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Author Fukuyasu, Yusuke| Kataoka, Hitomi U.| Honda, Miwako| Iwase, Toshihide| Ogawa, Hiroko| Sato, Masaru| Watanabe, Mayu| Fujii, Chikako| Wada, Jun| DeSantis, Jennifer| Hojat, Mohammadreza| Gonnella, Joseph S.|
Keywords Empathy Humanitude Medical education
Published Date 2021-06-04
Publication Title BMC Medical Education
Volume volume21
Issue issue1
Publisher BMC
Start Page 316
ISSN 1472-6920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 34088308
DOI 10.1186/s12909-021-02773-x
NAID 120007089818
Web of Science KeyUT 000660873600001
Related Url isVersionOf https://doi.org/10.1186/s12909-021-02773-x
JaLCDOI 10.18926/AMO/62233
FullText URL 75_3_373.pdf
Author Yaylali, Guzin F.| Dedeoglu, Ozen | Topsakal, Senay| Herek, Duygu| Senol, Hande|
Abstract Osteocalcin (OC) is inversely related to body fat distribution and fasting glucose levels. We sought to observe the effect of OC on fat distribution and subclinical atherosclerosis as measured by carotid intima-media thickness (CIMT) in premenopausal obese women. In this prospective observational study, totally, 73 premenopausal obese women (aged 17-55 years) and 53 healthy women (aged 20-50 years) with normal weight were included as controls. Anthropometric measurements, total fat and fat ratio, insulin, fasting blood glucose, and OC levels were estimated. Ultrasonography was used to assess fat distribution, and fat thickness was measured in 4 regions. Subcutaneous fat (SCF), visceral fat (VF), and preperitoneal fat (PPF) thicknesses were considerably higher in obese subjects (p<0.01) than healthy controls, while OC levels were significantly lower. No correlation was observed between OC levels and SCF, VF, or PPF. In a multiple regression analysis, OC was significantly positively associated with SCF (p=0.04, Beta=0.284). No associations were observed between OC levels and VF, PPF, or CIMT. A significant association was observed between parathyroid hormone (PTH) and VF (p=0.021, Beta=0.284), and vitamin D levels were inversely associated with VF (p=0.002, r=−0.366). OC levels were lower in premenopausal obese women than normal-weight healthy controls, but OC exhibited no correlation with VF or PPF, and only a weak positive association with SCF. Additionally, VF was positively correlated with PTH and inversely correlated with vitamin D. These results suggest that OC may be an early indicator of lipid accumulation in te subcutaneous area and development of atherosclerosis.
Keywords body fat composition carotid intima-media thickness obesity osteocalcin premenopausal women
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 373
End Page 379
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176942
Web of Science KeyUT 000667147700013
NAID 120007089830
JaLCDOI 10.18926/AMO/62230
FullText URL 75_3_351.pdf
Author Mitamura, Katsuya| Norikane, Takashi| Yamamoto, Yuka| Ihara-Nishishita, Ayumi| Kobata, Takuya| Fujimoto, Kengo| Takami, Yasukage| Kudomi, Nobuyuki| Hoshikawa, Hiroshi| Nishiyama, Yoshihiro|
Abstract We assessed the role of 18F-FDG PET/CT texture indices for the differentiation of squamous cell carcinoma (SCC) and non-Hodgkin’s lymphoma (NHL) in the oropharynx. 18F-FDG PET/CT data for 27 patients with SCC and 25 patients with NHL in the oropharynx were investigated. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and six texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis [LGZE], and high graylevel zone emphasis [HGZE]) were derived from PET images. PET/CT parameters of the SCC patients were compared with those of the NHL patients. The diagnostic accuracy of the indices for differentiating SCC from NHL was calculated by a receiver operating characteristic curve analysis. 18F-FDG uptake in the oropharynx was observed in all of the patients. The SUVmax, MTV, and TLG did not differ significantly between the SCC and NHL groups, but two of the six texture indices (LGZE [p=0.004] and HGZE [p=0.03]) showed significant differences between the groups. LGZE was the best discriminative index for the differentiation of SCC and NHL (55.6% sensitivity, 88.0% specificity). The LGZE and HGZE texture indices derived from 18F-FDG PET/CT images may be useful in differentiating SCC and NHL in the oropharynx.
Keywords 18F-FDG PET/CT oropharyngeal squamous cell carcinoma malignant lymphoma texture
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 351
End Page 356
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176939
Web of Science KeyUT 000667147700010
NAID 120007089827
JaLCDOI 10.18926/AMO/62220
FullText URL 75_3_289.pdf
Author Miyamoto, Masakazu| Osawa, Kazuhiro| Miyoshi, Toru| Mori, Atsushi| Yoshikawa, Masaki| Oka, Takefumi| Ichikawa, Keishi| Nakamura, Kazufumi| Ito, Hiroshi|
Abstract Early treatment with an oral β-blocker is recommended in patients with a ST-segment–elevation myocardial infarction (STEMI). In this multicenter study, we evaluated the effects of a continuous administration of landiolol, an ultrashort-acting β-blocker, before primary percutaneous coronary intervention (PCI) on myocardial salvage and its safety in STEMI patients. A total of 47 Japanese patients with anterior or lateral STEMI undergoing a primary PCI within 12 h of symptom onset were randomized to receive intravenous landiolol (started at 3 μg/min/kg dose and continued to a total of 50 mg; n=23) or not (control; n=24). Patients with Killip class III or more were excluded. The primary outcome was the myocardial salvage index on cardiac magnetic resonance imaging (MRI) performed 5-7 days after the PCI. Cardiac MRI was performed in 35 patients (74%). The myocardial salvage index in the landiolol group was significantly greater than that in the control group (44.4±14.6% vs. 31.7±18.9%, respectively; p=0.04). There were no significant differences in adverse events at 24 h between the landiolol and control groups. A continuous administration of landiolol before a primary PCI may increase the degree of myocardial salvage without additional hemodynamic adverse effects within the first 24 h after STEMI.
Keywords myocardial infarction landiolol magnetic resonance imaging STEMI PCI
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 289
End Page 297
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176932
Web of Science KeyUT 000667147700004
NAID 120007089835
FullText URL fulltext.pdf
Author He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| La Rose, Jose| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun|
Keywords ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note Erratum in https://ousar.lib.okayama-u.ac.jp/62331|
Published Date 2021-05-31
Publication Title Frontiers In Oncology
Volume volume11
Publisher Frontiers Media S.A.
Start Page 665273
ISSN 2234-943X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version publisher
PubMed ID 34136397
DOI 10.3389/fonc.2021.665273
NAID 120007089841
Web of Science KeyUT 000661158800001
Related Url isVersionOf https://doi.org/10.3389/fonc.2021.665273
FullText URL fulltext.pdf
Author Yoshinaga, Kasumi| Araki, Motoo| Wada, Koichiro| Sekito, Takanori| Watari, Shogo| Maruyama, Yuki| Mitsui, Yosuke| Sadahira, Takuya| Kubota, Risa| Nishimura, Shingo| Edamura, Kohei| Kobayashi, Yasuyuki| Tanabe, Katsuyuki| Takeuchi, Hidemi| Kitagawa, Masashi| Kitamura, Shinji| Wada, Jun| Watanabe, Masami| Watanabe, Toyohiko| Nasu, Yasutomo|
Keywords diabetes mellitus kidney function kidney transplantation marginal donor
Published Date 2021-06-08
Publication Title Immunity Inflammation and Disease
Publisher Wiley
ISSN 2050-4527
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 34102025
DOI 10.1002/iid3.470
NAID 120007053366
Web of Science KeyUT 000658836600001
Related Url isVersionOf https://doi.org/10.1002/iid3.470
FullText URL fulltext.pdf
Author Mise, Koki| Imamura, Mariko| Yamaguchi, Satoshi| Watanabe, Mayu| Higuchi, Chigusa| Katayama, Akihiro| Miyamoto, Satoshi| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Hida, Kazuyuki| Nakato, Tatsuaki| Tone, Atsuhito| Teshigawara, Sanae| Matsuoka, Takashi| Kamei, Shinji| Murakami, Kazutoshi| Shimizu, Ikki| Miyashita, Katsuhiro| Ando, Shinichiro| Nunoue, Tomokazu| Yoshida, Michihiro| Yamada, Masao| Shikata, Kenichi| Wada, Jun|
Keywords cardiovascular event diabetes lectins N-glycans urinary biomarkers
Published Date 2021-05-24
Publication Title Frontiers In Cardiovascular Medicine
Volume volume8
Publisher Frontiers Media SA
Start Page 668059
ISSN 2297-055X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34109226
DOI 10.3389/fcvm.2021.668059
NAID 120007053373
Web of Science KeyUT 000658156400001
Related Url isVersionOf https://doi.org/10.3389/fcvm.2021.668059
FullText URL fulltext.pdf
Author Mizuki, Yutaka| Sakamoto, Shinji| Okahisa, Yuko| Yada, Yuji| Hashimoto, Nozomu| Takaki, Manabu| Yamada, Norihito|
Keywords DISC1 kalirin ARHGEF11 Akt/GSK3 beta Wnt beta-catenin
Published Date 2020-12-14
Publication Title International Journal of Neuropsychopharmacology
Volume volume24
Issue issue5
Publisher Oxford Univ Press
Start Page 367
End Page 382
ISSN 1461-1457
NCID AA11545519
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 33315097
DOI 10.1093/ijnp/pyaa097
NAID 120007045004
Web of Science KeyUT 000656192700001
Related Url isVersionOf https://doi.org/10.1093/ijnp/pyaa097
FullText URL fulltext.pdf
Author Matsuoka, Natsumi| Watanabe, Haruki| Kurooka, Naoko| Kato, Sumari| Higashi, Chika| Tanabe, Katsuyuki| Kinomura, Masaru| Fujii, Nobuharu| Sada, Ken-Ei| Sugiyama, Hitoshi| Wada, Jun|
Keywords acute kidney injury Evans syndrome autoimmune hemolytic anemia
Published Date 2021-04-01
Publication Title Internal Medicine
Volume volume60
Issue issue7
Publisher Japanese Society of Internal Medicine
Start Page 1055
End Page 1060
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33116016
DOI 10.2169/internalmedicine.5976-20
NAID 120007042384
Web of Science KeyUT 000637009100013
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5976-20
FullText URL fulltext.pdf
Author Fujisawa, Satoshi| Komatsubara, Motoshi| Tsukamoto-Yamauchi, Naoko| Iwata, Nahoko| Nada, Takahiro| Wada, Jun| Otsuka, Fumio|
Keywords anterior pituitary bone morphogenetic protein (BMP) corticotrope orexin pro-opiomelanocortin (POMC)
Published Date 2021-04-27
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue9
Publisher MDPI
Start Page 4553
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33925368
DOI 10.3390/ijms22094553
NAID 120007039921
Web of Science KeyUT 000650347100001
Related Url isVersionOf https://doi.org/10.3390/ijms22094553
FullText URL fulltext.pdf
Author Asano, Yosuke| Matsumoto, Yoshinori| La Rose, Rose, Jose| He, Fang| Katsuyama, Takayuki| Ziyi, Wang| Tsuji, Shigetomo| Kamioka, Hiroshi| Rottapel, Robert| Wada, Jun|
Published Date 2021-04-19
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33875686
DOI 10.1038/s41598-021-87716-8
NAID 120007039923
Web of Science KeyUT 000642583500018
