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著者 Omori, Kazuhiro| Furukawa, Kohei| Usubuchi, Masatoshi| Hamada, Tomofumi| Shien, Tadahiko| Yoshida, Michihiro| Nakatsuka, Yuki| Hotta, Katsuyuki| Ibaragi, Soichiro| Takashiba, Shogo|
発行日 2026-06-04
出版物タイトル PLOS One
21巻
6号
出版者 Public Library of Science (PLoS)
開始ページ e0350803
ISSN 1932-6203
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2026 Omori et al.
論文のバージョン publisher
PubMed ID 42241429
DOI 10.1371/journal.pone.0350803
関連URL isVersionOf https://doi.org/10.1371/journal.pone.0350803
フルテキストURL fulltext.pdf
著者 Higo, Hisao| Senoo, Satoru| Makimoto, Satoko| Nagano, Tomohiro| Kondo, Takumi| Yamamoto, Haruchika| Tanaka, Shin| Miyoshi, Kentaroh| Sugimoto, Seiichiro| Toyooka, Shinichi| Maeda, Yoshinobu| Togashi, Yosuke| Miyahara, Nobuaki|
キーワード hematopoietic stem cell transplantation late-onset non-infectious pulmonary complications lung transplantation pneumothorax
発行日 2026-05-28
出版物タイトル Clinical Transplantation
40巻
6号
出版者 Wiley
開始ページ e70582
ISSN 0902-0063
NCID AA10694240
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2026 The Author(s).
論文のバージョン publisher
PubMed ID 42206540
DOI 10.1111/ctr.70582
関連URL isVersionOf https://doi.org/10.1111/ctr.70582
フルテキストURL fulltext.pdf
著者 Mori, Shunsuke| Suzawa, Ken| Tomita, Koji| Yamamoto, Haruchika| Nakajima, Kumi| Tanaka, Shin| Torigoe, Hidejiro| Shien, Kazuhiko| Miyoshi, Kentaroh| Okazaki, Mikio| Sugimoto, Seiichiro| Hiraki, Takao| Toyooka, Shinichi|
キーワード anomalous systemic arterial supply basal lung segment segmentectomy endovascular embolization pulmonary infarction
発行日 2026
出版物タイトル Surgical Case Reports
12巻
1号
出版者 Japan Surgical Society
開始ページ cr.26-0288
ISSN 2198-7793
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2026 The Author(s).
論文のバージョン publisher
PubMed ID 42199479
DOI 10.70352/scrj.cr.26-0288
関連URL isVersionOf https://doi.org/10.70352/scrj.cr.26-0288
著者 Akagi, Satoshi| Kasahara, Shingo| Ejiri, Kentaro| Nakamura, Kazufumi| Yuasa, Shinsuke|
キーワード Adult congenital heart diseases pulmonary arterial hypertension PAH-targeted drugs systemic-to-pulmonary shunt treat and repair strategy
備考 This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Clinical Pharmacology on 2026-05-26, available at: https://doi.org/10.1080/17512433.2026.2678439.| This fulltext file will be available in May 2027.|
発行日 2026-05-26
出版物タイトル Expert Review of Clinical Pharmacology
出版者 Informa UK Limited
ISSN 1751-2433
NCID AA1215713X
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 42161857
DOI 10.1080/17512433.2026.2678439
関連URL isVersionOf https://doi.org/10.1080/17512433.2026.2678439
フルテキストURL fulltext.pdf
著者 Fujii, Yuki| Matsumoto, Kazuyuki| Ueki, Toru| Himei, Hitomi| Sakakihara, Ichiro| Ueta, Eijiro| Toyokawa, Tatsuya| Harada, Ryo| Ogawa, Taiji| Tomoda, Takeshi| Kato, Hironari| Mitsuhashi, Toshiharu| Sato, Ryosuke| Matsumi, Akihiro| Miyamoto, Kazuya| Uchida, Daisuke| Horiguchi, Shigeru| Tsutsumi, Koichiro| Otsuka, Motoyuki|
キーワード delayed bleeding endoscopic papillectomy post-resection site prophylactic hemostasis second-look endoscopy
発行日 2026-05
出版物タイトル Therapeutic Advances in Gastroenterology
19巻
出版者 SAGE Publications
ISSN 1756-2848
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s), 2026.
論文のバージョン publisher
PubMed ID 42169697
DOI 10.1177/17562848261439231
Web of Science KeyUT 001770149000001
関連URL isVersionOf https://doi.org/10.1177/17562848261439231
フルテキストURL fulltext.pdf
著者 Yoshida, Keimei| Hosokawa, Kazuya| Hiraide, Takahiro| Akagi, Satoshi| Ejiri, Kentaro| Taniguchi, Yu| Adachi, Shiro| Inami, Takumi| Nakanishi, Naohiko| Kataoka, Masaharu| Satoh, Taijyu| Tatebe, Shunsuke| Shinke, Toshiro| Tomita, Hideshi| Akazawa, Yusuke| Higaki, Takashi| Tagawa, Koshiro| Ishikita, Ayako| Asakawa, Soshun| Abe, Kohtaro|
発行日 2026-03
出版物タイトル BMJ Open
16巻
3号
出版者 BMJ
開始ページ e113430
ISSN 2044-6055
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © Author(s) (or their employer(s)) 2026.
論文のバージョン publisher
PubMed ID 41819579
DOI 10.1136/bmjopen-2025-113430
Web of Science KeyUT 001722112600001
関連URL isVersionOf https://doi.org/10.1136/bmjopen-2025-113430
著者 Yasui, Kozo| Yashiro, Masato|
キーワード Dupilumab Sarcoidosis IL-4 IL-13 Th1-Th2 balance
備考 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00431-026-07051-w| This fulltext file will be available in May 2027.|
発行日 2026-05-13
出版物タイトル European Journal of Pediatrics
185巻
6号
出版者 Springer Science and Business Media LLC
開始ページ 391
ISSN 1432-1076
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026
論文のバージョン publisher
PubMed ID 42126659
DOI 10.1007/s00431-026-07051-w
関連URL isVersionOf https://doi.org/10.1007/s00431-026-07051-w
フルテキストURL fulltext.pdf
著者 Zou, Yajuan| Hu, Yalei| Yu, Jie| Komatsu, Naoki| Nishina, Yuta| Bianco, Alberto|
キーワード carbondots carbonnanotubes graphene nanodiamonds proteins
発行日 2026-04-18
出版物タイトル Advanced Materials
出版者 Wiley
開始ページ e23328
ISSN 0935-9648
NCID AA10742128
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2026 The Author(s).
論文のバージョン publisher
PubMed ID 41999247
DOI 10.1002/adma.202523328
Web of Science KeyUT 001742956000001
関連URL isVersionOf https://doi.org/10.1002/adma.202523328
フルテキストURL fulltext.pdf
著者 GharehTapeh, Elmira Abbasi| Watanabe, Takaichi| Horkay, Ferenc| Hou, Can| Lopez, Carlos G.| Hohenschutz, Max|
キーワード Polyelectrolyte Counterion condensation Carboxymethyl cellulose SAXS Conductivity Ion pairing
発行日 2026-04-26
出版物タイトル Cellulose
出版者 Springer Science and Business Media LLC
ISSN 0969-0239
NCID AA11006365
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2026
論文のバージョン publisher
DOI 10.1007/s10570-026-07021-3
Web of Science KeyUT 001748189500001
関連URL isVersionOf https://doi.org/10.1007/s10570-026-07021-3
タイトル(別表記) Current status and challenges of precision cancer medicine
著者 遠西 大輔|
キーワード がん個別化医療 がんゲノム医療 マルチオミクス解析 悪性リンパ腫
出版物タイトル 岡山医学会雑誌
発行日 2026-04-01
138巻
1号
開始ページ 10
終了ページ 14
ISSN 0030-1558
関連URL isVersionOf https://doi.org/10.4044/joma.138.10
言語 日本語
著作権者 Copyright (c) 2026 岡山医学会
論文のバージョン publisher
DOI 10.4044/joma.138.10
フルテキストURL fulltext.pdf
著者 Mori, Izumi C.|
キーワード Ca2+ signaling CDPK Signal decoding Stomata
発行日 2026-04-29
出版物タイトル Journal of Plant Research
出版者 Springer
ISSN 0918-9440
NCID AA10900218
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © The Author(s) 2026
論文のバージョン publisher
PubMed ID 42053755
DOI 10.1007/s10265-026-01703-6
関連URL isVersionOf https://doi.org/10.1007/s10265-026-01703-6
フルテキストURL fulltext.pdf
著者 Takakura, Hiroaki| Tanai, Airi| Kunisada, Yuki| Kikuta, Shogo| Kitagawa, Norio| Ibaragi, Soichiro| Hur, Mi-Sun| Aslam, Rizwan| Tubbs, R. Shane| Iwanaga, Joe|
キーワード Anatomy Cadaver Trigeminal nerve Oral and maxillofacial Histology
発行日 2026-04-27
出版物タイトル Anatomy & Cell Biology
出版者 Korean Association of Anatomists
ISSN 2093-3665
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2026. Anatomy & Cell Biology
論文のバージョン publisher
PubMed ID 42036147
DOI 10.5115/acb.25.150
関連URL isVersionOf https://doi.org/10.5115/acb.25.150
著者 Morihara, Ryuta| Nomura, Emi| Osakada, Yosuke| Yunoki, Taijun| Takemoto, Mami| Yamashita, Toru| Ishiura, Hiroyuki|
キーワード Corticobasal degeneration CBD Corticobasal syndrome CBS Armstrong's criteria
備考 © 2026 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.|
発行日 2026-04
出版物タイトル Parkinsonism & Related Disorders
145巻
出版者 Elsevier BV
開始ページ 108229
ISSN 1353-8020
NCID AA11054368
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2026 Published by Elsevier Ltd.
論文のバージョン author
PubMed ID 41671870
DOI 10.1016/j.parkreldis.2026.108229
Web of Science KeyUT 001689377900001
関連URL isVersionOf https://doi.org/10.1016/j.parkreldis.2026.108229
フルテキストURL fulltext.pdf
著者 Kitamura, Hiroshi| Matsushima, Noriaki| Sato, Misato|
キーワード Durable goods Exclusive supply chain Vertical relation Selling versus leasing
発行日 2026-07
出版物タイトル Transportation Research Part E: Logistics and Transportation Review
211巻
出版者 Elsevier BV
開始ページ 104882
ISSN 1366-5545
NCID AA11125309
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 © 2026 The Author(s).
論文のバージョン publisher
DOI 10.1016/j.tre.2026.104882
関連URL isVersionOf https://doi.org/10.1016/j.tre.2026.104882
JaLCDOI 10.18926/AMO/70457
フルテキストURL 80_2_147.pdf
著者 Sakamoto, Shinya| Tabuchi, Motoyasu| Hamada, Akira| Yoshimatsu, Rika| Saisaka, Yuichi| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro|
抄録 Common bile duct (CBD) injury after blunt abdominal trauma is rare and difficult to diagnose. Delayed recognition leads to severe morbidity. A 70-year-old Japanese man was admitted after sustaining blunt abdominal trauma. Ultrasonography revealed intra-abdominal fluid, suggesting bleeding. Contrast-enhanced computed tomography revealed pancreatic head injury, intra-abdominal bleeding, and pseudoaneurysm of the anterior superior pancreatoduodenal artery (ASPDA). Bile duct injury was not evident. The application of transarterial embolization (TAE) controlled the bleeding. Canulation into the pancreatic or biliary duct was not possible during endoscopic retrograde cholangiopancreatography. An emergency laparotomy revealed severe pancreatic head and extrahepatic bile duct injuries. Pancreaticoduodenectomy/Child reconstruction was performed. Complete CBD transection was confirmed. The patient was ultimately discharged without complications. Early recognition, timely surgical management, and intensive care are essential for favorable outcomes in patients who have sustained abdominal trauma.
キーワード blunt abdominal trauma intensive care emergency laparotomy pancreatoduodenectomy
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2026-04
80巻
2号
出版者 Okayama University Medical School
開始ページ 147
終了ページ 152
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン publisher
査読 有り
レファレンス Zago TM, Pereira BMT, Calderan TRA, Hirano ES and Fraga GP: Extrahepatic duct injury in blunt trauma: two case reports and a literature review. Indian J Surg (2014) 76: 303-307.| Feliciano DV: Biliary injuries as a result of blunt and penetrating trauma. Surg Clin North Am (1994) 74: 897-907.| Balzarotti R, Cimbanassi S, Chiara O, Zabbialini G and Smadja C: Isolated extrahepatic bile duct rupture: a rare consequence of blunt abdominal trauma. Case report and review of the literature. World J Emerg Surg (2012) 7: 16.| Ishida T, Hayashi E, Tojima Y and Sakakibara M: Rupture of the common bile duct due to blunt trauma, presenting difficulty in diagnosis. BMJ Case Rep (2018) 11: e227400.| Ghosh S, Kazi FN and Sharma JVP: Extrahepatic bile duct injury caused by blunt abdomen trauma: a case report. Cureus (2022) 14: e25748.| Sanford Z, Abdolmaali K, Robinson D and Denning D: Blunt trauma: an uncommon cause of common bile duct injury. Trauma Case Rep (2015) 1: 44-48.| Zakaria HM, Oteem A, Gaballa NK, Hegazy O, Nada A, Zakareya T, Omar H, Abdelkawy H, Abdeldayem H and Gad EH: Risk factors and management of different types of biliary injuries in blunt abdominal trauma: single-center retrospective cohort study. Ann Med Surg (Lond) (2020) 52: 36-43.| Agarwal H, Gupta A and Kumar S: An overview of Pancreatic Trauma. J Pancreatol (2020) 3: 139-146.| Iacono C, Zicari M, Conci S, Valdegamberi A, De Angelis M, Pedrazzani C, Ruzzenente A and Guglielmi A: Management of pancreatic trauma: a pancreatic surgeonʼs point of view. Pancreatology (2016) 16: 302-308.| Krige JE, Nicol AJ and Navsaria PH: Emergency pancreatoduodenectomy for complex injuries of the pancreas and duodenum. HPB (Oxford) (2014) 16: 1043-1049.| Leppäniemi A, Tolonen M, Tarasconi A, Segovia-Lohse H, Gamberini E, Kirkpatrick AW, Ball CG, Parry N, Sartelli M, Wolbrink D, van Goor H, Baiocchi G, Ansaloni L, Biffl W, Coccolini F, Di Saverio S, Kluger Y, Moore E and Catena F: 2019 WSES guidelines for the management of severe acute pancreatitis. World J Emerg Surg (2019) 14: 27.| Turan ÖF, Çankaya Gökdere D, Genç M, Bulut B, Akkanöz M, Mutlu H and Yazıcı R: Predictive factors of mortality in patients with abdominal trauma. Ulus Travma Acil Cerrahi Derg (2025) 31: 276-282.| van der Wilden GM, Yeh D, Hwabejire JO, Klein EN, Fagenholz PJ, King DR, de Moya MA, Chang Y and Velmahos GC: Trauma Whipple: do or donʼt after severe pancreaticoduodenal injuries? An analysis of the national trauma data bank (NTDB). World J Surg (2014) 38: 335-340.| Ylimartimo AT, Koskela M, Lahtinen S, Kaakinen T, Vakkala M and Liisanantti J: Outcomes in patients requiring intensive care unit (ICU) admission after emergency laparotomy: a retrospective study. Acta Anaesthesiol Scand (2022) 66: 954-960.|
JaLCDOI 10.18926/AMO/70456
フルテキストURL 80_2_141.pdf
著者 Sakamoto-Tokunaga, Moe| Katsuyama, Takayuki| Matoba, Masaki| Tamura, Tomokazu| Kubota, Natsuki| Terajima, Yuya| Shidahara, Kenta| Hirose, Kei| Matsumoto, Kazuya| Nawachi, Shoichi| Nakadoi, Takato| Katayama, Yu| Hayashi, Keigo| Miyawaki, Yoshia| Katsuyama, Eri| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Tsuji, Shuma| Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Wada, Jun|
抄録 VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.
キーワード necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence
Amo Type Case Report
出版物タイトル Acta Medica Okayama
発行日 2026-04
80巻
2号
出版者 Okayama University Medical School
開始ページ 141
終了ページ 145
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン publisher
査読 有り
JaLCDOI 10.18926/AMO/70453
フルテキストURL 80_2_109.pdf
著者 Sonoi, Mika| Sonoi, Norihiro| Koyama, Yoko|
抄録 This study examined the effects of interprofessional education (IPE) on dietetics students during clinical training, focusing on changes in their attitudes toward IPE and their fundamental competencies. Eighty third-year female students (mean age, 21.0 years) at a Japanese women’s university participated. Self-administered surveys were conducted before and after clinical training to assess attitudes toward IPE using the Readiness for Interprofessional Learning Scale (RIPLS) and the Shakaijin Kisoryoku (SKL; Fundamental Competencies for Working Persons) scale. Quantitative data were analyzed using paired t-tests, chi-squared tests, and cluster analyses. Qualitative data from open-ended responses were analyzed thematically. RIPLS and SKL scores increased significantly, from 65.3 to 68.9, and from 28. 4 to 33. 2, respectively (p<0.001). All 12 SKL items showed significant improvement. In free responses, “initiative” (66 mentions), “communication” (10), and “execution” (8) were the most frequently cited as improved competencies. Cluster analysis identified three groups: increasing scores (n=25), high baseline (n=30), and minimal change (n=25). No significant correlation was found between changes in RIPLS and SKL scores (r=−0.108, p=0.355). IPE integrated into clinical training may enhance dietetics students’ attitudes toward interprofessional collaboration and contribute to the development of professional identity. Individualized, phased IPE implementation is recommended to accommodate differences in learner readiness.
キーワード interprofessional education dietetics students clinical training professional competencies transformative learning
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2026-04
80巻
2号
出版者 Okayama University Medical School
開始ページ 109
終了ページ 117
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン publisher
査読 有り
JaLCDOI 10.18926/AMO/70452
フルテキストURL 80_2_099.pdf
著者 Nguyen Trung Thanh| Nakamichi, Ryo| Shimamura, Yasunori| Saito, Taichi| Ishihara, Takeshi| Furutani, Tomoki| Shitozawa, Hisakazu| Noda, Tomoyuki| Ozaki, Toshifumi|
抄録 Although the performance of minimally invasive plate osteosynthesis (MIPO) via the anteroinferior approach is increasingly adopted for midshaft clavicle fractures, the influence of fracture morphology on clinical outcomes under a standardized protocol is unclear. We retrospectively analyzed the cases of 54 patients who underwent anteroinferior MIPO for an acute midshaft clavicle fracture (AO/OTA types B1, B2, B3) performed by a single surgeon across three affiliated institutions (2009-2022). We evaluated the clinical outcomes, i.e., the surgical time, incision length, radiographic union, reduction accuracy, range of motion, pain (visual analog scale [VAS]), and complications and compared them among the three AO/OTA subtypes. The mean incision length (3.4 cm) and surgical time (71-79 min) were similar among the groups (both p>0.2). All fractures achieved radiographic union at a mean of 3.5 months. Postoperative alignment and clavicular length were maintained (length reduction −1.0±2.2 mm [B1], −0.5±2.0 mm [B2], −0.6±1.8 mm [B3]; p=0.825; angulation −0.8±3.4°, −1.1±3.1°, −0.3±3.3°; p=0.888). At 3 months, shoulder elevation and abduction were 169°-175° (p=0.079) and 164°-175° (p=0.324). Pain was minimal (100-mm VAS: ≤1 mm; p=0.782). One plate-fatigue failure occurred; no supraclavicular-nerve symptoms were recorded. Anteroinferior MIPO yielded consistent outcomes across AO/OTA types, with excellent union rates, functional recovery, and few complications, indicating that this technique is safe and reproducible for the surgical management of midshaft clavicle fractures.
キーワード clavicle fracture minimally invasive plate osteosynthesis anteroinferior plating AO/OTA classification
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2026-04
80巻
2号
出版者 Okayama University Medical School
開始ページ 99
終了ページ 107
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン publisher
査読 有り
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JaLCDOI 10.18926/AMO/70451
フルテキストURL 80_2_085.pdf
著者 Shiba, Takahiko| Takamori, Mitsuhito| Katagiri, Sayaka| Kobayashi, Ryota| Kawauchi, Aki| Ohsugi, Yujin| Lin, Peiya| Ekuni, Daisuke| Egusa, Masahiko| Iwata, Takanori| Maeda, Shigeru|
抄録 Individuals with Down syndrome (DS) are more susceptible to periodontal disease; however, microbial changes following treatment remain insufficiently understood. This study evaluated the effects of nonsurgical periodontal therapy on clinical outcomes and oral microbiome dynamics in 6 patients with DS using 16S rRNA gene amplicon sequencing. Bacterial diversity, composition, network structure, and predicted functional pathways were analyzed using dental plaque samples. Bleeding on probing decreased significantly (p=0.047) after treatment, with a trend toward reduction in periodontal inflamed surface area (p=0.05). The abundance of Fusobacteria at the class level decreased significantly after treatment. The abundance of Mogibacterium timidum was higher in the pretreatment group than in the posttreatment group. M. timidum was positively correlated with Treponema denticola and associated with multiple bacterial taxa in the network during pretreatment. Predicted functional pathways related to aromatic compound degradation were more abundant in posttreatment samples than in pretreatment samples. An increase in the abundance of Fusobacterium and the positive correlation between T. denticola and M. timidum, together with their associations with other periodontal pathogens before treatment, may contribute to the development of periodontitis in individuals with DS. Nonsurgical periodontal therapy produces measurable clinical improvement and promotes microbial shifts in patients with DS.
キーワード Down Syndrome 16S rRNA Gene Amplicon Sequencing periodontitis nonsurgical periodontal treatment oral microbiome
Amo Type Original Article
出版物タイトル Acta Medica Okayama
発行日 2026-04
80巻
2号
出版者 Okayama University Medical School
開始ページ 85
終了ページ 97
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 英語
著作権者 Copyright Ⓒ 2026 by Okayama University Medical School
論文のバージョン publisher
査読 有り
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フルテキストURL fulltext20260414-01.pdf
著者 Hara, Hideaki| Miyamoto, Yuki| Han, Junseok| Omoto, Riku| Imai, Yasutaka| Yoshimi, Akihiro| Yoshimura, Koji| Yoshimura, Motohiko| Sasao, Noboru|
備考 This is an Accepted Manuscript of an article published by American Physical Society.|
発行日 2026-04-08
出版物タイトル Physical Review A
113巻
4号
出版者 American Physical Society (APS)
開始ページ 043713
ISSN 2469-9926
NCID AA10764867
資料タイプ 学術雑誌論文
言語 英語
OAI-PMH Set 岡山大学
著作権者 ©2026 American Physical Society
論文のバージョン author
DOI 10.1103/fvvx-wtyd
関連URL isVersionOf https://doi.org/10.1103/fvvx-wtyd