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JaLCDOI 10.18926/AMO/66927
FullText URL 78_2_185.pdf
Author Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun|
Abstract The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients.
Keywords obesity type 2 diabetes COVID-19 vaccination
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 185
End Page 191
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38688836
Web of Science KeyUT 001227932200002
FullText URL fulltext.pdf
Author Ishida, Hikaru| Yasui, Norihisa| Yamashita, Atsuko|
Published Date 2024-03-22
Publication Title PLoS ONE
Volume volume19
Issue issue3
Publisher Public Library of Science
Start Page e0300981
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Ishida et al.
File Version publisher
PubMed ID 38517842
DOI 10.1371/journal.pone.0300981
Web of Science KeyUT 001190821200043
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0300981
FullText URL fulltext.pdf
Author Oguni, Kohei| Yamamoto, Koichiro| Nakano, Yasuhiro| Soejima, Yoshiaki| Suyama, Atsuhito| Takase, Ryosuke| Yasuda, Miho| Hasegawa, Kou| Otsuka, Fumio|
Keywords acromegaly growth hormone (GH) GH deficiency (GHD) insulin-like growth factor (IGF)-I pituitary gland
Published Date 2024-03-26
Publication Title Frontiers in Endocrinology
Volume volume15
Publisher Frontiers Media
Start Page 1381083
ISSN 1664-2392
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Oguni, Yamamoto, Nakano, Soejima, Suyama, Takase, Yasuda, Hasegawa and Otsuka.
File Version publisher
PubMed ID 38596224
DOI 10.3389/fendo.2024.1381083
Web of Science KeyUT 001198436000001
Related Url isVersionOf https://doi.org/10.3389/fendo.2024.1381083
FullText URL fulltext.pdf
Author Kano, Yuzuki| Yamaguchi, Satoshi| Mise, Koki| Kawakita, Chieko| Onishi, Yasuhiro| Kurooka, Naoko| Sugawara, Ryosuke| Albuayjan, Haya Hamed Hassan| Nakatsuka, Atsuko| Eguchi, Jun| Wada, Jun|
Keywords diabetes mellitus diabetic nephropathy metabolism obesity tubular epithelium
Published Date 2023-12-08
Publication Title Kidney360
Volume volume5
Issue issue2
Publisher Ovid Technologies (Wolters Kluwer Health)
Start Page 182
End Page 194
ISSN 2641-7650
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2023 The Author(s).
File Version publisher
PubMed ID 38062578
DOI 10.34067/kid.0000000000000333
Web of Science KeyUT 001178403800002
Related Url isVersionOf https://doi.org/10.34067/kid.0000000000000333
FullText URL fulltext.pdf
Author Taniguchi, Rikako| Moriya, Yuto| Dohmae, Naoshi| Suzuki, Takehiro| Nakahara, Kengo| Kubota, Sho| Takasugi, Nobumasa| Uehara, Takashi|
Keywords Nitric oxide S-Nitrosylation Protein arginine methyltransferase 1 (PRMT1) RNA metabolism Dead-box helicase 3X-linxed (DDX3)
Published Date 2024-03
Publication Title Journal of Pharmacological Sciences
Volume volume154
Issue issue3
Publisher Japanese Pharmacological Society
Start Page 209
End Page 217
ISSN 1347-8613
NCID AA11806667
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Authors.
File Version publisher
PubMed ID 38395522
DOI 10.1016/j.jphs.2023.12.012
Web of Science KeyUT 001180873100001
Related Url isVersionOf https://doi.org/10.1016/j.jphs.2023.12.012
FullText URL fulltext.pdf
Author Komai, Masato| Noda, Yuka| Ikeda, Atsuya| Kaneshiro, Nanaka| Kamikubo, Yuji| Sakurai, Takashi| Uehara, Takashi| Takasugi, Nobumasa|
Keywords alzheimer's disease apolipoproteins nuclear receptors/RXR transcription sphingosine phosphate astrocytes amyloid β sphingosine kinase 2 low-density lipoprotein receptor-related protein 4
Published Date 2024-03
Publication Title Journal of Lipid Research
Volume volume65
Issue issue3
Publisher Elsevier
Start Page 100510
ISSN 0022-2275
NCID AA00701215
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 THE AUTHORS.
File Version publisher
PubMed ID 38280459
DOI 10.1016/j.jlr.2024.100510
Web of Science KeyUT 001194192200001
Related Url isVersionOf https://doi.org/10.1016/j.jlr.2024.100510
FullText URL fulltext.pdf
Author Nakano, Yasuhiro| Sunada, Naruhiko| Tokumasu, Kazuki| Honda, Hiroyuki| Otsuka, Yuki| Sakurada, Yasue| Matsuda, Yui| Hasegawa, Toru| Omura, Daisuke| Ochi, Kanako| Yasuda, Miho| Hagiya, Hideharu| Ueda, Keigo| Otsuka, Fumio|
Keywords Diabetes mellitus Endocrine disorders Long COVID Metabolic disorders Thyroid disease
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-55526-3|
Published Date 2024-03-05
Publication Title Scientific Reports
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 5446
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 38443459
DOI 10.1038/s41598-024-55526-3
Web of Science KeyUT 001180457200009
Related Url isVersionOf https://doi.org/10.1038/s41598-024-55526-3
FullText URL fulltext.pdf
Author Matsumoto, Kazuya| Miyawaki, Yoshia| Katsuyama, Takayuki| Nakadoi, Takato| Shidahara, Kenta| Hirose, Kei| Nawachi, Shoichi| Asano, Yosuke| Katayama, Yu| Katsuyama, Eri| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Mori, Atsushi| Akagi, Satoshi| Sada, Ken-Ei| Wada, Jun|
Keywords pulmonary arterial hypertension anti-U1 RNP antibody corticosteroid cyclophosphamide
Published Date 2024-03-01
Publication Title Internal Medicine
Volume volume63
Issue issue5
Publisher Japanese Society of Internal Medicine
Start Page 671
End Page 676
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 37468249
DOI 10.2169/internalmedicine.1407-22
Web of Science KeyUT 001179673600001
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.1407-22
FullText URL fulltext20240226-03.pdf
Author Zhou, Wenhao| Kawashima, Shusuke| Ishino, Takamasa| Kawase, Katsushige| Ueda, Youki| Yamashita, Kazuo| Watanabe, Tomofumi| Kawazu, Masahito| Dansako, Hiromichi| Suzuki, Yutaka| Nishikawa, Hiroyoshi| Inozume, Takashi| Nagasaki, Joji| Togashi, Yosuke|
Keywords cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1
Note Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.|
Published Date 2024-02-27
Publication Title Cell Reports
Volume volume43
Issue issue2
Publisher Elsevier BV
Start Page 113797
ISSN 2211-1247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 38363680
DOI 10.1016/j.celrep.2024.113797
Web of Science KeyUT 001185865700001
Related Url isVersionOf https://doi.org/10.1016/j.celrep.2024.113797
FullText URL fulltext.pdf
Author Matsumoto, Kazuya| Matsumoto, Yoshinori| Nawachi, Shoichi| Asano, Yosuke| Katayama, Yu| Miyawaki, Yoshia| Katsuyama, Takayuki| Katsuyama, Eri| Nasu, Yoshihisa| Sada, Ken-Ei| Wada, Jun|
Keywords Nail-patella syndrome Rheumatoid arthritis Joint dislocation Iliac horn Case report
Note The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-024-07242-2|
Published Date 2024-02-14
Publication Title BMC Musculoskeletal Disorders
Volume volume25
Issue issue1
Publisher BMC
Start Page 139
ISSN 1471-2474
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 38355529
DOI 10.1186/s12891-024-07242-2
Web of Science KeyUT 001162669400002
Related Url isVersionOf https://doi.org/10.1186/s12891-024-07242-2
JaLCDOI 10.18926/AMO/66671
FullText URL 78_1_053.pdf
Author Ichikawa, Yukiko| Ogino, Tetsuya|
Abstract Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy.
Keywords cold compress fever hyperthermia thermal conductivity thermoregulation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 61
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419315
Web of Science KeyUT 001203658200009
JaLCDOI 10.18926/AMO/66664
FullText URL 78_1_001.pdf
Author Sun, Cuiming| Matsukawa, Akihiro|
Abstract Liver fibrosis, which ultimately leads to liver cirrhosis and hepatocellular carcinoma, is a major health burden worldwide. The progression of liver fibrosis is the result of the wound-healing response of liver to repeated injury. Hepatic macrophages are cells with high heterogeneity and plasticity and include tissue-resident macrophages termed Kupffer cells, and recruited macrophages derived from circulating monocytes, spleen and peritoneal cavity. Studies have shown that hepatic macrophages play roles in the initiation and progression of liver fibrosis by releasing inflammatory cytokines/chemokines and pro-fibrogenic factors. Furthermore, the development of liver fibrosis has been shown to be reversible. Hepatic macrophages have been shown to alternately regulate both the regression and turnover of liver fibrosis by changing their phenotypes during the dynamic progression of liver fibrosis. In this review, we summarize the role of hepatic macrophages in the progression and regression of liver fibrosis.
Keywords ERK-MAPK SPRED2 fibrosis macrophages
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38419308
Web of Science KeyUT 001203658200006
FullText URL fulltext.pdf
Author Kanao, Tadayoshi|
Keywords tetrathionate hydrolase reduced inorganic sulfur compounds dissimilatory sulfur metabolism S4-intermediate pathway acidophiles chemoautotroph
Published Date 2024-01-29
Publication Title Frontiers in Microbiology
Volume volume15
Publisher Frontiers Media
Start Page 1338669
ISSN 1664-302X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Kanao.
File Version publisher
PubMed ID 38348185
DOI 10.3389/fmicb.2024.1338669
Web of Science KeyUT 001160607900001
Related Url isVersionOf https://doi.org/10.3389/fmicb.2024.1338669
FullText URL fulltext.pdf
Author Hashimoto, Mana| Takahashi, Haruka| Tabata-Okubo, Kaori| Nagaoka, Noriyuki| Tokunaga, Kazuaki| Matsumori, Haruka| Ishihara, Yoshihito| Kaku, Masaru| Iimura, Tadahiro| Hara, Toru| Kamioka, Hiroshi|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-48786-y|
Published Date 2023-12-12
Publication Title Scientific Reports
Volume volume13
Issue issue1
Publisher Nature Portfolio
Start Page 22028
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023
File Version publisher
PubMed ID 38086873
DOI 10.1038/s41598-023-48786-y
Web of Science KeyUT 001126179100035
Related Url isVersionOf https://doi.org/10.1038/s41598-023-48786-y
FullText URL fulltext.pdf
Author Tsuji, Kenji| Nakanoh, Hiroyuki| Takahashi, Kensaku| Morita, Takafumi| Sang, Yizhen| Fukushima, Kazuhiko| Matsuoka-Uchiyama, Natsumi| Onishi, Yasuhiro| Uchida, Haruhito A.| Kitamura, Shinji| Wada, Jun|
Published Date 2023-12
Publication Title Kidney Medicine
Volume volume5
Issue issue12
Publisher Elsevier
Start Page 100733
ISSN 2590-0595
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 The Authors.
File Version publisher
PubMed ID 38046910
DOI 10.1016/j.xkme.2023.100733
Web of Science KeyUT 001124701500001
Related Url isVersionOf https://doi.org/10.1016/j.xkme.2023.100733
Title Alternative The 47th Annual Meeting of the Japan Society of Women's Nutrition and Metabolism
Author Masuyama, Hisashi|
Publication Title Journal of Okayama Medical Association
Published Date 2023-12-01
Volume volume135
Issue issue3
Start Page 179
End Page 180
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.135.179
language Japanese
Copyright Holders Copyright (c) 2023 岡山医学会
File Version publisher
DOI 10.4044/joma.135.179
FullText URL fulltext.pdf
Author Tsuji, Kenji| Nakanoh, Hiroyuki| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun|
Keywords microRNA acute kidney injury biomarker mesenchymal stem cell
Published Date 2023-09-09
Publication Title Diagnostics
Volume volume13
Issue issue18
Publisher MDPI
Start Page 2893
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 37761260
DOI 10.3390/diagnostics13182893
Web of Science KeyUT 001119215900001
Related Url isVersionOf https://doi.org/10.3390/diagnostics13182893
FullText URL fulltext.pdf
Author Shinoda-Ito, Yuki| Hirai, Anna| Omori, Kazuhiro| Ideguchi, Hidetaka| Yamamoto, Hideki| Kato, Fumino| Obata, Kyoichi| Ogawa, Tatsuo| Nakano, Keisuke| Nakadoi, Takato| Katsuyama, Eri| Ibaragi, Soichiro| Yamamoto, Tadashi| Nagatsuka, Hitoshi| Hirasawa, Akira| Takashiba, Shogo|
Keywords Ligneous periodontitis Plasminogen deficiency PLG Behcet's disease Gingival hyperplasia
Note The version of record of this article, first published in BMC Oral Health, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12903-023-03586-8|
Published Date 2023-11-08
Publication Title BMC Oral Health
Volume volume23
Issue issue1
Publisher BMC
Start Page 843
ISSN 1472-6831
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37940896
DOI 10.1186/s12903-023-03586-8
Web of Science KeyUT 001101860500001
Related Url isVersionOf https://doi.org/10.1186/s12903-023-03586-8
JaLCDOI 10.18926/AMO/66156
FullText URL 77_6_635.pdf
Author Ikeda, Tomohiro| Okamura, Kazunori| Hasegawa, Masaki| Tanaka, Satoshi| Kanai, Shusaku|
Abstract In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
Keywords whey protein electrical stimulation muscle strength healthy volunteers
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-12
Volume volume77
Issue issue6
Publisher Okayama University Medical School
Start Page 635
End Page 645
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 38145938
Web of Science KeyUT 001164631200009
FullText URL K0006890_abstract_review.pdf K0006890_fulltext.pdf K0006890_summary.pdf
Author WANG, YUZE|
Published Date 2023-09-25
Content Type Thesis or Dissertation
Grant Number 甲第6890号
Granted Date 2023-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023 by the authors.