検索結果 24169 件
| 著者 | Mandai, Hiroki| Irie, Shunsuke| Mitsudo, Koichi| Suga, Seiji| |
|---|---|
| 発行日 | 2011-10-20 |
| 出版物タイトル | Molecules |
| 巻 | 16巻 |
| 号 | 10号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | 押木 俊之| |
|---|---|
| 出版物タイトル | |
| 資料タイプ | その他 |
| タイトル（別表記） | Initial Development of the U.S. Supreme Court’s Speedy Trial Doctrine |
|---|---|
| フルテキストURL | olj_061_3_628_588.pdf |
| 著者 | 原田 和往| |
| 出版物タイトル | 岡山大學法學會雜誌 |
| 発行日 | 2012-02-28 |
| 巻 | 61巻 |
| 号 | 3号 |
| 開始ページ | 628 |
| 終了ページ | 588 |
| ISSN | 0386-3050 |
| 言語 | 日本語 |
| 論文のバージョン | publisher |
| NAID | 40019230458 |
| 著者 | Tanaka, Toshiyuki| Tajima, Ichirou| Kato, Yuichi| Nishihara, Yasushi| Shinjoh, Hirofumi| |
|---|---|
| 発行日 | 2011-02-22 |
| 出版物タイトル | Applied Catalysis B: Environmental |
| 巻 | 102巻 |
| 号 | 3-4号 |
| 資料タイプ | 学術雑誌論文 |
| 著者 | Nishihara, Yasushi| Saito, Daisuke| Inoue, Eiji| Okada, Yoshiaki| Miyazaki, Mikihiro| Inoue, Yoshiaki| Takagi, Kentaro| |
|---|---|
| 発行日 | 2010-01-13 |
| 出版物タイトル | Tetrahedron Letters |
| 巻 | 51巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
| JaLCDOI | 10.18926/AMO/48083 |
|---|---|
| フルテキストURL | 66_1_67.pdf |
| 著者 | Sasaki, Shinsuke| Murakami, Naoki| Matsumura, Yuko| Ichimura, Mika| Mori, Masaharu| |
| 抄録 | This study investigated the appropriate tourniquet pressure (TP) and duration of tourniquet application for venipuncture by calculating the venous cross-section (VCS) area on ultrasonography. Twenty healthy volunteers without cardiovascular risk factors were enrolled in this study. A target vein (either a cephalic or median cubital vein) was selected on ultrasonography. The pneumatic tourniquet was inflated using a rapid cuff inflator system at setting pressure for 120sec. TP strength was varied from 20mmHg to 100mmHg, in 20mmHg increments. The order of TP was randomized. Compari-sons among more than 3 groups were performed by one-way repeated-measures ANOVA and the Bonferroni method. The VCS area increased rapidly until 10sec after tourniquet inflation. The VCS area then increased gradually until 30sec after tourniquet inflation. After that, the VCS area did not increase remarkably. The VCS area increased with TP strength up to 80mmHg, but the VCS area at TP 100mmHg decreased to less than that at TP 40mmHg. Based on these results, we recommend a tourniquet pressure of 60mmHg, and duration of tourniquet application is 30 to 60sec for venipuncture. |
| キーワード | venipuncture tourniquet pressure tourniquet duration venous cross-section area ultrasonography |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 67 |
| 終了ページ | 71 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358141 |
| Web of Science KeyUT | 000300800700009 |
| JaLCDOI | 10.18926/AMO/48081 |
|---|---|
| フルテキストURL | 66_1_53.pdf |
| 著者 | Nakamura, Keiichiro| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji| |
| 抄録 | The purpose of this study was to evaluate prognostic factors for epithelial ovarian cancer. We found that the pretreatment values of maximum standardized uptake (SUVmax) of the primary tumor by positron emission tomography/computed tomography (PET/CT), tumor marker CA125 and C-reactive protein (CRP) were correlated with clinical characteristics and prognosis for such patients. The clinical parameters and prognoses and their correlations with SUVmax of primary tumor, CA125 and CRP were examined for 51 patients with primary ovarian cancer. The SUVmax of the primary tumor had a statistically significant association with stage (p＝0.010) and histology (p＝0.001). CA125 was significant associated with stage (p＝0.011), histology (p＝0.005) and lymph node metastasis (p＝0.025). CRP was also significantly associated with stage (p＝0.049). Disease-free survival rates of patients exhibiting a high SUVmax, CA125 and CRP were significantly lower than those exhibiting a low SUVmax, CA125 and CRP levels (p＝0.008, 0.034, and 0.037, respectively). Furthermore, overall survival rates of patients exhibiting a high SUVmax were significantly lower than those exhibiting a low SUVmax (p＝0.049).The high SUVmax of primary tumor is an important factor for identifying ovarian cancer patients with a predictor for poor prognosis. |
| キーワード | ovarian cancer SUVmax of primary tumor CA125 C-reactive protein predictor for poor prognosis |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 53 |
| 終了ページ | 60 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358139 |
| Web of Science KeyUT | 000300800700007 |
| JaLCDOI | 10.18926/AMO/48079 |
|---|---|
| フルテキストURL | 66_1_31.pdf |
| 著者 | Utsumi, Hiroya| Terashi, Hiroo| Ishimura, Yohei| Takazawa, Tomoko| Hayashi, Akito| Mochizuki, Hideki| Okuma, Yasuyuki| Orimo, Satoshi| Takahashi, Kazushi| Yoneyama, Mitsuru| Mitoma, Hiroshi| |
| 抄録 | To quantify gait bradykinesia during daily activity in patients with Parkinson's disease (PD), we measured movement-induced accelerations over more than 24h in 50 patients with PD and 17 age-matched normal controls, using a new device, the portable gait rhythmogram. Acceleration values induced by various movements, averaged each 10 min, exhibited a gamma distribution. The mean value of the distribution curve was used as an index of the "amount of overall movement per 24h". Characteristic changes were observed in both the gait cycle and gait acceleration. During hypokinesia, the gait cycle became either faster or slower. A number of patients with marked akinesia/bradykinesia showed a reduced and narrow range of gait acceleration, i.e., a range of floor reaction forces. The results suggest that assessment of the combination of changes in gait cycle and gait acceleration can quantitatively define the severity of gait bradykinesia. |
| キーワード | Parkinson's disease gait disorders portable gait rhythmogram |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 31 |
| 終了ページ | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358137 |
| Web of Science KeyUT | 000300800700005 |
| JaLCDOI | 10.18926/AMO/48078 |
|---|---|
| フルテキストURL | 66_1_23.pdf |
| 著者 | Watanabe, Toyohiko| Inoue, Miyabi| Ishii, Ayano| Yamato, Toyoko| Yamamoto, Masumi| Sasaki, Katsumi| Kobayashi, Yasuyuki| Araki, Motoo| Uehara, Shinya| Saika, Takashi| Kumon, Hiromi| |
| 抄録 | Polypropylene mesh implants for the correction of pelvic organ prolapse (POP) are now available in Japan. We developed an innovative approach for correcting POP by placing polypropylene mesh transvaginally with laparoscopic assistance. From June 2007 through March 2010, sixteen consecutive patients with symptomatic stage 2 or 3 pelvic organ prolapse underwent the laparoscopic-assisted tension-free vaginal mesh procedure at Okayama University Hospital. All patients were evaluated before and at 1, 3, 6, and 12 months after surgery. Female sexual function was also evaluated with the Female Sexual Function Index (FSFI). The procedure was performed successfully without significant complications. Fifteen of 16 patients were considered anatomically cured (93.8%) at 12 months postoperatively. One patient with a recurrent stage 3 vaginal vault prolapse required sacral colpopexy six months postoperatively. Total FSFI scores improved significantly from 10.3±1.3 at baseline to 18.0±1.2 at 12 months after surgery. The laparoscopic-assisted trans-vaginal mesh is a safe, effective, and simple procedure for POP repairs. The procedure not only restores anatomic relationships but also improves sexual function. |
| キーワード | tension-free vaginal mesh pelvic organ prolapse laparoscopic female urology sexual function |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 23 |
| 終了ページ | 29 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358136 |
| Web of Science KeyUT | 000300800700004 |
| JaLCDOI | 10.18926/AMO/48077 |
|---|---|
| フルテキストURL | 66_1_17.pdf |
| 著者 | Hayashida, Keiichi| Takeda, Yoshihiro| Katsuda, Toshizo| Yamamoto, Kenyu| Suesada, Yasuhide| Shibata, Moeko| Azuma, Masami| |
| 抄録 | Proximal femoral bone mineral density (BMD) can be measured by dual energy X-ray absorptiometry method in the neck, trochanter, intertrochanter, total and Ward's triangle area. Ward's triangle area of the proximal femur is a smaller area to measure than the others, and the position varies, depending on the status of inner rotation of the target leg. In this study, the measurements of the proximal femoral BMD in women were carried out on the neck, trochanter, intertrochanter, total and Ward's triangle area with the, subjects' legs turned 15 degrees toward the inside. The Ward's BMD were measured using Ward's cognitive method, in which the measured BMD were compared among age groups of 50-59, 60-69, 70-79 and 80-89 to determine whether this process could reveal decreased femoral BMD in elderly women. The correlation between BMD and age was tested using the Pearson correlation coefficient. In all measured parts, the BMD of women age 50-59 were significantly higher than those of women age 80-89. The correlations between BMD and age were negative in all measured parts, and the most negative correlation was between age and Ward's BMD. The study using Ward's cognitive method showed an inverse correlation between Ward's BMD and age in women. |
| キーワード | proximal femoral BMD dual energy X-ray absorptiometry Wardʼs BMD Wardʼs cognitive method |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 17 |
| 終了ページ | 21 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358135 |
| Web of Science KeyUT | 000300800700003 |
| JaLCDOI | 10.18926/AMO/48076 |
|---|---|
| フルテキストURL | 66_1_7.pdf |
| 著者 | Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi| |
| 抄録 | The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer. |
| キーワード | REIC Dickkopf-3 gene therapy prostate cancer preclinical study |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 7 |
| 終了ページ | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358134 |
| Web of Science KeyUT | 000300800700002 |
| JaLCDOI | 10.18926/AMO/48075 |
|---|---|
| フルテキストURL | 66_1_1.pdf |
| 著者 | Udono, Heiichiro| |
| 抄録 | Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation. The pathway requires that, in order to be degraded by proteosomes, the extracellular antigens must have access to the cytosol across the endosomal membranes. Although the cross-presentation phenomena was first identified in the 1970s, the molecular mechanism responsible for the translocation is still not fully understood. In this context, we have recently found that cytosolic heat shock protein (HSP)90 translocates internalized antigen to the cytosol in DCs. Our results revealed the important role that cytosolic HSP90 plays in cross-presentation by pulling out endosomal antigen to the cytosol. |
| キーワード | heat shock protein 90 dendritic cells cross-presentation proteasome cytotoxic T cell immunity |
| Amo Type | Review |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2012-02 |
| 巻 | 66巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 1 |
| 終了ページ | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2012 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 22358133 |
| Web of Science KeyUT | 000300800700001 |
| 著者 | 寺田 忠司| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 楠本 知行| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 上杉 達也| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 渡邊 直美| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 林 隆宏| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 田村 麻衣子| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 万代 康弘| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
| 著者 | 清水 一好| |
|---|---|
| 発行日 | 2011-12-31 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |