result 859 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Li, Yuying| Wang, Qiong| Jia, Huimin| Ishikawa, Kazuya| Kosami, Ken-Ichi| Ueba, Takahiro| Tsujimoto, Atsumi| Yamanaka, Miki| Yabumoto, Yasuyuki| Miki, Daisuke| Sasaki, Eriko| Fukao, Yoichiro| Fujiwara, Masayuki| Kaneko-Kawano, Takako| Tan, Li| Kojima, Chojiro| Wing, Rod A.| Sebastian, Alfino| Nishimura, Hideki| Fukada, Fumi| Niu, Qingfeng| Shimizu, Motoki| Yoshida, Kentaro| Terauchi, Ryohei| Shimamoto, Ko| Kawano, Yoji| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5| |
| Published Date | 2024-05-30 |
| Publication Title | Nature Communications |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4610 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 38816417 |
| DOI | 10.1038/s41467-024-48943-5 |
| Web of Science KeyUT | 001236316700012 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-024-48943-5 |
| JaLCDOI | 10.18926/AMO/67204 |
|---|---|
| FullText URL | 78_3_285.pdf |
| Author | Hirano, Shuichiro| Otani, Yoshihiro| Fujii, Kentaro| Date, Isao| |
| Abstract | Organized chronic subdural hematoma (OCSDH) is a relatively rare condition that forms over a longer period of time compared to chronic subdural hematoma and is sometimes difficult to diagnose with preoperative imaging. We resected an intracranial lesion in a 37-year-old Japanese man; the lesion had been increasing in size for >17 years. The preoperative diagnosis based on imaging findings was meningioma; however, pathological findings revealed OCSDH. Clinicians should be aware that OCSDH mimics other tumors and consider surgical strategies for this disease. |
| Keywords | meningioma organized chronic subdural hematoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902217 |
| Web of Science KeyUT | 001267351900002 |
| JaLCDOI | 10.18926/AMO/67195 |
|---|---|
| FullText URL | 78_3_205.pdf |
| Author | Hagiya, Hideharu| |
| Abstract | The global pandemic of COVID-19 has underscored the significance of establishing and sustaining a practical and efficient infection control system for the benefit and welfare of society. Infectious disease (ID) specialists are expected to take on leadership roles in enhancing organizational infrastructures for infection prevention and control (IPC) at the hospital, community, and national levels. However, due to an absolute shortage and an uneven distribution, many core hospitals currently lack the ID specialists. Given the escalating global risk of emerging and re-emerging infectious diseases as well as antimicrobial resistance pathogens, the education and training of ID specialists constitutes an imperative concern. As demonstrated by historical changes in the healthcare reimbursement system, the establishment and enhancement of IPC measures is pivotal to ensuring medical safety. The existing structure of academic society-driven certification and training initiatives for ID specialists, contingent upon the discretionary decisions of individual physicians, possesses both quantitative and qualitative shortcomings. In this article, I first address the present situations and challenges related to ID specialists and then introduce my idea of securing ID specialists based on the new concepts and platforms; (i) ID Specialists as National Credentials, (ii) Establishment of the Department of Infectious Diseases in Medical and Graduate Schools, (iii) Endowed ID Educative Courses Funded by Local Government and Pharmaceutical Companies, and (iv) Recruitment of Young Physicians Engaged in Healthcare Services in Remote Areas. As clarified by the COVID-19 pandemic, ID specialists play a crucial role in safeguarding public health. Hopefully, this article will advance the discussion and organizational reform for the education and training of ID specialists. |
| Keywords | antimicrobial resistance emerging infectious diseases infection prevention and control medical education silent pandemic |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-06 |
| Volume | volume78 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 205 |
| End Page | 213 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38902208 |
| Web of Science KeyUT | 001267351000001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Vo, Quan Duy| Saito, Yukihiro| Ida, Toshihiro| Nakamura, Kazufumi| Yuasa, Shinsuke| |
| Published Date | 2024-05-21 |
| Publication Title | PLoS ONE |
| Volume | volume19 |
| Issue | issue5 |
| Publisher | Public Library of Science |
| Start Page | e0302537 |
| ISSN | 1932-6203 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Vo et al. |
| File Version | publisher |
| PubMed ID | 38771829 |
| DOI | 10.1371/journal.pone.0302537 |
| Web of Science KeyUT | 001228816000059 |
| Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0302537 |
| FullText URL | K0006986_abstract_review.pdf K0006986_fulltext.pdf K0006986_summary.pdf |
|---|---|
| Author | MORIMOTO, Kosaku| |
| Published Date | 2024-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6986号 |
| Granted Date | 2024-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © The Author(s), 2023. |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Eguchi, Ritsuko| Sekhar, Halubai| Kimura, Koji| Masai, Hirokazu| Happo, Naohisa| Ikeda, Mitsuki| Yamamoto, Yuki| Utsumi, Masaki| Goto, Hidenori| Takabayashi, Yasuhiro| Tajiri, Hiroo| Hayashi, Koichi| Kubozono, Yoshihiro| |
| Published Date | 2024-05-01 |
| Publication Title | ACS Omega |
| Volume | volume9 |
| Issue | issue19 |
| Publisher | American Chemical Society |
| Start Page | 21287 |
| End Page | 21297 |
| ISSN | 2470-1343 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38764676 |
| DOI | 10.1021/acsomega.4c01395 |
| Web of Science KeyUT | 001228034300001 |
| Related Url | isVersionOf https://doi.org/10.1021/acsomega.4c01395 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sakamoto, Hirotaka| Inutsuka, Ayumu| |
| Keywords | GFP with a palmitoylation signal (palGFP) plasmalemma localization neurosecretory vesicle immunoelectron microscopy oxytocin |
| Published Date | 2024-04-25 |
| Publication Title | ACTA HISTOCHEMICA ET CYTOCHEMICA |
| Volume | volume57 |
| Issue | issue2 |
| Publisher | The Japan Society of Histochemistry and Cytochemistry |
| Start Page | 85 |
| End Page | 88 |
| ISSN | 0044-5991 |
| NCID | AA00508022 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Japan Society of Histochemistry and Cytochemistry |
| File Version | publisher |
| PubMed ID | 38695035 |
| DOI | 10.1267/ahc.24-00001 |
| Web of Science KeyUT | 001223234800003 |
| Related Url | isVersionOf https://doi.org/10.1267/ahc.24-00001 |
| FullText URL | fulltext20240512-01.pdf |
|---|---|
| Author | Zhai, Yun| Morihara, Ryuta| Feng, Tian| Hu, Xinran| Fukui, Yusuke| Bian, Zhihong| Bian, Yuting| Yu, Haibo| Sun, Hongming| Takemoto, Mami| Nakano, Yumiko| Yunoki, Taijun| Tang, Ying| Ishiura, Hiroyuki| Yamashita, Toru| |
| Keywords | Alzheimer's disease Hypoperfusion Cerebral vascular remodeling Scallop-derived plasmalogen pSTAT3/PIM1/NFATc1 axis |
| Note | © 2024 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-04-01 |
| Publication Title | Brain Research |
| Volume | volume1828 |
| Publisher | Elsevier BV |
| Start Page | 148790 |
| ISSN | 0006-8993 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 Elsevier B.V. |
| File Version | author |
| PubMed ID | 38272156 |
| DOI | 10.1016/j.brainres.2024.148790 |
| Web of Science KeyUT | 001173928400001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.brainres.2024.148790 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sudoh, Taku| Ikeda, Shuhei| Shigenobu, Keisuke| Tsuzuki, Seiji| Dokko, Kaoru| Watanabe, Masayoshi| Shinoda, Wataru| Ueno, Kazuhide| |
| Published Date | 2023-06-20 |
| Publication Title | The Journal of Physical Chemistry C |
| Volume | volume127 |
| Issue | issue25 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 12295 |
| End Page | 12303 |
| ISSN | 1932-7447 |
| NCID | AA1217589X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| DOI | 10.1021/acs.jpcc.3c02112 |
| Web of Science KeyUT | 001016710400001 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jpcc.3c02112 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Obayashi, Ippei| Yoshiwaki, Michio| |
| Keywords | Topological data analysis Persistent homology Algorithm Algebraic topology |
| Note | The version of record of this article, first published in Discrete & Computational Geometry, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00454-023-00544-7| |
| Published Date | 2023-08-18 |
| Publication Title | Discrete & Computational Geometry |
| Volume | volume70 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 645 |
| End Page | 670 |
| ISSN | 0179-5376 |
| NCID | AA1067900X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| DOI | 10.1007/s00454-023-00544-7 |
| Web of Science KeyUT | 001051805700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s00454-023-00544-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hochi, Hiroaki| Kubota, Satoshi| Takigawa, Masaharu| Nishida, Takashi| |
| Published Date | 2023-08-17 |
| Publication Title | Carcinogenesis |
| Volume | volume44 |
| Issue | issue8-9 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 695 |
| End Page | 707 |
| ISSN | 0143-3334 |
| NCID | AA00141799 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37590989 |
| DOI | 10.1093/carcin/bgad057 |
| Web of Science KeyUT | 001061431500001 |
| Related Url | isVersionOf https://doi.org/10.1093/carcin/bgad057 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Keiichiro| Matsuoka, Hirofumi| Yorimitsu, Masae| Ogawa, Mariko| Kanemori, Miho| Sueoka, Kotaro| Kozai, Ayumi| Nakamura, Hiroko| Haruma, Tomoko| Shiroyama, Yuko| Hayata, Yuu| Sugii, Hirokazu| Ueda, Akiko| Kurihara, Shuichi| Urayama, Saiko| Shimizu, Miyuki| Masuyama, Hisashi| |
