検索結果 - 岡山大学学術成果リポジトリ

Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetic Kidney Disease: A Multicenter, Open-Label, Prospective Study

フルテキストURL	fulltext20220921-3.pdf
著者	Uchida, Haruhito A.\| Nakajima, Hirofumi\| Hashimoto, Masami\| Nakamura, Akihiko\| Nunoue, Tomokazu\| Murakami, Kazuharu\| Hosoya, Takeshi\| Komoto, Kiichi\| Taguchi, Takashi\| Akasaka, Takaaki\| Shiosakai, Kazuhito\| Sugimoto, Kotaro\| Wada, Jun\|
発行日	2022-9-7
出版物タイトル	Advances in Therapy
出版者	Springer Science and Business Media LLC
ISSN	0741-238X
NCID	AA10703556
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022
論文のバージョン	publisher
PubMed ID	36070133
DOI	10.1007/s12325-022-02294-z
Web of Science KeyUT	000852459600002

Perceived Efficacy and Anxiety of Teachers in Japan toward Supporting Students with Chronic Illness in Mainstream School

JaLCDOI	10.18926/bgeou/63921
フルテキストURL	bgeou_180_027_037.pdf
著者	Yoshitoshi, Munehisa\| Tsushima, Yasuko\| Murakami, Rie\| Takahashi, Kiriko\|
抄録	The objective of this study was to examine mainstream school teachers’ anxiety and selfefficacy to teaching students with chronic illness. A survey was completed by 59 elementary and 44 junior high school teachers in Japan. Results indicated that the majority of teacher respondents perceived themselves as inadequate to teach students with chronic illness due to lack of practical knowledge and experience. A high proportion of respondents indicated that they had no academic training (62.1%) and no teaching experience (72.8%) for supporting students with chronic illness. On the other hand, there is a positive relationship between selfefficacy, anxiety level and academic training or teaching experience for supporting students with chronic illness. That is, teachers with practical experience teaching students with chronic illness in the classroom and teachers with more academic training in inclusive approaches demonstrated higher efficacy and lower anxiety than teachers without these experiences or with less training in inclusive teaching approaches. All teachers must be equipped with the extensive knowledge of how best to assist students with chronic illness. Additional efforts are needed to adequately support students with chronic illness in the regular education classroom.
出版物タイトル	岡山大学大学院教育学研究科研究集録
発行日	2022-08-26
巻	180巻
開始ページ	27
終了ページ	37
ISSN	1883-2423
言語	英語
論文のバージョン	publisher

Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice

フルテキストURL	fulltext.pdf
著者	Kataoka, Takahiro\| Naoe, Shota\| Murakami, Kaito\| Fujimoto, Yuki\| Yukimine, Ryohei\| Tanaka, Ayumi\| Yamaoka, Kiyonori\|
キーワード	autoimmune diseases cytokine antioxidant function lipopolysaccharide radon inhalation
発行日	2022-08-26
出版物タイトル	International Journal Of Environmental Research And Public Health
巻	19巻
号	17号
出版者	MDPI
開始ページ	10632
ISSN	1660-4601
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 by the authors.
論文のバージョン	publisher
PubMed ID	36078348
DOI	10.3390/ijerph191710632
Web of Science KeyUT	000851073300001
関連URL	isVersionOf https://doi.org/10.3390/ijerph191710632

The Association between Preoperative Blood Pressure Elevations and Postoperative Adverse Outcomes after Non-cardiac Surgery: A Single-center Retrospective Observational Study

JaLCDOI	10.18926/AMO/63902
フルテキストURL	76_4_429.pdf
著者	Yamadori, Yusuke\| Hirao, Tomohiro\| Nlandu R. Ngatu\| Kanda, Kanae\| Syed Mahfuz Al Hasan\| Murakami, Akitsu\| Mashima, Yukinori\| Shirakami, Gotaro\|
抄録	Blood pressure (BP) often rises before surgery. This study investigated whether BP elevation immediately before surgery was associated with adverse outcomes. Medical records of 11,732 patients (average age: 61 years; male: 47.4%) who underwent non-cardiac elective inpatient surgery under general anesthesia at Kagawa University Hospital between January 2011 and June 2019 were reviewed. Differences between the first BP values measured on the day before surgery and the first BP values in the operating room were defined as Δ systolic BP (ΔSBP) and Δ diastolic BP (ΔDBP). The relationships between ΔSBP/ΔDBP and 30-day mortality, 30-day readmission, and over-the-standard length of hospital stay (OSLOS) were assessed. OSLOS was defined as a hospital stay longer than mean+2 standard deviations and was calculated using the Japanese Diagnosis Procedure Combination data. In univariate analysis, the differences in ΔSBP and ΔDBP between the OSLOS and standard LOS groups were both 2 mmHg. In multivariate logistic regression analysis, only ΔDBP was associated with OSLOS. The adjusted odds ratio (95% confidence interval) for the largest quartile was 1.31 (1.02-1.69) (p<0.05). ΔDBP was associated with OSLOS; however, there may be little need to worry about large ΔSBPs and ΔDBPs in clinical practice.
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	429
終了ページ	437
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123158
Web of Science KeyUT	000882167300009

Central and Enteric Neuroprotective Effects by Eucommia ulmoides Extracts on Neurodegeneration in Rotenone-induced Parkinsonian Mouse

JaLCDOI	10.18926/AMO/63889
フルテキストURL	76_4_373.pdf
著者	Imafuku, Fuminori\| Miyazaki, Ikuko\| Sun, Jin\| Kamimai, Sunao\| Shimizu, Takashi\| Toyota, Toshiaki\| Okamoto, Yusei\| Isooka, Nami\| Kikuoka, Ryo\| Kitamura, Yoshihisa\| Asanuma, Masato\|
抄録	Parkinson’s disease (PD) is a progressive neurodegenerative disease of both the central and peripheral / enteric nervous systems. Oxidative stress and neuroinflammation are associated with the pathogenesis of PD, suggesting that anti-oxidative and anti-inflammatory compounds could be neuroprotective agents for PD. Eucommia ulmoides (EU) is a traditional herbal medicine which exerts neuroprotective effects by anti-inflammatory and anti-oxidative properties. Our previous study showed that treatment with chlorogenic acid, a component of EU, protected against neurodegeneration in the central and enteric nervous systems in a PD model. In this study, we examined the effects of EU extract (EUE) administration on dopaminergic neurodegeneration, glial response and α-synuclein expression in the substantia nigra pars compacta (SNpc), and intestinal enteric neurodegeneration in low-dose rotenone-induced PD model mice. Daily oral administration of EUE ameliorated dopaminergic neurodegeneration and α-synuclein accumulation in the SNpc. EUE treatment inhibited rotenone- induced decreases in the number of total astrocytes and in those expressing the antioxidant molecule metallothionein. EUE also prevented rotenone-induced microglial activation. Furthermore, EUE treatment exerted protective effects against intestinal neuronal loss in the PD model. These results suggest that EU exerts neuroprotective effects in the central and enteric nervous systems of rotenone-induced parkinsonism mice, in part by glial modification.
キーワード	Eucommia ulmoides dopamine neuron enteric neuron glia Parkinson’s disease
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-08
巻	76巻
号	4号
出版者	Okayama University Medical School
開始ページ	373
終了ページ	383
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	36123151
Web of Science KeyUT	000882167300003

Characterization of the oral and fecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony

フルテキストURL	ManuscriptFinal20220908-3.pdf Table1_20220908-3.pdf Fig20220908-3.pdf Supplementary20220908-3.pdf
著者	Uchiyama, Jumpei\| Osumi, Takafumi\| Mizukami, Keijiro\| Fukuyama, Tomoki\| Shima, Ayaka\| Unno, Asaka\| Takemura‐Uchiyama, Iyo\| Une, Yumi\| Murakami, Hironobu\| Sakaguchi, Masahiro\|
キーワード	oral gut microbiota atopic dermatitis Shiba Inu dog colony canine
備考	This is a pre-copyedited, author-produced version of an article accepted for publication in [Letters in Applied Microbiology] following peer review. The version of record [J. Uchiyama, T. Osumi, K. Mizukami, T. Fukuyama, A. Shima, A. Unno, I. Takemura‐Uchiyama, Y. Une, H. Murakami, M. Sakaguchi, Characterization of the oral and faecal microbiota associated with atopic dermatitis in dogs selected from a purebred Shiba Inu colony, Letters in Applied Microbiology, Volume 75, Issue 6, 1 December 2022, Pages 1607–1616, https://doi.org/10.1111/lam.13828] is available online at: [https://doi.org/10.1111/lam.13828].\| This fulltext is available in Dec. 2023.\|
発行日	2022-12-01
出版物タイトル	Letters in Applied Microbiology
巻	75巻
号	6号
出版者	Oxford University Press
開始ページ	1607
終了ページ	1616
ISSN	0266-8254
NCID	AA10462245
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 The Society for Applied Microbiology
論文のバージョン	author
PubMed ID	36067033
DOI	10.1111/lam.13828
Web of Science KeyUT	000853313000001
関連URL	isVersionOf https://doi.org/10.1111/lam.13828

