| JaLCDOI | 10.18926/AMO/54811 |
|---|---|
| FullText URL | 70_6_477.pdf |
| Author | Nishida, Keiichiro| Machida, Takahiro| Horita, Masahiro| Hashizume, Kenzo| Nakahara, Ryuichi| Nasu, Yoshihisa| Ohashi, Hideki| Saiga, Kenta| Ozaki, Toshifumi| |
| Abstract | The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p＜0.001). Twenty-four feet (89 ) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot. |
| Keywords | shortening oblique osteotomy rheumatoid arthritis forefoot screw fixation |
| Amo Type | Original Article |
| Published Date | 2016-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 477 |
| End Page | 483 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003673 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Misawa, Haruo| Takigawa, Tomoyuki| Yamane, Kentaro| Tsuji, Hironori| Takei, Yoshitaka| Ozaki, Toshifumi| |
| Keywords | Peripheral neuropathic pain Mirogabalin Pregabalin Adverse event |
| Published Date | 2020-05-26 |
| Publication Title | Journal of Orthopaedic Surgery and Research |
| Volume | volume15 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 191 |
| ISSN | 1749-799X |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32456647 |
| DOI | 10.1186/s13018-020-01709-3 |
| Web of Science KeyUT | 000538017400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s13018-020-01709-3 |
| JaLCDOI | 10.18926/AMO/48692 |
|---|---|
| FullText URL | 66_4_363.pdf |
| Author | Tanaka, Masato| Sugimoto, Yoshihiro| Misawa, Haruo| Takigawa, Tomoyuki| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Spinal deformity is an important clinical manifestation after surgery for spinal cord tumors. One-third of patients who receive laminectomies and irradiation of the spinal column develop scoliosis, kyphosis, or kyphoscoliosis. Recent reports indicate good results after scoliosis surgery using segmental pedicle screws and a navigation system, but these reported studies have not included surgery for post-laminectomy kyphosis. Hooks and wires are ineffective in such patients who undergo laminectomy, and there are also high perioperative risks with insertion of pedicle screws because landmarks have been lost. Here, we report on the 5-year follow-up of a 13-year-old male patient with post-laminectomy and post-irradiation thoracic kyphoscoliosis after surgical treatment of spinal astrocytoma. Posterior segmental pedicle screw fixation was performed safely using a computer-assisted technique. The authors present the first case report for treatment of this condition using a navigation system. |
| Keywords | astrocytoma scoliosis kyphoscoliosis navigation segmental pedicle screw fixation |
| Amo Type | Case Report |
| Published Date | 2012-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume66 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 368 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22918210 |
| Web of Science KeyUT | 000307918900010 |
| JaLCDOI | 10.18926/AMO/31575 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime| |
| Abstract | <p>We report second malignant neoplasms which developed between 7 and 19 years after treatment in 3 pediatric patients with osteosarcoma. Two patients had been treated with only surgery, and another patient had been treated with a combination of surgery with chemotherapy and radiation therapy for primary lesions. Pediatric patients with osteosarcoma, in particular, require careful long-term follow-up to monitor not only metastases but also development of second malignant neoplasms.</p> |
| Keywords | osteosarcoma second malignancy |
| Amo Type | Article |
| Published Date | 1993-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume47 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 8506750 |
| Web of Science KeyUT | A1993LA45200010 |
| JaLCDOI | 10.18926/AMO/54980 |
|---|---|
| FullText URL | 71_2_119.pdf |
| Author | Oda, Yoshiaki| Takigawa, Tomoyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Akazawa, Hirofumi| Ozaki, Toshifumi| |
| Abstract | Patients with cerebral palsy (CP) frequently present with scoliosis; however, the pattern of curve progression is difficult to predict. We aimed to clarify the natural course of the progression of scoliosis and to identify scoliosis predictors. This was a retrospective, single-center, observational study. Total of 92 CP patients from Asahikawasou Ryouiku Iryou Center in Okayama, Japan were retrospectively analyzed. Cobb angle, presence of hip dislocation and pelvic obliquity, and Gross Motor Function Classification System (GMFCS) were investigated. Severe CP was defined as GMFCS level IV or V. The mean observation period was 10.7 years. Thirtyfour severe CP patients presented with scoliosis and were divided into 3 groups based on their clinical courses: severe, moderate and mild. The mean Cobb angles at the final follow-up were 129°, 53°, and 13° in the severe, moderate, and mild groups, respectively. The average progressions from 18 to 25 years were 2.7°/year, 0.7°/year, and 0.1°/year in the severe, moderate, and mild curve groups, respectively. We observed the natural course of scoliosis and identified 3 courses based on the Cobb angle at 15 and 18 years of age. This method of classification may help clinicians predict the patients’ disease progression. |
| Keywords | severe cerebral palsy scoliosis natural course Cobb angle progression |
| Amo Type | Original Article |
| Published Date | 2017-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 126 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420893 |
| Author | Furumatsu, Takayuki| Shukunami, Chisa| Amemiya-Kudo, Michiyo| Shimano, Hitoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2010-01 |
| Publication Title | The International Journal of Biochemistry & Cell Biology |
| Volume | volume42 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2017-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/54824 |
| JaLCDOI | 10.18926/AMO/55308 |
|---|---|
| FullText URL | 71_4_315.pdf |
| Author | Fujii, Yosuke| Endo, Hirosuke| Mitani, Shigeru| Akazawa, Hirofumi| Tetsunaga, Tomonori| Miyake, Takamasa| Yamada, Kazuki| Aoki, Kiyoshi| Ozaki, Toshifumi| |
| Abstract | We retrospectively reviewed 29 hips in which intertrochanteric osteotomies were performed for severe slipped capital femoral epiphyses. Mean age at surgery: 12.6 years. Mean follow-up period: 6 years. At the final follow-up evaluation, one patient had coxalgia, and six hips showed a limited range of motion. A pistol-grip deformity was observed in 13 hips, osteoarthritis in two hips, and a bump existed in 19 hips on the latest radiographs. Gradual remodeling of the bumps was observed post-operatively in 22 hips. The mean α and β angles and offset α and β improved over time. The remodeling proceeded rapidly for 1 year post-surgery. We compared hips classified as β angles of ≥ 63° to < 63° at the final follow-up evaluation, the mean β angle 1 year post-surgery, and the mean ratio of improvement of the β angle per year from 1 year post-surgery to the final follow up, which differed significantly. Nearly all of the patients who underwent intertrochanteric osteotomies had residual morphologic abnormalities, but few had clinical symptoms. The β angle 1 year post-surgery and the ratio of remodeling of the bump from 1 year post-surgery to the final follow-up can be regarded as a potential predictor of morphologic results after intertrochanteric osteotomy. |
| Keywords | slipped capital femoral epiphyses intertrochanteric osteotomy residual femoral deformity femoroacetabular impingement bone remodeling |
| Amo Type | Original Article |
| Published Date | 2017-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume71 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28824187 |
| JaLCDOI | 10.18926/AMO/49043 |
|---|---|
| FullText URL | 66_6_469.pdf |
| Author | Shiozaki, Yasuyuki| Ito, Yasuo| Sugimoto, Yoshihisa| Tomioka, Masao| Shimokawa, Tetsuya| Mazaki, Tetsuro| Koshimune, Koichiro| Tanaka, Masato| Ozaki, Toshifumi| |
| Abstract | In this study, we studied the relationship between fracture patterns and motor function recovery in 70 consecutive patients with cervical spinal cord injury. Fractures were categorized into 6 fracture types and subdivided into stages according to the Allen-Ferguson classification system:compressive flexion (CF), distractive flexion (DF), compressive extension (CE), distractive extension (DE), vertical compression (VC) and lateral flexion (LF). Paralysis was evaluated using the American Spinal Injury Association (ASIA) impairment scale at the time of injury and 3 months afterwards. The residual rate of complete motor palsy (ASIA grade A or B) at the final examination was higher in those patients with DE fractures than those with CF, DF or CE. The final outcomes were as follows. Of the 14 patients who were classified with CF fractures, residual palsy was frequently seen in patients who had stage 5 injury. Of the 27 patients with DF fractures, residual palsy occurred in about half of the patients who had stage 4 or 5 injury. Of the 18 patients with CE fractures, residual palsy occurred in half of the patients with stage 3 injury or higher. Finally, of the 7 patients with DE fractures, the rate of residual palsy was high even for the stage 1 and 2 cases;indeed, all DE patients who had complete motor palsy at the first examination had residual palsy at the final examination. Accordingly, we conclude that motor recovery may be related to fracture pattern. |
| Keywords | cervical spinal cord injury motor function recovery fracture patterns |
| Amo Type | Original Article |
| Published Date | 2012-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume66 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 473 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23254581 |
| Web of Science KeyUT | 000312966100006 |
| JaLCDOI | 10.18926/AMO/31335 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime| |
| Abstract | <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p> |
| Keywords | osteosarcoma bone transport reconstruction |
| Amo Type | Article |
| Published Date | 1998-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume52 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 9548997 |
| Web of Science KeyUT | 000072264100010 |
