result 1284 件
JaLCDOI | 10.18926/AMO/61435 |
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FullText URL | 75_1_55.pdf |
Author | Kubo, Yujiro| Watanabe, Mototsugu| Choshi, Haruki| Matsubara, Kei| Shiotani, Toshio| Kataoka, Kazuhiko| |
Abstract | Small pulmonary lesions are often difficult to localize during thoracoscopic surgery. We describe a new com-puted tomography (CT)-guided pleural dye-marking method for small peripheral pulmonary lesions that does not involve a visceral pleural puncture. We used this technique for 23 lesions (22 patients) who underwent tho-racoscopic partial lung resection (Nov. 2016-Jan. 2018). With the patient in the lateral decubitus position, pre-operative CT-guided marking on the skin over the lesion was performed. During the surgery, we marked the visceral pleura with a skin marker directly or with an infant-size nutrition catheter with crystal violet at the tip through a venous indwelling needle inserted perpendicular to the skin marking. We localized and resected the lesions in all cases, without complications. The median nodule size measured histopathologically was 8 (4-20) mm overall, and 7 (0-20) mm of the solid part; the median distance from the visceral pleura to the nodule was 9 (1-33) mm. The median operation time was 67 (37-180) min. The median postoperative hospital stay was 3 (3-11) days. Our CT-guided pleural dye-marking method is useful and safe for the localization of small periph-eral pulmonary lesions in thoracoscopic partial lung resections. |
Keywords | Small pulmonary lesion ground glass nodule marking localization thoracocentesis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-02 |
Volume | volume75 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 55 |
End Page | 61 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33649614 |
JaLCDOI | 10.18926/AMO/61431 |
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FullText URL | 75_1_31.pdf |
Author | Miyamaru, Satoru| Murakami, Daizo| Nishimoto, Kohei| Saito, Haruki| Miyamoto, Yusuke| Hirota, Kaoruko| Ise, Momoko| Orita, Yorihisa| |
Abstract | Although the lung is the most common site of distant metastases from head and neck squamous cell carcinoma (HNSCC), the number of reports about the effects of pulmonary metastasectomy for the treatment of lung metastasis from HNSCC is limited. Metachronous pulmonary metastases were detected in 45 HNSCC patients at Kumamoto University Hospital from 1998 to 2018. Twenty-two patients underwent an operative resection (Ope group) and 23 underwent chemotherapy (Chemo group). The 3-year overall survival (OS) rate and median OS were evaluated. The effects of adjuvant chemotherapy after pulmonary metastasectomy and of new drugs (cetuximab and nivolumab), in the chemo group were also assessed. The 3-year OS rates and median OS were: Ope, 66.1% and 31.5 months; Chemo, 39.7% and 18 months, respectively. In the Ope group, addi-tional recurrences were significantly fewer in the patients who underwent adjuvant chemotherapy post-surgery versus the patients who underwent surgery alone (p = 0.013). In the Chemo group, the 3-year OS rate of the patients who received new drugs was significantly better than that of the patients who did not (p = 0.021). Adjuvant chemotherapy after pulmonary metastasectomy may be a preferable treatment option for preventing recurrences. Cetuximab and nivolumab have a potential to improve OS. |
Keywords | pulmonary metastasis head and neck squamous cell carcinoma pulmonary metastasectomy adjuvant chemotherapy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-02 |
Volume | volume75 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 31 |
End Page | 37 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33649611 |
JaLCDOI | 10.18926/AMO/61430 |
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FullText URL | 75_1_25.pdf |
Author | Tetsunaga, Tomonori| Tetsunaga, Tomoko| Yamada, Kazuki| Sanki, Tomoaki| Kawamura, Yoshi| Ozaki, Toshifumi| |
Abstract | In bipolar hemiarthroplasty (BHA), it is important to preserve soft tissue to reduce the risk of postoperative dislocation. A variety of surgical approaches for BHA are available, but extra care is needed with muscle- and tendon-preserving approaches in geriatric patients. We investigated the usefulness of BHA using a conjoined tendon-preserving posterior (CPP) approach, in which only the external obturator muscle is dissected, in geri-atric patients. We retrospectively analyzed the cases of 40 femoral neck fracture patients (10 men, 30 women) aged ≥ 80 years who underwent BHA using the CPP approach. The patients’ average age was 85.8 years (80-94 years). We examined the operation time, bleeding, preservation of short external rotator muscles, complica-tions, and stem alignment and subsidence from postoperative radiographs. Although gemellus inferior muscle injury was detected in 4 patients (10%), the hip joint stability was very excellent in all cases. There was no intraoperative fracture or postoperative dislocation. On postoperative radiographs, all femoral stems were in a neutral position. There was no stem subsidence in all 40 patients. BHA using the CPP approach appeared to be useful even in geriatric patients. |
Keywords | bipolar hip arthroplasty geriatric patient conjoined tendon-preserving posterior approach |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-02 |
Volume | volume75 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 25 |
End Page | 30 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33649610 |
FullText URL | fulltext.pdf |
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Author | YASUHARA, Takao| MURAI, Satoshi| MIKUNI, Nobuhiro| MIYAMOTO, Susumu| DATE, Isao| |
Keywords | artificial bone cranioplasty infection re-operation titanium plate |
Published Date | 2020 |
Publication Title | Neurologia medico-chirurgica |
Volume | volume60 |
Issue | issue7 |
Publisher | The Japan Neurosurgical Society |
Start Page | 337 |
End Page | 350 |
ISSN | 0470-8105 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by The Japan Neurosurgical Society |
PubMed ID | 32536658 |
DOI | 10.2176/nmc.oa.2020-0051 |
Web of Science KeyUT | 000548315700003 |
Related Url | isVersionOf https://doi.org/10.2176/nmc.oa.2020-0051 |
FullText URL | fulltext.pdf |
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Author | Toh, Norihisa| Kotani, Yasuhiro| Akagi, Teiji| Kuroko, Yosuke| Baba, Kenji| Otsuki, Shin-ichi| Kasahara, Shingo| Ito, Hiroshi| |
Keywords | Pulmonary atresia with intact ventricular septum adult congenital heart disease outcome |
Published Date | 2020-06-17 |
Publication Title | Congenital Heart Disease |
Volume | volume15 |
Issue | issue1 |
Publisher | Wiley |
Start Page | 1 |
End Page | 11 |
ISSN | 1747-079X |
NCID | AA12157082 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
DOI | 10.32604/CHD.2020.011579 |
Web of Science KeyUT | 000564363500001 |
Related Url | isVersionOf https://doi.org/10.32604/CHD.2020.011579 |
FullText URL | fulltext.pdf |
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Author | Takagi, Kosei | Kimenai, Hendrikus J. A. N.| Terkivatan, Turkan| Tran, Khe T. C.| Ijzermans, Jan N. M.| Minnee, Robert C.| |
Keywords | Kidney transplantation Living donors Nephrectomy Laparoscopy Hand-assisted laparoscopy Learning curve Education Teaching |
Published Date | 2020-06-15 |
Publication Title | Surgical Endoscopy |
Publisher | Springer |
ISSN | 0930-2794 |
NCID | AA10750363 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The authors. |
File Version | publisher |
PubMed ID | 32556762 |
DOI | 10.1007/s00464-020-07727-w |
Web of Science KeyUT | 000540992500014 |
Related Url | isVersionOf https://doi.org/10.1007/s00464-020-07727-w |
FullText URL | fulltext.pdf |
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Author | Shimada, Yasushi| Yoshiyama, Masahiro| Tagami, Junji| Sumi, Yasunori| |
Keywords | Optical coherence tomography Diagnosis Caries Tooth crack NCCL Tooth wear Age-related changes |
Published Date | 2020-11 |
Publication Title | Japanese Dental Science Review |
Volume | volume56 |
Issue | issue1 |
Publisher | ELSEVIER SCI LTD |
Start Page | 109 |
End Page | 118 |
ISSN | 1882-7616 |
NCID | AA12334461 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 33033549 |
