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Author Nishikori, Asami| Nishimura, Midori Filiz| Nishimura, Yoshito| Otsuka, Fumio| Maehama, Kanna| Ohsawa, Kumiko| Momose, Shuji| Nakamura, Naoya| Sato, Yasuharu|
Keywords Castleman disease idiopathic multicentric Castleman disease idiopathic plasmacytic lymphadenopathy plasma cell morphology
Published Date 2022-09-07
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue18
Publisher MDPI
Start Page 10301
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36142213
DOI 10.3390/ijms231810301
Web of Science KeyUT 000856382100001
Related Url isVersionOf https://doi.org/10.3390/ijms231810301
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Author Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Abe, Makoto| Sakae, Hiroyuki| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Tanaka, Takehiro| Kawano, Seiji| Otsuka, Fumio| Kawahara, Yoshiro| Yanai, Hiroyuki| Okada, Hiroyuki|
Keywords eradication flow cytometry Helicobacter pylori T lymphocytes
Published Date 2022-08-26
Publication Title Medicine
Volume volume101
Issue issue34
Publisher Lippincott Williams & Wilkins
Start Page e30241
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 36042652
DOI 10.1097/MD.0000000000030241
Web of Science KeyUT 000847532100050
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000030241
FullText URL fulltext.pdf
Author Li, Chunning| Yoshimura, Teizo| Tian, Miao| Wang, Yuze| Kondo, Takamasa| Yamamoto, Ken-Ichi| Fujisawa, Masayoshi| Ohara, Toshiaki| Sakaguchi, Masakiyo| Matsukawa, Akihiro|
Keywords Breast cancer Metastasis Exosomes Epithelial mesenchymal transition Tumor microenvironment
Published Date 2022-09-12
Publication Title Breast Cancer Research
Volume volume24
Issue issue1
Publisher BMC
Start Page 60
ISSN 1465-5411
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022.
File Version publisher
PubMed ID 36096830
DOI 10.1186/s13058-022-01557-5
Web of Science KeyUT 000853036400001
Related Url isVersionOf https://doi.org/10.1186/s13058-022-01557-5
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Murayama, Somay Yamagata| Nakamura, Masahiko| Hamada, Kenta| Tanaka, Takehiro| Okada, Hiroyuki|
Published Date 2022-07-20
Publication Title Case Reports In Gastrointestinal Medicine
Volume volume2022
Publisher Hindawi Ltd
Start Page 4254605
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Masaya Iwamuro et al.
File Version publisher
PubMed ID 35911659
DOI 10.1155/2022/4254605
Web of Science KeyUT 000853251100001
Related Url isVersionOf https://doi.org/10.1155/2022/4254605
JaLCDOI 10.18926/AMO/63908
FullText URL 76_4_479.pdf
Author Ogawa, Chikako| Hirasawa, Akira| Sogawa, Reimi| Hasuoka, Kayoko| Tomida, Shuta| Futagawa, Mashu| Urakawa, Yusaku| Kochi, Mariko| Yamamoto, Hideki| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract A hereditary breast and ovarian cancer (HBOC) pedigree was detected via liquid biopsy, and cancer prevention was initiated for the patient’s daughter, after receiving a definitive result from BRCA genetic testing. A 48-yearold woman with ovarian cancer was administered precision medicine, which used cell-free DNA from plasma. The results revealed a pathogenic variant of BRCA1 as a presumed germline pathogenic mutation. We confirmed the germline pathological variant BRCA1 c.81-1G> A and suggested treatment with a PARP inhibitor. One of her three children had the variant, was diagnosed as an unaffected pathogenic variant carrier, and was advised to initiate surveillance.
Keywords hereditary breast and ovarian cancer (HBOC) BRCA 1 presumed germline pathogenic variants (PGPV) germline findings cancer precision medicine
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 479
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123164
Web of Science KeyUT 000882167300012
JaLCDOI 10.18926/AMO/63907
FullText URL 76_4_473.pdf
Author Tsuboi, Nobushige| Ishida, Joji| Shimazu, Yosuke| Edaki, Hisanori| Uneda, Atsuhito| Otani, Yoshihiro| Fujii, Kentaro| Kurozumi, Kazuhiko| Ennishi, Daisuke| Yanai, Hiroyuki| Date, Isao|
Abstract Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.
Keywords glioneuronal tumor with neuropil-like islands genomic profiling
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 473
End Page 477
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123163
JaLCDOI 10.18926/AMO/63904
FullText URL 76_4_447.pdf
Author Umemura, Hiroshi| Fukuda, Yoshiaki| Miyashita, Tetsuo| Nakayama, Tomohiro|
Abstract The erythrocyte sedimentation rate (ESR) is a widely used marker of inflammation, but the detailed mechanisms underlying the ESR remain unclear. We retrospectively collected laboratory data from our hospital’s laboratory information system, and performed multiple linear regression analysis and correlation analysis to determine relationships between the ESR and other laboratory test parameters. The alpha-2, beta-2, and gamma fractions from serum protein electrophoresis, serum immunoglobulin (Ig) G, IgA, IgM, and complement C3 levels, plasma fibrinogen levels, and platelet count showed positive effects on the ESR; however, the serum albumin level showed negative effects. Since erythrocytes are negatively charged, an increase in positively charged proteins and a decrease in negatively charged albumin were suggested to increase the ESR. Notably, C-reactive protein (CRP) showed the third-strongest correlation with the ESR despite having no significant effect on the ESR. We also reviewed cases with discordant ESR and CRP levels to compare the disease profiles of high ESR/low CRP patients and low ESR/high CRP patients. The patients with high ESR/low CRP had a completely different disease profile from those with low ESR/high CRP. Since the ESR and CRP have different roles, they should be used as markers in a context-dependent manner.
Keywords complement erythrocyte sedimentation rate fibrinogen immunoglobulin serum protein electrophoresis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 447
End Page 455
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123160
JaLCDOI 10.18926/AMO/63901
FullText URL 76_4_423.pdf
Author Takahashi, Satoshi| Kushibe, Takuya| Akezaki, Yoshiteru| Horiike, Norio|
Abstract We compared the effects of an exercise intervention with that of exercise combined with nutrition therapy in patients with possible malnutrition and sarcopenia admitted to a recovery rehabilitation ward, and we examined the differences in the patients’ physical function and activities of daily living (ADLs). There were 16 patients in the Exercise group with exercise therapy and ADL exercises, and 14 patients in the Combined intervention group with exercise therapy, ADL exercises, and nutrition therapy. The survey items were body weight, body mass index, grip strength, lower-leg circumference, gait speed, and ADLs, each of which was measured at the baseline and at 2 weeks, 4 weeks, and at discharge. Significant improvements in grip strength were observed in the Combined intervention group as follows: at 4 weeks>at 2 weeks (p<0.05), and at discharge>baseline and 2 weeks (p<0.05). There were no significant changes in the Exercise group, and an interaction was recognized in both groups. Comprehensive rehabilitation including nutrition therapy is necessary for patients with possible malnutrition and/or sarcopenia, as our results indicate that nutrition therapy in addition to exercise therapy has the effect of promoting improvements of physical function in such patients.
Keywords sarcopenia rehabilitation exercise therapy nutrition therapy grip strength
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 423
End Page 428
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123157
Web of Science KeyUT 000882167300008
JaLCDOI 10.18926/AMO/63894
FullText URL 76_4_399.pdf
Author Kajiwara, Yukiko| Iwamoto, Takayuki| Zhu, Yidan| Kochi, Mariko| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi|
Abstract According to a recent report, a low Ki67 level after short-term preoperative hormone therapy (post-Ki67) might suggest a more favorable prognosis compared with a high post-Ki67 level in patients with hormone receptorpositive/human epidermal growth factor 2-negative (HR+/HER2−) breast cancer with high levels of Ki67. This study aimed to evaluate the pre-treatment genetic differences between these two patient groups. Forty-five luminal B-like patients were stratified into two groups, namely, a group with high (H→H) and one with low (H→L) Ki67 levels after short-term preoperative aromatase inhibitor (AI) treatment. We compared pre-treatmentgene expression profiles between the two groups. In gene level analysis, there was no significant difference between the two groups by the class comparison test. In pathway analysis, five metabolism-related gene sets were significantly upregulated in the H→L group (p≤0.05). In the search for novel targets, five genes (PARP, BRCA2, FLT4, CDK6, and PDCD1LG2) showed significantly higher expression in the H→H group (p≤0.05). Several metabolism-related pathways were associated with sensitivity to AI. In the future, it will be necessary to seek out new therapeutic strategies for the poor prognostic group with high post-Ki67.
Keywords breast cancer short-term hormone therapy gene expression profiling Ki-67 targeted therapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 399
End Page 408
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123154
Web of Science KeyUT 000882167300005
FullText URL fulltext.pdf
Author Nara, Shigetoshi| Fujii, Hiroshi| Tsukada, Hiromichi| Tsuda, Ichiro|
Published Date 2022-08-19
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 14172
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35986200
DOI 10.1038/s41598-022-18313-6
Web of Science KeyUT 000842561700031
Related Url isVersionOf https://doi.org/10.1038/s41598-022-18313-6
JaLCDOI 10.18926/AMO/63889
FullText URL 76_4_373.pdf
Author Imafuku, Fuminori| Miyazaki, Ikuko| Sun, Jin| Kamimai, Sunao| Shimizu, Takashi| Toyota, Toshiaki| Okamoto, Yusei| Isooka, Nami| Kikuoka, Ryo| Kitamura, Yoshihisa| Asanuma, Masato|
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification.
Keywords Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-08
Volume volume76
Issue issue4
Publisher Okayama University Medical School
Start Page 373
End Page 383
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36123151
Web of Science KeyUT 000882167300003
FullText URL fulltext20221006-1.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Fujii, Nobuharu| Fujii, Kentaro| Kondo, Eisei|
Published Date 2022
Publication Title Journal of Clinical and Experimental Hematopathology
Volume volume62
Issue issue3
Publisher Japanese Society for Lymphoreticular Tissue Research
Start Page 187
End Page 189
ISSN 1346-4280
NCID AA11556796
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 35732410
DOI 10.3960/jslrt.22007
Related Url isVersionOf https://doi.org/10.3960/jslrt.22007
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Author Hada, Yoshiko| Uchida, Haruhito A.| Umebayashi, Ryoko| Yoshida, Masashi| Wada, Jun|
Keywords cilostazol angiotensin II fibrosis osteopontin cAMP-PKA
Published Date 2022-08-13
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue16
Publisher MDPI
Start Page 9065
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 36012328
DOI 10.3390/ijms23169065
Web of Science KeyUT 000845679000001
Related Url isVersionOf https://doi.org/10.3390/ijms23169065
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Author Sukegawa, Shintaro| Tanaka, Futa| Nakano, Keisuke| Hara, Takeshi| Yoshii, Kazumasa| Yamashita, Katsusuke| Ono, Sawako| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
Published Date 2022-08-02
Publication Title Scientific Reports
Volume volume12
Issue issue1
Publisher Nature Portfolio
Start Page 13281
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35918498
DOI 10.1038/s41598-022-17602-4
Web of Science KeyUT 000836651200038
Related Url isVersionOf https://doi.org/10.1038/s41598-022-17602-4
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Author Yokoyama, Tomonori| Mukai, Takao| Kodama, Naoki| Takao, Kana| Hiraoka, Takashi| Arai, Nobuyuki| Yano, Jitsuro| Nagatsuka, Hiroaki| Manda, Yousuke| Hanayama, Kozo| Minagi, Shogo|
Keywords oral medicine rehabilitation medicine geriatric medicine
Published Date 2022-07-14
Publication Title BMJ Open
Volume volume12
Issue issue7
Publisher BMJ Publishing Group
Start Page e060040
ISSN 2044-6055
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Author(s) (or their employer(s)) 2022.
File Version publisher
PubMed ID 35835521
DOI 10.1136/bmjopen-2021-060040
Web of Science KeyUT 000826598000008
Related Url isVersionOf https://doi.org/10.1136/bmjopen-2021-060040
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Author Ono, Kisho| Sato, Kohei| Nakamura, Tomoya| Yoshida, Yume| Murata, Shogo| Yoshida, Kunihiro| Kanemoto, Hideka| Umemori, Koki| Kawai, Hotaka| Obata, Kyoichi| Ryumon, Shoji| Hasegawa, Kazuaki| Kunisada, Yuki| Okui, Tatsuo| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira|
Keywords oral cancer spheroid three-dimensional culture anticancer drug
Published Date 2022-07-18
Publication Title International Journal Of Medical Sciences
Volume volume19
Issue issue8
Publisher Ivyspring International Publisher
Start Page 1320
End Page 1333
ISSN 1449-1907
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The author(s).
File Version publisher
PubMed ID 35928727
DOI 10.7150/ijms.74109
Web of Science KeyUT 000830781500011
Related Url isVersionOf https://doi.org/10.7150/ijms.74109
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Author Watanabe, Shiho| Ochiai, Hiroko| Sakuma, Hisashi| Mori, Taisuke| Yazawa, Masaki| Oka, Aiko| Kishi, Kazuo|
Keywords muscle fiber type facial paralysis dualinnervation masseter muscle
Published Date 2022-07-16
Publication Title International Journal Of Molecular Sciences
Volume volume23
Issue issue14
Publisher MDPI
Start Page 7856
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35887204
DOI 10.3390/ijms23147856
Web of Science KeyUT 000832132200001
Related Url isVersionOf https://doi.org/10.3390/ijms23147856
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Author Shimizu, Rieko| Sukegawa, Shintaro| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Nakamura, Tomoya| Fujimura, Ai| Fujisawa, Ayaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
Keywords anti-resorptive agent-related osteonecrosis of the jaw bisphosphonate denosumab retrospective study risk factor tooth extraction
Published Date 2022-07-18
Publication Title Healthcare
Volume volume10
Issue issue7
Publisher MDPI
Start Page 1332
ISSN 2227-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35885858
DOI 10.3390/healthcare10071332
Web of Science KeyUT 000831605200001
Related Url isVersionOf https://doi.org/10.3390/healthcare10071332
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Author Sukegawa, Shintaro| Sukegawa, Yuka| Hasegawa, Kazuaki| Ono, Sawako| Nakamura, Tomoya| Fujimura, Ai| Fujisawa, Ayaka| Nakano, Keisuke| Takabatake, Kiyofumi| Kawai, Hotaka| Mukainaka, Yumika| Nagatsuka, Hitoshi| Furuki, Yoshihiko|
Keywords hepatitis B hepatitis C human immunodeficiency virus pre-operative examination
Published Date 2022-07-20
Publication Title Healthcare
Volume volume10
Issue issue7
Publisher MDPI
Start Page 1348
ISSN 2227-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by the authors.
File Version publisher
PubMed ID 35885875
DOI 10.3390/healthcare10071348
Web of Science KeyUT 000832459200001
Related Url isVersionOf https://doi.org/10.3390/healthcare10071348
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Kuraoka, Sakiko| Hamada, Kenta| Abe, Makoto| Kono, Yoshiyasu| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords esophagogastroduodenoscopy gastric erosion gastric ulcer zinc acetate dihydrate
Published Date 2022-07-01
Publication Title Internal Medicine
Volume volume61
Issue issue13
Publisher The Japanese Society of Internal Medicine
Start Page 1931
End Page 1938
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 35781269
DOI 10.2169/internalmedicine.8625-21
Web of Science KeyUT 000823060200001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.8625-21