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ID 41015
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Title Alternative
Studies on Passive Anaphylaxis of Isolated Guinea Pig Intestine Part I Studies on Minimal Sensitizing Antibody Dose and Minimal Antigen Dose
Author
Nasu, Shozo
Abstract
Using crystalline hen's ovalbumin, an experiment on passive Schulz-Dale reaction in guinea pigs was done. The results are as follows: 1). After 24 hours of incubation period, the minimal sensitizing dose of antiserum which would cause passive Schulz-Dale reaction in guinea pigs is 0.5 unit per 1 ml guinea pig blood. 2). As the dose of sensitizing antibody increases, the dose of antigen lessons, but the critical dose depends upon the individual animal. Furthermore no definite propotional relation exists between the two. 3). The minimal antigen dose on minimal sensitzing antibody dose is the binding zone equivalent dose by Ogata's method or the 1/4 of it. 4). The most appropriate antigen dose to cause anaphylaxis to the isolated guinea pig intestine which is passively sensitized is the binding zone equivalent dose of the antibody used in this reaction. 5). Comparing bovine serum which is complex antigen and crystalline hen's ovalbumin which is simple antigen, the minimal antibody sensitizing dose is extermely small in quantity in the latter when in passive Shulz-Dale reaction.
Published Date
1959-07-10
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue7-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
4487
End Page
4495
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/7-2/71_7-2_4487/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma