JaLCDOI 10.18926/AMO/57713
FullText URL 73_6_495.pdf
Author Masuda, Shin| Furumatsu, Takayuki| Okazaki, Yoshiki| Kamatsuki, Yusuke| Okazaki, Yuki| Kodama, Yuya| Hiranaka, Takaaki| Nakata, Eiji| Ozaki, Toshifumi|
Abstract Medial meniscus posterior root tear causes rapid knee cartilage degradation by inducing posteromedial displacement of the medial meniscus. We evaluated medial meniscus posterior extrusion before and after pullout repair for medial meniscus posterior root tear using magnetic resonance images. Twenty-eight patients with symptomatic medial meniscus posterior root tear were included. The inclusion criteria were: acute (< 3 months) or chronic (≥3 months) medial meniscus posterior root tear after painful popping events. The exclusion criteria were: other meniscus and anterior cruciate ligament injuries. We measured medial meniscus posterior extrusion and medial meniscus anteroposterior interval at knee flexion angles of 10° and 90° preoperatively and at 3 months postoperatively. The posterior extrusion at 90° knee flexion decreased from 4.42±1.38 mm preoperatively to 3.09±1.06 mm (p<0.001) postoperatively, while at 10° knee flexion it was −4.17±1.63 mm preoperatively and −3.77±1.72mm postoperatively, showing no significant change. The anteroposterior interval at 10° knee flexion increased from 19.74±4.27 mm preoperatively to 22.15±5.10 mm postoperatively (p<0.001); at 90° knee flexion, it increased from 16.81±4.51 mm preoperatively to 19.20±4.30 mm postoperatively (p<0.001). Medial meniscus posterior extrusion and movement decreased after pullout repair. Pullout repair for medial meniscus posterior root tear improves medial meniscus posterior extrusion, especially at 90° knee flexion.
Keywords medial meniscus posterior root tear pullout repair extrusion open magnetic resonance imaging
Amo Type Original Article
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 495
End Page 501
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871331
Web of Science KeyUT 000503431400004
JaLCDOI 10.18926/AMO/60373
FullText URL 74_4_345.pdf
Author Tanaka, Takaaki| Furumatsu, Takayuki| Hiranaka, Takaaki| Okazaki, Yuki| Masudaa, Kenji| Senoa, Noritaka| Ozaki, Toshifumi|
Abstract The aim of this study was to evaluate tunnel coalition and inter-tunnel distance by comparing the tibial tunnel position in double-bundle anterior cruciate ligament (ACL) reconstruction performed with a conventional guide versus a posterolateral (PL) divergence (PLD) guide. Subjects were 43 patients (ACL tip aimer: 20 knees; PLD guide: 23 knees) who underwent double-bundle ACL reconstruction between September 2014 and December 2017. In all cases, the tibial tunnel position, tunnel edge distance and tunnel angles were evaluated based on CT images. Clinical outcome was evaluated using the Lachman test, pivot-shift test, and Lysholm score. Tibial tunnel positions were similar between the conventional and PLD guide groups, while tibial tunnel edge distance was significantly less in the conventional group. Tunnel coalition was observed in 5 knees in the conventional and no knees in the PLD guide group. Distance between two tibial tunnel centers was 9.1 mm for the tip aimer, and 10.5 mm for the PLD guide. Creation of the PL tunnel tended to involve insertion from a more medial aspect for the PLD guide group than the conventional guide group. No differences in clinical outcomes were noted. The PLD guide can be used to create anatomically-positioned PL tunnels, and reduce the probability of occurrence of tunnel coalition.
Keywords anterior cruciate ligament reconstruction tibial tunnel position PL divergence guide tunnel coalition
Amo Type Original Article
Published Date 2020-08
Publication Title Acta Medica Okayama
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 345
End Page 350
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843766
Web of Science KeyUT 000562508700010
NAID 120006880212
JaLCDOI 10.18926/AMO/32851
FullText URL fulltext.pdf
Author Shintani, Mai| Senda, Masuo| Takayanagi, Tomoko| Katayama, Yoshimi| Furusawa, Kazunari| Okutani, Tamami| Kataoka, Masaki| Ozaki, Toshifumi|
Abstract <p>To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners.</p>
Keywords service dog HRQOL SF-36v2 people with physical disability
Amo Type Original Article
Published Date 2010-04
Publication Title Acta Medica Okayama
Volume volume64
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 113
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20424665
Web of Science KeyUT 000276996900004
FullText URL J_Orthop_Sci_22_4_715.pdf fig.pdf
Author Lu, Zhichao| Furumatsu, Takayuki| Fujii, Masataka| Maehara, Ami| Ozaki, Toshifumi|
Keywords vascular endothelial growth factor (VEGF) meniscus meniscal injury hypoxia-inducible factor-1α (HIF-1α)
Note This is an Accepted Manuscript of an article published by Elsevier|
Published Date 2017-07
Publication Title Journal of Orthopaedic Science
Volume volume22
Issue issue4
Publisher Elsevier
Start Page 715
End Page 721
ISSN 0949-2658
NCID AA11052566
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 28318650
DOI 10.1016/j.jos.2017.02.006
Web of Science KeyUT 000407394700022
Related Url isVersionOf https://doi.org/10.1016/j.jos.2017.02.006
JaLCDOI 10.18926/AMO/61437
FullText URL 75_1_71.pdf
Author Sanki, Tomoaki| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Kawamura, Yoshi| Ozaki, Toshifumi|
Abstract Intra-operative acetabular fracture is a total hip arthroplasty complication that can occur during cementless cup insertion, especially in osteoporotic patients. We conducted this biomechanical study to investigate the impact resistance of the acetabulum with simulated bones of different density by drop-weight impact testing. Low- and high-density polyurethane foam blocks were used as osteoporotic and healthy bone models, respectively. Polyurethane blocks were used as the acetabular cancellous bone. Composite sheets were used as the acetabu-lum’s medial cortex. The testing revealed that the osteoporotic bone model’s impact resistance was significantly lower than that the healthy bone model’. In the healthy bone model, even thin acetabular cancellous bone with ≥ 1 mm acetabulum medial cortex was less likely to fracture. In the osteoporotic bone model, fracture was pos-sible without ≥ 1 mm medial cortex of the acetabulum and thick acetabular cancellous bone. Although impac-tion resistance differs due to bone quality, the impaction resistance in this osteoporotic bone model was equiv-alent to that healthy bone model’s when a thick medial wall was present. To avoid intra-operative acetabulum fracture, surgeons should consider both the bone quality and the thicknesses of the medial cortex and acetabu-lar cancellous bone.
Keywords intra-operative acetabular fracture drop weight impact testing total hip arthroplasty impact resistance
Amo Type Original Article
Published Date 2021-02
Publication Title Acta Medica Okayama
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 71
End Page 77
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/30972
FullText URL fulltext.pdf
Author Endo, Hirosuke| Asaumi, Koji| Mitani, Shigeru| Noda, Tomoyuki| Minagawa, Hiroshi| Tetsunaga, Tomonori| Ozaki, Toshifumi|
Abstract <p>A minimally invasive plate osteosynthesis technique using a locking compression plate (LCP) has been used widely in trauma cases. Its advantages are that the MIPO technique does not interfere with the fracture site and thus provides improved biological healing, and that the LCP has excellent angular stability. Its use in bone lengthening, however, has not been established. In such cases, it is desirable to shorten the external skeletal fixation period as much as possible. Here, the MIPO technique using an LCP was applied to femoral distraction osteogenesis in an attempt to shorten the external skeletal fixation period. For femoral lengthening, the MIPO technique was performed in 2 stages. Orthofix external fixators (Orthofix, England) were used to insert screws from the anterolateral side rather than from the lateral side of the femur for bone lengthening. When sufficient callus formation was detected postoperatively at the site of bone lengthening, and the absence of infection was ensured, limb draping was performed, including a whole external fixator, and then the MIPO technique was applied with an LCP. In 3 cases (5 limbs), the average duration of external skeletal fixation was 134days, the average external-fixation index was 24days/cm, and the average consolidation index was 22days/cm. The MIPO technique using an LCP made it possible to shorten the external skeletal fixation-wearing period in femoral lengthening.</p>
Keywords femoral lengthening minimally invasive plate osteosynthesis locking compression plate external skeletal fixation external-fixation index
Amo Type Original Article
Published Date 2008-10
Publication Title Acta Medica Okayama
Volume volume62
Issue issue5
Publisher Okayama University Medical School
Start Page 333
End Page 339
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18985094
Web of Science KeyUT 000260391300008
FullText URL fulltext.pdf
Author Saito, Taichi| Noda, Tomoyuki| Kondo, Hiroya| Demiya, Koji| Nezu, Satoshi| Yokoo, Suguru| Matsuhashi, Minami| Uehara, Takenori| Shimamura, Yasunori| Kodama, Masayuki| Ozaki, Toshifumi|
Abstract Alternative Septic arthritis in distal interphalangeal (DIP) joints sometimes occurs in association with mucous cysts or after the surgical treatment of mallet fingers. Recently, several studies have demonstrated...