| JaLCDOI | 10.18926/AMO/31340 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ozaki, Toshifumi| Nakatsuka, Yoichi| Kawai, Akira| Akazawa, Hirofumi| Kunisada, Toshiyuki| Inoue, Hajime| |
| Abstract | <p>There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p> |
| Keywords | osteosarcoma bone transport reconstruction |
| Amo Type | Article |
| Published Date | 1998-02 |
| Publication Title | Acta Medica Okayama |
| Volume | volume52 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 70 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 9548997 |
| Web of Science KeyUT | 000072264100010 |
| JaLCDOI | 10.18926/AMO/32654 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ozaki, Toshifumi| Inoue, Hajime| Sugihara, Shinsuke| Sumii, Hiroshi| |
| Abstract | <p>Radiological findings on the fate of grafted Kiel bone implants for the treatment of bone tumors were evaluated in 25 lesions. The mean follow-up period was 14.8 years, ranging from 5 to 21.8 years. We classified the radiological findings into 4 grades; Excellent (4 lesions), Good (14 lesions), Fair (2 lesions), and Poor (5 lesions). All cases of the Poor grade were polyostotic fibrous dysplasia. The younger the patient at the time of the operation, the more rapidly Kiel bone grafts tended to be incorporated. The grafted bone can become enmeshed in the structure of the recipient bed (Good or Excellent grades) within 10 years in most cases, except in polyostotic fibrous dysplasia.</p> |
| Keywords | xenogeneic bone bone grafting bone neoplasms |
| Amo Type | Article |
| Published Date | 1992-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume46 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 87 |
| End Page | 92 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 1575062 |
| Web of Science KeyUT | A1992HR48400005 |
| JaLCDOI | 10.18926/AMO/31814 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Minagawa, Hiroshi| Aiga, Ayako| Endo, Hirosuke| Mitani, Shigeru| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| Abstract | <p>This retrospective study assessed the radiographic results of 16 patients with avascular necrosis following treatment for developmental dislocation of the hip (DDH) who were subsequently treated between 1991 and 2005 by rotation acetabular osteotomy (RAO) combined with femoral intertrochan-teric osteotomy (FIO). Initial treatment was by Pavlik harness, cast fixation, or overhead traction. The parameters that showed consistent improvement were the index of centralization, the index of acetabular coverage, adequate reduction of the greater trochanter, and abductor sufficiency. The combined procedure appears to be effective in cases in which preoperative planning shows a reasonable expectation of congruency and osteoarthritis is limited to the early stages.</p> |
| Keywords | rotation acetabular osteotomy femoral intertrochanteric osteotomy combined procedure developmental dysplasia of hip avascular necrosis |
| Amo Type | Original Article |
| Published Date | 2009-08 |
| Publication Title | Acta Medica Okayama |
| Volume | volume63 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 169 |
| End Page | 175 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 19727201 |
| Web of Science KeyUT | 000269228400002 |
| JaLCDOI | 10.18926/AMO/31850 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ohmori, Takao| Endo, Hirosuke| Mitani, Shigeru| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi| |
| Abstract | <p>In 1957, Pavlik introduced the Pavlik harness as a useful treatment for developmental dislocation of the hip (DDH), and subsequent studies have documented favorable outcomes among patients treated with this device. However, there are only a few articles reporting how early radiographic measurements can be used to determine the prognosis after treatment with the Pavlik harness. In this study, 217 hips from 192 patients whose DDH treatment with the Pavlik harness was initiated before they were 6 months old and whose follow-up lasted at least 14 years (rate, 63.8%) were analyzed using measurements from radiographs taken immediately before and after harness treatment, and at 1, 2, and 3 years of age. Severin's classification at the final follow-up was I or II in 71.9% and III or IV in 28.1% of the hips, respectively. Avascular necrosis of the femoral head (AVN) was seen in 10% of the hips. Stepwise multiple regression analysis was performed to retrospectively determine whether any radiographic factors were related to the final classification as Severin I/II or III/IV. Receiver opera-ting characteristic (ROC) curves were drawn for these factors, and a Wiberg OE angle (Point O was the middle point of the proximal metaphyseal border of the femur) of 2 degrees on the 3-year radiographs was found to be the most useful screening value for judging the acetabular development of DDH cases after treatment with a Pavlik harness, with a sensitivity of 71% a specificity of 93%, and a likelihood ratio of 10.1.</p> |
| Keywords | developmental dislocation of the hip long-term follow up radiographic measurement stepwise multiple regression analysis acetabular development |
