FullText URL fulltext.pdf
Author Ohtsuki, Takashi| Hatipoglu, Omer F.| Asano, Keiichi| Inagaki, Junko| Nishida, Keiichiro| Hirohata, Satoshi|
Keywords cell migration-inducing hyaluronidase 1 (CEMIP) chondrocyte hyaluronan mechanical strain nuclear factor kappa B (NF-kappa B) osteoarthritis
Published Date 2020-04-29
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue9
Publisher MDPI
Start Page 3140
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32365591
DOI 10.3390/ijms21093140
Web of Science KeyUT 000535581700111
Related Url isVersionOf https://doi.org/10.3390/ijms21093140
Author 西田 圭一郎|
Published Date 1995-09-30
Publication Title
Content Type Thesis or Dissertation
Author Demircan, Kadir| Hirohata, Satoshi| Nishida, Keiichiro| Hatipoglu, Omer F.| Oohashi, Toshitaka| Yonezawa, Tomoko| Apte, Suneel S.| Ninomiya, Yoshifumi|
Published Date 2005-5
Publication Title Arthritis & Rheumatism
Volume volume52
Issue issue5
Content Type Journal Article
FullText URL fulltext.pdf
Author Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi|
Published Date 2019-10-15
Publication Title Experimental Cell Research
Volume volume383
Issue issue2
Publisher Elsevier
Start Page 111556
ISSN 00144827
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 31415758
DOI 10.1016/j.yexcr.2019.111556
Web of Science KeyUT 000488145400017
Related Url isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556
JaLCDOI 10.18926/AMO/30956
FullText URL fulltext.pdf
Author Doi, Hideyuki| Nishida, Keiichiro| Yorimitsu, Masanori| Komiyama, Takamitsu| Kadota, Yasutaka| Tetsunaga, Tomonori| Yoshida, Aki| Kubota, Satoshi| Takigawa, Masaharu| Ozaki, Toshifumi|
Abstract <p>Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type II collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1beta expression was also signifi cantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.</p>
Keywords IL-4 MMP cathepsin B mechanical stress aggrecanase
Amo Type Original Article
Published Date 2008-04
Publication Title Acta Medica Okayama
Volume volume62
Issue issue2
Publisher Okayama University Medical School
Start Page 119
End Page 126
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18464888
Web of Science KeyUT 000255297600008
Author Tetsunaga, Tomonori| Furumatsu, Takayuki| Abe, Nobuhiro| Nishida, Keiichiro| Naruse, Keiji| Ozaki, Toshifumi|
Published Date 2009-09-18
Publication Title Journal of Biomechanics
Volume volume42
Issue issue13
Content Type Journal Article
JaLCDOI 10.18926/AMO/57957
FullText URL 74_1_77.pdf
Author Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.
Keywords idiopathic chondrolysis hip joint medication bump arthroscopy
Amo Type Case Report
Published Date 2020-02
Publication Title Acta Medica Okayama
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 77
End Page 81
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099253
reference Waldenstrom H : On necrosis of the joint cartilage by epiphyseolysis capitis femoralis. Acta Chir Scand (1930) 67: 936-946.| Jones BS: Adolescent chondrolysis of the hip joint. South African Med J (1971) 45: 196-202.| Duncan JW, Nasca R and Schrantz J: The bizarre stiff hip. Possible Idiopathic Chondrolysis. J Am Med Assoc (1975) 231: 382-385.| Segaren N, Abdul-Jabar, Segaren N and Hashemi-Nejad A: Idiopathic chodrolysis of the hip: presentation, natural history and treatment options. J Pediatr Orthop B (2014) 23: 112-116.| Hoven H, Keessen W and Kuis W: Idiopathic chondrolysis of the hip; a distinct clinical entity ? Acta Orthop Scand (1989) 60: 661-663.| Dechosilpa C, Mulpruek P, Woratanarat P and Thiabratana P: Idiopathic chondrolysis of hip. Idiopathic Chondrolysis of Hip (ICH): report of three cases. Malaysian Orthopaedic J (2014) 8: 30-32.| Sureka J, Jakkani RK, Inbaraji A and Panwar S: Idiopathic chondrolysis of hip. Jpn J Radiol (2011) 29: 283-285.| Daluga DJ and Millar EA: Idipathic chondrolysis of the hip. J Pediatr Orthop (1989) 9: 405-411.| Johnson K, Haigh SF, Ehtisham S, Ryder C and Gardner-Medwin J: Childhood idiopathic chondrolysis of the hip; MRI features. Pediatr Radiol (2003) 33: 194-199.| Laor T and Crawford AH: Idiopathic chondrolysis of the hip in children; early MRI findings. AJR (2009) 192: 526-531.| Khoshhal KI, Awaad Y and Abbak AA: Botulinum neurotoxin-A in idiopathic chondrolysis; a case report of two cases. J Pediatr Orthop B (2014) 23: 441-446.| Picazo DR, Perez FD, Ortega PJ and Aparicio NG: An usual case of chondrolysis of the hip; a possible etiology for a rare condition - a case report. J Pediatr Orthop B (2016) 25: 533-538.| Appleyard DV, Schiller JR, Eberson CP and Ehrlich MG: Idiopathic chondrolysis treated with eternercept. Orthopedics (2009) 32: 214‒217.| Roy DR and Crawford AH: Idiopathic chondrolysis of the hip; management by subtotal capsulectomy and aggressive rehabilitation. J Pediatr Orthop (1988) 8: 203-207.| Garcia ADC, Fernandez PL, Gonzalez MPC, Garcia AC, Gonzalez LR and Jimenez JP: Idiopathic chondrolysis of the hip; long term evolution. J Pediatr Orthop (1999) 19: 449-454.|
JaLCDOI 10.18926/AMO/51867
FullText URL 67_5_311.pdf
Author Nishida, Keiichiro| Hashizume, Hiroyuki| Matsukawa, Akihiro| Hashizume, Kenzo| Shimamura, Yasunori| Torigoe, Yasuyuki| Ozaki, Toshifumi|
Abstract We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up.
Keywords occult compression fracture metacarpal head avascular necrosis osteochondral autograft
Amo Type Case Report
Published Date 2013-10
Publication Title Acta Medica Okayama
Volume volume67
Issue issue5
Publisher Okayama University Medical School
Start Page 311
End Page 317
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24145731
Web of Science KeyUT 000325836100005
JaLCDOI 10.18926/AMO/40012
FullText URL fulltext.pdf
Author Sasaki, Kentaro| Senda, Masuo| Nishida, Keiichiro| Ota, Haruyuki|
Abstract We examined whether the preoperative time required for the Timed "Up and Go" (TUG) test could predict the risk for deep venous thrombosis (DVT) in patients with hip osteoarthritis after total hip arthroplasty (THA). Eighteen patients with DVT diagnosed by venography were selected, and 18 without DVT of the same age and sex and with the same operated side as the DVT group were selected as a control group. We evaluated the 5 preoperative factors that might affect the occurrence of DVT complications, as follows:disease duration, body mass index, serum total cholesterol, subjective pain evaluated by the visual analog scale, and TUG. The JOA hip score (pain, range of motion, walking ability, and daily life) was also evaluated before surgery. As a postoperative factor, we checked the postoperative day when weight-bearing was initiated. As a result, TUG (DVT, 18.4+/-4.0 sec vs. control, 15.0+/-3.2 sec;p0.01) was only significantly different between the 2 groups. The ROC curve revealed that the cut-off point of 15.3 sec in preoperative time for TUG was sensitive (83.3%) and specific (61.1%) for DVT after THA (odds ratio7.0;95% confidence interval, 1.6-30.8). These results suggested that low preoperative ambulatory ability in patients with hip osteoarthritis might be associated with DVT after THA. An improvement in TUG before surgery might contribute to a decrease in the occurrence of DVT after THA.
Keywords preoperative Timed “Up and Go” test deep venous thrombosis total hip arthroplasty hip osteoarthritis
Amo Type Original Article
Published Date 2010-06
Publication Title Acta Medica Okayama
Volume volume64
Issue issue3
Publisher Okayama University Medical School
Start Page 197
End Page 201
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20596131
Web of Science KeyUT 000279094300006
JaLCDOI 10.18926/AMO/31628
FullText URL fulltext.pdf
Author Masaoka, Shunji| Hashizume, Hiroyuki| Senda, Masuo| Nishida, Keiichiro| Nagoshi, Mitsuru| Inoue, Hajime|
Abstract <p>Seventy-nine shoulders suspected of rotator cuff tears were examined by ultrasonography (US) and forty-three received surgery. Long and short axis scans were performed and findings of each were separately classified according to a five-grade system, and the results were correlated with the actual extent of tear observed during surgery. Internal echogenicity and subacromial impingement were analyzed before and after surgery. A accuracy of US in detecting rotator cuff tears was analyzed. In addition, the correlation between cuff shape observed by US before surgery and actual shape observed during surgery was assessed. It was noted that cuff thinning and abnormalities in shape did not recover to normal after surgery. However, in the cases of discontinuities observed by US before surgery, US findings indicated that the torn cuff was anchored to the greater tuberosity and functional during active motion. Although post-operative US findings were not normal, clinical results were good in most cases. Sensitivity of US for detecting rotator cuff tear was 100% and specificity 94%. US is non-invasive, cost effective and allows the physician to examine the joint while it is in motion. Therefore, at this time, we use US as a screening method for detecting rotator cuff tears. Furthermore, US allows us to check for re-tears while the joint is in motion, which is essential for accurate diagnosis.</p>
Keywords rotator cuff tear ultrasonography diagnostic image
Amo Type Article
Published Date 1999-04
Publication Title Acta Medica Okayama
Volume volume53
Issue issue2
Publisher Okayama University Medical School
Start Page 81
End Page 89
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000080058700004
JaLCDOI 10.18926/AMO/31296
FullText URL fulltext.pdf
Author Takeuchi, Kazuhiro| Inoue, Hajime| Yokoyama, Yoshiki| Senda, Masuo| Ota, Yusuke| Abe, Nobuhiro| Nishida, Keiichiro|
Abstract <p>We studied the magnetic resonance imaging (MRI) of 120 knees in 86 rheumatoid arthritis (RA) patients and of 14 unaffected knees in 12 control cases. We also developed a scoring system as a quantitative analysis method. We divided the MRI into 10 items, and classified the severity of the symptoms into 4 grades (score 0 to 3). The average total score increased according to the radiographic grade. Soft tissue lesions were clearly detected, even in the early stages of RA. Items such as synovial proliferation showed a high score even in the early stages, suggesting that it was the initial symptom of RA. The score also showed a correlation with the inflammatory signs. These results suggest that this scoring system is very sensitive and yields a good reflection of RA activity. We demonstrated that this system is simple and convenient for routine diagnostic use. We further demonstrated that it is useful for following the advancement of RA and for evaluating the response to treatment.</p>
Keywords rheumatoid arthritis magnetic resonance imaging scoring system synovial membrane
Amo Type Article
Published Date 1998-08
Publication Title Acta Medica Okayama
Volume volume52
Issue issue4
Publisher Okayama University Medical School
Start Page 211
End Page 224
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9781272
Web of Science KeyUT 000075623600006
Author Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54824
Title Alternative Hospital and clinic cooperation for the treatment of rheumatoid arthritis in Okayama Prefecture, Japan
FullText URL 126_209.pdf
Author Sada, Ken-ei| Nishida, Keiichiro| Yamanaka, Takao| Misaki, Kenta| Wakabayashi, Hiroshi| Shinoda, Junko| Takagi, Toru| Yano, Ryusuke| Nakamura, Akihiko| Nanba, Yoshifumi| Morita, Yoshitaka| Koyama, Yoshinobu| Yamamoto, Keiji| Ezawa, Kazuhiko| Ota, Yusuke| Yoshihara, Yoshiki| Miyoshi, Shinya| Natsumeda, Masamitsu| Usui, Masaaki| Yoshinaga, Yasuhiko| Hayashi, Takashi| Yamamura, Masahiro| Hashizume, Hiroyuki|
Abstract Objective: To survey the current status and problems of cooperation between clinics and hospitals in Okayama Prefecture, Japan for the treatment of rheumatoid arthritis (RA).  Methods: We distributed a questionnaire to 300 of the 983 Okayama Prefecture clinics that had either an internal medicine or orthopedic surgery department, from December 2013 to February 2014. The questionnaire covered practice pattern for RA treatment in clinics, current status of the hospital and clinic cooperation, and acceptance of the biologic therapy.  Results: One hundred clinics responded to the questionnaire. Seventy percent of the clinics reported making referrals to rheumatologists before the initiation of RA treatment, and half of the other 30% of the clinics administered methotrexate as the first-line treatment for RA by their own decision. Sixty-six clinics cooperated with flagship hospitals, conducting medical and laboratory examinations, providing prescriptions, and treating common diseases of patients. These clinics expected the cooperating rheumatologists to follow-up patients every 3 to 6 months and to make the diagnosis, make decisions regarding RA treatment changes, and perform surgery. Seventy-one percent of the clinics responded that cooperation with a hospital is possible even for patients who are administered biologics. As reasons for no cooperation with the flagship hospitals, clinics noted the lack of information about rheumatologists in the area and recent trends in the management of RA.  Conclusion: The current study reported, for the first time, the actual conditions of management of RA in clinics, as well as future problems of hospital and clinic cooperation in Okayama Prefecture.
Keywords 病診連携(hospital and clinic cooperation) 関節リウマチ(rheumatoid arthritis) 生物学的製剤(biologics) メトトレキサート(methotrexate)
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 209
End Page 215
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.209
NAID 130004903246
Author Shimamura, Yasunori| Inoue, Madoka| Ozawa, Masatugu| Kanazawa, Tomoko| Saitou, Taiichi| Nakahara, Ryuichi| Noda, Tomoyuki| Nishida, Keiichiro| Ozaki, Toshifumi|
Published Date 2011-08-01
Publication Title 岡山医学会雑誌
Volume volume123
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/32855
FullText URL fulltext.pdf
Author Shimamura, Yasunori| Nishida, Keiichiro| Imatani, Junya| Noda, Tomoyuki| Hashizume, Hiroyuki| Ohtsuka, Aiji| Ozaki, Toshifumi|
Abstract <p>We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods:an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were:Group I, 98.9+/-32.6;Group II, 108.5+/-27.2;Group III, 50.0+/-7.5;and Group IV, 34.5+/-12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p0.05). In the extension loading test, the mean failure loads were:Group I, 34.0+/-12.4;Group II, 51.0+/-14.8;Group III, 19.3+/-6.0;and Group IV, 14.7+/-3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.</p>
Keywords distal humerus fracture biomechanics internal fixation elderly
Amo Type Original Article
Published Date 2010-04
Publication Title Acta Medica Okayama
Volume volume64
Issue issue2
Publisher Okayama University Medical School
Start Page 115
End Page 120
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20424666
Web of Science KeyUT 000276996900005
JaLCDOI 10.18926/AMO/57720
FullText URL 73_6_537.pdf
Author Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka|
Abstract High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty.
Keywords high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery
Amo Type Case Report
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 537
End Page 542
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871338
Web of Science KeyUT 000503431400011
Author Murakami, Takuro| Piao, Da Xun| Ohtsuka, Aiji| Nishida, Keiichiro|
Published Date 1996-10-31
Publication Title 岡山医学会雑誌
Volume volume108
Issue issue9-10
Content Type Journal Article
Author 西田 圭一郎|
Published Date 2006-01-04
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/54811
FullText URL 70_6_477.pdf
Author Nishida, Keiichiro| Machida, Takahiro| Horita, Masahiro| Hashizume, Kenzo| Nakahara, Ryuichi| Nasu, Yoshihisa| Ohashi, Hideki| Saiga, Kenta| Ozaki, Toshifumi|
Abstract The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p<0.001). Twenty-four feet (89 ) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot.
Keywords shortening oblique osteotomy rheumatoid arthritis forefoot screw fixation
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 477
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003673
JaLCDOI 10.18926/AMO/53119
FullText URL 69_1_29.pdf
Author Nakahara, Ryuichi| Nishida, Keiichiro| Hashizume, Kenzo| Harada, Ryouzou| Machida, Takahiro| Horita, Masahiro| Ohtsuka, Aiji| Ozaki, Toshifumi|
Abstract The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r=0.27), OMERACT total score (r=0.43) and synovial volume (r=0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well.
Keywords magnetic resonance imaging rheumatoid arthritis outcome measures in rheumatology clinical trials scoring system direct volume measuring medical work station
Amo Type Original Article
Published Date 2015-02
Publication Title Acta Medica Okayama
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 35
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703168
Web of Science KeyUT 000349740300003
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53113