Keywords Hand Induced membrane Masquelet technique Septic arthritis The small joint
Published Date 2020-02-29
Publication Title Trauma Case Reports
Volume volume25
Start Page 100268
ISSN 23526440
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Ltd.
File Version publisher
PubMed ID 1890833
DOI 10.1016/j.tcr.2019.100268
Related Url isVersionOf https://doi.org/10.1016/j.tcr.2019.100268
JaLCDOI 10.18926/AMO/57714
FullText URL 73_6_503.pdf
Author Kamatsuki, Yusuke| Furumatsu, Takayuki| Miyazawa, Shinichi| Kodama, Yuya| Hino, Tomohito| Okazaki, Yoshiki| Masuda, Shin| Okazaki, Yuki| Noda, Tomoyuki| Yamakawa, Yasuaki| Tetsunaga, Tomoko| Ozaki, Toshifumi|
Abstract Clinical studies have demonstrated that transtibial pullout repair led to favorable midterm outcomes in patients with medial meniscus posterior root tears (MMPRTs) although medial meniscal extrusion (MME) continued to be present. It has been unclear whether these residual postoperative MMEs existed after the pullout repair or had progressed at the very short-term evaluation after surgery. We sought to determine which characteristics of patients with MMPRTs influence the incidence of postoperative MME. The cases of 23 patients whose date of injury was known were analyzed. All patients underwent MMPRT pullout fixation. Preoperative and 3-month postoperative magnetic resonance imaging (MRI) examinations were performed. MME was retrospectively assessed on the mid-coronal plane of MRI scans. The preoperative and postoperative MME values were 4.2±1.2 mm and 4.3±1.5 mm, respectively (p=0.559). Pullout repair surgery was performed significantly earlier after the MMPRT-specific injury in patients whose postoperative MME improved compared to the patients whose MME did not improve (p<0.001). Our findings demonstrated that an early transtibial pullout repair of an MMPRT was more effective in reducing MME than a late repair. Surgeons should not miss the optimal timing for the pullout repair of an MMPRT, considering the period from the injury and the preoperative MME.
Keywords medial meniscus posterior root tear pullout repair medial meniscus extrusion magnetic resonance imaging
Amo Type Original Article
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 503
End Page 510
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871332
Web of Science KeyUT 000503431400005
Author Furumatsu, Takayuki| Matsumoto, Emi| Kanazawa, Tomoko| Fujii, Masataka| Lu, Zhichao| Kajiki, Ryotaro| Ozaki, Toshifumi|
Published Date 2013-05-31
Publication Title Journal of Biomechanics
Volume volume46
Issue issue9
Content Type Journal Article
JaLCDOI 10.18926/AMO/57947
FullText URL 74_1_7.pdf
Author Sanki, Tomoaki| Endo, Hirosuke| Tetsunaga, Tomonori| Furumatsu, Takayuki| Yamada, Kazuki| Ozaki, Toshifumi|
Abstract We investigated the relationship between the initial contact status and stress shielding in total hip arthroplasty (THA) using fit-and-fill type straight-stem implants. In addition we evaluated the clinical and radiographic outcomes. Subjects were 100 hips of 94 patients who underwent THA and were followed-up for ≥10 years. Contact areas with the femoral cortical bone were investigated according to the zonal distribution of Gruen using postoperative CT images. Depending on the number of contact areas, the patients were classified into high contact [HC], medium contact [MC], and low contact [LC] groups. Radiographic and clinical outcomes were evaluated. In the HC group (20 hips), severe stress shielding was observed in 12 hips, which was statistically significant (p=0.008). In the LC group (29 hips), mild stress shielding was observed in 27 hips which was statistically significant (p<0.001). No significant differences were observed among the 3 groups in clinical outcomes, Harris hip score (p=0.719) or Japanese Orthopedic Association (JOA) score (p=0.301). In insertion of cementless collared fit-and-fill type straight-stem implants, severe late stress shielding of the femoral bone may occur if high contact of the femoral component is achieved. However, the degree of stress shielding does not result in adverse clinical outcomes.
Keywords fit-and-fill stress shielding cementless straight stem total hip arthroplasty
Amo Type Original Article
Published Date 2020-02
Publication Title Acta Medica Okayama
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099243
Web of Science KeyUT 000516606200002
NAID 120006795614
FullText URL CORR477_8_1892.pdf
Author Kunisada, Toshiyuki| Fujiwara, Tomohiro| Hasei, Joe| Nakata, Eiji| Senda, Masuo| Ozaki, Toshifumi|
Published Date 2019-08
Publication Title Clinical Orthopaedics and Related Research
Volume volume477
Issue issue8
Publisher Lippincott, Williams & Wilkins
Start Page 1892
End Page 1901
ISSN 0009-921X
NCID AA00607942
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30985613
DOI 10.1097/CORR.0000000000000764
Web of Science KeyUT 000509664400024
Related Url isVersionOf https://doi.org/10.1097/CORR.0000000000000764
Author Mochizuki, Yusuke| Tazawa, Hiroshi| Demiya, Koji| Kure, Miho| Kondo, Hiroya| Komatsubara, Tadashi| Sugiu, Kazuhisa| Hasei, Joe| Yoshida, Aki| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Oncolytic adenovirus hTERT Immunogenic cell death ATP CD8
Note This is a post-peer-review, pre-copyedit version of an article published in Cancer Immunology, Immunotherapy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00262-020-02774-7. </br>This fulltext is available in Nov. 2021.|
Published Date 2020-11-05
Publication Title Cancer Immunology, Immunotherapy
Publisher Springer
Start Page 0340-7004
NCID AA00598499
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33151368
DOI 10.1007/s00262-020-02774-7
Web of Science KeyUT 000586350500002
Related Url isVersionOf https://doi.org/10.1007/s00262-020-02774-7
Author Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi|
Published Date 2010-08-02
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/31849
FullText URL fulltext.pdf
Author Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yasuo| Kunisada, Toshiyuki| Misawa, Haruo| Koshimune, Koichiro| Ozaki, Toshifumi|
Abstract <p>Surgical treatment of metastatic spinal cord compression is controversial. The purpose of this study was to investigate the effectiveness of our current surgical treatments and the use of spinal instrumentation. In this retrospective study covering the years between 1990 and 2006, 100 patients with spinal metastases which were secondary to various cancers underwent posterior and/or anterior decompression with spinal stabilization for the purposes of reduction of pain, and/or to help correct or improve neurological deficits. The group was made up of 60 men and 40 women whose ages ranged from 16 to 83 years (average of 60 years), and the average follow-up period was 14 months. The effect of treatment upon pain relief and neural deficits was assessed, and the cumulative survival rate was calculated by the Kaplan-Meier method. The average surgical time was 185min. This was calculated based on the following times, listed here with the surgery type:178min for posterior surgery;245min for anterior surgery;465 min for combined surgery;and 475min for total en bloc spondylectomy. Average blood loss during surgery was 1,630 ml for posterior surgery, 1,760 ml for anterior surgery, 1,930 ml for combined surgery, and 3,640 ml for total en bloc spondylectomy. Preoperative pain and paralysis were improved by 88% and 53%, respectively. In regards to surgical complications, postoperative epidural hematoma was observed in 2 patients, and instrumentation-related infection was observed in 1. Only 2 patients died within 2 months of surgery. In conclusion, posterior and/or anterior decompression with spinal stabilization is a safe and effective treatment for patients with spinal metastases, and can improve their quality of life.</p>
Keywords spinal metastasis spinal surgery instrumentation
Amo Type Original Article
Published Date 2009-06
Publication Title Acta Medica Okayama
Volume volume63
Issue issue3
Publisher Okayama University Medical School
Start Page 145
End Page 150
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19571901
Web of Science KeyUT 000267388200004
JaLCDOI 10.18926/AMO/30758
FullText URL fulltext.pdf
Author Tanaka, Masato| Nakahara, Shinnosuke| Ito, Yauo| Nakanishi, Kazuo| Sugimoto, Yoshihisa| Ikuma, Hisanori| Ozaki, Toshifumi|
Abstract <p>The purpose of this study was to investigate the surgical outcomes and to determine indicators of the necessity of surgical intervention. Twelve consecutive patients harboring symptomatic sacral perineural cysts were treated between 1995 and 2003. All patients were assessed for neurological deficits and pain by neurological examination. Magnetic resonance of imaging, computerized tomography, and myelography were performed to detect signs of delayed filling of the cysts. We performed a release of the valve and imbrication of the sacral cysts with laminectomies in 8 cases or recapping laminectomies in 4 cases. After surgery, symptoms improved in 10 (83%) of 12 patients, with an average follow-up of 27 months. Ten patients had sacral perineural cysts with signs of positive filling defect. Two (17%) of 12 patients experienced no significant improvement. In one of these patients, the filling defect was negative. In conclusion, a positive filling defect may become an indicator of good treatment outcomes.</p>
Keywords Tarlov cyst sacral perineural cyst meningeal cyst meningeal diverticulum sacral radiculopathy
Amo Type Article
Published Date 2006-02
Publication Title Acta Medica Okayama
Volume volume60
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16508691
Web of Science KeyUT 000235538900008
JaLCDOI 10.18926/AMO/49047
FullText URL 66_6_499.pdf
Author Sugimoto, Yoshihisa| Tanaka, Masato| Nakahara, Ryuichi| Misawa, Haruo| Kunisada, Toshiyuki| Ozaki, Toshifumi|
Abstract An 11 year-old girl had 66 degrees of kyphosis in the thoracolumbar junction. For the purpose of planning for kyphosis correction, we created a 3-D, full-scale model of the spine and consulted spinal navigation. Three-dimensional models are generally used as tactile guides to verify the surgical approach and portray the anatomic relations specific to a given patient. We performed posterior fusion from Th10 to L3, and vertebral column resection of Th12 and L1. Screw entry points, directions, lengths and diameters were determined by reference to navigation. Both tools were useful in the bone resection. We could easily detect the posterior element to be resected using the 3D model. During the anterior bony resection, navigation helped us to check the disc level and anterior wall of the vertebrae, which were otherwise difficult to detect due to their depth in the surgical field. Thus, the combination of navigation and 3D models helped us to safely perform surgery for a patient with complex spinal deformity.
Keywords congenital scoliosis kyphosis navigation 3-dimensional models
Amo Type Case Report
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 499
End Page 502
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254585
Web of Science KeyUT 000312966100010
Author Hiranaka, Takaaki| Furumatsu, Takayuki| Okazaki, Yuki| Yamawaki, Tadashi| Okazaki, Yoshiki| Kodama, Yuya| Kamatsuki, Yusuke| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Bilateral injury Predictor Medial tibial slope Sensitivity and specificity
Note This is a post-peer-review, pre-copyedit version of an article published in Knee Surgery, Sports Traumatology, Arthroscopy. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00167-020-06079-1. </br>This fulltext is available in June 2021.|
Published Date 2020-06-01
Publication Title Knee Surgery, Sports Traumatology, Arthroscopy
Publisher Springer
ISSN 0942-2056
NCID AA10973641
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version Author
PubMed ID 32488369
DOI 10.1007/s00167-020-06079-1
Web of Science KeyUT 000538465000003
Related Url isVersionOf https://doi.org/10.1007/s00167-020-06079-1
JaLCDOI 10.18926/AMO/48560
FullText URL 66_3_213.pdf
Author Kataoka, Masaki| Kunisada, Toshiyuki| Tanaka, Masato| Takeda, Ken| Itani, Satoru| Sugimoto, Yoshihisa| Misawa, Haruo| Senda, Masuo| Nakahara, Shinnosuke| Ozaki, Toshifumi|
Abstract There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model:gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR]=6.80, p<0.001), metastasis to major organs (HR=2.01, p=0.005), disease-free interval before spinal metastasis (HR=1.77, p=0.028), and extra-spinal bone metastasis (HR=1.75, p=0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis.
Keywords spine metastasis survival prognostic factor cancer
Amo Type Original Article
Published Date 2012-06
Publication Title Acta Medica Okayama
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 213
End Page 219
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729101
Web of Science KeyUT 000305669700004
JaLCDOI 10.18926/AMO/52901
FullText URL 68_5_313.pdf
Author Yamane, Kentaro| Tanaka, Masato| Sugimoto, Yoshihisa| Ichimura, Kouichi| Ozaki, Toshifumi|
Abstract Ossified meningioma is classified histologically as a phenotype of metaplastic meningioma, and it is extremely rare. There are only 12 cases involving ossified spinal meningiomas in the literature. We present the case of a 61-year-old female with a primary tumor within the ventral spinal canal at T12. Although we performed a total tumor excision using an ultrasonic bone aspirator, a temporary deterioration of motor evoked potentials (MEPs) was observed during curettage with a Kerrison rongeur. The neurologic findings worsened immediately after surgery. Histologically, the tumor was diagnosed as a metaplastic meningioma with osseous differentiation. In order to avoid spinal cord injury, great care must be taken when removing an ossified meningioma located on the ventral spinal cord.
Keywords spinal metaplastic meningioma osseous differentiation ossified meningioma ultrasonic bone aspirator post-operative course
Amo Type Case Report
Published Date 2014-10
Publication Title Acta Medica Okayama
Volume volume68
Issue issue5
Publisher Okayama University Medical School
Start Page 313
End Page 316
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25338489
Web of Science KeyUT 000343269300009
Author Furumatsu, Takayuki| Ozaki, Toshifumi| Asahara, Hiroshi|
Published Date 2009-05
Publication Title The International Journal of Biochemistry & Cell Biology
Volume volume41
Issue issue5
Content Type Journal Article