DOI | 10.1016/j.jdsr.2020.08.001 |
Web of Science KeyUT | 000598681800015 |
Related Url | isVersionOf https://doi.org/10.1016/j.jdsr.2020.08.001 |
JaLCDOI | 10.18926/AMO/61211 |
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FullText URL | 74_6_521.pdf |
Author | Itazaki, Yujiro| Tsujimoto, Hironori| Sugasawa, Hidekazu| Yaguchi, Yoshihisa| Nomura, Shinsuke| Ito, Nozomi| Harada, Manabu| Sugihara, Takao| Tsuchiya, Satoshi| Ishibashi, Yusuke| Kouzu, Keita| Kishi, Yoji| Ueno, Hideki | |
Abstract | We report a successful dissection of metastatic posterior thoracic para-aortic lymph node (No. 112aoP) via bilateral thoracoscopic surgery. With the anesthetized patient (a 73-year-old Japanese woman) in the prone position, two working ports were inserted for the left-side approach, and artificial pneumothorax was created. Thoracoscopic examination revealed a swollen LN posterior to the descending aorta. Fat and metastatic LNs posterior to the aorta were dissected from the aortic arch level to the diaphragm while preserving intercostal arteries. For the right-side approach, two working ports were inserted and a routine thoracoscopic esophagec-tomy was performed. Gastric conduit reconstruction was achieved laparoscopically. Operation time for the left thoracic procedure: 54 min; estimated blood loss: almost none. No recurrence was detected 24 months post-operatively. There are several surgical options for approaching No. 112aoP, including transhiatal, left thora-cotomy, and thoracoscopy. Although a wide dissection of the posterior thoracic para-aortic area has not been reported, it may be feasible and safe if the artery of Adamkiewicz and intercostal arteries are preserved. A min-imally invasive bilateral thoracoscopic approach for a thoracoscopic esophagectomy is safe and useful for esophageal cancer patients with solitary No. 112aoP metastasis. |
Keywords | bilateral approach posterior thoracic para-aortic lymph node thoracoscopic esophagectomy |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 521 |
End Page | 524 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361872 |
Web of Science KeyUT | 000601203600008 |
NAID | 120006948950 |
FullText URL | fulltext.pdf |
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Author | Nishii, Kazuya| Ohashi, Kadoaki| Tamura, Tomoki| Ninomiya, Kiichiro| Matsubara, Takehiro| Senoo, Satoru| Kano, Hirohisa| Watanabe, Hiromi| Oda, Naohiro| Makimoto, Go| Higo, Hisao| Kato, Yuka| Ninomiya, Takashi| Kubo, Toshio| Yamamoto, Hiromasa | Tomida, Shuta| Hotta, Katsuyuki| Tabata, Masahiro| Toyooka, Shinichi| Maeda, Yoshinobu| Kiura, Katsuyuki| |
Keywords | non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs |
Published Date | 2020-12 |
Publication Title | Oncology Letters |
Volume | volume20 |
Issue | issue6 |
Publisher | Spandidos Publications |
Start Page | 393 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33193853 |
DOI | 10.3892/ol.2020.12256 |
Web of Science KeyUT | 000595649300005 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2020.12256 |
FullText URL | fulltext.pdf |
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Author | Shimada, Yasushi| Yoshiyama, Masahiro| Tagami, Junji| Sumi, Yasunori| |
Keywords | Optical coherence tomography Diagnosis Caries Tooth crack NCCL Tooth wear Age-related changes |
Published Date | 2020-11-30 |
Publication Title | Japanese Dental Science Review |
Volume | volume56 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 109 |
End Page | 118 |
ISSN | 1882-7616 |
NCID | AA12334461 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 33033549 |
DOI | 10.1016/j.jdsr.2020.08.001 |
Web of Science KeyUT | 000598681800015 |
Related Url | isVersionOf https://doi.org/10.1016/j.jdsr.2020.08.001 |
FullText URL | fulltext210412_3.pdf |
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Author | Asano, Takao| Osaki, Yusuke| |
Keywords | Decision analysis Investment analysis Capital investment Smooth ambiguity model Technology shock |
Note | © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejor.2020.11.047] . | |
Published Date | 2020-12-05 |
Publication Title | European Journal of Operational Research |
Volume | volume293 |
Issue | issue1 |
Publisher | Elsevier |
Start Page | 304 |
End Page | 311 |
ISSN | 03772217 |
NCID | AA0017802X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
DOI | 10.1016/j.ejor.2020.11.047 |
Web of Science KeyUT | 000628803700022 |
Related Url | isVersionOf https://doi.org/10.1016/j.ejor.2020.11.047 |
FullText URL | fulltext.pdf |
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Author | Miyaji, Mary| Furuta, Ryohei| Hosoya, Osamu| Sano, Kuniaki| Hara, Norikazu| Kuwano, Ryozo| Kang, Jiyoung| Tateno, Masaru| Tsutsui, Kimiko M.| Tsutsui, Ken| |
Keywords | Biochemistry Molecular biology |
Published Date | 2020-10-29 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 18550 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 33122676 |
DOI | 10.1038/s41598-020-75004-w |
Web of Science KeyUT | 000587689500013 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-75004-w |
FullText URL | fulltext.pdf |
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Author | Kashiwa, Misa| Shimada, Yasushi| Sadr, Alireza| Yoshiyama, Masahiro| Sumi, Yasunori| Tagami, Junji| |
Keywords | occlusal tooth wear erosive tooth wear SS-OCT 3D imaging enamel thickness dentin exposure demineralization |
Published Date | 2020-10-23 |
Publication Title | Sensors |
Volume | volume20 |
Issue | issue21 |
Publisher | MDPI |
Start Page | 6016 |
ISSN | 1424-8220 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33113981 |
DOI | 10.3390/s20216016 |
Web of Science KeyUT | 000589312100001 |
Related Url | isVersionOf https://doi.org/10.3390/s20216016 |
FullText URL | fulltext.pdf Fig1-5.pdf |
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Author | Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Uchida, Daisuke| Tomoda, Takeshi| Muro, Shinichiro| Okada, Hiroyuki| |
Published Date | 2019-09 |
Publication Title | Endoscopy |
Volume | volume51 |
Issue | issue9 |
Publisher | Thieme Gruppe |
Start Page | E265 |
End Page | E266 |
ISSN | 0013-726X |
NCID | AA00635110 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 31071749 |
DOI | 10.1055/a-0896-2498 |
Web of Science KeyUT | 000484585300014 |
Related Url | isVersionOf https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0896-2498 |
JaLCDOI | 10.18926/AMO/60880 |
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FullText URL | 74_6_505.pdf |
Author | Ohara, Toshiaki| Sakurama, Kazufumi| Hiramatsu, Satoshi| |
Abstract | Vascular-access interventions are necessary for the continuation of hemodialysis, and they are performed under X-ray guidance. During interventions, patients’ accidental falls from the bed are a serious problem, and spe-cialized fixation systems for hemodialysis patients to prevent their falls from the bed have been lacking. We developed a new fixation plate made of polypropylene homopolymer and tested its ability to prevent such falls retrospectively. This plate, which we named the ‘vascular-access intervention assistance plate,’ offers functional features such as the concurrent fixation of the body and either arm and an arm space with serrations for fixing a forearm strap. We performed computer simulations to examine the strength of the plate, and we evaluated the efficacy of fall prevention by reviewing patients’ medical records. The results demonstrated that the functional design of the plate provides good operability via accurate concurrent fixations of the body and arm. The com-puter simulation analysis results indicated the plate’s sufficient strength. The medical records analysis revealed three accidental falls before the plate’s introduction (401 patients, 1,437 interventions), and none after plate introduction (683 patients, 1,872 interventions). Accidental falls were significantly prevented by use of the plate (p < 0.05). The dementia rate and type of procedure were not significantly different between the patients who fell and those who did not. This vascular-access intervention assisted plate provides good operability and safety by preventing accidental falls among hemodialysis patients. |
Keywords | hemodialysis fall accident incident vascular access |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 505 |
End Page | 511 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361870 |
Web of Science KeyUT | 000601203600006 |
NAID | 120006948959 |
FullText URL | mjou_063_123_131.pdf |
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Author | Lee, Min Ho| |
Abstract | Given Jacobi forms, we determine associated Jacobi-like forms, whose coefficients are quasimodular forms. We then use these quasimodular forms to construct differential operators on modular forms, which are expressed in terms of the Fourier coefficients of the given Jacobi forms. |
Keywords | Jacobi forms Jacobi-like forms modular forms quasimodular forms |
Published Date | 2021-01 |
Publication Title | Mathematical Journal of Okayama University |
Volume | volume63 |
Issue | issue1 |
Publisher | Department of Mathematics, Faculty of Science, Okayama University |
Start Page | 123 |
End Page | 131 |
ISSN | 0030-1566 |
NCID | AA00723502 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright©2021 by the Editorial Board of Mathematical Journal of Okayama University |
FullText URL | fulltext.pdf |
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Author | Oyama, Takanori| Noda, Takuo| Washio, Kana| Shimada, Akira| |
Keywords | growing teratoma syndrome immature teratoma ovarian tumor pediatric |
Published Date | 2020-09-18 |
Publication Title | Medicine |
Volume | volume99 |
Issue | issue38 |
Publisher | Lippincott, Williams & Wilkins |
Start Page | e22297 |
ISSN | 0025-7974 |
NCID | AA00728867 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 the Author(s). |
File Version | publisher |
PubMed ID | 32957389 |
DOI | 10.1097/MD.0000000000022297 |
Web of Science KeyUT | 000579298600086 |
Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000022297 |
FullText URL | Int_Orthop_44_381.pdf |
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Author | Fujiwara, Tomohiro| Tsuda, Yusuke| Stevenson, Jonathan| Parry, Michael| Jeys, Lee| |
Keywords | Chordoma Sacrum Surgery Margin width Radiotherapy |
Note | This is a post-peer-review, pre-copyedit version of an article published in International Orthopaedics. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00264-019-04460-5. This fulltext is available in Dec. 2020.| |
Published Date | 2019-12-20 |
Publication Title | International Orthopaedics |
Volume | volume44 |
Issue | issue2 |
Publisher | Springer |
Start Page | 381 |
End Page | 389 |
ISSN | 0341-2695 |
NCID | AA0068148X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 31863159 |
DOI | 10.1007/s00264-019-04460-5 |
Web of Science KeyUT | 000503665100004 |
Related Url | isVersionOf https://doi.org/10.1007/s00264-019-04460-5 |
FullText URL | fulltext.pdf |
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Author | Osumi, Ryuta| Wang, Ziyi| Ishihara, Yoshihito| Odagaki, Naoya| Iimura, Tadahiro| Kamioka, Hiroshi| |
Keywords | Sclerostin distribution Lacuno-canalicular system Mechanical unloading |
Note | This is an Accepted Manuscript of an article published by Springer.| |
Published Date | 2020-08-25 |
Publication Title | Journal of Bone and Mineral Metabolism |
Volume | volume39 |
Publisher | Springer |
Start Page | 148 |
End Page | 159 |
ISSN | 0914-8779 |
NCID | AA10747551 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32844318 |
DOI | 10.1007/s00774-020-01135-9 |
Web of Science KeyUT | 000562686600001 |
Related Url | isVersionOf https://link.springer.com/article/10.1007/s00774-020-01135-9 |
FullText URL | fulltext.pdf |
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Author | Shimada, Yasushi| Burrow, Michael F.| Araki, Kazuyuki| Zhou, Yuan| Hosaka, Keiichi| Sadr, Alireza| Yoshiyama, Masahiro| Miyazaki, Takashi| Sumi, Yasunori| Tagami, Junji| |
Keywords | Dental caries Dental lasers Laboratory techniques and procedures |
Published Date | 2020-09-25 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 15754 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 32978464 |
DOI | 10.1038/s41598-020-72838-2 |
Web of Science KeyUT | 000577248100029 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-72838-2 |