| JaLCDOI | 10.18926/AMO/62782 |
|---|---|
| FullText URL | 75_5_663.pdf |
| Author | Sadahira, Takuya| Maruyama, Yuki| Hiyama, Yoshiki| Kitano, Hiroyuki| Yamada, Hiroki| Goto, Takayuki| Kondo, Tsubasa| Shigemura, Katsumi| Mitsui, Yosuke| Iwata, Takehiro| Edamura, Kohei| Araki, Motoo| Watanabe, Masami| Takenaka, Tadasu| Teishima, Jun| Miyata, Yasuyoshi| Ishikawa, Kiyohito| Takaoka, Ei-Ichiro| Miyazaki, Jun| Takahashi, Satoshi| Masumori, Naoya| Kiyota, Hiroshi| Fujisawa, Masato| Yamamoto, Shingo| Sakuma, Takafumi| Kusumi, Norihiro| Ichikawa, Takaharu| Watanabe, Toyohiko| Nasu, Yoshitsugu| Tsugawa, Masaya| Nasu, Yasutomo| Wada, Koichiro| |
| Abstract | The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants. |
| Keywords | antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 663 |
| End Page | 667 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703052 |
| Web of Science KeyUT | 000711568400007 |
| NAID | 120007166667 |
| JaLCDOI | 10.18926/AMO/62781 |
|---|---|
| FullText URL | 75_5_659.pdf |
| Author | Ino, Riku| Sada, Ken-ei | Miyauchi, Atsushi| Hashimoto, Daisuke| Nojima, Shigeru| Yamanaka, Shingo| Kawamura, Masafumi| |
| Abstract | A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient’s carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology. |
| Keywords | leptomeningeal carcinomatosis gastric cancer carcinoembryonic antigen cerebrospinal fluid cytology |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 659 |
| End Page | 661 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703051 |
| Web of Science KeyUT | 000711568400006 |
| NAID | 120007166666 |
| JaLCDOI | 10.18926/AMO/62780 |
|---|---|
| FullText URL | 75_5_653.pdf |
| Author | Tsuchie, Hiroyuki | Miyakoshi, Naohisa| Nagasawa, Hiroyuki| Nanjo, Hiroshi| Shimada, Yoichi| |
| Abstract | We present an extremely rare case of deep angiomyxoma (DAM) in the thigh that was misdiagnosed as desmoid-type fibromatosis. A 40-year-old Japanese woman presented with a mass on the left thigh. The histological diagnosis by needle biopsy was desmoid-type fibromatosis; the tumor grew slowly and was resected 4 years later. The histological diagnosis from the resected tumor was DAM. As of 16 months post-surgery, the patient has not noticed any local recurrence. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence in areas relatively close to the pelvis. |
| Keywords | deep angiomyxoma thigh desmoid-type fibromatosis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 653 |
| End Page | 657 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703050 |
| Web of Science KeyUT | 000711568400005 |
| NAID | 120007166665 |
| JaLCDOI | 10.18926/AMO/62779 |
|---|---|
| FullText URL | 75_5_647.pdf |
| Author | Uotani, Koji| Yamauchi, Taro| Sano, Keisuke| Sonobe, Hiroshi| Fujiwara, Yoshihiro| Maste, Praful Suresh| Sonawane, Sumeet | Tanaka, Masato| |
| Abstract | Sacral schwannoma is a rare tumor with relatively few symptoms; it thus tends to be large at diagnosis and is challenging to treat surgically. We present the case of a 12-year-old girl with a large sacral schwannoma that was successfully surgically resected using O-arm navigation in a two-stage operation. First, we performed tumor resection from the posterior aspect with assisted O-arm navigation. One week later, resection from the anterior aspect was conducted with posterior spinopelvic fixation and fibula graft. We performed partial resection of the tumor from the anterior and posterior aspects as much as possible. O-arm navigation contributed to precise and safe tumor resection and implant insertion. |
| Keywords | sacral schwannoma cellular schwannoma spinal tumor intradural extramedullary tumor O-arm navigation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 647 |
| End Page | 652 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703049 |
| Web of Science KeyUT | 000711568400004 |
| NAID | 120007166664 |
| JaLCDOI | 10.18926/AMO/62778 |
|---|---|
| FullText URL | 75_5_641.pdf |
| Author | Zulema Rosalia Arias Martinez| Jorge Luis Lopez Videla Montaño| Yamashiro, Keisuke| Shinoda-Ito, Yuki| Yamamoto, Tadashi| Takashiba, Shogo| |
| Abstract | This case report highlights the importance of using a dental operating microscope (DOM) and ultrasonic endodontic tips (UETs) to locate all root canals in the lower first premolar. A 53-year-old woman presented to our clinic with pain in the lower right first premolar. After a detailed search using a DOM and UETs, three root canals were found, prepared with rotary HyFlex endodontic files, and obturated using the lateral condensation technique. At the five-year follow-up after treatment, the tooth was completely restored and fulfilling its function, with no signs or symptoms of any post-treatment flare-up. |
| Keywords | dental operating microscope lower first premolar multiple canals ultrasonic endodontic tips |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 641 |
| End Page | 645 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703048 |
| Web of Science KeyUT | 000711568400003 |
| NAID | 120007166663 |
| JaLCDOI | 10.18926/AMO/62777 |
|---|---|
| FullText URL | 75_5_637.pdf |
| Author | Mehta, Rahul| Tanaka, Masato| Oda, Yoshiaki| Fujiwara, Yoshihiro| Uotani, Koji| Arataki, Shinya| Yamauchi, Taro| |
| Abstract | Among studies evaluating minimally invasive surgical (MIS) decompression of the L5 root, techniques involving transtubular endoscopic decompression under O-arm navigation are rare. We present the case of a 68-yearold woman with left leg pain, muscle weakness and gait disturbance of one month duration. The patient underwent transtubular endoscopic decompression under O-arm navigation. There is no radiation hazard to the operating room staff with this procedure. After surgery, the patient had significant pain relief and her left lower limb motor function had improved by follow-up at one year. C-arm-free endoscopic L5 root decompression is a safe and effective procedure. |
| Keywords | C-arm-free, navigation O-arm navigation endoscopic surgery L5 root decompression |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 637 |
| End Page | 640 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703047 |
| Web of Science KeyUT | Transtubular Endoscopic Posterolateral Decompression of the L5 Root under Navigation and O-arm: A Technical Note 000711568400002 |
| NAID | 120007166677 |
| JaLCDOI | 10.18926/AMO/62776 |
|---|---|
| FullText URL | 75_5_631.pdf |
| Author | Yamamoto, Koichiro| Omura, Daisuke| Yamane, Mai| Son, Reina| Hasegawa, Kou| Honda, Hiroyuki| Obika, Mikako| Minao, Nozomu| Edahiro, Satoru| Yamada, Norihito| Otsuka, Fumio| |
| Abstract | Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN. |
| Keywords | anorexia nervosa glucagon hypoglycemic coma insulin-like growth factor-I liver injury |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 631 |
| End Page | 636 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703046 |
| Web of Science KeyUT | Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa 000711568400001 |
| NAID | 120007166676 |
| JaLCDOI | 10.18926/AMO/62775 |
|---|---|
| FullText URL | 75_5_625.pdf |
| Author | Iwamuro, Masaya| Yamasaki, Yasushi| Tanaka, Takehiro| Asada, Noboru| Matsuoka, Ken-ichi| Hiraoka, Sakiko| Kawahara, Yoshiro| Okada, Hiroyuki| |
| Abstract | A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases. |
| Keywords | colorectal lymphoma follicular lymphoma diffuse large B-cell lymphoma histologic transformation |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 625 |
| End Page | 629 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703045 |
| Web of Science KeyUT | 000711561300001 |
| NAID | 120007166675 |
| JaLCDOI | 10.18926/AMO/62774 |
|---|---|
| FullText URL | 75_5_611.pdf |
| Author | Zhou, Yu| Furutani, Michiyo| Athurupana, Rukmali| Nakatsuka, Mikiya| |
| Abstract | Family members are critical mediators of the experiences of transgender people. We studied whether transgen-der subjects had disclosed their identity to their families and their families’ reactions after the disclosure. We also evaluated the subjects’ mental state and its association with disclosure status. Transgender people were recruited for this anonymous questionnaire survey in the Okayama University Hospital gender clinic. Subjects disclosed their identity to family members at the following rates: 68.7% to the father, 89.1% to the mother, 59.1% to a brother, 77.8% to a sister, and 47.6% to grandparents. Fathers had the lowest rate (26.7%) of posi-tive reactions, while over 50% of fathers showed an ambiguous response. Approximately 20% of parents showed a negative response. The majority of parents agreed to hormonal treatment and sex-reassignment sur-gery and that the transgender child should live with the gender they wanted to express. However, the rate of subjects with mood and anxiety disorders according to the Kessler 6 scale was significantly higher in those who experienced negative or ambiguous reactions from family members compared to those who experienced posi-tive reactions. Educational and mental health professionals should support the disclosure process of transgen-der people as well as their family members. |
| Keywords | disclosure family functioning gender nonconformity mental health transgender |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 611 |
| End Page | 623 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703044 |
| Web of Science KeyUT | 000711561600008 |
| NAID | 120007166674 |
| JaLCDOI | 10.18926/AMO/62773 |
|---|---|
| FullText URL | 75_5_601.pdf |
| Author | Mitsuhashi, Toshiharu| |
| Abstract | Research suggests that the fundamental concepts of epidemiology cannot be sufficiently learned in traditional lectures, and interactive learning is necessary. However, few studies have investigated interactive epidemiology education in general, or peer instruction (PI) in particular. This study investigated the effect of PI. Study par-ticipants were fourth-year medical students. The attitude of participants in regard to PI learning was examined in a non-PI and a PI group. The Survey of Attitudes Toward Statistics (SATS) (containing six sub-categories) was conducted as a learning-attitudes index. The pre- and post-lecture scores were compared between the non-PI and PI groups using double robust (DR) estimation. The non-PI and PI groups consisted of 20 and 121 student participants, respectively. In DR estimation, affect exhibited the lowest SATS score changes, at −0.51 (95% confidence interval −0.78 to −0.24; p-value < 0.001), whereas effort exhibited the highest score changes of 0.01 (95% confidence interval −0.30 to 0.32; p-value = 0.952). The epidemiology lecture with PI did not increase the SATS scores. This might be due to issues related to the experimental design. Further research investigating the effects of interactive epidemiology education, it will be necessary to develop tools for assessing the learning of epidemiological concepts and to improve the research design. |
| Keywords | medical students peer instruction epidemiological education learning attitude double robust esti-mation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 601 |
| End Page | 609 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703043 |
| Web of Science KeyUT | 000711561600007 |
| NAID | 120007166673 |
| JaLCDOI | 10.18926/AMO/62772 |
|---|---|
| FullText URL | 75_5_595.pdf |
| Author | Imai, Norio| Endo, Naoto| Suda, Ken| Suzuki, Hayato| |
| Abstract | Multidisciplinary approaches such as fracture liaison services (FLS) have been introduced in some countries to reduce medical complications and secondary fractures in patients with fragility hip fracture. We aimed to investigate outcomes in patients with fragility hip fracture following the introduction of FLS. Patients > 50 years old who experienced fragility hip fractures between January 1, 2015 and December 31, 2017 were enrolled, and divided into a control group (without FLS; 94 patients) and FLS group (373 patients). We found that the time from injury to surgery decreased significantly from 2.42 to 1.83 days (p = 0.003), the proportion of patients who underwent surgery within 36 h of injury increased significantly (p = 0.014), and the number of cases with complications after admission decreased significantly (p = 0.004) in the FLS group. Patients with a Barthel index ≥ 80 were more common in the FLS than the control group at 6 , 12, and 24 months following injury (p = 0.046 , 0.018, and 0.048, respectively). Multiple logistic regression analysis revealed the factors associated with postoperative complications and death within 12 or 24 months after injury. Our results indicate that FLS contributed to earlier recovery, rehabilitation following surgery and rehabilitation of medical complications following admission; improved patient activity; and decreased secondary hip fractures. |
| Keywords | postoperative complications fracture liaison services hip fractures multidisciplinary approaches |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 595 |
| End Page | 600 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703042 |
| Web of Science KeyUT | 000711561600006 |
| NAID | 120007166672 |
| JaLCDOI | 10.18926/AMO/62771 |
|---|---|
| FullText URL | 75_5_585.pdf |
| Author | Omiya, Hiroki| Takatori, Makoto| Yunoki, Keiji| Morimatsu, Hiroshi| |
| Abstract | Many patients develop acute kidney injury (AKI) after vascular surgery. In this retrospective observational study, we investigated the risk factors for AKI defined using the Kidney Disease Improving Global Outcomes criteria after total arch replacement (TAR). Additionally, we investigated the influence of temperature manage-ment during cardiopulmonary bypass (CPB) on postoperative renal function by propensity score-matched anal-ysis. We retrospectively analyzed 161 consecutive patients who underwent TAR between 2016 and 2019. Postoperative AKI occurred in 48.7% of the patients. In the multivariate analysis, male sex (odds ratio [OR] 3.95, 95% confidence interval [95%CI] 1.56-8.27, p = 0.002), ACE inhibitors/ARB medication (OR 3.19, 95%CI 1.49-6.82, p = 0.003), preoperative chronic kidney disease (OR 2.47, 95%CI 1.17-5.23, p = 0.02), pro-longed CPB time (OR 2.36, 95%CI 1.05-5.34, p = 0.04), and lower body ischemic time during CPB (OR 2.20, 95%CI 1.05-4.46, p = 0.04) were identified as independent risk factors for AKI. Propensity score-matched anal-ysis showed no significant difference in the risk of AKI following TAR between mild hypothermia or normo-thermia and moderate hypothermia (37.2% vs. 41.9%, p = 0.83). In conclusion, modifiable risk factors for AKI included prolonged CPB time and lower body ischemic time. Temperature management during CPB had no clear effect on outcomes. |
| Keywords | acute kidney injury total arch replacement cardiopulmonary bypass lower body ischemic time |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 585 |
| End Page | 593 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703041 |
| Web of Science KeyUT | 000711561600005 |
| NAID | 120007166671 |
| JaLCDOI | 10.18926/AMO/62770 |
|---|---|
| FullText URL | 75_5_575.pdf |
| Author | Suzuki, Hayato| Imai, Norio| Hirano, Yuki| Endo, Naoto| |
| Abstract | HipCOMPASS, a mechanical intraoperative support device used in total hip arthroplasty (THA), improves the cup-alignment accuracy. However, the alignment accuracy achieved by HipCOMPASS has not been specifically examined in obese patients. In this study, we retrospectively evaluated the relation between alignment accuracy and several obesity-related parameters in 448 consecutive patients who underwent primary THA using HipCOMPASS. We used computed tomography (CT) to measure the preoperative soft-tissue thickness of the anterior-superior iliac spine (ASIS) and pubic symphysis and the differences between preoperative and postoperative cup angle based on the cup-alignment error. We found significant correlations between the absolute value of radiographic anteversion difference and body mass index (r = 0.205), ASIS thickness (r = 0.419), and pubic symphysis thickness (r = 0.434). The absolute value of radiographic inclination difference was significantly correlated with ASIS (r = 0.257) and pubic symphysis thickness (r = 0.202). The receiver operating characteristic curve showed a pubic symphysis thickness of 37.2 mm for a ≥ 5° implantation error in both radiographic inclination and anteversion simultaneously. The cup-alignment error for HipCOMPASS was large in patients whose pubic symphysis thickness was ≥ 37.2 mm on preoperative CT. Our results indicate that methods other than HipCOMPASS, including computed tomography-based navigation systems, might be preferable in obese patients. |
| Keywords | HipCOMPASS total hip arthroplasty cup-alignment accuracy body mass index soft-tissue thickness |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 575 |
| End Page | 583 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703040 |
| Web of Science KeyUT | 000711561600004 |
| NAID | 120007166670 |
| JaLCDOI | 10.18926/AMO/62769 |
|---|---|
| FullText URL | 75_5_567.pdf |
| Author | Takase, Ryosuke| Hagiya, Hideharu| Honda, Hiroyuki| Nakano, Yasuhiro| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Kataoka, Hitomi| Hanayama, Yoshihisa| Otsuka, Fumio| |
| Abstract | Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults. |
| Keywords | influenza, elderly fever respiratory symptom |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 567 |
| End Page | 574 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703039 |
| Web of Science KeyUT | 000711561600003 |
| NAID | 120007166669 |
| JaLCDOI | 10.18926/AMO/62768 |
|---|---|
| FullText URL | 75_5_557.pdf |
| Author | Takeshima Kohara, Hiroko| Ikeda, Mitsunori | Okawa, Masami| |
| Abstract | This study examined the relationship between skin physiological indices and pressure ulcers in elderly people. The subjects were 55 bedridden elderly Japanese patients with a median age of 85 years. The following parame-ters were measured using non-invasive devices: skin surface temperature, moisture content in the stratum corneum, moisture content in the dermis, transepidermal water loss as an index of skin barrier function, skin erythema and skin elasticity. The sacral and 2 heel areas were observed as sites predisposed to pressure ulcers. Within one month after measuring the skin physiological indices, we confirmed pressure ulcers of National Pressure Ulcer Advisory Panel classification Stage II or worse based on medical records. Among the 55 patients, 4 (7.3%) prospectively developed a total of 5 pressure ulcers within 16 days. Only the skin erythema score was significantly higher with than without pressure ulcers (p < 0.001). We performed a binary logistic regression analysis and confirmed a significant relationship between pressure-ulcer development and the level of erythema (odds ratio = 1.026; 95% confidence interval: 1.011-1.042). Skin erythema increased before the development of pressure ulcers. Taken together, our results show that the high skin erythema score can be a predictive indicator of pressure ulcers. |
| Keywords | elderly people erythema pressure ulcer skin |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 557 |
| End Page | 565 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703038 |
| Web of Science KeyUT | 000711561600002 |
| NAID | 120007166668 |
| JaLCDOI | 10.18926/AMO/62767 |
|---|---|
| FullText URL | 75_5_549.pdf |
| Author | Isooka, Nami| Miyazaki, Ikuko| Asanuma, Masato| |
| Abstract | Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. The loss of nigrostriatal dopaminergic neurons produces its characteristic motor symptoms, but PD patients also have non-motor symptoms such as constipation and orthostatic hypotension. The pathological hallmark of PD is the presence of α-synuclein-containing Lewy bodies and neurites in the brain. However, the PD pathology is observed in not only the central nervous system (CNS) but also in parts of the peripheral nervous system such as the enteric nervous system (ENS). Since constipation is a typical prodromal non-motor symptom in PD, often preceding motor symptoms by 10-20 years, it has been hypothesized that PD pathology propagates from the ENS to the CNS via the vagal nerve. Discovery of pharmacological and other methods to halt this progression of neurodegeneration in PD has the potential to improve millions of lives. Astrocytes protect neurons in the CNS by secretion of neurotrophic and antioxidative factors. Similarly, astrocyte-like enteric glial cells (EGCs) are known to secrete neuroprotective factors in the ENS. In this article, we summarize the neuroprotective function of astrocytes and EGCs and discuss therapeutic strategies for the prevention of neurodegeneration in PD targeting neurotrophic and antioxidative molecules in glial cells. |
| Keywords | Parkinson’s disease astrocyte enteric glial cell neurotrophic factor antioxidative molecule |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-10 |
| Volume | volume75 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 549 |
| End Page | 556 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34703037 |
| Web of Science KeyUT | 000711561600001 |
| NAID | 120007166678 |