Related Url isVersionOf https://doi.org/10.1038/s41598-021-87716-8
FullText URL fulltext.pdf
Author Liang, Yin| Wang, Mengxue| Wang, Chen| Liu, Yun| Naruse, Keiji| Takahashi, Ken|
Keywords prediabetes atherosclerosis metabolic syndrome obesity endothelial dysfunction exosome microRNA
Published Date 2021-04-15
Publication Title International Journal of Molecular Sciences
Volume volume22
Issue issue8
Publisher MDPI
Start Page 4108
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 33921168
DOI 10.3390/ijms22084108
NAID 120007034439
Web of Science KeyUT 000644360200001
Related Url isVersionOf https://doi.org/10.3390/ijms22084108
JaLCDOI 10.18926/AMO/61905
FullText URL 75_2_225.pdf
Author Xue, Haowei| Furumatsu, Takayuki| Okazaki, Yuki | Hiranaka, Takaaki| Kintaka, Keisuke | Zhang, Ximing| Yoshida, Aki| Ozaki, Toshifumi|
Abstract A 65-year-old man presented with a left medial meniscus (MM) posterior root tear (PRT). Unicompartmental knee arthroplasty was performed 12 months after transtibial pullout repair of the MMPRT. Repaired MM posterior root tissue was subjected to histological analysis. Immunostaining and picrosirius red staining showed sufficient deposition of type I collagen, and hematoxylin-eosin staining using a polarized microscope showed well-aligned fiber orientation in the repaired tissue. The repaired posterior root (post-transtibial pullout repair) showed mature and well-aligned ligament-like tissue. Preserving the MM posterior root remnant to mimic the original posterior root tissue might be useful when performing pullout repair.
Keywords medial meniscus posterior root tear unicompartmental knee arthroplasty histological analysis case report
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 225
End Page 230
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953430
NAID 120007029882
JaLCDOI 10.18926/AMO/61878
FullText URL 75_2_125.pdf
Author Kijima, Yasufumi| Kondo, Naoki| Okumura, Go| Endo, Naoto|
Abstract Rheumatoid arthritis (RA) affects the hip joints. The microarchitecture of the cancellous bone in RA-affected hip joints has been unclear. Here we investigated the bone metabolism changes in the subcapital cancellous bone of destructive hips of RA patients (n=26 patients; 28 hip joints) which were classified by Larsen grade on X-ray into the groups: destructive hip (Des) (Larsen grade IV, n=18) and neck fracture (Fx) (Larsen grade 0 or 1, n=10). The femoral heads of the Des-group showed significantly higher trabecular thickness versus those of the Fx-group (179±30.8 vs. 151±23.5 μm, p=0.02). The Des-group had significantly higher osteoid volume/tissue volume (OV/TV) and osteoid volume/bone volume (OV/BV) ratios than the Fx-group (OV/TV: 0.72±0.70% vs. 0.27±0.32%, p=0.028; OV/BV: 2.96±2.85% vs. 1.24±1.31%, p=0.039). The osteoblast and osteoclast surface areas of the Des-group were remarkably higher than those of the Fx-group (9.80±10.9 vs. 0.15±0.15%, p=0.0005; 0.34±0.48 vs. 0.06±0.06%, p=0.0285, respectively). The T-scores of hip (femoral neck) bone mineral density (BMD) of the Fx-group were significantly lower versus those of the Des-group (−3.1±0.76 vs. −1.6±1.17, p<0.01). Increased osteoid and resorption parameters and higher femoral neck BMD demonstrate a high bone-turnover state in response to destructive changes in the hips of RA patients.