| Keywords | olaparib olaparib plus bevacizumab niraparib renal function |
| Published Date | 2023-09-14 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume54 |
| Issue | issue1 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37721176 |
| DOI | 10.1093/jjco/hyad125 |
| Web of Science KeyUT | 001068527100001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad125 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nakamura, Keiichiro| Matsuoka, Hirofumi| Kubo, Kotaro| Shirakawa, Shinsuke| Ida, Naoyuki| Haraga, Junko| Ogawa, Chikako| Okamoto, Kazuhiro| Nagao, Shoji| Masuyama, Hisashi| |
| Keywords | returning to the same workplace gynecologic neoplasms sick leave |
| Published Date | 2023-11-23 |
| Publication Title | Japanese Journal of Clinical Oncology |
| Volume | volume54 |
| Issue | issue3 |
| Publisher | Oxford University Press (OUP) |
| Start Page | 292 |
| End Page | 296 |
| ISSN | 1465-3621 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37995280 |
| DOI | 10.1093/jjco/hyad159 |
| Web of Science KeyUT | 001108594700001 |
| Related Url | isVersionOf https://doi.org/10.1093/jjco/hyad159 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nagao, Shoji| Tamura, Jun| Shibutani, Takashi| Miwa, Maiko| Kato, Tomoyasu| Shikama, Ayumi| Takei, Yuji| Kamiya, Natsuko| Inoue, Naoki| Nakamura, Kazuto| Inoue, Aya| Yamamoto, Koji| Fujiwara, Keiichi| Suzuki, Mitsuaki| |
| Keywords | Neoadjuvant chemotherapy Epithelial ovarian cancer Adjuvant chemotherapy Interval debulking surgery Primary debulking surgery |
| Note | The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-023-02329-7| |
| Published Date | 2023-05-04 |
| Publication Title | International Journal of Clinical Oncology |
| Volume | volume28 |
| Issue | issue6 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 804 |
| End Page | 815 |
| ISSN | 1341-9625 |
| NCID | AA11086579 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37140771 |
| DOI | 10.1007/s10147-023-02329-7 |
| Web of Science KeyUT | 000980331700002 |
| Related Url | isVersionOf https://doi.org/10.1007/s10147-023-02329-7 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ishiura, Hiroyuki| Tsuji, Shoji| Toda, Tatsushi| |
| Note | The version of record of this article, first published in Journal of Human Genetics, is available online at Publisher’s website: http://dx.doi.org/10.1038/s10038-022-01116-y| |
| Published Date | 2023-01-20 |
| Publication Title | Journal of Human Genetics |
| Volume | volume68 |
| Issue | issue3 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 169 |
| End Page | 174 |
| ISSN | 1434-5161 |
| NCID | AA11206160 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 36670296 |
| DOI | 10.1038/s10038-022-01116-y |
| Web of Science KeyUT | 000916021000001 |
| Related Url | isVersionOf https://doi.org/10.1038/s10038-022-01116-y |
| JaLCDOI | 10.18926/AMO/66927 |
|---|---|
| FullText URL | 78_2_185.pdf |
| Author | Takahashi, Hiroko| Eguchi, Jun| Watanabe, Mayu| Nakayama, Masanori| Wada, Jun| |
| Abstract | The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. |
| Keywords | obesity type 2 diabetes COVID-19 vaccination |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 185 |
| End Page | 191 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688836 |
| Web of Science KeyUT | 001227932200002 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| FullText URL | 78_2_151.pdf |
| Author | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| Abstract | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| Keywords | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 151 |
| End Page | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Wataru| Kuratsune, Masatoshi| Iseki, Akiko| Kuyama, Shoichi| |
| Published Date | 2024-03-27 |
| Publication Title | Rheumatology Advances in Practice |
| Volume | volume8 |
| Issue | issue2 |
| Publisher | Oxford University Press |
| Start Page | rkae045 |
| ISSN | 2514-1775 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024. |
| File Version | publisher |
| PubMed ID | 38618140 |
| DOI | 10.1093/rap/rkae045 |
| Web of Science KeyUT | 001201694800001 |
| Related Url | isVersionOf https://doi.org/10.1093/rap/rkae045 |
| JaLCDOI | 10.18926/AMO/66915 |
|---|---|
| FullText URL | 78_2_123.pdf |
| Author | Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT. |
| Keywords | GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 134 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688830 |
| Web of Science KeyUT | 001229151800004 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| FullText URL | 78_2_095.pdf |
| Author | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| Abstract | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| Keywords | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-04 |
| Volume | volume78 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |
