prostate cancer or renal cell carcinoma. We performed 34 11C-choline PET/CT scans before/after a combined total of 17 courses of treatment in 6 patients with prostate cancer and 2 with renal cell carcinoma. The 17 treatments including hormonal therapy, radiotherapy, chemotherapy, radium-223, molecular target therapy, radiofrequency ablation, transcatheter arterial embolization, and cancer immunotherapy yielded 1 (5.9%) complete metabolic response (CMR), 3 (17.6%) partial metabolic responses (PMRs), 2 (11.8%) stable metabolic diseases (SMDs), and 11 (64.7%) progressive metabolic diseases (PMDs). Target lesions were observed in bone (n=14), lymph nodes (n=5), lung (n=2), prostate (n=2), and pleura (n=1), with CMR in 4, PMR in 10, SMD in 8 and PMD in 2 lesions. SUVmax values of the target lesions before and after treatment were 7.87±2.67 and 5.29±3.98, respectively, for a mean reduction of −35.4±43.6%. The response for the 8 prostate cancer-treatment courses was PMD, which correlated well with changes in serum prostatic specific antigen (PSA) (7 of 8 cases showed increased PSA). 11C-choline-PET/CT may be an effective tool for detecting viable residual tumors and evaluating treatment response in prostate cancer and renal cell carcinoma patients.
キーワード treatment response 11C-choline PET/CT prostate cancer renal cell carcinoma
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 341
終了ページ 347
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439957
JaLCDOI 10.18926/AMO/56935
フルテキストURL 73_4_333.pdf
著者 Kuwaki, Kenji| Nouso, Kazuhiro| Miyashita, Manabi| Makino, Yasuhiro| Hagihara, Hiroaki| Moriya, Akio| Adachi, Takuya| Wada, Nozomu| Yasunaka, Yuki| Yasunaka, Tetsuya| Takeuchi, Yasuto| Onishi, Hideki| Nakamura, Shinichiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
抄録 Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.
キーワード antipyretic hepatocellular carcinoma therapeutic chemoembolization steroid
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 333
終了ページ 339
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439956
JaLCDOI 10.18926/AMO/56934
フルテキストURL 73_4_325.pdf
著者 Ueno, Tsuyoshi| Maki, Yuho| Sugimoto, Ryujiro| Suehisa, Hiroshi| Yamashita, Motohiro| Harada, Daijiro| Kozuki, Toshiyuki| Nogami, Naoyuki|
抄録 Therapeutic approaches to bronchopleural fistula (BPF) closure after lung resection are surgical or endoscopic interventions. We evaluated therapeutic outcomes to determine the optimal approach. We reviewed 15 patients who had developed BPF after lung resection for thoracic malignant diseases at our institution in the 10 years since 2008. The patients were 11 men and 4 women (mean age 68 years). We performed one pneumonectomy, 6 lobectomies, 7 segmentectomies, and one partial resection for malignant diseases. The median interval from lung resection to the BPF diagnosis was 46 days. The BPF-associated mortality rate was 26.7% (4/15). The rate of successful BPF closure was 66.6% (10/15). The endoscopic and surgical intervention success rates were 14.2% (1/7) and 69.2% (9/13), respectively (p<0.01). Of 5 patients who had failed BPF treatments, 4 died, and one transferred out without BPF closure. The therapeutic outcomes were related to preoperative comorbidities, performance status at the BPF diagnosis, time intervals from lung resection to BPF diagnosis, and presence of active pneumonia. The difference between endoscopic and surgical outcomes was nonsignificant, although the surgical intervention success rate was somewhat higher. The selection of endoscopic or surgical intervention for BPF does not significantly affect therapeutic outcomes.
キーワード bronchopleural fistula endoscopic intervention surgical intervention
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 325
終了ページ 331
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439955
JaLCDOI 10.18926/AMO/56933
フルテキストURL 73_4_315.pdf
著者 Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya|
抄録 The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains.
キーワード periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 315
終了ページ 323
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439954
JaLCDOI 10.18926/AMO/56931
フルテキストURL 73_4_299.pdf
著者 Hiranaka, Takaaki| Nishida, Keiichiro| Konishiike, Taizo| Ozaki, Toshifumi| Mikasa, Motohiko|
抄録 The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable
キーワード humeral head replacement tuberosity-overlapping technique bone union of tuberosities cable wire cementless stem
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 299
終了ページ 305
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439952
JaLCDOI 10.18926/AMO/56930
フルテキストURL 73_4_285.pdf
著者 Otani, Yoshihiro| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao|
抄録 Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
キーワード glioma cytoskeletons invasion microtubules
Amo Type Review
出版物タイトル Acta Medica Okayama
発行日 2019-08
73巻
4号
出版者 Okayama University Medical School
開始ページ 285
終了ページ 297
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 CopyrightⒸ 2019 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 31439951
JaLCDOI 10.18926/bgeou/56927
タイトル(別表記) A Study of Dazai Osamu’s Hashire Merosu : Focusing on “Being Trusted”
フルテキストURL bgeou_171_(001)_(008).pdf
著者 木村 功|
抄録  本論では、「走れメロス」の主人公メロスの人物像を、「葡萄の季節」、「二つの約束」、「信頼されてゐる」ことの、三つの観点から読みなおした。「葡萄の季節」では、メロスと妹婿になる牧人の、結婚式の時期の齟齬から見えてくる問題を指摘した。「二つの約束」では、王とセリヌンティウスの二人にとっての約束の意味の相違に注目し、メロスがセリヌンティウスへの意識が低いことを指摘した上で、メロスが「信頼されてゐる」ことの意味を理解したことが、「恐ろしく大きいもの」という発言に繋がると考えた。以上の考察から、「走れメロス」は友情をテーマとする作品というだけでなく、他者から信頼される意味を理解することに注目した作品であることを明らかにした。
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2019-07-26
171巻
開始ページ (1)
終了ページ (8)
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120006711420
JaLCDOI 10.18926/bgeou/56919
タイトル(別表記) A Comparative Study on Teacher Training Systems
フルテキストURL bgeou_171_001_012.pdf
著者 尾上 雅信| 梶井 一暁| 河野 将之| 秋永 沙穂| 瀨良 美璃亜| 王 運佳|
抄録  本研究では現在の日本において喫緊の課題である教員の働き方改革について,現行の教員養成制度と諸外国の教員養成制度について取り上げ,研究対象とした諸外国の教員養成の歴史を踏まえて比較・考察を行った。その結果,日本では教員養成の高度化が進んでいないことなどが明らかになっただけでなく,教員養成制度を改革することで新任教員だけでなく現職の教員にとっても良い影響を及ぼす可能性があることがわかった。長時間労働,新任教員の依願退職者数の増加など多くの課題を抱えている日本において諸外国の教員養成制度は,これからの教員養成について示唆を与えている。
キーワード 教員養成制度 国際比較 日本 アメリカ フランス 中国
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2019-07-26
171巻
開始ページ 1
終了ページ 12
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
NAID 120006711412
フルテキストURL bgeou_171_contents.pdf
出版物タイトル 岡山大学大学院教育学研究科研究集録
発行日 2019-07-26
171巻
ISSN 1883-2423
言語 日本語
論文のバージョン publisher
タイトル(別表記) Annual report / Institute of Plant Science and Resources, Okayama University
フルテキストURL IPSR_26.pdf
著者 岡山大学資源植物科学研究所|
出版物タイトル 岡山大学資源植物科学研究所報告
発行日 2019-03-31
26巻
開始ページ 1
終了ページ 71
ISSN 2186-4918
言語 日本語
論文のバージョン publisher
ファイルURL 04631kogomemizu.jpg k-kogomemizu.jpg
APG3科 イラクサ科 (Urticaceae)
YList ylist.info/ylist_detail_display.php?pass=2561
データベース 日本の雑草 種子画像データデース
データベース(別表記) Naturalized plants in Japan : Seed-Image database
公開者 岡山大学 資源植物科学研究所 野生植物グループ
資料タイプ データ・データベース
公式URL http://www.rib.okayama-u.ac.jp/wild/okayama_kika_v2/Seed-image-database-J.html|
フルテキストURL NatCom_10_1_3022.pdf
著者 Belay, Iyasu Getachew| Tanaka, Ryoji| Kitagawa, Hiroshi| Kobayashi, Katsura| Nakamura, Eizo|
発行日 2019-07
出版物タイトル Nature Communications
10巻
1号
出版者 Springer Nature Publishing AG
開始ページ 3022
ISSN 20411723
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2019
論文のバージョン publisher
PubMed ID 31289264
DOI 10.1038/s41467-019-10832-7
Web of Science KeyUT 000474506700008
関連URL isVersionOf https://doi.org/10.1038/s41467-019-10832-7
フルテキストURL oer_051_1_contents_eng.pdf
出版物タイトル 岡山大学経済学会雑誌
発行日 2019-07-16
51巻
1号
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2019 岡山大学経済学会
論文のバージョン publisher
JaLCDOI 10.18926/OER/56912
タイトル(別表記) J. H. Clapham, An Economic History of Modern Britain, vol. 3, Machines and National Rivalries (1887-1914), with an Epilogue (1914-1929), Outline, Chap.8
フルテキストURL oer_051_1_059_083.pdf
著者 一ノ瀬 篤|
出版物タイトル 岡山大学経済学会雑誌
発行日 2019-07-16
51巻
1号
開始ページ 59
終了ページ 83
ISSN 2433-4146
言語 日本語
著作権者 Copyright © 2019 岡山大学経済学会
論文のバージョン publisher
NAID 120006652411