検索結果 25000 件
| JaLCDOI | 10.18926/AMO/47265 |
|---|---|
| フルテキストURL | 65_6_395.pdf |
| 著者 | Harada, Sosuke| Sato, Shuhei| Suzuki, Etsuji| Okumura, Yoshihiro| Hiraki, Takao| Gobara, Hideo| Mimura, Hidefumi| Kanazawa, Susumu| Kaji, Mitsumasa| Fujiwara, Toshiyoshi| |
| 抄録 | The aim of the present study was to assess the diagnostic usefulness of Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the prediction of local recurrence of malignant lung tumors by analyzing the pre-radiofrequency ablation (RFA) maximal standardized uptake value (SUVmax). We performed a historical cohort study of consecutive malignant lung tumors treated by RFA from January 2007 to May 2008 at Okayama University Hospital. We selected only lung tumors examined by PET/CT within 90 days before RFA and divided them (10 primary and 29 metastatic) into 3 groups according to their tertiles of SUVmax. We calculated recurrence odds ratios in the medium group and the high group compared to the low group using multivariate logistic analysis. After we examined the relationship between SUVmax and recurrence in a crude model, we adjusted for some factors. Tumors with higher SUVmax showed higher recurrence odds ratios (medium group;1.84, high group;4.14, respectively). The tumor size also increased the recurrence odds ratio (2.67);we thought this was mainly due to selection bias because we excluded tumors less than 10mm in diameter. This study demonstrated the pre-RFA SUVmax in PET/CT may be a prognostic factor for local recurrence of malignant lung tumors. |
| キーワード | fluorodeoxyglucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) radiofrequency ablation (RFA) lung |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 395 |
| 終了ページ | 402 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189480 |
| Web of Science KeyUT | 000298516900006 |
| JaLCDOI | 10.18926/AMO/47262 |
|---|---|
| フルテキストURL | 65_6_369.pdf |
| 著者 | Terada, Chuji| Yoshida, Aki| Nasu, Yoshihisa| Mori, Shuji| Tomono, Yasuko| Tanaka, Masato| Takahashi, Hideo K.| Nishibori, Masahiro| Ozaki, Toshifumi| Nishida, Keiichiro| |
| 抄録 | We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1β, but not TNFα, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1β and TNFα promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1β and TNFα secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA. |
| キーワード | HMGB-1 RAGE chondrocyte osteoarthritis cartilage |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 369 |
| 終了ページ | 377 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189477 |
| Web of Science KeyUT | 000298516900003 |
| JaLCDOI | 10.18926/AMO/47261 |
|---|---|
| フルテキストURL | 65_6_363.pdf |
| 著者 | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| 抄録 | The link between changes in a subject's metabolic syndrome components and his estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese men. We used data from 120 Japanese men (45.5±8.4 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant differences in eGFR between men with and without metabolic syndrome components at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, almost all metabolic syndrome components were significantly improved. However, eGFR was significantly decreased. The changes in eGFR were weakly correlated with abdominal circumference (r＝－0.232, p＝0.0106). A decrease in abdominal circumference may be associated with improving eGFR in Japanese men. |
| キーワード | abdominal circumference estimated glomerular filtration rate (eGFR) metabolic syndrome lifestyle modification |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 363 |
| 終了ページ | 367 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189476 |
| Web of Science KeyUT | 000298516900002 |
| JaLCDOI | 10.18926/AMO/47260 |
|---|---|
| フルテキストURL | 65_6_353.pdf |
| 著者 | Ichihara, Eiki| Kiura, Katsuyuki| Tanimoto, Mitsune| |
| 抄録 | Angiogenesis is an essential process in tumor growth. The concept of angiogenesis, when proposed by Folksman in 1971, had a great impact on cancer research and therapy, as the survival and proliferation of cancer depend on angiogenesis, which could be a target of cancer therapy. In subsequent decades, numerous antiangiogenic agents were developed, and some of them have been applied clinically. However, angiogenesis includes a complex and multistep process that has not been sufficiently elucidated. In this review, we focus on signaling pathways related with tumor angiogenesis and several antiangiogenic agents approved by the United States Food and Drug Administration or under investigation. |
| キーワード | angiogenesis cancer |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2011-12 |
| 巻 | 65巻 |
| 号 | 6号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 353 |
| 終了ページ | 362 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2011 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22189475 |
| Web of Science KeyUT | 000298516900001 |
| 著者 | 押木 俊之| |
|---|---|
| 出版物タイトル | |
| 資料タイプ | その他 |
| 著者 | ヴァラドワジ プラディープ リシクリスナ| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 月岡 清夏| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 俵 志江| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 藤井 直| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 川﨑 元| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 盛 茗| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 薛 鋳| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 珠玖 隆行| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 谷内 秀輔| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 依光 武志| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 宝 力道| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 坂口 舞| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 平田 泰三| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 松下 裕一| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 武 寛| |
|---|---|
| 発行日 | 2011-09-30 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |