
検索結果 818 件
| フルテキストURL | fulltext20240716-01.pdf |
|---|---|
| 著者 | Katsumata, Emiko| Tsuruta, Takeshi| Sonoyama, Kei| Yoshida, Takashi| Sasaki, Mio| Teraoka, Mao| Wang, Tianyang| Nishino, Naoki| |
| キーワード | gut bacteria immunoglobulin A lard |
| 備考 | This is the peer reviewed version of the following article: E. Katsumata, T. Tsuruta, K. Sonoyama, T. Yoshida, M. Sasaki, M. Teraoka, T. Wang, N. Nishino, Unabsorbed Fecal Fat Content Correlates with a Reduction of Immunoglobulin a Coating of Gut Bacteria in High-Lard Diet-Fed Mice. Mol. Nutr. Food Res. 2024, 68, 2400078. https://doi.org/10.1002/mnfr.202400078, which has been published in final form at https://doi.org/10.1002/mnfr.202400078. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jul. 2025.| |
| 発行日 | 2024-07-04 |
| 出版物タイトル | Molecular Nutrition & Food Research |
| 巻 | 68巻 |
| 号 | 15号 |
| 出版者 | Wiley |
| 開始ページ | 2400078 |
| ISSN | 1613-4125 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Wiley-VCH GmbH |
| 論文のバージョン | author |
| PubMed ID | 38965658 |
| DOI | 10.1002/mnfr.202400078 |
| Web of Science KeyUT | 001262016700001 |
| 関連URL | isVersionOf https://doi.org/10.1002/mnfr.202400078 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Li, Yuying| Wang, Qiong| Jia, Huimin| Ishikawa, Kazuya| Kosami, Ken-Ichi| Ueba, Takahiro| Tsujimoto, Atsumi| Yamanaka, Miki| Yabumoto, Yasuyuki| Miki, Daisuke| Sasaki, Eriko| Fukao, Yoichiro| Fujiwara, Masayuki| Kaneko-Kawano, Takako| Tan, Li| Kojima, Chojiro| Wing, Rod A.| Sebastian, Alfino| Nishimura, Hideki| Fukada, Fumi| Niu, Qingfeng| Shimizu, Motoki| Yoshida, Kentaro| Terauchi, Ryohei| Shimamoto, Ko| Kawano, Yoji| |
| 備考 | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-024-48943-5| |
| 発行日 | 2024-05-30 |
| 出版物タイトル | Nature Communications |
| 巻 | 15巻 |
| 号 | 1号 |
| 出版者 | Nature Portfolio |
| 開始ページ | 4610 |
| ISSN | 2041-1723 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024 |
| 論文のバージョン | publisher |
| PubMed ID | 38816417 |
| DOI | 10.1038/s41467-024-48943-5 |
| Web of Science KeyUT | 001236316700012 |
| 関連URL | isVersionOf https://doi.org/10.1038/s41467-024-48943-5 |
| JaLCDOI | 10.18926/AMO/67207 |
|---|---|
| フルテキストURL | 78_3_301.pdf |
| 著者 | Nakazaki, Kiyoshi| Hirai, Satoshi| Hishikawa, Tomohito| |
| 抄録 | We report a case of a large vestibular schwannoma in an 80-year-old female patient that shrank after palliative Gamma Knife radiosurgery (GKS). Neurological symptoms included hearing deterioration and facial palsy. The tumor volume was 21.9 mL. Craniotomy was considered high-risk, and conventional GKS was risky, owing to the risk of transient enlargement. Therefore, GKS was performed on only a portion of the tumor. The marginal dose (12 Gy) volume was 3.8 mL (17.4%). The tumor began to shrink after transient enlargement. Sixty months later, the tumor volume was only 3.1 mL, and the patient was able to maintain independent activities of daily living without salvage treatment. |
| キーワード | vestibular schwannoma Gamma Knife radiosurgery large volume palliative elderly patient |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 301 |
| 終了ページ | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902220 |
| Web of Science KeyUT | 001267340600001 |
| JaLCDOI | 10.18926/AMO/67205 |
|---|---|
| フルテキストURL | 78_3_291.pdf |
| 著者 | Minagi, Hitoshi| Aoki, Hideki| Doita, Susumu| Miyake, Eiki| Ogawa, Toshihiro| Taniguchi, Fumitaka| Watanabe, Megumi| Arata, Takashi| Katsuda, Koh| Tanakaya, Kohji| |
| 抄録 | In the clinical course of malignant melanoma, which can metastasize to multiple organs, gallbladder metastases are rarely detected. A 69-year-old man who underwent resection of a primary malignant melanoma was subsequently treated with nivolumab for lung metastases and achieved complete response. Seven years after surgery, multiple nodules were found in the gallbladder, and he underwent laparoscopic cholecystectomy. The postoperative diagnosis was metastases of malignant melanoma. He has been recurrence-free 8 months after surgery. If radical resection is possible, such surgery should be performed for gallbladder metastases found in patients with other controlled lesions of malignant melanoma. |
| キーワード | malignant melanoma gallbladder metastasis laparoscopic cholecystectomy |
| Amo Type | Case Report |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 291 |
| 終了ページ | 294 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902218 |
| Web of Science KeyUT | 001267351900003 |
| JaLCDOI | 10.18926/AMO/67199 |
|---|---|
| フルテキストURL | 78_3_245.pdf |
| 著者 | Akagawa, Manabu| Saito, Hidetomo| Takahashi, Yasuhiro| Iwamoto, Yosuke| Iida, Junpei| Yoshikawa, Takayuki| Abe, Toshiki| Saito, Kimio| Kijima, Hiroaki| Kasukawa, Yuji| Hongo, Michio| Miyakoshi, Naohisa| |
| 抄録 | Although several studies have suggested a possible association between sarcopenia and knee osteoarthritis (OA) in the elderly, there remains no definitive evidence. Recently, however, the serum creatinine/cystatin C ratio (sarcopenia index: SI) was reported to correlate with skeletal muscle mass. The present retrospective study therefore investigated the impact of reduced skeletal muscle mass on advanced knee OA using SI. In 55 individuals scheduled for knee osteotomy or knee arthroplasty, correlations between SI and patient-reported outcomes such as the Knee Society Score (KSS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS) were explored. Significant associations were found between SI and the KSS functional activity score (β=0.37; p=0.022), KOOS subscale for activities of daily living (β=0.42; p=0.0096), and OKS (β=0.42; p=0.0095). This study underscores the role of reduced muscle mass in functional outcomes and introduces SI as a valuable marker for assessing muscle loss in knee OA patients. |
| キーワード | knee osteoarthritis sarcopenia index reduced muscle mass activities of daily living functional activity |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-06 |
| 巻 | 78巻 |
| 号 | 3号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 245 |
| 終了ページ | 250 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38902212 |
| Web of Science KeyUT | 001267351000005 |
| フルテキストURL | fulltext20240530-04.pdf |
|---|---|
| 著者 | Hyodo, Aiko| Mikami, Ayaka| Horie, Kengo| Mitoh, Yoshihiro| Ninomiya, Yuzo| Iida, Seiji| Yoshida, Ryusuke| |
| キーワード | taste recognition threshold resting saliva bicarbonate xerostomia TAS1R |
| 備考 | © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Jun. 2025.| |
| 発行日 | 2024-09 |
| 出版物タイトル | Archives of Oral Biology |
| 巻 | 165巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 106013 |
| ISSN | 0003-9969 |
| NCID | AA00548457 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Elsevier Ltd. |
| 論文のバージョン | author |
| PubMed ID | 38833772 |
| DOI | 10.1016/j.archoralbio.2024.106013 |
| Web of Science KeyUT | 001251481700001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.archoralbio.2024.106013 |
| フルテキストURL | K0007014_abstract_review.pdf K0007014_fulltext.pdf K0007014_summary.pdf |
|---|---|
| 著者 | 福村 優華| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第7014号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(歯学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 by the authors. |
| フルテキストURL | K0007012_abstract_review.pdf K0007012_fulltext.pdf K0007012_summary.pdf |
|---|---|
| 著者 | 吉田 国弘| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第7012号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(歯学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 Japanese Association for Oral Biology. |
| フルテキストURL | K0007008_abstract_review.pdf K0007008_fulltext.pdf K0007008_summary.pdf |
|---|---|
| 著者 | 梅森 洸樹| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第7008号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(歯学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 The Author(s). |
| フルテキストURL | K0006996_abstract_review.pdf K0006996_fulltext.pdf |
|---|---|
| 著者 | 森 淳史| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6996号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(医学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 by the authors. |
| フルテキストURL | K0006962_abstract_review.pdf K0006962_fulltext.pdf K0006962_summary.pdf |
|---|---|
| 著者 | 小松原 将| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6962号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(医学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| フルテキストURL | K0006953_abstract_review.pdf K0006953_fulltext.pdf K0006953_other_figure.pdf K0006953_other1_Supplementary Figures.pdf K0006953_other2_Supplementary Table.pdf K0006953_summary.pdf |
|---|---|
| 著者 | 吉本 匡志| |
| 発行日 | 2024-03-25 |
| 資料タイプ | 学位論文 |
| 学位授与番号 | 甲第6953号 |
| 学位授与年月日 | 2024-03-25 |
| 学位・専攻分野 | 博士(医学) |
| 授与大学 | 岡山大学 |
| 言語 | 英語 |
| 著作権者 | © 2023 Elsevier B.V. |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Nishihara, Takahiro| Miyoshi, Toru| Nakashima, Mitsutaka| Miki, Takashi| Toda, Hironobu| Yoshida, Masatoki| Ichikawa, Keishi| Osawa, Kazuhiro| Yuasa, Shinsuke| |
| キーワード | Metabolic dysfunction-associated fatty liver disease Coronary computed tomography angiography High-risk plaque Obstructive stenosis |
| 備考 | The version of record of this article, first published in Cardiovascular Diabetology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12933-024-02268-1| |
| 発行日 | 2024-05-10 |
| 出版物タイトル | Cardiovascular Diabetology |
| 巻 | 23巻 |
| 号 | 1号 |
| 出版者 | BMC |
| 開始ページ | 167 |
| ISSN | 1475-2840 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2024. |
| 論文のバージョン | publisher |
| PubMed ID | 38730426 |
| DOI | 10.1186/s12933-024-02268-1 |
| Web of Science KeyUT | 001218501800001 |
| 関連URL | isVersionOf https://doi.org/10.1186/s12933-024-02268-1 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Yoshida, Atsuki| Ito, Ayumi| Yasui, Norihisa| Yamashita, Atsuko| |
| キーワード | calmodulin cytosol sweet taste taste receptor type 1 umami taste |
| 発行日 | 2023-08-01 |
| 出版物タイトル | The Journal of Biochemistry |
| 巻 | 174巻 |
| 号 | 5号 |
| 出版者 | Oxford University Press (OUP) |
| 開始ページ | 451 |
| 終了ページ | 459 |
| ISSN | 0021-924X |
| NCID | AA00694073 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023. |
| 論文のバージョン | publisher |
| PubMed ID | 37527916 |
| DOI | 10.1093/jb/mvad060 |
| Web of Science KeyUT | 001044633000001 |
| 関連URL | isVersionOf https://doi.org/10.1093/jb/mvad060 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Umeda, Yuzo| Yoshida, Ryuichi| Fuji, Tomokazu| Yasui, Kazuya| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| キーワード | Hepaticojejunostomy Robotic surgery Pancreatoduodenectomy Biliary complications |
| 備考 | The version of record of this article, first published in Langenbeck's Archives of Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00423-023-03020-1| |
| 発行日 | 2023-07-20 |
| 出版物タイトル | Langenbeck's Archives of Surgery |
| 巻 | 408巻 |
| 号 | 1号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 284 |
| ISSN | 1435-2451 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023 |
| 論文のバージョン | publisher |
| PubMed ID | 37468703 |
| DOI | 10.1007/s00423-023-03020-1 |
| Web of Science KeyUT | 001032102900001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s00423-023-03020-1 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Takagi, Kosei| Hata, Nanako| Kimura, Jiro| Kikuchi, Satoru| Noma, Kazuhiro| Yasui, Kazuya| Fuji, Tomokazu| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| キーワード | Virtual reality Robotic simulations Educational video Robotic surgery Learning curve Cumulative sum analysis |
| 備考 | The version of record of this article, first published in Journal of Robotic Surgery, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11701-023-01556-4| |
| 発行日 | 2023-03-11 |
| 出版物タイトル | Journal of Robotic Surgery |
| 巻 | 17巻 |
| 号 | 4号 |
| 出版者 | Springer Science and Business Media LLC |
| 開始ページ | 1547 |
| 終了ページ | 1553 |
| ISSN | 1863-2491 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2023 |
| 論文のバージョン | publisher |
| PubMed ID | 36905486 |
| DOI | 10.1007/s11701-023-01556-4 |
| Web of Science KeyUT | 000946947400001 |
| 関連URL | isVersionOf https://doi.org/10.1007/s11701-023-01556-4 |
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Uotani, Koji| Tazawa, Hiroshi| Hasei, Joe| Fujiwara, Tomohiro| Yoshida, Aki| Yamakawa, Yasuaki| Omori, Toshinori| Sugiu, Kazuhisa| Komatsubara, Tadashi| Kondo, Hiroya| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hata, Toshiaki| Kunisada, Toshiyuki| Takeda, Ken| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
| 発行日 | 2024-02-20 |
| 出版物タイトル | PLoS ONE |
| 巻 | 19巻 |
| 号 | 2号 |
| 出版者 | Public Library of Science |
| 開始ページ | e0298292 |
| ISSN | 1932-6203 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2024 Uotani et al. |
| 論文のバージョン | publisher |
| PubMed ID | 38377118 |
| DOI | 10.1371/journal.pone.0298292 |
| Web of Science KeyUT | 001176939600021 |
| 関連URL | isVersionOf https://doi.org/10.1371/journal.pone.0298292 |
| JaLCDOI | 10.18926/AMO/66924 |
|---|---|
| フルテキストURL | 78_2_151.pdf |
| 著者 | Komatsubara, Tadashi| Tazawa, Hiroshi| Hasei, Joe| Omori, Toshinori| Sugiu, Kazuhisa| Mochizuki, Yusuke| Demiya, Koji| Yoshida, Aki| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Urata, Yasuo| Kagawa, Shunsuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
| 抄録 | Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors. |
| キーワード | soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 151 |
| 終了ページ | 161 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688833 |
| Web of Science KeyUT | 001229151800007 |
| JaLCDOI | 10.18926/AMO/66923 |
|---|---|
| フルテキストURL | 78_2_143.pdf |
| 著者 | Shigematsu, Hisayuki| Yamashita, Natsumi| Suehisa, Hiroshi| Ueno, Tsuyoshi| Ryuko, Tsuyoshi| Sugihara, Takahito| Nakashima, Shohei| Sano, Yoshifumi| Yamashita, Motohiro| |
| 抄録 | Travel burden is a poor prognostic factor for many cancers worldwide because it hinders optimal diagnosis and treatment planning. Currently, the impact of travel burden on survival after surgery for non-small cell lung cancer (NSCLC) in Japan is largely unexplored. We examined the impact of travel distance on the postoperative outcomes of patients with NSCLC in Ehime Prefecture, Japan. The data of 1212 patients who underwent surgical resection for NSCLC were retrospectively reviewed. Patients were divided into quartiles based on the travel distance from their home to the hospital (≤ 13 km, 13-40 km, 40-57 km, and > 57 km) in Ehime Prefecture. We found no significant differences among the quartiles in baseline clinicopathological characteristics, including sex, smoking status, histology, surgical procedure, clinical stage, and pathological stage. Overall survival (OS) and relapse-free survival (RFS) also were not significantly different among the travel distance quartiles. We conclude that travel distance did not impact OS or RFS among patients with NSCLC who underwent surgical resection at our institution. |
| キーワード | non-small cell lung cancer travel distance travel burden lung surgery surgical outcome |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 143 |
| 終了ページ | 149 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688832 |
| Web of Science KeyUT | 001229151800006 |
| JaLCDOI | 10.18926/AMO/66912 |
|---|---|
| フルテキストURL | 78_2_095.pdf |
| 著者 | Itano, Junko| Kiura, Katsuyuki| Maeda, Yoshinobu| Miyahara, Nobuaki| |
| 抄録 | The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases. |
| キーワード | neuropeptide y Y1 receptor airway immune response bronchial epithelial cells respiratory disease |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 95 |
| 終了ページ | 106 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688827 |
| Web of Science KeyUT | 001229151800001 |