| Amo Type | Original Article |
| Published Date | 2009-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume63 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 123 |
| End Page | 128 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 19571898 |
| Web of Science KeyUT | 000267388200001 |
| FullText URL | J_Orthop_Sci_21_4_524.pdf fig.pdf |
|---|---|
| Author | Furumatsu, Takayuki| Maehara, Ami| Ozaki, Toshifumi| |
| Note | This is an Accepted Manuscript of an article published by Elsevier| |
| Published Date | 2016-07 |
| Publication Title | Journal of Orthopaedic Science |
| Volume | volume21 |
| Issue | issue4 |
| Publisher | Elsevier |
| Start Page | 524 |
| End Page | 529 |
| ISSN | 0949-2658 |
| NCID | AA11052566 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 27113646 |
| DOI | 10.1016/j.jos.2016.02.013 |
| Web of Science KeyUT | 000381142800020 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jos.2016.02.013 |
| FullText URL | Knee26_3_653.pdf tables.pdf Fig.pdf |
|---|---|
| Author | Furumatsu, Takayuki| Okazaki, Yuki| Kodama, Yuya| Okazaki, Yoshiki| Masuda, Shin| Kamatsuki, Yusuke| Takihira, Shota| Hiranaka, Takaaki| Yamawaki, Tadashi| Ozaki, Toshifumi| |
| Keywords | Clinical outcome Medial meniscus Meniscal healing Posterior root tear Transtibial pullout repair |
| Published Date | 2019-06-30 |
| Publication Title | The Knee |
| Volume | volume26 |
| Issue | issue3 |
| Publisher | Elsevier |
| Start Page | 653 |
| End Page | 659 |
| ISSN | 09680160 |
| NCID | AA10996272 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 Elsevier B.V. All rights reserved. |
| File Version | author |
| PubMed ID | 30902517 |
| DOI | 10.1016/j.knee.2019.02.007 |
| Web of Science KeyUT | 000474504500017 |
| Related Url | isVersionOf https://doi.org/10.1016/j.knee.2019.02.007 |
| JaLCDOI | 10.18926/AMO/54818 |
|---|---|
| FullText URL | 70_6_515.pdf |
| Author | Fujii, Masataka| Furumatsu, Takayuki| Kadota, Yasutaka| Shimamura, Yoshinobu| Tsuchimochi, Shigeyuki| Ozaki, Toshifumi| |
| Abstract | The present report describes the first known, case of a pseudoaneurysm of the perforating branch of the deep femoral artery following anterior cruciate ligament (ACL) reconstruction. A 19-year-old man underwent ACL reconstruction using the outside-in femoral tunnel-creation method. Seven days after the surgery, he complained of abnormal thigh pain and had swelling with local heat on the distal lateral thigh. Magnetic resonance imaging, computed tomography, and color Doppler ultrasonography showed the pseudoaneurysm in the thigh. Resection surgery was successfully performed by a vascular surgeon 12 days after ACL reconstruction. Careful examination and awareness of postoperative symptoms such as thigh pain and swelling after ACL reconstruction were critical for the early diagnosis of pseudoaneurysm. |
| Keywords | pseudoaneurysm perforating branch of the deep femoral artery anterior cruciate ligament |
| Amo Type | Case Report |
| Published Date | 2016-12 |
| Publication Title | Acta Medica Okayama |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 515 |
| End Page | 518 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003680 |
| Author | Kikuchi, Takeshi| Kubota, Satoshi| Asaumi, Koji| Kawaki, Harumi| Nishida, Takashi| Kawata, Kazumi| Mitani, Shigeru| Tabata, Yasuhiko| Ozaki, Toshifumi| Takigawa, Masaharu| |
|---|---|
| Published Date | 2008-06 |
| Publication Title | Tissue Engineering Part A |
| Volume | volume14 |
| Issue | issue6 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/30776 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Makihata, Eiichi| Kuroda, Masahiro| Kawai, Akira| Ozaki, Toshifumi| Sugihara, Shinsuke| Inoue, Hajime| Joja, Ikuo| Asaumi, Junichi| Kawasaki, Shoji| Hiraki, Yoshio| |
| Abstract | <p>We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P < 0.05) in patients whose Time ≥ 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p> |
| Keywords | soft tissue tumor hyperthermia radiotherapy chemotherapy |
| Amo Type | Article |
| Published Date | 1997-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume51 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 93 |
| End Page | 99 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 9142346 |
| Web of Science KeyUT | A1997WX19600006 |
| FullText URL | JOS24_6_1058.pdf Figs.pdf Table.pdf |
|---|---|
| Author | Hiranaka, Takaaki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Sugiu, Kazuhisa| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Takihira, Shota| Miyazawa, Shinichi| Nakata, Eiji| Ozaki, Toshifumi| |
| Note | This fulltext will be available in Nov 2020 | |
| Published Date | 2019-08-20 |
| Publication Title | Journal of Orthopaedic Science |
| Volume | volume24 |
| Issue | issue6 |
| Publisher | Elsevier |
| Start Page | 1058 |
| End Page | 1063 |
| ISSN | 09492658 |
| NCID | AA11052566 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. |
| File Version | author |
| PubMed ID | 31444009 |
| DOI | 10.1016/j.jos.2019.08.001 |
| Web of Science KeyUT | 000496202800019 |
| Related Url | isVersionOf https://doi.org/10.1016/j.jos.2019.08.001 |
