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Author La, The Mon| Tachibana, Hiromi| Li, Shun-Ai| Abe, Tadashi| Seiriki, Sayaka| Nagaoka, Hikaru| Takashima, Eizo| Takeda, Tetsuya| Ogawa, Daisuke| Makino, Shin-Ichi| Asanuma, Katsuhiko| Watanabe, Masami| Tian, Xuefei| Ishibe, Shuta| Sakane, Ayuko| Sasaki, Takuya| Wada, Jun| Takei, Kohji| Yamada, Hiroshi|
Keywords dynamin microtubules podocyte primary process
Published Date 2020-10-17
Publication Title FASEB Journal
Volume volume34
Issue issue12
Publisher Wiley
Start Page 16449
End Page 16463
ISSN 0892-6638
NCID AA1066874X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 33070431
DOI 10.1096/fj.202001240RR
NAID 120006900792
Web of Science KeyUT 000581167100001
Related Url isVersionOf https://doi.org/10.1096/fj.202001240RR
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Author Osumi, Ryuta| Wang, Ziyi| Ishihara, Yoshihito| Odagaki, Naoya| Iimura, Tadahiro| Kamioka, Hiroshi|
Keywords Sclerostin distribution Lacuno-canalicular system Mechanical unloading
Note This is an Accepted Manuscript of an article published by Springer.|
Published Date 2020-08-25
Publication Title Journal of Bone and Mineral Metabolism
Volume volume39
Publisher Springer
Start Page 148
End Page 159
ISSN 0914-8779
NCID AA10747551
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32844318
DOI 10.1007/s00774-020-01135-9
Web of Science KeyUT 000562686600001
Related Url isVersionOf https://link.springer.com/article/10.1007/s00774-020-01135-9
JaLCDOI 10.18926/AMO/60805
FullText URL 74_5_435.pdf
Author Fujishita, Keigo| Oka, Satoshi| Kamei, Katsuhiko| Tani, Katsuma| Fujisawa, Yuka| Kitamura, Wataru| Machida, Takuya| Imai, Toshi|
Abstract A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia.
Keywords disseminated fusariosis Fusarium fujikuroi species complex allogeneic hematopoietic stem cell transplantation acute myeloid leukemia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 435
End Page 441
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106701
Web of Science KeyUT 000581970100010
NAID 120006892931
JaLCDOI 10.18926/AMO/60799
FullText URL 74_5_401.pdf
Author Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi|
Abstract Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC.
Keywords differentiated thyroid carcinoma juvenile children
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 406
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106695
Web of Science KeyUT 000581970100004
NAID 120006892925
FullText URL fulltext.pdf
Author Nojima, Ichiro| Eikawa, Shingo| Tomonobu, Nahoko| Hada, Yoshiko| Kajitani, Nobuo| Teshigawara, Sanae| Miyamoto, Satoshi| Tone, Atsuhito| Uchida, Haruhito A.| Nakatsuka, Atsuko| Eguchi, Jun| Shikata, Kenichi| Udono, Heiichiro| Wada, Jun|
Keywords Cytokines Diabetes Endocrine system and metabolic diseases Immunology Tumour immunology
Published Date 2020-09-10
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 14928
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32913271
DOI 10.1038/s41598-020-71946-3
Web of Science KeyUT 000571915100049
Related Url isVersionOf https://doi.org/10.1038/s41598-020-71946-3
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Author Mitalo, Oscar W.| Otsuki, Takumi| Okada, Rui| Obitsu, Saeka| Masuda, Kanae| Hojo, Yuko| Matsuura, Takakazu| Mori, Izumi C.| Abe, Daigo| Asiche, William O.| Akagi, Takashi| Kubo, Yasutaka| Ushijima, Koichiro|
Keywords 1-methylcyclopropene carotenoids chlorophyll Citrus limon ethylene low temperature peel degreening phytohormones transcriptome
Published Date 2020-05-06
Publication Title Journal of Experimental Botany
Volume volume71
Issue issue16
Publisher Oxford University Press
Start Page 4778
End Page 4796
ISSN 0022-0957
NCID AA00697526
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020.
File Version publisher
PubMed ID 32374848
DOI 10.1093/jxb/eraa206
Web of Science KeyUT 000573250000015
Related Url isVersionOf https://doi.org/10.1093/jxb/eraa206
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Author Tsuji, Kenji| Kitamura, Shinji| Sang, Yizhen| Fukushima, Kazuhiko| Wada, Jun|
Keywords Kidney stem cell Regeneration Acute kidney injury Growth factor
Published Date 2020-07
Publication Title Stem Cell Research
Volume volume46
Publisher Elsevier
Start Page 101865
ISSN 1873-5061
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32505897
DOI 10.1016/j.scr.2020.101865
Web of Science KeyUT 000568783800002
Related Url isVersionOf https://doi.org/10.1016/j.scr.2020.101865
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Author Matsuoka-Uchiyama, Natsumi| Tsuji, Kenji| Fukushima, Kazuhiko| Kitamura, Shinji| Uchida, Haruhito A.| Sugiyama, Hitoshi| Takahashi, Naoki| Iwano, Masayuki| Wada, Jun|
Published Date 2020-06-18
Publication Title Kidney International Reports
Volume volume5
Issue issue9
Publisher Elsevier
Start Page 1576
End Page 1580
ISSN 24680249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 International Society of Nephrology
File Version publisher
PubMed ID 32954083
DOI 10.1016/j.ekir.2020.06.010
Related Url isVersionOf https://doi.org/10.1016/j.ekir.2020.06.010
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Author Shen, Lianhua| Yamamoto, Takushi| Tan, Xian Wen| Ogata, Koretsugu| Ando, Eiji| Ozeki, Eiichi| Matsuura, Eiji|
Keywords Atherosclerosis Low-density lipoprotein (LDL) Oxidized LDL (oxLDL) Oxidized lipids; Imaging mass microscopy (iMScope) Mass spectroscopy (MS)
Published Date 2020-08-28
Publication Title Atherosclerosis
Volume volume311
Publisher Elsevier
Start Page 1
End Page 12
ISSN 00219150
NCID AA00553457
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32911376
DOI 10.1016/j.atherosclerosis.2020.08.001
Related Url isVersionOf https://doi.org/10.1016/j.atherosclerosis.2020.08.001
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Author Shikata, Kenichi| Haneda, Masakazu| Ninomiya, Toshiharu| Koya, Daisuke| Suzuki, Yoshiki| Suzuki, Daisuke| Ishida, Hitoshi| Akai, Hiroaki| Tomino, Yasuhiko| Uzu, Takashi| Nishimura, Motonobu| Maeda, Shiro| Ogawa, Daisuke| Miyamoto, Satoshi| Makino, Hirofumi| the Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT‐Japan) collaborative group|
Keywords Diabetic kidney disease Diabetic nephropathy Diabetic Nephropathy Remission and Regression Team Trial in Japan
Published Date 2020-08-08
Publication Title Journal of Diabetes Investigation
Volume volume12
Issue issue2
Publisher Wiley
Start Page 207
End Page 216
ISSN 2040-1116
NCID AA12488319
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors
File Version publisher
PubMed ID 32597548
DOI 10.1111/jdi.13339
NAID 120006880216
Web of Science KeyUT 000557091100001
Related Url isVersionOf https://doi.org/10.1111/jdi.13339
JaLCDOI 10.18926/AMO/60370
FullText URL 74_4_319.pdf
Author Isoyama, Satoshi| Kimura, Satoshi| Morimatsu, Hiroshi|
Abstract Little is known about the role of a strong ions in humans with respiratory abnormalities. In this study, we investigated the associations between partial carbon dioxide pressure (pCO2) and each of sodium ion (Na+) concentrations, chloride ion (Cl−) concentrations and their difference (SIDNa-Cl). Blood gas data were obtained from patients in a teaching hospital intensive care unit between August 2013 and January 2017. The association between pCO2 and SIDNa-Cl was defined as the primary outcome. The associations between pCO2 and [Cl−], [Na+] and other strong ions were secondary outcomes. pCO2 was stratified into 10 mmHg-wide bands and treated as a categorical variable for comparison. As a result, we reviewed 115,936 blood gas data points from 3,840 different ICU stays. There were significant differences in SIDNa-Cl, [Cl−], and [Na+] among all categorized pCO2 bands. The respective pCO2 SIDNa-Cl, [Cl−], and [Na+] correlation coefficients were 0.48, −0.31, and 0.08. SIDNa-Cl increased and [Cl−] decreased with pCO2, with little relationship between pCO2 and [Na+] across subsets. In conclusion, we found relatively strong correlations between pCO2 and SIDNa-Cl in the multiple blood gas datasets examined. Correlations between pCO2 and chloride concentrations, but not sodium concentrations, were further found to be moderate in these ICU data.
Keywords acid-base phenomena Stewart approach strong ion difference chlorine ion partial carbon dioxide pressure
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 319
End Page 325
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843763
Web of Science KeyUT 000562508700007
NAID 120006880209
JaLCDOI 10.18926/AMO/60368
FullText URL 74_4_301.pdf
Author Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki|
Abstract Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex.
Keywords ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 301
End Page 306
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843761
Web of Science KeyUT 000562508700005
NAID 120006880207
FullText URL fulltext.pdf
Author Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun|
Keywords immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy
Published Date 2020-07-09
Publication Title Diagnostics
Volume volume10
Issue issue7
Publisher MDPI
Start Page 466
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32660112
DOI 10.3390/diagnostics10070466
Web of Science KeyUT 000557155500001
Related Url isVersionOf https://doi.org/10.3390/diagnostics10070466
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Author Hada, Yoshiko| Uchida, Haruhito A.| Otaka, Nozomu| Onishi, Yasuhiro| Okamoto, Shugo| Nishiwaki, Mariko| Takemoto, Rika| Takeuchi, Hidemi| Wada, Jun|
Keywords chlorogenic acid vascular senescence nuclear factor erythroid 2-related factor 2 heme oxygenase-1
Published Date 2020-06-25
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue12
Publisher MDPI
Start Page 4527
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32630570
DOI 10.3390/ijms21124527
Web of Science KeyUT 000554678300001
Related Url isVersionOf https://doi.org/10.3390/ijms21124527
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Author Tanabe, Katsuyuki| Kanzaki, Hiromitsu| Wada, Takahira| Nakashima, Yuri| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Keywords case report gastric cancer IgA nephropathy nivolumab steroid
Published Date 2020-05-22
Publication Title Medicine
Volume volume99
Issue issue21
Publisher Lippincott, Williams & Wilkins
Start Page e20464
ISSN 0025-7974
NCID AA00728867
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 the Author(s).
File Version publisher
PubMed ID 32481351
DOI 10.1097/MD.0000000000020464
Web of Science KeyUT 000551508200106
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000020464
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Author Yanpirat, Patcha| Nakatsuji, Yukari| Hiraga, Shota| Fujitani, Yoshiko| Izumi, Terumi| Masuda, Sachiko| Mitsui, Ryoji| Nakagawa, Tomoyuki| Tani, Akio|
Keywords lanthanide methylotroph XoxF methanol dehydrogenase Methylobacteriumspecies
Published Date 2020-05-30
Publication Title Microorganisms
Volume volume8
Issue issue6
Publisher MDPI
Start Page 822
ISSN 2076-2607
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32486139
DOI 10.3390/microorganisms8060822
Web of Science KeyUT 000549300700001
Related Url isVersionOf https://doi.org/10.3390/microorganisms8060822
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Author Miyake, Hiromasa| Tanabe, Katsuyuki| Tanimura, Satoshi| Nakashima, Yuri| Morioka, Tomoyo| Masuda, Kana| Sugiyama, Hitoshi| Sato, Yasufumi| Wada, Jun|
Keywords acute kidney injury ischemia-reperfusion oxidative stress vasohibin-2 peritubular capillaries
Published Date 2020-06-26
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue12
Publisher MDPI
Start Page 4545
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32604722
DOI 10.3390/ijms21124545
Web of Science KeyUT 000549478900001
Related Url isVersionOf https://doi.org/10.3390/ijms21124545
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Author Sang, Yizhen| Tsuji, Kenji| Inoue-Torii, Akiko| Fukushima, Kazuhiko| Kitamura, Shinji| Wada, Jun|
Keywords semaphorin3A podocyte proteinuria apoptosis c-Jun N-terminal kinase
Published Date 2020-06-08
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4099
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32521824
DOI 10.3390/ijms21114099
Web of Science KeyUT 000543400300361
Related Url isVersionOf https://doi.org/10.3390/ijms21114099
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Author Fukushima, Kazuhiko| Kitamura, Shinji| Tsuji, Kenji| Sang, Yizhen| Wada, Jun|
Keywords sodium glucose co-transporter 2 inhibitor mammalian target of rapamycin (mTOR) autophagy obesity multi lamellar body
Published Date 2020-06-05
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue11
Publisher MDPI
Start Page 4054
ISSN 1422-0067
NCID AA12038549
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors
File Version publisher
PubMed ID 32517059
DOI 10.3390/ijms21114054
Web of Science KeyUT 000543400300316
Related Url isVersionOf https://doi.org/10.3390/ijms21114054
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Author Yamamura, Yuriko| Matsumoto, Yoshinori| Tadokoro, Koh| Ohta, Yasuyuki| Sato, Kota| Yamashita, Toru| Yamamura, Masahiro| Sada, Ken-Ei| Abe, Koji| Wada, Jun|
Keywords Noninvasive pressure support ventilation Statin-associated necrotizing myopathy BIPAP
Published Date 2020-06-03
Publication Title BMC Pulmonary Medicine
Volume volume20
Issue issue1
Publisher BMC
Start Page 156
ISSN 1471-2466
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32493279
DOI 10.1186/s12890-020-01195-7
Web of Science KeyUT 000540247100001
Related Url isVersionOf https://doi.org/10.1186/s12890-020-01195-7