result 1423 件
| JaLCDOI | 10.18926/AMO/65978 |
|---|---|
| FullText URL | 77_5_545.pdf |
| Author | Iwamuro, Masaya| Tanaka, Shouichi| Toyokawa, Tatsuya| Nishimura, Mamoru| Tsuzuki, Takao| Miyahara, Koji| Negishi, Shin| Ohya, Shogen| Tanaka, Takehiro| Otsuka, Motoyuki| |
| Abstract | To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant. |
| Keywords | esophagogastroduodenoscopy gastric lesion amyloidosis light chain |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 545 |
| End Page | 552 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899266 |
| Web of Science KeyUT | 001094245100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shan, Qiusheng| Takabatake, Kiyofumi| Kawai, Hotaka| Oo, May Wathone| Sukegawa, Shintaro| Fujii, Masae| Nakano, Keisuke| Nagatsuka, Hitoshi| |
| Keywords | oral squamous cell carcinoma tumor-associated macrophages cancer stroma tumor microenvironment microvessel density microarray |
| Published Date | 2022-05-06 |
| Publication Title | International Journal of Oncology |
| Volume | volume60 |
| Issue | issue6 |
| Publisher | Spandidos Publications |
| Start Page | 78 |
| ISSN | 1019-6439 |
| NCID | AA10992511 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Shan et al. |
| File Version | publisher |
| PubMed ID | 35514301 |
| DOI | 10.3892/ijo.2022.5368 |
| Web of Science KeyUT | 000795124900001 |
| Related Url | isVersionOf https://doi.org/10.3892/ijo.2022.5368 |
| JaLCDOI | 10.18926/AMO/65974 |
|---|---|
| FullText URL | 77_5_517.pdf |
| Author | Horiguchi, Shigeru| Matsumoto, Kazuyuki| Morimoto, Kosaku| Matsumi, Akihiro| Terasawa, Hiroyuki| Fujii, Yuki| Yamazaki, Tatsuhiro| Tsutsumi, Koichiro| Kato, Hironari| |
| Abstract | We investigated the effect of modified FOLFIRINOX (mFFX) in unresectable pancreatic cancer by retrospectively analyzing the cases of 43 patients who underwent BRCA testing (germline, n=11; somatic, n=26; both germline and somatic, n=6). The association between BRCA mutations and therapeutic effect was clarified. Six patients tested positive for germline pathogenic variants. Familial pancreatic cancer (33% vs. 3%, p=0.006) and peritoneal disseminated lesions (66% vs. 8%, p<0.001) were significantly more common in patients with germline pathogenic variants. The partial response (PR) rate was 100% in the germline BRCA-positive patients, and 27% in the germline BRCA-negative patients (p<0.001). The median progression-free survival (PFS) was not reached for any germline BRCA-positive patients but was 9.0 months for the germline BRCA-negative patients (p=0.042). Patients with stage IV BRCA-associated pancreatic cancer had better overall survival than those with non-BRCA-associated pancreatic cancer, although the difference was nonsignificant (not reached vs. 655 days, p=0.061). Our results demonstrate that a PR and prolonged PFS can be expected in germline BRCA-positive patients after treatment with mFFX. Our findings also suggest that germline BRCA pathogenic variants may be useful as biomarkers for the therapeutic effect of mFFX in patients with pancreatic cancer. |
| Keywords | BRCA FOLFIRINOX pancreatic cancer progression-free survival pathogenic variant |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 517 |
| End Page | 525 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899263 |
| Web of Science KeyUT | 001108661600009 |
| JaLCDOI | 10.18926/AMO/65968 |
|---|---|
| FullText URL | 77_5_461.pdf |
| Author | Homma, Daisuke| Minato, Izumi| Imai, Norio| Miyasaka, Dai| Sakai, Yoshinori| Horigome, Yoji| Suzuki, Hayato| Dohmae, Yoichiro| Endo, Naoto| |
| Abstract | This study aimed to determine which muscle the gluteus maximus, gluteus medius, gluteus minimus (Gmin), or tensor fasciae latae (TFL) contributes most to hip abduction strength and to identify effective sites for cross-sectional area (CSA) Gmin and TFL measurement in hip osteoarthritis (OAhip) patients. Twenty-eight patients with OAhip were included. The muscle CSA and volume were determined using magnetic resonance imaging. Peak isometric strength was determined using hand-held dynamometry. Muscle volumes were normalized to the total muscle volume of hip abductors. Multiple regression analysis was performed. The difference between the CSA of Gmin and TFL was calculated, and correlations with volume and muscle strength were determined. Gmin volume was related to abductor muscle strength (p=0.042). The peak CSA of the Gmin correlated with muscle volume and strength. The CSA of the TFL correlated with volume, with no difference between the CSA of the most protruding part of the lesser trochanter and peak CSA. Gmin volume was strongly related to abductor muscle strength. Peak CSA is a useful parameter for assessing the CSA of the Gmin among patients with OAhip. The CSA of the TFL should be measured at the most protruding part of the lesser trochanter. |
| Keywords | gluteus minimus tensor fasciae latae cross-sectional area muscle volume hip osteoarthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 461 |
| End Page | 469 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899257 |
| Web of Science KeyUT | 001108661600003 |
| FullText URL | fulltext20231012-01.pdf |
|---|---|
| Author | Matsuda, Naoki| Yamamoto, Hiromasa| Habu, Tomohiro| Iwata, Kazuma| Matsubara, Kei| Tanaka, Shin| Hashimoto, Kohei| Shien, Kazuhiko| Suzawa, Ken| Miyoshi, Kentaroh| Toji, Tomohiro| Okazaki, Mikio| Sugimoto, Seiichiro| Takahashi, Katsuhito| Toyooka, Shinichi| |
| Note | The version of record of this article, first published in Annals of Surgical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1245/s10434-023-14176-x| |
| Published Date | 2023-09-01 |
| Publication Title | Annals of Surgical Oncology |
| Volume | volume30 |
| Issue | issue13 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 8727 |
| End Page | 8734 |
| ISSN | 1068-9265 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37658268 |
| DOI | 10.1245/s10434-023-14176-x |
| Web of Science KeyUT | 001060201900008 |
| Related Url | isVersionOf https://doi.org/10.1245/s10434-023-14176-x |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Khazan, Negar| Kim, Kyu Kwang| Hansen, Jeanne N.| Singh, Niloy A.| Moore, Taylor| Snyder, Cameron W. A.| Pandita, Ravina| Strawderman, Myla| Fujihara, Michiko| Takamura, Yuta| Jian, Ye| Battaglia, Nicholas| Yano, Naohiro| Teramoto, Yuki| Arnold, Leggy A.| Hopson, Russell| Kishor, Keshav| Nayak, Sneha| Ojha, Debasmita| Sharon, Ashoke| Ashton, John M.| Wang, Jian| Milano, Michael T.| Miyamoto, Hiroshi| Linehan, David C.| Gerber, Scott A.| Kawar, Nada| Singh, Ajay P.| Tabdanov, Erdem D.| Dokholyan, Nikolay V.| Kakuta, Hiroki| Jurutka, Peter W.| Schor, Nina F.| Rowswell-Turner, Rachael B.| Singh, Rakesh K.| Moore, Richard G.| |
| Published Date | 2022-04-11 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume65 |
| Issue | issue8 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 6039 |
| End Page | 6055 |
| ISSN | 0022-2623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35404047 |
| DOI | 10.1021/acs.jmedchem.1c01878 |
| Web of Science KeyUT | 000797573100012 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ono-Minagi, Hitomi| Nohno, Tsutomu| Serizawa, Takashi| Usami, Yu| Sakai, Takayoshi| Okano, Hideyuki| Ohuchi, Hideyo| |
| Keywords | salivary and lacrimal glands development three germ layers neural crest |
| Published Date | 2023-09-05 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume24 |
| Issue | issue18 |
| Publisher | MDPI |
| Start Page | 13692 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| PubMed ID | 37761995 |
