result 47501 件
| JaLCDOI | 10.18926/AMO/40129 |
|---|---|
| FullText URL | 64_4_219.pdf |
| Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
| Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
| Keywords | ACTH imipramine lithium proliferation Ki-67 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-08 |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 223 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802538 |
| Web of Science KeyUT | 000281384400002 |
| JaLCDOI | 10.18926/AMO/40128 |
|---|---|
| FullText URL | 64_4_213.pdf |
| Author | Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi| |
| Abstract | Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB. |
| Keywords | adrenal cortex angiotensin II aldosterone bone morphogenetic protein |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-08 |
| Volume | volume64 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 213 |
| End Page | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20802537 |
| Web of Science KeyUT | 000281384400001 |
| Author | Inoue, Seiji| |
|---|---|
| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Hosokawa, Shinobu| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Isobe, Midori| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kojo, Shoichiro| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kikumoto, Yoko| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nishiguchi, Mitsuhisa| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Katsumata, Atsushi| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Otsuka, Atsushi| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Tanaka, Masamichi| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Hashizume, Kenzo| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Aochi, Seiko| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Nishiyama, Yasuhiro| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Yoshida, Hidenori| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kotaka, Tatsuya| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Takahata, Hiroyuki| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kawabata, Takuya| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Suemitsu, Shunsuke| |
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| Published Date | 2010-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | 野崎 貴博| 中村 大介| 光本 順| 能城 修一| 佐々木 由香| |
|---|---|
| Published Date | 2006-03-15 |
| Publication Title | 岡山大学構内遺跡発掘調査報告 |
| Volume | volume22 |
| Content Type | Research Paper |
