このエントリーをはてなブックマークに追加
ID 41015
フルテキストURL
71_4487.pdf 3.52 MB
タイトル(別表記)
Studies on Passive Anaphylaxis of Isolated Guinea Pig Intestine Part I Studies on Minimal Sensitizing Antibody Dose and Minimal Antigen Dose
著者
那須 昭三 岡山大学医学部衛生学教室
抄録
Using crystalline hen's ovalbumin, an experiment on passive Schulz-Dale reaction in guinea pigs was done. The results are as follows: 1). After 24 hours of incubation period, the minimal sensitizing dose of antiserum which would cause passive Schulz-Dale reaction in guinea pigs is 0.5 unit per 1 ml guinea pig blood. 2). As the dose of sensitizing antibody increases, the dose of antigen lessons, but the critical dose depends upon the individual animal. Furthermore no definite propotional relation exists between the two. 3). The minimal antigen dose on minimal sensitzing antibody dose is the binding zone equivalent dose by Ogata's method or the 1/4 of it. 4). The most appropriate antigen dose to cause anaphylaxis to the isolated guinea pig intestine which is passively sensitized is the binding zone equivalent dose of the antibody used in this reaction. 5). Comparing bovine serum which is complex antigen and crystalline hen's ovalbumin which is simple antigen, the minimal antibody sensitizing dose is extermely small in quantity in the latter when in passive Shulz-Dale reaction.
発行日
1959-07-10
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
71巻
7-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
4487
終了ページ
4495
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/71/7-2/71_7-2_4487/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma