A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial

Sadahira, Takuya; Maruyama, Yuki; Hiyama, Yoshiki; Kitano, Hiroyuki; Yamada, Hiroki; Goto, Takayuki; Kondo, Tsubasa; Shigemura, Katsumi; Mitsui, Yosuke; Iwata, Takehiro; Edamura, Kohei; Araki, Motoo; Watanabe, Masami; Takenaka, Tadasu; Teishima, Jun; Miyata, Yasuyoshi; Ishikawa, Kiyohito; Takaoka, Ei-Ichiro; Miyazaki, Jun; Takahashi, Satoshi; Masumori, Naoya; Kiyota, Hiroshi; Fujisawa, Masato; Yamamoto, Shingo; Sakuma, Takafumi; Kusumi, Norihiro; Ichikawa, Takaharu; Watanabe, Toyohiko; Nasu, Yoshitsugu; Tsugawa, Masaya; Nasu, Yasutomo; Wada, Koichiro

ID	62782
JaLCDOI	10.18926/AMO/62782
FullText URL	75_5_663.pdf 1.99 MB
Author	Sadahira, Takuya Department of Urology, Okayama University Hospital Maruyama, Yuki Department of Urology, Okayama University Hospital Hiyama, Yoshiki Hakodate Goryoukaku Hospital Kitano, Hiroyuki Hiroshima University Hospital Yamada, Hiroki Jikei University Katsushika Medical Center Goto, Takayuki Kyoto University Hospital Kondo, Tsubasa Nagasaki University Hospital Shigemura, Katsumi Kobe University Hospital Mitsui, Yosuke Department of Urology, Okayama University Hospital Iwata, Takehiro Department of Urology, Okayama University Hospital Edamura, Kohei Department of Urology, Okayama University Hospital Araki, Motoo Department of Urology, Okayama University Hospital Watanabe, Masami Department of Urology, Okayama University Hospital Takenaka, Tadasu Japanese Red Cross Okayama Hospital Teishima, Jun Hiroshima University Hospital Miyata, Yasuyoshi Nagasaki University Hospital Ishikawa, Kiyohito Fujita Health University Hospital Takaoka, Ei-Ichiro Internationla University of Health and Welfare Hospital Miyazaki, Jun Internationla University of Health and Welfare Hospital Takahashi, Satoshi Sapporo Medical University Hospital Masumori, Naoya Sapporo Medical University Hospital Kiyota, Hiroshi Jikei University Katsushika Medical Center Fujisawa, Masato Kobe University Hospital Yamamoto, Shingo Hyogo College of Medicine College Hospital Sakuma, Takafumi Okayama Medical Center Kusumi, Norihiro Okayama Medical Center Ichikawa, Takaharu Okayama Medical Center Watanabe, Toyohiko Department of Urology, Okayama University Hospital Nasu, Yoshitsugu Okayama Rosai Hospital Tsugawa, Masaya Okayama City General Medical Center Nasu, Yasutomo Department of Urology, Okayama University Hospital Wada, Koichiro Department of Urology, Okayama University Hospital
Abstract	The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.
Keywords	antibiotic prophylaxis selective culture media prostate biopsy fluoroquinolone-resistant extended- spectrum beta-lactamase
Amo Type	Clinical Study Protocol
Publication Title	Acta Medica Okayama
Published Date	2021-10
Volume	volume75
Issue	issue5
Publisher	Okayama University Medical School
Start Page	663
End Page	667
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34703052
Web of Science KeyUT	000711568400007
NAID	120007166667