| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| FullText URL | 65_6_369.pdf |
| Author | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| Abstract | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| Keywords | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2011-12 |
| Volume | volume65 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 369 |
| End Page | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Futagawa, Mashu| Okazaki, Tetsuya| Nakata, Eiji| Fukano, Chika| Osumi, Risa| Kato, Fumino| Urakawa, Yusaku| Yamamoto, Hideki| Ozaki, Toshifumi| Hirasawa, Akira| |
| Note | The version of record of this article, first published in Human Genome Variation, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41439-024-00299-4| |
| Published Date | 2024-11-26 |
| Publication Title | Human Genome Variation |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 42 |
| ISSN | 2054-345X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2024 |
| File Version | publisher |
| PubMed ID | 39592598 |
| DOI | 10.1038/s41439-024-00299-4 |
| Web of Science KeyUT | 001363412200001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41439-024-00299-4 |
| JaLCDOI | 10.18926/AMO/63405 |
|---|---|
| FullText URL | 76_2_121.pdf |
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Hiranaka, Takaaki| Kamatsuki, Yusuke| Nakata, Eiji| Tetsunaga, Tomonori| Yamane, Kentaro| Ozaki, Toshifumi| |
| Abstract | Bone marrow edema (BME) after meniscus injury and risk factors for subchondral insufficiency fracture of the knee (SIFK) have been reported. However, their association with medial meniscus posterior root tear (MMPRT) remains unknown. We investigated the association of BME volume (BME-V), posterior shinycorner lesion (PSCL), and SIFK with MMPRT to examine the correlations between BME-V and medial meniscus extrusion (MME), PSCL and duration from injury to the time of magnetic resonance imaging (duration), and SIFK and duration. Twenty-nine patients who underwent surgery for MMPRT were included (mean age, 59.2; range, 39-84). The presence of PSCL, femoral BME-V (cm3), and SIFK grade (1-4) were evaluated. Preoperative factors, such as MME (mm) and duration (weeks), were investigated using multivariate linear/ logistic regression analyses. Multivariate linear regression analysis revealed duration as a significant factor for high-grade SIFK (p<0.01). Multivariate logistic regression analysis revealed duration as a significant factor for the presence of PSCL (odds ratio=0.94, p<0.05). A long duration of MMPRT leads to severe MME and highgrade SIFK (3 and 4), often resulting in knee arthroplasty. Early diagnosis of MMPRT and pullout repair can prevent severe MME and high-grade SIFK. |
| Keywords | medial meniscus posterior root tear subchondral insufficiency fracture bone marrow edema meniscus extrusion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 121 |
| End Page | 127 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503439 |
| Web of Science KeyUT | 000792374900003 |
| JaLCDOI | 10.18926/AMO/66673 |
|---|---|
| FullText URL | 78_1_071.pdf |
| Author | Kaneda, Daisuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Hotta, Yoshifumi| Naniwa, Shuichi| Ozaki, Toshifumi| |
| Abstract | We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute. |
| Keywords | AVANTA silicone implant boutonniere deformity implant fracture thumb metacarpophalangeal joint arthroplasty rheumatoid arthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 78 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419317 |
| Web of Science KeyUT | 001203658200011 |
| FullText URL | fulltext20210607-5.pdf figure20210607-5.pdf table20210607-5.pdf |
|---|---|
| Author | Zhang, Ximing| Furumatsu, Takayuki| Okazaki, Yuki| Hiranaka, Takaaki| Kodama, Yuya| Xue, Haowei| Okazaki, Yoshiki| Ozaki, Toshifumi| |
| Note | This is an Accepted Manuscript of an article published by Elsevier This fulltext is available in July 2021.| |
| Published Date | 2020-07-04 |
| Publication Title | Journal of Orthopaedic Science |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 430 |
| End Page | 434 |
| ISSN | 09492658 |
| NCID | AA11052566 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. |
| File Version | author |
| PubMed ID | 32636137 |
| DOI | 10.1016/j.jos.2020.04.018 |
| Web of Science KeyUT | 000651122300020 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jos.2020.04.018 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hasei, Joe| Nakahara, Ryuichi| Otsuka, Yujiro| Nakamura, Yusuke| Hironari, Tamiya| Kahara, Naoaki| Miwa, Shinji| Ohshika, Shusa| Nishimura, Shunji| Ikuta, Kunihiro| Osaki, Shuhei| Yoshida, Aki| Fujiwara, Tomohiro| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | artificial intelligence clinical decision support diagnostic imaging image annotation osteosarcoma detection |
| Published Date | 2024-09-02 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | 3695 |
| End Page | 3704 |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39223070 |
| DOI | 10.1111/cas.16330 |
| Web of Science KeyUT | 001302420900001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16330 |
| JaLCDOI | 10.18926/AMO/49259 |
|---|---|
| FullText URL | 67_1_65.pdf |
| Author | Sakata, Kenichiro| Furumatsu, Takayuki| Abe, Nobuhiro| Miyazawa, Shinichi| Sakoma, Yoshimasa| Ozaki, Toshifumi| |
| Abstract | Bone marrow-stimulating techniques such as microfracture and subchondral drilling are valuable treatments for full-thickness cartilage defects. However, marrow stimulation-derived reparative tissues are not histologically well-documented in human osteoarthritis. We retrospectively investigated cartilage repairs after marrow stimulation for the treatment of large cartilage defects in osteoarthritic knees. Tissues were obtained from patients who underwent total knee arthroplasty (TKA) after arthroscopic marrow stimulation in medial compartmental osteoarthritis. Clinical findings and cartilage repair were assessed. Sections of medial femoral condyles were histologically investigated by safranin O staining and anti-type II collagen antibody. Marrow stimulation decreased the knee pain in the short term. However, varus leg alignment gradually progressed, and TKA conversions were required. The grade of cartilage repair was not improved. Marrow stimulations resulted in insufficient cartilage regeneration on medial femoral condyles. Safranin O-stained proteoglycans and type II collagen were observed in the deep zone of marrow-stimulated holes. This study demonstrated that marrow stimulation resulted in failed cartilage repair for the treatment of large cartilage defects in osteoarthritic knees. Our results suggest that arthroscopic marrow stimulation might not improve clinical symptoms for the long term in patients suffering large osteoarthritic cartilage defects. |
| Keywords | bone marrow stimulation microfracture subchondral drilling osteoarthritis of the knee cartilage repair |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-02 |
| Volume | volume67 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23439511 |
| Web of Science KeyUT | 000316829900009 |
| JaLCDOI | 10.18926/AMO/61905 |
|---|---|
| FullText URL | 75_2_225.pdf |
| Author | Xue, Haowei| Furumatsu, Takayuki| Okazaki, Yuki | Hiranaka, Takaaki| Kintaka, Keisuke | Zhang, Ximing| Yoshida, Aki| Ozaki, Toshifumi| |
| Abstract | A 65-year-old man presented with a left medial meniscus (MM) posterior root tear (PRT). Unicompartmental knee arthroplasty was performed 12 months after transtibial pullout repair of the MMPRT. Repaired MM posterior root tissue was subjected to histological analysis. Immunostaining and picrosirius red staining showed sufficient deposition of type I collagen, and hematoxylin-eosin staining using a polarized microscope showed well-aligned fiber orientation in the repaired tissue. The repaired posterior root (post-transtibial pullout repair) showed mature and well-aligned ligament-like tissue. Preserving the MM posterior root remnant to mimic the original posterior root tissue might be useful when performing pullout repair. |
| Keywords | medial meniscus posterior root tear unicompartmental knee arthroplasty histological analysis case report |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-04 |
| Volume | volume75 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 225 |
| End Page | 230 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33953430 |
| NAID | 120007029882 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uotani, Koji| Fujiwara, Tomohiro| Ueda, Koji| Yoshida, Aki| Iwata, Shintaro| Morita, Takuya| Kiyono, Masahiro| Kunisada, Toshiyuki| Takeda, Ken| Hasei, Joe| Yoshioka, Yusuke| Ochiya, Takahiro| Ozaki, Toshifumi| |
| Keywords | circulating biomarker Ewing sarcoma extracellular vesicles liquid biopsy proteome |
| Published Date | 2024-09-22 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue11 |
| Publisher | Wiley |
| Start Page | 3660 |
| End Page | 3671 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Author(s). |
| File Version | publisher |
| PubMed ID | 39307979 |
| DOI | 10.1111/cas.16343 |
| Web of Science KeyUT | 001318444100001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16343 |
| JaLCDOI | 10.18926/AMO/57957 |
|---|---|
| FullText URL | 74_1_77.pdf |
| Author | Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi| |
| Abstract | Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. |
| Keywords | idiopathic chondrolysis hip joint medication bump arthroscopy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099253 |
| Web of Science KeyUT | 000516606200012 |
| NAID | 120006795624 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kawada, Koki| Furumatsu, Takayuki| Fukuba, Mikao| Tamura, Masanori| Higashihara, Naohiro| Okazaki, Yuki| Yokoyama, Yusuke| Katayama, Yoshimi| Hamada, Masanori| Ozaki, Toshifumi| |
| Keywords | Clinical score Medial meniscus Medial meniscus extrusion Muscle strength Posterior root tear Quadriceps |
| Note | The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-023-06858-0| |
| Published Date | 2023-09-12 |
| Publication Title | BMC Musculoskeletal Disorders |
| Volume | volume24 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 727 |
| ISSN | 1471-2474 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 37700279 |
| DOI | 10.1186/s12891-023-06858-0 |
| Web of Science KeyUT | 001067181600004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12891-023-06858-0 |
| JaLCDOI | 10.18926/AMO/40011 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Honda, Mitsugi| Arita, Seizaburo| Mitani, Shigeru| Takeda, Yoshihiro| Ozaki, Toshifumi| Inamura, Keiji| Kanazawa, Susumu| |
| Abstract | Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH). The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images:the outward displacement rate, upward displacement rate, OE angle, and alpha angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%. |
| Keywords | X-ray image developmental dislocation of the hip acetabular dysplasia radiographic findings nonlinear multivariate analysis infant hip joint diagnostic support system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2010-06 |
| Volume | volume64 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 189 |
| End Page | 196 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 20596130 |
| Web of Science KeyUT | 000279094300005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin |
| Published Date | 2024-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume25 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1443 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 by the authors. |
| File Version | publisher |
| PubMed ID | 38338721 |
| DOI | 10.3390/ijms25031443 |
| Web of Science KeyUT | 001161430700001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms25031443 |
| FullText URL | OTSR105_1_107.pdf Fig.pdf |
|---|---|
| Author | Furumatsu, Takayuki| Okazaki, Yuki| Okazaki, Yoshiki| Hino, Tomohito| Kamatsuki, Yusuke| Masuda, Shin| Miyazawa, Shinichi| Nakata, Eiji| Hasei, Joe| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Keywords | Descending knee motion Injury pattern Medial meniscus Posterior root tear Squatting |
| Published Date | 2019-02-28 |
| Publication Title | Orthopaedics & Traumatology: Surgery & Research |
| Volume | volume105 |
| Issue | issue1 |
| Publisher | Elsevier |
| Start Page | 107 |
| End Page | 111 |
| ISSN | 18770568 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30442555 |
| DOI | 10.1016/j.otsr.2018.10.001 |
| Web of Science KeyUT | 000456541300018 |
| Related Url | isVersionOf https://doi.org/10.1016/j.otsr.2018.10.001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ueda, Masataka| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Takatori, Ryo| Shitozawa, Hisakazu| Uotani, Koji| Shinohara, Kennsuke| Oda, Yoshiaki| Ozaki, Toshifumi| |
| Keywords | AIS cognitive-behavioral therapy EQ5D HADS insomnia pain-liaison outpatient clinic sleep disorders |
| Published Date | 2024-08-09 |
| Publication Title | Medicine |
| Volume | volume103 |
| Issue | issue32 |
| Publisher | Lippincott, Williams & Wilkins |
| Start Page | e39113 |
| ISSN | 0025-7974 |
| NCID | AA00728867 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 the Author(s). |
| File Version | publisher |
| PubMed ID | 39121265 |
| DOI | 10.1097/MD.0000000000039113 |
| Web of Science KeyUT | 001287977800045 |
| Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000039113 |
| FullText URL | fulltext20240130-02.pdf fig20240130-02.pdf |
|---|---|
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Yokoyama, Yusuke| Higashihara, Naohiro| Tamura, Masanori| Kawada, Koki| Xue, Haowei| Ozaki, Toshifumi| |
| Keywords | intercondylar notch width intercondylar osteophyte medial meniscus posterior root tear transtibial pullout repair |
| Note | This is the pre-peer reviewed version of the following article: [Hiranaka, T., Furumatsu, T., Yokoyama, Y., Higashihara, N., Tamura, M., Kawada, K. et al. (2024) Intercondylar notch width and osteophyte width impact meniscal healing and clinical outcomes following transtibial pullout repair of medial meniscus posterior root tears. Knee Surgery, Sports Traumatology, Arthroscopy, 32, 116–123. https://doi.org/10.1002/ksa.12032], which has been published in final form at [https://doi.org/10.1002/ksa.12032]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| This fulltext file will be available in Jan. 2025.| |
| Published Date | 2024-01-04 |
| Publication Title | Knee Surgery, Sports Traumatology, Arthroscopy |
| Volume | volume32 |
| Issue | issue1 |
| Publisher | Wiley |
| Start Page | 116 |
| End Page | 123 |
| ISSN | 0942-2056 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. |
| File Version | author |
| PubMed ID | 38226691 |
| DOI | 10.1002/ksa.12032 |
| Web of Science KeyUT | 001135891400001 |
| Related Url | isVersionOf https://doi.org/10.1002/ksa.12032 |
| JaLCDOI | 10.18926/AMO/30956 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi| |
| Abstract | Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes. |
| Keywords | IL-4 MMP cathepsin B mechanical stress aggrecanase |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2008-04 |
| Volume | volume62 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 126 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 18464888 |
| Web of Science KeyUT | 000255297600008 |
| JaLCDOI | 10.18926/AMO/64364 |
|---|---|
| FullText URL | 77_1_71.pdf |
| Author | Yamakawa, Yasuaki| Kamatsuki, Yusuke| Noda, Tomoyuki| Kure, Miho| Miyazawa, Shinichi| Ozaki, Toshifumi| |
| Abstract | We report a case of ipsilateral periprosthetic fractures above and below the knee that occurred at different times due to navigation tracker pin and bone fragility. A 66-year-old Japanese woman with rheumatoid arthritis (RA) underwent a total knee arthroplasty. Four months post-surgery, a periprosthetic fracture above the knee at the navigation pin hole was detected. She underwent osteosynthesis and could walk independently, but she developed an ipsilateral tibial component fracture. Conservative treatment with a splint was followed by bone union. Patients with RA treated with oral steroids tend to develop ipsilateral periprosthetic fractures around the knee due to bone fragility. |
| Keywords | periprosthetic fracture total knee arthroplasty navigation system bone fragility |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-02 |
| Volume | volume77 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 71 |
| End Page | 74 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36849147 |
| Web of Science KeyUT | 000952992100005 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naniwa, Shuichi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Ohtsuki, Takashi| Hotta, Yoshifumi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Otsuka, Noriaki| Ozaki, Toshifumi| |
| Keywords | osteoarthritis chondrocyte mechanical stress LRP4 Agrin β-catenin SOX9 |
| Published Date | 2025-01-24 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1007 |
| ISSN | 1661-6596 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 by the authors. |
| File Version | publisher |
| PubMed ID | 39940775 |
| DOI | 10.3390/ijms26031007 |
| Web of Science KeyUT | 001418599900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms26031007 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hiranaka, Takaaki| Miyazawa, Shinichi| Furumatsu, Takayuki| Kodama, Yuya| Kamatsuki, Yusuke| Masuda, Shin| Okazaki, Yuki| Kintaka, Keisuke| Ozaki, Toshifumi| |
| Keywords | Total knee arthroplasty Extension gap Flexion gap Predictor Navigation system |
| Published Date | 2022-01-22 |
| Publication Title | BMC Musculoskeletal Disorders |
| Volume | volume23 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 78 |
| ISSN | 1471-2474 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35065647 |
| DOI | 10.1186/s12891-022-05035-z |
| Web of Science KeyUT | 000745608100002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12891-022-05035-z |