Phylogenic analysis of new viral cluster of large phages with unusual DNA genomes containing uracil in place of thymine in gene-sharing network, using phages S6 and PBS1 and relevant uncultured phages derived from sewage metagenomics

フルテキストURL	fulltext20220830-2.pdf table20220830-2pdf.pdf Figs20220830-2.pdf Supplementary_data.pdf
著者	Uchiyama, Jumpei\| Takemura-Uchiyama, Iyo\| Gotoh, Kazuyoshi\| Kato, Shin-ichiro\| Sakaguchi, Yoshihiko\| Murakami, Hironobu\| Fukuyama, Tomoki\| Kaneki, Mao\| Matsushita, Osamu\| Matsuzaki, Shigenobu\|
キーワード	Environmental virus Jumbophage Metagenomics Evolution Uncultured phage
備考	© 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.virusres.2022.198881] . \|
発行日	2022-10-02
出版物タイトル	Virus Research
巻	319巻
出版者	Elsevier BV
開始ページ	198881
ISSN	0168-1702
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 Elsevier B.V.
論文のバージョン	author
PubMed ID	35934259
DOI	10.1016/j.virusres.2022.198881
Web of Science KeyUT	000841172200001
関連URL	isVersionOf https://doi.org/10.1016/j.virusres.2022.198881

Sequential Development of Putaminal Hemorrhage and Corona Radiata Infarction in the Same Lenticulostriate Arterial Territory

JaLCDOI	10.18926/AMO/63743
フルテキストURL	76_3_329.pdf
著者	Inomata, Yuki\| Hanaoka, Yoshiki\| Fujii, Yu\| Ogiwara, Toshihiro\| Horiuchi, Tetsuyoshi\|
抄録	Putaminal hemorrhage is a common type of spontaneous cerebral hemorrhage. However, to our knowledge, there have been no reports of sequential cerebral hemorrhage and infarction in the same perforating arterial territory. Herein, we present the first reported case of the sequential development of putaminal hemorrhage and corona radiata infarction in the same lenticulostriate arterial (LSA) territory. Early intensive blood pressure lowering treatment may have aggravated ischemic damage. If a patient presents with motor weakness that cannot be explained by putaminal hemorrhage, the sequential development of corona radiata infarction in the same LSA territory should be ruled out.
キーワード	arterial dissection cerebral hemorrhage cerebral infarction lenticulostriate artery perforating artery
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	329
終了ページ	332
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790364
Web of Science KeyUT	000823568300012

Evaluation of Fast Diffusion Kurtosis Imaging Using New Software Designed for Widespread Clinical Use

JaLCDOI	10.18926/AMO/63739
フルテキストURL	76_3_297.pdf
著者	Kuroda, Masahiro\| Konishi, Kohei\| Sugimoto, Kohei\| Yoshimura, Yuuki\| Hamada, Kentaro\| Khasawnehc, Abdullah\| Barham, Majd\| Tekiki, Nouha\| Sugianto, Irfan\| Bamgbose, Babatunde O.\| Ishizaka, Hinata\| Shimizu, Yudai\| Nakamitsu, Yuki\| Al-Hammad, Wlla E.\| Kamizaki, Ryo\| Kurozumi, Akira\| Matsushita, Toshi\| Ohno, Seiichiro\| Kanazawa, Susumu\| Asaumi, Junichi\|
抄録	Clinical research using restricted diffusion-weighted imaging, especially diffusion kurtosis (DK) imaging, has been progressing, with reports on its effectiveness in the diagnostic imaging of cerebral infarctions, neurodegenerative diseases, and tumors, among others. However, the application of DK imaging in daily clinical practice has not spread because of the long imaging time required and the use of specific software for image creation. Herein, with the aim of promoting clinical research using DK imaging at any medical facility, we evaluated fast DK imaging using a new software program. We developed a new macro program that produces DK images using general-purpose, inexpensive software (Microsoft Excel and ImageJ), and we evaluated fast DK imaging using bio-phantoms and a healthy volunteer in clinical trials. The DK images created by the new software with diffusion-weighted images captured with short-time imaging sequences were similar to the original DK images captured with long-time imaging sequences. The DK images using three b-values, which can reduce the imaging time by 43%, were equivalent to the DK images using five b-values. The DK imaging technique developed herein might allow any medical facility to increase its daily clinical use of DK imaging and easily conduct clinical research.
キーワード	fast diffusion kurtosis imaging mean kurtosis restricted diffusion Excel ImageJ
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-06
巻	76巻
号	3号
出版者	Okayama University Medical School
開始ページ	297
終了ページ	305
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35790360
Web of Science KeyUT	000823568300009

Structural basis for the absence of low-energy chlorophylls in a photosystem I trimer from Gloeobacter violaceus

フルテキストURL	fulltext.pdf
著者	Kato, Koji\| Hamaguchi, Tasuku\| Nagao, Ryo\| Kawakami, Keisuke\| Ueno, Yoshifumi\| Suzuki, Takehiro\| Uchida, Hiroko\| Murakami, Akio\| Nakajima, Yoshiki\| Yokono, Makio\| Akimoto, Seiji\| Dohmae, Naoshi\| Yonekura, Koji\| Shen, Jian-Ren\|
キーワード	photosystem I cryo-EM low-energy Chl Gloeobacter Other
発行日	2022-04-11
出版物タイトル	Elife
巻	11巻
出版者	eLIFE SCIENCES PUBL LTD
開始ページ	e73990
ISSN	2050-084X
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© Kato et al.
論文のバージョン	publisher
PubMed ID	35404232
DOI	10.7554/eLife.73990
Web of Science KeyUT	000790476900001
関連URL	isVersionOf https://doi.org/10.7554/eLife.73990

Clinicopathological Features and Surgical Outcomes of Small Bowel Metastasis from Renal Cell Carcinoma

JaLCDOI	10.18926/AMO/63409
フルテキストURL	76_2_155.pdf
著者	Kimura, Jiro\| Okabayashi, Takehiro\| Sui, Kenta\| Tabuchi, Motoyasu\| Iwata, Jun\| Hata, Yasuhiro\| Iiyama, Tatsuo\| Ono, Noriaki\|
抄録	Small bowel metastasis from renal cell carcinoma (RCC) is rare, and its clinicopathological characteristics are unclear; thus, we revisited the concept of this tumor and reviewed its diagnostic and treatment modalities. We filtered MEDLINE searches of articles published in English between 1950 and 2019, and identified 100 patients who had undergone treatment, including 1 patient from our clinic. We extracted patient characteristics, treatment, and prognostic data, resulting in clinicopathological data on 100 patients (83 men, 17 women). Mean age was 63 years (range, 16-86 years). Tumor sites were duodenum, jejunum, ileum, and multiple sites in 30, 37, 25, and 7 patients, respectively. The 1-, 3-, and 5-year overall survival rates after diagnosis were 53.0%, 36.0%, and 36.0%. Curative resection patients showed 62.1% 5-year survival after surgery, vs. 27.5% in noncurative surgical management cases. Good prognoses can be expected if these tumors are identified early for complete removal. Surgery is the only curative option. To determine the best management strategy and improve prognostic accuracy, we continue to collect and analyze epidemiological and pathological data. Although this condition is rare, surgery should be considered if curative resection is expected. Prognosis after curative resection is not poor, but recurrence is not unlikely.
キーワード	renal cell carcinoma small bowel metastasis intestine tumor
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-04
巻	76巻
号	2号
出版者	Okayama University Medical School
開始ページ	155
終了ページ	165
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35503443
Web of Science KeyUT	000792374900007

Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model

フルテキストURL	fulltext20220414-1.pdf
著者	Kataoka, Takahiro\| Naoe, Shota\| Murakami, Kaito\| Yukimine, Ryohei\| Fujimoto, Yuki\| Kanzaki, Norie\| Sakoda, Akihiro\| Mitsunobu, Fumihiro\| Yamaoka, Kiyonori\|
キーワード	radon cytokine oxidative stress rheumatoid arthritis immunomodulation function
発行日	2022
出版物タイトル	Journal of Clinical Biochemistry and Nutrition
巻	70巻
号	2号
出版者	The Society for Free Radical Research Japan
開始ページ	154
終了ページ	159
ISSN	0912-0009
NCID	AA10710201
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2022 JCBN
論文のバージョン	publisher
PubMed ID	35400822
DOI	10.3164/jcbn.21-91
Web of Science KeyUT	000763105900009
関連URL	isVersionOf https://doi.org/10.3164/jcbn.21-91

Heterogeneous IgE reactivities to Staphylococcus pseudintermedius strains in dogs with atopic dermatitis, and the identification of DM13-domain-containing protein as a bacterial IgE-reactive molecule

フルテキストURL	fulltext20220413-1.pdf FeaturedImage20220413-1.pdf figures20220413-1.pdf tables20220413-1.pdf SI20220413-1.pdf
著者	Takemura-Uchiyama, Iyo\| Tsurui, Hiroki\| Shimakura, Hidekatsu\| Nasukawa, Tadahiro\| Imanishi, Ichiro\| Uchiyama, Jumpei\| Fukuyama, Tomoki\| Sakamoto, Shuji\| Morisawa, Keiko\| Fujimura, Masato\| Murakami, Hironobu\| Kanamaru, Shuji\| Kurokawa, Kenji\| Kawamoto, Keiko\| Iyori, Keita\| Sakaguchi, Masahiro\|
キーワード	Staphylococcus pseudintermedius atopic dermatitis IgE dogs DM13-domain-containing protein exacerbation factor
備考	This is a pre-copyedited, author-produced version of an article accepted for publication in [insert journal title] following peer review. The version of record [insert complete citation information here] is available online at: https://doi.org/10.1093/femsle/fnac019\|
発行日	2022
出版物タイトル	FEMS Microbiology Letters
巻	369巻
号	1号
出版者	Oxford University Press (OUP)
開始ページ	fnac019
ISSN	1574-6968
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2022. Published by Oxford University Press on behalf of FEMS.
論文のバージョン	author
PubMed ID	35191469
DOI	10.1093/femsle/fnac019
Web of Science KeyUT	000764887500001
関連URL	isVersionOf https://doi.org/10.1093/femsle/fnac019

Rapidly Progressive Stenosis of the Left Main Trunk Ostium Starting 21 Months After Stent Implantation

JaLCDOI	10.18926/AMO/63219
フルテキストURL	76_1_99.pdf
著者	Naito, Yoichiro\| Yoshikawa, Masaki\| Nakamura, Kazufumi\| Kubo, Motoki\| Sugiyama, Hiroyasu\| Suzuki, Hideyuki\| Fujita, Shinpei\| Arai, Yasunori\| Takahashi, Sho\| Kato, Yuichi\| Yoshida, Yu\| Akai, Hiroaki\| Murakami, Shuhei\| Ito, Hiroshi\|
抄録	Rapidly progressive in-stent restenosis (ISR) after stent deployment from the left main trunk (LMT) to the left anterior descending artery (LAD) without plaque at the LMT ostium has not been reported. A 60-year-old Japanese man with a history of scleroderma, pulmonary fibrosis, and type 2 diabetes developed acute myocardial infarction of the right coronary artery (RCA) and was treated by emergency percutaneous coronary intervention (PCI) for RCA. Nine days later he underwent PCI from the LMT to the LAD. Follow-up coronary angiography (CAG) at 9 and 21 months post-PCI did not reveal ISR in any lesion, but the patient experienced cardiac arrest at 25 months post-PCI. Emergency CAG after resuscitation revealed ISR of the LMT ostium; emergency PCI was conducted. The development of ISR at the ostium of the LMT although the patient was free of plaque 4 months before is extremely unusual. This rare ISR of the LMT ostium progressed rapidly after follow-up CAG revealed no ISR at 21 months post-stent implantation.
キーワード	left main trunk in-stent restenosis cardiopulmonary arrest
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-02
巻	76巻
号	1号
出版者	Okayama University Medical School
開始ページ	99
終了ページ	104
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35237006
Web of Science KeyUT	000762933000003

Cystic Intracranial Recurrence of Olfactory Neuroblastoma without Accumulation on Fluorine-18-fluorodeoxyglucose Positron Emission Tomography

JaLCDOI	10.18926/AMO/63218
フルテキストURL	76_1_93.pdf
著者	Ishi, Yukitomo\| Yamaguchi, Shigeru\| Hatanaka, Kanako C.\| Takakuwa, Emi\| Motegi, Hiroaki\| Honda, Taishi\| Kobayashi, Hiroyuki\| Terasaka, Shunsuke\| Homma, Akihiro\| Fujimura, Miki\| Houkin, Kiyohiro\|
抄録	A 66-year-old man underwent multimodal treatment for olfactory neuroblastoma (ONB). When he was 72 years old, a cystic intracranial lesion without accumulation on fluorine-18-fluorodeoxyglucose positron emission tomography was detected. Surgical resection was performed when the patient was 73 years old. The pathological examination revealed recurrence of ONB, and the patient underwent focal irradiation. At age 81, he presented with a second recurrence in the right occipital lobe with radiological and pathological findings similar to the prior recurrence. This case suggests that pathological confirmation should be considered in cases with atypical radiological findings following the treatment of ONB.
キーワード	cystic recurrence esthesioneuroblastoma fluorine-18-fluorodeoxyglucose positron emission tomography intracranial recurrence olfactory neuroblastoma
Amo Type	Case Report
出版物タイトル	Acta Medica Okayama
発行日	2022-02
巻	76巻
号	1号
出版者	Okayama University Medical School
開始ページ	93
終了ページ	98
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35237005
Web of Science KeyUT	000762933000002

Development and Evaluation of a Short-time Imaging Method for the Clinical Study of the Apparent Diffusion Coefficient Subtraction Method

JaLCDOI	10.18926/AMO/63205
フルテキストURL	76_1_25.pdf
著者	Sugimoto, Kohei\| Kuroda, Masahiro\| Yoshimura, Yuuki\| Hamada, Kentaro\| Khasawneh, Abdullah\| Barham, Majd\| Tekiki, Nouha\| Konishi, Kohei\| Ishizaka, Hinata\| Shimizu, Yudai\| Nakamitsu, Yuki\| Al-Hammad, Wlla E. \| Kamizaki, Ryo\| Kanazawa, Susumu\| Asaumi, Junichi\|
抄録	The apparent diffusion coefficient subtraction method (ASM) was developed as a new restricted diffusionweighted imaging technique for magnetic resonance imaging (MRI). The usefulness of the ASM has been established by in vitro basic research using a bio-phantom, and clinical research on the application of the ASM for the human body is needed. Herein, we developed a short-time sequence for ASM imaging of the heads of healthy volunteers (n=2), and we investigated the similarity between the obtained ASM images and diffusion kurtosis (DK) images to determine the utility of the ASM for clinical uses. This study appears to be the first to report ASM images of the human head. We observed that the short-time sequence for the ASM imaging of the head can be scanned in approx. 3 min at 1.5T MRI. The noise reduction effect of median filter processing was confirmed on the ASM images scanned by this sequence. The obtained ASM images showed a weak correlation with the DK images, indicating that the ASM images are restricted diffusion-weighted images. The new shorttime imaging sequence could thus be used in clinical studies applying the ASM.
キーワード	apparent diffusion coefficient apparent diffusion coefficient subtraction method diffusion kurtosis imaging restricted diffusion short-time imaging
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-02
巻	76巻
号	1号
出版者	Okayama University Medical School
開始ページ	25
終了ページ	32
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35236995
Web of Science KeyUT	000762812700004

Extending Treatment Intervals of R-CHOP Therapy Might Be Acceptable for Some Patients with Non-indolent Non-Hodgkin’s B-cell Lymphoma

JaLCDOI	10.18926/AMO/63204
フルテキストURL	76_1_17.pdf
著者	Fujishita, Keigo\| Yasuhisa, Sando\| Oka, Satoshi\| Fujisawa, Yuka\| Machida, Takuya\| Imai, Toshi\|
抄録	R-CHOP therapy is generally performed every 3 weeks. We investigated the effects of extending the interval of R-CHOP therapy for > 1 week on the prognoses of patients with non-indolent non-Hodgkin’s B-cell lymphoma. Among the 338 patients with non-indolent non-Hodgkin’s B-cell lymphoma who received initial chemotherapy at our institution, we focused on 178 patients who received R-CHOP therapy and analyzed the outcomes of the patients stratified by the treatment intervals. The estimated 3-year overall survival (OS) for the entire population was 82.1%. Patients treated at intervals of ≥ 4 weeks were significantly older, and they had significantly longer follow-up periods and lower relative dose intensity. But the estimated 3-year OS was comparable to those treated at <4 weeks (83.3% vs. 80.5% p=0.947). In a multivariate analysis, age and the dose of anti-cancer agents had significant impacts on OS, but there was no significant relationship regarding the treatment intervals. Propensity score matching confirmed the same result. R-CHOP therapy every around 4 weeks could achieve relatively good survival in some selected patients with non-indolent non-Hodgkin’s B-cell lymphoma.
キーワード	R-CHOP therapy relative dose intensity non-Hodgkin’s lymphoma
Amo Type	Original Article
出版物タイトル	Acta Medica Okayama
発行日	2022-02
巻	76巻
号	1号
出版者	Okayama University Medical School
開始ページ	17
終了ページ	24
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2022 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	35236994
Web of Science KeyUT	000762812700003

Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients with Type 2 Diabetes: A Multicenter Prospective Study with 5-year Follow up（U-CARE Study 2)

フルテキストURL	K0006448_abstract_review.pdf K0006448_fulltext.pdf
著者	今村麻理子\|
発行日	2021-09-24
資料タイプ	学位論文
学位授与番号	甲第6448号
学位授与年月日	2021-09-24
学位・専攻分野	博士（医学）
授与大学	岡山大学
言語	英語
著作権者	Copyright © 2021 Mise, Imamura, Yamaguchi, Watanabe, Higuchi, Katayama, Miyamoto, Uchida, Nakatsuka, Eguchi, Hida, Nakato, Tone, Teshigawara, Matsuoka, Kamei, Murakami, Shimizu, Miyashita, Ando, Nunoue, Yoshida, Yamada, Shikata and Wada.

Chiral exciplex dyes showing circularly polarized luminescence: extension of the excimer chirality rule

フルテキストURL	fulltext.pdf
著者	Takaishi, Kazuto\| Murakami, Sho\| Iwachido, Kazuhiro\| Ema, Tadashi\|
発行日	2021-10-18
出版物タイトル	Chemical Science
出版者	Royal Society of Chemistry
ISSN	2041-6520
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© 2021 The Author(s).
論文のバージョン	publisher
DOI	10.1039/d1sc04403f
Web of Science KeyUT	000710634200001
関連URL	isVersionOf https://doi.org/10.1039/d1sc04403f

Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections

JaLCDOI	10.18926/AMO/62820
フルテキストURL	75_6_763.pdf
著者	Iwata, Takehiro\| Sadahira, Takuya\| Maruyama, Yuki\| Sekito, Takanori\| Yoshinaga, Kasumi\| Watari, Shogo\| Nagao, Kentaro\| Kawada, Tatsushi\| Tominaga, Yusuke\| Nishimura, Shingo\| Takamoto, Atsushi\| Sako, Tomoko\| Edamura, Kohei\| Kobayashi, Yasuyuki\| Araki, Motoo\| Ishii, Ayano\| Watanabe, Masami\| Watanabe, Toyohiko\| Nasu, Yasutomo\| Wada, Koichiro\|
抄録	The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants.
キーワード	genitourinary tract infections fluoroquinolone resistance extended-spectrum beta-lactamase
Amo Type	Clinical Study Protocol
出版物タイトル	Acta Medica Okayama
発行日	2021-12
巻	75巻
号	6号
出版者	Okayama University Medical School
開始ページ	763
終了ページ	766
ISSN	0386-300X
NCID	AA00508441
資料タイプ	学術雑誌論文
言語	英語
著作権者	Copyright Ⓒ 2021 by Okayama University Medical School
論文のバージョン	publisher
査読	有り
PubMed ID	34955548
Web of Science KeyUT	000735319800006
NAID	120007180272