Keywords bone histomorphometry rheumatoid arthritis destructive hip femoral neck fracture bone turnover
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 125
End Page 131
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953418
NAID 120007029905
FullText URL fulltext.pdf
Author Miyawaki, Yoshia| Shimizu, Sayaka| Ogawa, Yusuke| Sada, Ken-Ei| Katayama, Yukitoshi| Asano, Yosuke| Hayashi, Keigo| Yamamura, Yuriko| Hiramatsu-Asano, Sumie| Ohashi, Keiji| Morishita, Michiko| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Yajima, Nobuyuki| Yoshimi, Ryusuke| Shimojima, Yasuhiro| Ohno, Shigeru| Kajiyama, Hiroshi| Ichinose, Kunihiro| Sato, Shuzo| Fujiwara, Michio| Yamazaki, Hajime| Yamamoto, Yosuke| Wada, Jun| Fukuhara, Shunichi|
Keywords Systemic lupus erythematosus Glucocorticoid Emotional health Patient-reported outcome Depression Anxiety Cross-sectional study
Published Date 2021-03-10
Publication Title Arthritis Research & Therapy
Volume volume23
Issue issue1
Publisher BMC
ISSN 1478-6354
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2021
File Version publisher
PubMed ID 33691746
DOI 10.1186/s13075-021-02466-2
NAID 120007019117
Web of Science KeyUT 000627856600002
Related Url isVersionOf https://doi.org/10.1186/s13075-021-02466-2
FullText URL fulltext20210407_3.pdf
Author Mizukawa, Tomomi| Nishida, Takashi| Akashi, Sho| Kawata, Kazumi| Kikuchi, Sumire| Kawaki, Harumi| Takigawa, Masaharu| Kamioka, Hiroshi| Kubota, Satoshi|
Note This is an Accepted Manuscript of an article published by Wiley| This fulltext is available in Mar 2022|
Published Date 2021-03-03
Publication Title Journal of Cellular Physiology
Publisher Wiley
ISSN 0021-9541
NCID AA00694856
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33655492
DOI 10.1002/jcp.30348
Web of Science KeyUT 000624456400001
Related Url isVersionOf https://doi.org/10.1002/jcp.30348
FullText URL fulltext20210407_02.pdf
Author Elseoudi, Abdellatif| Nishida, Takashi| Mizukawa, Tomomi| Hattori, Takako| Kawata, Kazumi| Taha, Eman A.| Takigawa, Masaharu| Kubota, Satoshi|
Keywords FGF-1 CCN2 Osteoarthritis Chondrocytes Cartilage
Note This is an Accepted Manuscript of an article published by Springer| This fulltext is available in Jan 2022|
Published Date 2021-1-4
Publication Title Journal of Cell Communication and Signaling
Volume volume15
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 81
End Page 91
ISSN 1873-9601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33398720
DOI 10.1007/s12079-020-00600-4
Web of Science KeyUT 000604809900001
Related Url isVersionOf https://doi.org/10.1007/s12079-020-00600-4
FullText URL fulltext.pdf
Author Nunoue, Tomokazu| Yamaguchi, Satoshi| Teshigawara, Sanae| Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Niki, Toshiro| Wada, Jun|
Published Date 2021-03-16
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature
Start Page 5991
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33727589
DOI 10.1038/s41598-021-85080-1
NAID 120007004155
Web of Science KeyUT 000630512100015
Related Url isVersionOf https://doi.org/10.1038/s41598-021-85080-1
FullText URL fulltext.pdf
Author Nakatsuka, Atsuko| Yamaguchi, Satoshi| Eguchi, Jun| Kakuta, Shigeru| Iwakura, Yoichiro| Sugiyama, Hitoshi| Wada, Jun|
Published Date 2021-03-19
Publication Title Communications Biology
Volume volume4
Issue issue1
Publisher Nature
Start Page 373
ISSN 2399-3642
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33742129
DOI 10.1038/s42003-021-01902-y
NAID 120007004153
Web of Science KeyUT 000631555700003
Related Url isVersionOf https://doi.org/10.1038/s42003-021-01902-y
FullText URL fulltext.pdf
Author Kojina, Moeko| Suzuki, Keiichiro| Nishiwaki, Akane| Aiba, Tetsuya|
Keywords acute inflammation CYP2C11 hepatic drug metabolism, nateglinide
Published Date 2021-01-01
Publication Title Biological and Pharmaceutical Bulletin
Volume volume44
Issue issue1
Publisher Pharmaceutical Society of Japan
Start Page 96
End Page 102
ISSN 0918-6158
NCID AA10885497
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Pharmaceutical Society of Japan
File Version publisher
PubMed ID 33390555
DOI 10.1248/bpb.b20-00677
Web of Science KeyUT 000620798500015
Related Url isVersionOf https://doi.org/10.1248/bpb.b20-00677