result 1351 件
| JaLCDOI | 10.18926/AMO/64043 |
|---|---|
| FullText URL | 76_5_605.pdf |
| Author | Teraishi, Fuminori| Jikuhara, Atsushi| Ogawa, Ryunosuke| Fujiwara, Toshiyoshi| |
| Abstract | An 84-year-old female underwent open right hemicolectomy with D3 lymph node dissection for cecal cancer, pathologically identified as pT4aN2M0 Stage IIIc and BRAF mutation-positive. Due to early recurrence of abdominal wall and right lateral lymph nodes, the patient was treated with FOLFOXIRI+Bevacizumab. Imaging after 5 courses of chemotherapy found tumor shrinkage and no new metastases. The patient did not tolerate chemotherapy well, and tumor resection was performed. Microsatellite instability (MSI) testing using multiplex polymerase chain reaction (PCR) fragment analysis revealed MSI-high status. The patient is currently recurrence-free without chemotherapy at 1 year postoperatively. BRAF-mutated colorectal cancer has a poor prognosis, and may require resection of the metastatic or recurrent tumor after comprehensive evaluation. |
| Keywords | BRAF V600E mutation cecal cancer, MSI-high |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 605 |
| End Page | 608 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352809 |
| Web of Science KeyUT | 000884907100015 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sukegawa, Shintaro| Tanaka, Futa| Hara, Takeshi| Yoshii, Kazumasa| Yamashita, Katsusuke| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko| |
| Published Date | 2022-10-08 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 16925 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 36209283 |
| DOI | 10.1038/s41598-022-21408-9 |
| Web of Science KeyUT | 000865228800021 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-21408-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobashi, Mayu| Iwamuro, Masaya| Kuraoka, Sakiko| Inoo, Shoko| Okanoue, Shotaro| Satomi, Takuya| Hamada, Kenta| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Tanaka, Takehiro| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Keywords | familial adenomatous polyposis gastric adenoma gastric cancer phenotypic variations |
| Published Date | 2022-10-14 |
| Publication Title | Medicine |
| Volume | volume101 |
| Issue | issue41 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | e30997 |
| ISSN | 0025-7974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 the Author(s). |
| File Version | publisher |
| PubMed ID | 36254079 |
| DOI | 10.1097/MD.0000000000030997 |
| Web of Science KeyUT | 000868085500032 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000030997 |
| FullText URL | fulltext20230112-5.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Tanaka, Takehiro| Omote, Rika| Okada, Toshiaki| Notohara, Kenji| Okada, Kazuya| |
| Published Date | 2022 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume62 |
| Issue | issue4 |
| Publisher | Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 226 |
| End Page | 237 |
| ISSN | 1346-4280 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 36171112 |
| DOI | 10.3960/jslrt.22015 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.22015 |
| FullText URL | fulltext20221017-3.pdf figure20221017-3.pdf |
|---|---|
| Author | Morizane, Shin| Sunagawa, Ko| Nomura, Hayato| Ouchida, Mamoru| |
| Keywords | Atopic dermatitis Serine protease Kallikrein-related peptidases Lympho-epithelial Kazal-type-related inhibitor Protease -activated receptor 2 |
| Note | © 2022 Japanese Society for Investigative Dermatology. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jdermsci.2022.06.004] . | This fulltext is available in July 2023.| |
| Published Date | 2022-07 |
| Publication Title | Journal of Dermatological Science |
| Volume | volume107 |
| Issue | issue1 |
| Publisher | Elsevier BV |
| Start Page | 2 |
| End Page | 7 |
| ISSN | 0923-1811 |
| NCID | AA1075636X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Japanese Society for Investigative Dermatology |
| File Version | author |
| PubMed ID | 35817663 |
| DOI | 10.1016/j.jdermsci.2022.06.004 |
| Web of Science KeyUT | 000863858700001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jdermsci.2022.06.004 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tomonobu, Nahoko| Kinoshita, Rie| Wake, Hidenori| Inoue, Yusuke| Ruma, I. Made Winarsa| Suzawa, Ken| Gohara, Yuma| Komalasari, Ni Luh Gede Yoni| Jiang, Fan| Murata, Hitoshi| Yamamoto, Ken-Ichi| Sumardika, I. Wayan| Chen, Youyi| Futami, Junichiro| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Toyooka, Shinichi| Nishibori, Masahiro| Sakaguchi, Masakiyo| |
| Keywords | S100A8/A9 HRG metastasis |
| Published Date | 2022-09-07 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 10300 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36142212 |
| DOI | 10.3390/ijms231810300 |
| Web of Science KeyUT | 000858719600001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231810300 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yang, Guang| |
| Keywords | gastric adenocarcinoma of fundic gland microsatellite instability mismatch repair deficiency Wnt/beta-catenin signaling pathway |
| Published Date | 2022-08-26 |
| Publication Title | Medicine |
| Volume | volume101 |
| Issue | issue34 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | e30311 |
| ISSN | 0025-7974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 the Author(s). |
| File Version | publisher |
| PubMed ID | 36042639 |
| DOI | 10.1097/MD.0000000000030311 |
| Web of Science KeyUT | 000847532100073 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000030311 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishikori, Asami| Nishimura, Midori Filiz| Nishimura, Yoshito| Otsuka, Fumio| Maehama, Kanna| Ohsawa, Kumiko| Momose, Shuji| Nakamura, Naoya| Sato, Yasuharu| |
| Keywords | Castleman disease idiopathic multicentric Castleman disease idiopathic plasmacytic lymphadenopathy plasma cell morphology |
| Published Date | 2022-09-07 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 10301 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36142213 |
| DOI | 10.3390/ijms231810301 |
| Web of Science KeyUT | 000856382100001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231810301 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Abe, Makoto| Sakae, Hiroyuki| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Tanaka, Takehiro| Kawano, Seiji| Otsuka, Fumio| Kawahara, Yoshiro| Yanai, Hiroyuki| Okada, Hiroyuki| |
| Keywords | eradication flow cytometry Helicobacter pylori T lymphocytes |
| Published Date | 2022-08-26 |
| Publication Title | Medicine |
| Volume | volume101 |
| Issue | issue34 |
| Publisher | Lippincott Williams & Wilkins |
| Start Page | e30241 |
| ISSN | 0025-7974 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 the Author(s). |
| File Version | publisher |
| PubMed ID | 36042652 |
| DOI | 10.1097/MD.0000000000030241 |
| Web of Science KeyUT | 000847532100050 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000030241 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro| |
| Keywords | Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment |
| Published Date | 2022-09-12 |
| Publication Title | Breast Cancer Research |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 60 |
| ISSN | 1465-5411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 36096830 |
| DOI | 10.1186/s13058-022-01557-5 |
| Web of Science KeyUT | 000853036400001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13058-022-01557-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwamuro, Masaya| Murayama, Somay Yamagata| Nakamura, Masahiko| Hamada, Kenta| Tanaka, Takehiro| Okada, Hiroyuki| |
| Published Date | 2022-07-20 |
| Publication Title | Case Reports In Gastrointestinal Medicine |
| Volume | volume2022 |
| Publisher | Hindawi Ltd |
| Start Page | 4254605 |
| ISSN | 2090-6528 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Masaya Iwamuro et al. |
| File Version | publisher |
| PubMed ID | 35911659 |
| DOI | 10.1155/2022/4254605 |
| Web of Science KeyUT | 000853251100001 |
| Related Url | isVersionOf https://doi.org/10.1155/2022/4254605 |
| JaLCDOI | 10.18926/AMO/63908 |
|---|---|
| FullText URL | 76_4_479.pdf |
| Author | Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi| |
| Abstract | A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance. |
| Keywords | hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123164 |
| Web of Science KeyUT | 000882167300012 |
| JaLCDOI | 10.18926/AMO/63907 |
|---|---|
| FullText URL | 76_4_473.pdf |
| Author | Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao| |
| Abstract | Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully. |
| Keywords | glioneuronal tumor with neuropil-like islands genomic profiling |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 473 |
| End Page | 477 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123163 |
| JaLCDOI | 10.18926/AMO/63904 |
|---|---|
| FullText URL | 76_4_447.pdf |
| Author | Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro| |
| Abstract | The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner. |
| Keywords | complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 447 |
| End Page | 455 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123160 |
| JaLCDOI | 10.18926/AMO/63901 |
|---|---|
| FullText URL | 76_4_423.pdf |
| Author | Takahashi, Satoshi| Kushibe, Takuya| Akezaki, Yoshiteru| Horiike, Norio| |
| Abstract | We compared the effects of an exercise intervention with that of exercise combined with nutrition therapy in patients with possible malnutrition and sarcopenia admitted to a recovery rehabilitation ward, and we examined the differences in the patients’ physical function and activities of daily living (ADLs). There were 16 patients in the Exercise group with exercise therapy and ADL exercises, and 14 patients in the Combined intervention group with exercise therapy, ADL exercises, and nutrition therapy. The survey items were body weight, body mass index, grip strength, lower-leg circumference, gait speed, and ADLs, each of which was measured at the baseline and at 2 weeks, 4 weeks, and at discharge. Significant improvements in grip strength were observed in the Combined intervention group as follows: at 4 weeks>at 2 weeks (p<0.05), and at discharge>baseline and 2 weeks (p<0.05). There were no significant changes in the Exercise group, and an interaction was recognized in both groups. Comprehensive rehabilitation including nutrition therapy is necessary for patients with possible malnutrition and/or sarcopenia, as our results indicate that nutrition therapy in addition to exercise therapy has the effect of promoting improvements of physical function in such patients. |
| Keywords | sarcopenia rehabilitation exercise therapy nutrition therapy grip strength |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 423 |
| End Page | 428 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123157 |
| Web of Science KeyUT | 000882167300008 |
| JaLCDOI | 10.18926/AMO/63894 |
|---|---|
| FullText URL | 76_4_399.pdf |
| Author | Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
| Abstract | According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67. |
| Keywords | breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 399 |
| End Page | 408 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123154 |
| Web of Science KeyUT | 000882167300005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nara, Shigetoshi| Fujii, Hiroshi| Tsukada, Hiromichi| Tsuda, Ichiro| |
| Published Date | 2022-08-19 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 14172 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35986200 |
| DOI | 10.1038/s41598-022-18313-6 |
| Web of Science KeyUT | 000842561700031 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-18313-6 |
| JaLCDOI | 10.18926/AMO/63889 |
|---|---|
| FullText URL | 76_4_373.pdf |
| Author | Imafuku, Fuminori| Miyazaki, Ikuko| Sun, Jin| Kamimai, Sunao| Shimizu, Takashi| Toyota, Toshiaki| Okamoto, Yusei| Isooka, Nami| Kikuoka, Ryo| Kitamura, Yoshihisa| Asanuma, Masato| |
| Abstract | Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification. |
| Keywords | Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-08 |
| Volume | volume76 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 373 |
| End Page | 383 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36123151 |
| Web of Science KeyUT | 000882167300003 |
| FullText URL | fulltext20221006-1.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Tanaka, Takehiro| Fujii, Nobuharu| Fujii, Kentaro| Kondo, Eisei| |
| Published Date | 2022 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume62 |
| Issue | issue3 |
| Publisher | Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 187 |
| End Page | 189 |
| ISSN | 1346-4280 |
| NCID | AA11556796 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 35732410 |
| DOI | 10.3960/jslrt.22007 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.22007 |
