Shien, Tadahiko - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Peripheral Blood T-Cell Receptor Repertoire and Host Immune Background in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy

JaLCDOI	10.18926/AMO/70852
FullText URL	80_3_169.pdf
Author	Nakamura, Yuki\| Iwamoto, Takayuki\| Kajiwara, Yukiko\| Hida, Akira\| Nakamoto, Shogo\| Miyoshi, Yuichiro\| Shien, Tadahiko\| Ikeda, Masahiko\| Doihara, Hiroyoshi\| Ogata, Ryohei\| Koike, Yoshikazu\| Nomura, Tsunehisa\| Tanaka, Katsuhiro\| Nakashima, Kazutaka\| Yamatsuji, Tomoki\| Taira, Naruto\|
Abstract	The association between peripheral blood T-cell receptor (TCR) repertoire and chemotherapy response remains unclear. We evaluated peripheral blood TCR repertoire and gut microbiota in 21 breast cancer patients receiving neoadjuvant chemotherapy (NAC) who were enrolled in the SBP-14 prospective cohort study between October 2019 and March 2022. We analyzed stool samples obtained pre-NAC and peripheral blood samples obtained pre- and post-NAC. The primary endpoint was the association between baseline peripheral blood TCR repertoire and treatment response. Eleven patients (52%) had hormone receptor-positive breast cancer. All patients received anthracyclines and taxanes, with anti-HER2 therapy for HER2-positive disease. TCR diversity (TCR alpha chain [TRA], p=0.095; TCR beta chain [TRB], p=0.051) and clonality (TRA, p=0.271; TRB, p=0.500) were not significantly associated with treatment response. Gut microbiota diversity was not correlated with TCR diversity (TRA: ρ=0.046, p=0.845; TRB: ρ=0.021, p=0.929); however, three bacterial orders (Erysipelotrichales, Bacillales, and Pasteurellales) were significantly associated with TCR repertoire. Baseline TCR repertoire was not associated with treatment response in this cohort of breast cancer patients.
Keywords	TCR repertoire gut microbiota neoadjuvant chemotherapy breast cancer
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2026-06
Volume	volume80
Issue	issue3
Publisher	Okayama University Medical School
Start Page	169
End Page	178
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2026 by Okayama University Medical School
File Version	publisher
Refereed	True

Differences in drug efficacy and prognosis between primary and metastatic sites for de novo stage IV breast cancer: an exploratory analysis of a phase III trial, JCOG1017

FullText URL	fulltext.pdf
Author	Tanaka, Kiyo\| Shimomura, Akihiko\| Ishitobi, Makoto\| Yamanaka, Takashi\| Tsukioki, Takahiro\| Iwata, Hiroji\| Hara, Fumikata\| Fujisawa, Tomomi\| Sasaki, Keita\| Sadachi, Ryo\| Kajikawa, Riku\| Sakai, Takehiko\| Sagara, Yasuaki\| Shigematsu, Hideo\| Ozaki, Yukinori\| Nozawa, Kazuki\| Sudo, Kazuki\| Naito, Yoichi\| Terata, Kaori\| Ishiba, Toshiyuki\| Fukuda, Haruhiko\| Shien, Tadahiko\|
Keywords	Discordance of treatment response between primary and metastatic sites De novo stage IV breast cancer Primary systemic therapy Overall survival
Published Date	2026-04-16
Publication Title	Breast Cancer
Volume	volume33
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	829
End Page	838
ISSN	1340-6868
NCID	AA1103354X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026
File Version	publisher
PubMed ID	41989526
DOI	10.1007/s12282-026-01846-3
Web of Science KeyUT	001741947600001
Related Url	isVersionOf https://doi.org/10.1007/s12282-026-01846-3

Clinical complete response and predictive factors in HER2-positive early breast cancer treated with neoadjuvant chemotherapy aimed at omission of surgery: an exploratory analysis of the JCOG1806 trial

FullText URL	fulltext.pdf
Author	Shigematsu, Hideo\| Fujisawa, Tomomi\| Hara, Fumikata\| Iwata, Hiroji\| Ishiba, Toshiyuki\| Ozaki, Yukinori\| Sakai, Takehiko\| Sagara, Yasuaki\| Shimomura, Akihiko\| Sudo, Kazuki\| Terata, Kaori\| Naito, Yoichi\| Nozawa, Kazuki\| Sasaki, Keita\| Mitome, Noriko\| Sadachi, Ryo\| Shibata, Taro\| Shien, Tadahiko\|
Keywords	Breast cancer Primary systemic therapy HER2 cCR Omission of surgery
Published Date	2026-01-22
Publication Title	International Journal of Clinical Oncology
Volume	volume31
Issue	issue3
Publisher	Springer Science and Business Media LLC
Start Page	528
End Page	536
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026
File Version	publisher
PubMed ID	41572060
DOI	10.1007/s10147-026-02967-7
Web of Science KeyUT	001667252800001
Related Url	isVersionOf https://doi.org/10.1007/s10147-026-02967-7

A multicenter, randomized, parallel-group confirmatory study protocol to evaluate the efficacy of Soft Protector CPC, a novel oral mucosal protectant, in preventing oral mucositis and alleviating pain in patients with breast cancer

FullText URL	fulltext.pdf
Author	Omori, Kazuhiro\| Furukawa, Kohei\| Usubuchi, Masatoshi\| Hamada, Tomofumi\| Shien, Tadahiko\| Yoshida, Michihiro\| Nakatsuka, Yuki\| Hotta, Katsuyuki\| Ibaragi, Soichiro\| Takashiba, Shogo\|
Published Date	2026-06-04
Publication Title	PLOS One
Volume	volume21
Issue	issue6
Publisher	Public Library of Science (PLoS)
Start Page	e0350803
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 Omori et al.
File Version	publisher
PubMed ID	42241429
DOI	10.1371/journal.pone.0350803
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0350803

Clinical significance on switching CDK4/6 inhibitors among 13,284 patients with metastatic breast cancer

FullText URL	fulltext.pdf
Author	Nishina, Takuya\| Tanioka, Maki\| Takada, Kenji\| Tsukioki, Takahiro\| Takahashi, Yuko\| Shien, Tadahiko\| Toyooka, Shinichi\|
Keywords	Cyclin-dependent kinase 4/6 inhibitors Endocrine therapy HR-positive/HER2-negative advanced breast cancer Progression-free survival Time to discontinuation
Published Date	2025-10-12
Publication Title	Breast Cancer
Volume	volume32
Issue	issue6
Publisher	Springer Science and Business Media LLC
Start Page	1405
End Page	1416
ISSN	1340-6868
NCID	AA1103354X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41076600
DOI	10.1007/s12282-025-01768-6
Web of Science KeyUT	001591967400001
Related Url	isVersionOf https://doi.org/10.1007/s12282-025-01768-6

A multi-institutional dummy run on segmentation variability and plan quality of stereotactic body radiotherapy for oligometastatic disease

FullText URL	fulltext.pdf
Author	Hirashima, Hideaki\| Matsuo, Yukinori\| Ishikura, Satoshi\| Nakamura, Mitsuhiro\| Nishibuchi, Ikuno\| Kawahara, Daisuke\| Shimada, Yoshihisa\| Nakahara, Yoshiro\| Nishio, Teiji\| Shikama, Naoto\| Watanabe, Shun-ichi\| Okamoto, Isamu\| Ishiba, Toshiyuki\| Hara, Fumikata\| Shien, Tadahiko\| Mizowaki, Takashi\|
Keywords	Oligometastatic disease Dummy run Segmentation variability Dose distribution accuracy
Published Date	2025-10
Publication Title	Physics and Imaging in Radiation Oncology
Volume	volume36
Publisher	Elsevier BV
Start Page	100857
ISSN	2405-6316
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	41323213
DOI	10.1016/j.phro.2025.100857
Web of Science KeyUT	001621253100001
Related Url	isVersionOf https://doi.org/10.1016/j.phro.2025.100857

Definitions of, Advances in, and Treatment Strategies for Breast Cancer Oligometastasis

FullText URL	fulltext.pdf
Author	Shien, Tadahiko\| Nakamoto, Shogo\| Fujiwara, Yuki\| Kosaka, Maya\| Narahara, Yuki\| Fujii, Kento\| Maeda, Reina\| Kato, Shutaro\| Mimata, Asuka\| Yoshioka, Ryo\| Kuwahara, Chihiro\| Tsukioki, Takahiro\| Takahashi, Yuko\| Iwatani, Tsuguo\| Tanioka, Maki\|
Keywords	oligo-recurrence breast cancer local therapy
Published Date	2025-07-21
Publication Title	Cancers
Volume	volume17
Issue	issue14
Publisher	MDPI AG
Start Page	2406
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40723288
DOI	10.3390/cancers17142406
Web of Science KeyUT	001539738700001
Related Url	isVersionOf https://doi.org/10.3390/cancers17142406

Primary tumour resection plus systemic therapy versus systemic therapy alone in metastatic breast cancer (JCOG1017, PRIM-BC): a randomised clinical trial

FullText URL	fulltext.pdf suppl.docx
Author	Shien, Tadahiko\| Hara, Fumikata\| Aogi, Kenjiro\| Yanagida, Yasuhiro\| Tsuneizumi, Michiko\| Yamamoto, Naohito\| Matsumoto, Hiroshi\| Suto, Akihiko\| Watanabe, Kenichi\| Harao, Michiko\| Kanbayashi, Chizuko\| Itoh, Mitsuya\| Kadoya, Takayuki\| Anan, Keisei\| Maeda, Shigeto\| Sasaki, Keita\| Ogawa, Gakuto\| Saji, Shigehira\| Fukuda, Haruhiko\| Iwata, Hiroji\|
Published Date	2025-07-04
Publication Title	British Journal of Cancer
Publisher	Springer Science and Business Media LLC
ISSN	0007-0920
NCID	AA00574355
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40615712
DOI	10.1038/s41416-025-03097-z
Web of Science KeyUT	001523009900001
Related Url	isVersionOf https://doi.org/10.1038/s41416-025-03097-z

Immediate breast reconstruction surgery for breast cancer: current status and future directions

FullText URL	fulltext.pdf suppl.docx
Author	Shien, Tadahiko\| Nogi, Hiroko\| Ogiya, Akiko\| Ishitobi, Makoto\| Yamauchi, Chikako\| Shimo, Ayaka\| Narui, Kazutaka\| Nagura, Naomi\| Seki, Hirohito\| Terata, Kaori\| Saiga, Miho\| Uchida, Tatsuya\| Sasada, Shinsuke\| Sakurai, Teruhisa\| Niikura, Naoki\| Mori, Hiroki\|
Keywords	Breast cancer Immediate reconstruction surgery Prognosis Complications
Note	The version of record of this article, first published in Breast Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12282-025-01723-5\|
Published Date	2025-05-26
Publication Title	Breast Cancer
Volume	volume32
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	630
End Page	637
ISSN	1340-6868
NCID	AA1103354X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40418512
DOI	10.1007/s12282-025-01723-5
Web of Science KeyUT	001494864200001
Related Url	isVersionOf https://doi.org/10.1007/s12282-025-01723-5

Japanese translation of the Functional Assessment of Cancer Therapy-Breast + 4 (FACT-B + 4) following international guidelines: a verification of linguistic validity

FullText URL	fulltext.pdf
Author	Tsukioki, Takahiro\| Takata, Nozomu\| Dennis, Saya R.\| Terata, Kaori\| Sagara, Yasuaki\| Sakai, Takehiko\| Takayama, Shin\| Kitagawa, Dai\| Kikawa, Yuichiro\| Takahashi, Yuko\| Iwatani, Tsuguo\| Hara, Fumikata\| Fujisawa, Tomomi\| Shien, Tadahiko\|
Keywords	Breast cancer FACT-B FACT-B+4 QOL
Note	The version of record of this article, first published in Breast Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12282-025-01701-x\|
Published Date	2025-05-08
Publication Title	Breast Cancer
Volume	volume32
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	773
End Page	782
ISSN	1340-6868
NCID	AA1103354X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40338515
DOI	10.1007/s12282-025-01701-x
Web of Science KeyUT	001483857300001
Related Url	isVersionOf https://doi.org/10.1007/s12282-025-01701-x

Detailed Ophthalmic and Pathological Features of Choroidal Metastasis From Breast Cancer: A Case Series of Five Patients

FullText URL	fulltext20250507-01.pdf
Author	Matsuo, Toshihiko\| Tanaka, Takehiro\| Shien, Tadahiko\| Muraoka, Atsushi\| Doihara, Hiroyoshi\|
Keywords	breast cancer chemotherapy choroidal metastasis estrogen receptor her2 immunostaining invasive ductal carcinoma ki-67 progesterone receptor radiation
Published Date	2025-05-04
Publication Title	Cureus
Volume	volume17
Issue	issue5
Publisher	Springer Science and Business Media LLC
Start Page	e83484
ISSN	2168-8184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Copyright 2025 Matsuo et al.
File Version	publisher
PubMed ID	40470417
DOI	10.7759/cureus.83484
Related Url	isVersionOf https://doi.org/10.7759/cureus.83484

Real-World Comparative Analysis of Trastuzumab Originator and Biosimilars: Safety, Efficacy, and Cost Effectiveness

FullText URL	fulltext.pdf
Author	Mamori, Tomoka\| Tanioka, Maki\| Takada, Kenji\| Hamano, Hirofumi\| Tsukioki, Takahiro\| Takahashi, Yuko\| Iwatani, Tsuguo\| Shien, Tadahiko\| Toyooka, Shinichi\|
Note	The version of record of this article, first published in BioDrugs, is available online at Publisher’s website: http://dx.doi.org/10.1007/s40259-024-00686-x\|
Published Date	2024-10-16
Publication Title	BioDrugs
Volume	volume39
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	131
End Page	142
ISSN	1173-8804
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39412713
DOI	10.1007/s40259-024-00686-x
Web of Science KeyUT	001333384600001
Related Url	isVersionOf https://doi.org/10.1007/s40259-024-00686-x

Comparison of proportions and prognostic impact of pathological complete response between evaluations of representative specimen and total specimen in primary breast cancer after neoadjuvant chemoradiotherapy: an ancillary study of JCOG0306

FullText URL	fulltext.pdf
Author	Shien, Tadahiko\| Tsuda, Hitoshi\| Sasaki, Keita\| Mizusawa, Junki\| Akiyama, Futoshi\| Kurosumi, Masafumi\| Sawaki, Masataka\| Tamura, Nobuko\| Tanaka, Kiyo\| Kogawa, Takahiro\| Takahashi, Mina\| Hayashi, Naoki\| Mukai, Hirofumi\| Masuda, Norikazu\| Hara, Fumikata\| Iwata, Hiroji\|
Keywords	Breast cancer Neoadjuvant chemoradiotherapy Pathological therapeutic effect Specimen sampling method
Note	The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-024-07408-5\|
Published Date	2024-06-27
Publication Title	Breast Cancer Research and Treatment
Volume	volume208
Publisher	Springer Science and Business Media LLC
Start Page	145-
End Page	154
ISSN	0167-6806
NCID	AA10623184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38935214
DOI	10.1007/s10549-024-07408-5
Web of Science KeyUT	001256954600001
Related Url	isVersionOf https://doi.org/10.1007/s10549-024-07408-5

Absolute lymphocyte count and neutrophil-to-lymphocyte ratio as predictors of CDK 4/6 inhibitor efficacy in advanced breast cancer

FullText URL	fulltext.pdf
Author	Nakamoto, Shogo\| Shien, Tadahiko\| Iwamoto, Takayuki\| Kubo, Shinichiro\| Yamamoto, Mari\| Yamashita, Tetsumasa\| Kuwahara, Chihiro\| Ikeda, Masahiko\|
Published Date	2024-04-30
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	9869
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38684839
DOI	10.1038/s41598-024-60101-x
Web of Science KeyUT	001211286800006
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-60101-x

The specific shapes of capillaries are associated with worse prognosis in patients with invasive breast cancer

FullText URL	fulltext.pdf
Author	Swe, Hnin‐Wint‐Wint\| Fujisawa, Masayoshi\| Ohara, Toshiaki\| Komatsubara, Yu\| Yoshimura, Teizo\| Shien, Tadahiko\| Matsukawa, Akihiro\|
Keywords	angiogenesis blood vessels breast cancer CD31 antigen immunohistochemistry microvessel density survival analysis
Published Date	2024-05-31
Publication Title	Pathology International
Volume	volume74
Issue	issue7
Publisher	Wiley
Start Page	394
End Page	407
ISSN	1320-5463
NCID	AA10984364
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	38818885
DOI	10.1111/pin.13442
Web of Science KeyUT	001235649700001
Related Url	isVersionOf https://doi.org/10.1111/pin.13442

Adrenergic microenvironment driven by cancer-associated Schwann cells contributes to chemoresistance in patients with lung cancer

FullText URL	fulltext.pdf
Author	Otani, Yusuke\| Katayama, Haruyoshi\| Zhu, Yidan\| Huang, Rongsheng\| Shigehira, Takafumi\| Shien, Kazuhiko\| Suzawa, Ken\| Yamamoto, Hiromasa\| Shien, Tadahiko\| Toyooka, Shinichi\| Fujimura, Atsushi\|
Keywords	adrenaline cancer-associated Schwann cells doublecortin microenvironment YAP/TAZ
Published Date	2024-04-27
Publication Title	Cancer Science
Volume	volume115
Issue	issue7
Publisher	Wiley
Start Page	2333
End Page	2345
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	38676373
DOI	10.1111/cas.16164
Web of Science KeyUT	001208622800001
Related Url	isVersionOf https://doi.org/10.1111/cas.16164

Prognostic impact of adjuvant endocrine therapy for estrogen receptor-positive and HER2-negative T1a/bN0M0 breast cancer

FullText URL	fulltext.pdf
Author	Sasada, Shinsuke\| Kondo, Naoto\| Hashimoto, Hiroya\| Takahashi, Yuko\| Terata, Kaori\| Kida, Kumiko\| Sagara, Yasuaki\| Ueno, Takayuki\| Anan, Keisei\| Suto, Akihiko\| Kanbayashi, Chizuko\| Takahashi, Mina\| Nakamura, Rikiya\| Ishiba, Toshiyuki\| Tsuneizumi, Michiko\| Nishimura, Seiichiro\| Naito, Yoichi\| Hara, Fumikata\| Shien, Tadahiko\| Iwata, Hiroji\|
Keywords	Breast cancer T1a/b Endocrine therapy Estrogen receptor Prognosis
Note	The version of record of this article, first published in Breast Cancer Research and Treatment, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10549-023-07097-6\|
Published Date	2023-09-09
Publication Title	Breast Cancer Research and Treatment
Volume	volume202
Issue	issue3
Publisher	Springer Science and Business Media LLC
Start Page	473
End Page	483
ISSN	0167-6806
NCID	AA10623184
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37688665
DOI	10.1007/s10549-023-07097-6
Web of Science KeyUT	001065105700004
Related Url	isVersionOf https://doi.org/10.1007/s10549-023-07097-6

Ectopic Breast Cancer Arising within an Axillary Lymph Node

JaLCDOI	10.18926/AMO/66676
FullText URL	78_1_089.pdf
Author	Toshima, Kei\| Shien, Tadahiko\| Nishimura, Midori Filiz\| Suzuki, Yoko\| Nakamoto, Shogo\| Uno, Maya\| Yoshioka, Ryo\| Tsukioki, Takahiro\| Takahashi, Yuko\| Iwamoto, Takayuki\| Iwatani, Tsuguo\| Yanai, Hiroyuki\|
Abstract	We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis.
Keywords	breast cancer ectopic breast cancer axillary lymph node
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2024-02
Volume	volume78
Issue	issue1
Publisher	Okayama University Medical School
Start Page	89
End Page	93
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38419320
Web of Science KeyUT	001204421300001

Lung Oligometastasis of Breast Cancer: Prospective Cohort Study of Treatment Strategies (SBP-06)

JaLCDOI	10.18926/AMO/66666
FullText URL	78_1_015.pdf
Author	Maeda, Reina\| Shien, Tadahiko\| Takahashi, Mina\| Kawada, Kengo\| Kajiwara, Yukiko\| Kubo, Shinichiro\| Takabatake, Daisuke\| Ohtani, Shoichiro\| Matsuoka, Kinya\| Hikino, Hajime\| Ogasawara, Yutaka\| Taira, Naruto\| Osumi, Shozo\| Ikeda, Masahiko\| Doihara, Hiroyoshi\|
Abstract	While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients.
Keywords	oligometastasis breast cancer lung metastasectomy
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-02
Volume	volume78
Issue	issue1
Publisher	Okayama University Medical School
Start Page	15
End Page	20
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38419310
Web of Science KeyUT	001203658200008

Current status and challenges of breast cancer prevention∼DNA methylation would lead to groundbreaking progress in breast cancer prevention∼

FullText URL	fulltext.pdf
Author	Tsukioki, Takahiro\| Khan, Seema A.\| Shien, Tadahiko\|
Keywords	Breast cancer Prevention Risk reduction mastectomy Chemoprevention Methylation
Note	The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00287-0\|
Published Date	2023-12-12
Publication Title	Genes and Environment
Volume	volume45
Issue	issue1
Publisher	BMC
Start Page	35
ISSN	1880-7046
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	38082340
DOI	10.1186/s41021-023-00287-0
Web of Science KeyUT	001121724100001
Related Url	isVersionOf https://doi.org/10.1186/s41021-023-00287-0