| DOI | 10.3390/ijms241813692 |
| Web of Science KeyUT | 001071736900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms241813692 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umemori, Koki| Ono, Kisho| Kanemoto, Hideka| Obata, Kyoichi| Kawai, Hotaka| Nakamura, Tomoya| Nakano, Keisuke| Ibaragi, Soichiro| Nagatsuka, Hitoshi| Sasaki, Akira| |
| Keywords | Pleomorphic adenoma (PA) upper lip lower lip minor salivary gland tumor case series |
| Published Date | 2022-10-27 |
| Publication Title | Gland Surgery |
| Volume | volume11 |
| Issue | issue10 |
| Publisher | AME Publishing Company |
| Start Page | 1730 |
| End Page | 1740 |
| ISSN | 2227-684X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Gland Surgery. |
| File Version | publisher |
| PubMed ID | 36353586 |
| DOI | 10.21037/gs-22-308 |
| Web of Science KeyUT | 000860255900001 |
| Related Url | isVersionOf https://doi.org/10.21037/gs-22-308 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohmori, Iori| Ouchida, Mamoru| Shinohara, Masakazu| Kobayashi, Kiyoka| Ishida, Saeko| Mashimo, Tomoji| |
| Keywords | animal model combined generalized and focal epilepsy oxidative stress thioredoxin |
| Published Date | 2022-05-28 |
| Publication Title | Epilepsia |
| Volume | volume63 |
| Issue | issue7 |
| Publisher | Wiley |
| Start Page | e80 |
| End Page | e85 |
| ISSN | 0013-9580 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35532890 |
| DOI | 10.1111/epi.17295 |
| Web of Science KeyUT | 000800706600001 |
| Related Url | isVersionOf https://doi.org/10.1111/epi.17295 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakata, Eiji| Kawai, Hotaka| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Inoue, Hirofumi| Futagawa, Mashu| Katayama, Haruyoshi| Itano, Takuto| Ozaki, Toshifumi| |
| Keywords | giant cell tumor of bone malignant transformation p53 denosumab molecular targeted therapy |
| Published Date | 2022-07-19 |
| Publication Title | Oncology Letters |
| Volume | volume24 |
| Issue | issue3 |
| Publisher | Spandidos Publications |
| Start Page | 319 |
| ISSN | 1792-1074 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Nakata et al. |
| File Version | publisher |
| PubMed ID | 35949597 |
| DOI | 10.3892/ol.2022.13439 |
| Web of Science KeyUT | 000840512400001 |
| Related Url | isVersionOf https://doi.org/10.3892/ol.2022.13439 |
| FullText URL | fulltext20230923-01.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Tanaka, Takehiro| |
| Keywords | myxoma orbital CD34 ethmoid sinus literature review |
| Published Date | 2023-09-22 |
| Publication Title | Journal of Investigative Medicine High Impact Case Reports |
| Volume | volume11 |
| Publisher | SAGE Publications |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 2324-7096 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 American Federation for Medical Research |
| File Version | publisher |
| PubMed ID | 37737575 |
| DOI | 10.1177/23247096231201013 |
| Web of Science KeyUT | 001070220300001 |
| Related Url | isVersionOf https://doi.org/10.1177/23247096231201013 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsumoto, Kazuyuki| Ohara, Toshiaki| Fujisawa, Masayoshi| Takaki, Akinobu| Takahara, Masahiro| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Matsukawa, Akihiro| Okada, Hiroyuki| |
| Keywords | Programmed death ligand 1 Bile tract neoplasm Biopsy specimen Immunohistochemistry |
| Note | The version of record of this article, first published in Journal of Gastrointestinal Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11605-021-05197-6| |
| Published Date | 2022-02-08 |
| Publication Title | Journal of Gastrointestinal Surgery |
| Volume | volume26 |
| Issue | issue6 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1213 |
| End Page | 1223 |
| ISSN | 1091-255X |
| NCID | AA11494553 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35137343 |
| DOI | 10.1007/s11605-021-05197-6 |
| Web of Science KeyUT | 000752761400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s11605-021-05197-6 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Hiromasa| Soh, Junichi| Okumura, Norihito| Suzuki, Hiroyuki| Nakata, Masao| Fujiwara, Toshiya| Gemba, Kenichi| Sano, Isao| Fujinaga, Takuji| Kataoka, Masafumi| Terazaki, Yasuhiro| Fujimoto, Nobukazu| Kataoka, Kazuhiko| Kosaka, Shinji| Yamashita, Motohiro| Inokawa, Hidetoshi| Inoue, Masaaki| Nakamura, Hiroshige| Yamashita, Yoshinori| Hotta, Katsuyuki| Yoshioka, Hiroshige| Morita, Satoshi| Matsuo, Keitaro| Sakamoto, Junichi| Date, Hiroshi| Toyooka, Shinichi| |
| Published Date | 2023-05-19 |
| Publication Title | PLoS ONE |
| Volume | volume18 |
| Issue | issue5 |
| Publisher | Public Library of Science |
| Start Page | e0285273 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Yamamoto et al. |
| File Version | publisher |
| PubMed ID | 37205678 |
| DOI | 10.1371/journal.pone.0285273 |
| Web of Science KeyUT | 001050599900034 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0285273 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morinaga, Takao| Inozume, Takashi| Kawazu, Masahito| Ueda, Youki| Sax, Nicolas| Yamashita, Kazuo| Kawashima, Shusuke| Nagasaki, Joji| Ueno, Toshihide| Lin, Jason| Ohara, Yuuki| Kuwata, Takeshi| Yukami, Hiroki| Kawazoe, Akihito| Shitara, Kohei| Honobe-Tabuchi, Akiko| Ohnuma, Takehiro| Kawamura, Tatsuyoshi| Umeda, Yoshiyasu| Kawahara, Yu| Nakamura, Yasuhiro| Kiniwa, Yukiko| Morita, Ayako| Ichihara, Eiki| Kiura, Katsuyuki| Enokida, Tomohiro| Tahara, Makoto| Hasegawa, Yoshinori| Mano, Hiroyuki| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Togashi, Yosuke| |
| Published Date | 2022-07-28 |
| Publication Title | Cancer Research Communications |
| Volume | volume2 |
| Issue | issue7 |
| Publisher | American Association for Cancer Research |
| Start Page | 739 |
| End Page | 753 |
| ISSN | 2767-9764 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors |
| File Version | publisher |
| PubMed ID | 36923281 |
| DOI | 10.1158/2767-9764.CRC-22-0050 |
| Web of Science KeyUT | 001048412300001 |
| Related Url | isVersionOf https://doi.org/10.1158/2767-9764.CRC-22-0050 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sun, Hongming| Morihara, Ryuta| Feng, Tian| Bian, Zhihong| Yu, Haibo| Hu, Xiao| Hu, Xinran| Bian, Yuting| Sasaki, Ryo| Fukui, Yusuke| Takemoto, Mami| Yunoki, Taijun| Nakano, Yumiko| Abe, Koji| Yamashita, Toru| |
| Keywords | ischemic stroke human cord blood-endothelial progenitor cells mechanical thrombectomy intimal hyperplasia |
| Published Date | 2023-08-24 |
| Publication Title | Cell Transplantation |
| Volume | volume32 |
| Publisher | SAGE Publications |
| ISSN | 0963-6897 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37615293 |
| DOI | 10.1177/09636897231193069 |
| Web of Science KeyUT | 001059017900001 |
| Related Url | isVersionOf https://doi.org/10.1177/09636897231193069 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Shumpei| Kinugasa, Hideaki| Yamasaki, Yasushi| Hirai, Mami| Ako, Soichiro| Takei, Kensuke| Igawa, Shoko| Yasutomi, Eriko| Oka, Shohei| Ohmori, Masayasu| Inokuchi, Toshihiro| Harada, Keita| Hiraoka, Sakiko| Nouso, Kazuhiro| Tanaka, Takehiro| Okada, Hiroyuki| |
| Keywords | colorectal ESD PECS electrocoagulation syndrome immunosuppressants and steroids post-ESD fever |
| Published Date | 2021-12-09 |
| Publication Title | DEN Open |
| Volume | volume2 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | e83 |
| ISSN | 2692-4609 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 The Authors. |
| File Version | publisher |
| PubMed ID | 35310725 |
| DOI | 10.1002/deo2.83 |
| Web of Science KeyUT | 001047024900091 |
| Related Url | isVersionOf https://doi.org/10.1002/deo2.83 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hiraoka, Tomohiro| Kawamura, Mai| Takada, Keisuke| Moriwake, Tadashi| |
| Keywords | Cystinuria Ureterolithiasis Cystine Acute appendicitis Case report |
| Published Date | 2022-10 |
| Publication Title | International Journal of Surgery Case Reports |
| Volume | volume99 |
| Publisher | Elsevier |
| Start Page | 107596 |
| ISSN | 2210-2612 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 36115118 |
| DOI | 10.1016/j.ijscr.2022.107596 |
| Web of Science KeyUT | 001043865800003 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ijscr.2022.107596 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kanzaki, Hiromitsu| Horii, Joichiro| Takenaka, Ryuta| Nakagawa, Hiroyuki| Matsueda, Kazuhiro| Tsuzuki, Takao| Kita, Masahide| Yamasaki, Yasushi| Tanaka, Takehiro| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Tomoda, Jun| Okada, Hiroyuki| |
| Published Date | 2022-06-10 |
| Publication Title | Endoscopy International Open |
| Volume | volume10 |
| Issue | issue06 |
| Publisher | Georg Thieme Verlag KG |
| Start Page | E712 |
| End Page | E718 |
| ISSN | 2364-3722 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022. The Author(s). |
| File Version | publisher |
| PubMed ID | 35859656 |
| DOI | 10.1055/a-1793-9439 |
| Web of Science KeyUT | 000826506700001 |
| Related Url | isVersionOf https://doi.org/10.1055/a-1793-9439 |
| JaLCDOI | 10.18926/AMO/65752 |
|---|---|
| FullText URL | 77_4_415.pdf |
| Author | Jelcic, Dzenis| Puzovic, Velibor| Benzon, Benjamin| Palada, Ivan| Jerković, Jelena| Vulic, Marko| |
| Abstract | The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset. |
| Keywords | vitamin D receptor immunohistochemistry early and late-onset preeclampsia |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 415 |
| End Page | 422 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635142 |
| Web of Science KeyUT | 001163659800006 |
| JaLCDOI | 10.18926/AMO/65748 |
|---|---|
| FullText URL | 77_4_377.pdf |
| Author | Morimoto, Kosaku| Takeuchi, Yasuto| Takaki, Akinobu| Wada, Nozomu| Oyama, Atsushi| Adachi, Takuya| Onishi, Hideki| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Liver fibrosis is an important phenomenon in non-alcoholic fatty liver disease (NAFLD) progression. Standard markers reflecting liver fibrosis, including the FIB-4 index, increase with age. This study aimed to identify fibrosis progression-related markers that are diagnostically beneficial even in aged individuals. Serum levels of pro- and anti-inflammatory cytokines were measured by multiple enzyme-linked immunosorbent assay. Two standard NAFLD or fibrosis progression-related markers — the FIB-4 index and APRI score — were analyzed along with cytokine levels to define the best approach to discriminate advanced fibrosis. Ninety-eight NAFLD patients were enrolled: 59 and 39 patients with fibrosis stages 1-2 and 3-4 respectively. In addition to the FIB-4 index and APRI score, the following factors showed significant differences between stages 1-2 and stages 3-4 in a multivariate analysis: platelet counts, IP-10, and RANTES. The fibrosis stage, FIB-4, APRI, PDGF-BB, and RANTES were related to the prognosis. In aged patients, IP-10, GM-CSF, and RANTES differed between stages 1-2 and stages 3-4. FIB-4 and APRI were beneficial for their correlation with fibrosis. However, to stratify either young or elderly advanced fibrosis patients, and to identify patients likely to have a bad outcome, RANTES was the best marker. |
| Keywords | NAFLD NASH liver fibrosis chemokine FIB-4 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 385 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635138 |
| Web of Science KeyUT | 001163659800009 |
